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国际医学放射学杂志 2019年第5期 630-631页

作者： j.s.Bae s.H.Kim B.Y.Hur W.Chang j.Park H.E.Park 刘畅 Department of Radiology Seoul National University Hospital

摘要目的本研究旨在与病理学比较,确定MRI评估直肠癌壁外静脉侵犯(EMVI)的预后价值;评估多个观察者间诊断性能。方法本研究回顾性分析2007年—2016年期

关键词： MRI 预后价值放射科医师直肠癌

Treg cells in pancreatic lymph nodes： the possible role in diabetogenesis and βcell regeneration in a TID model

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Cellular & Molecular Immunology 2012年第6期9卷 455-463页

作者： Benjamin K Nti janet L Markman suzanne Bertera Alexis j styche Robert j Lakomy Vladimir M subbotin Massimo Trucco Tatiana D Zorina Indiana University school of Medicine Indianapolis IN USA Cedars-sinai Medical Center Los Angeles CA USA Division of Irnmunogenetics Children's Hospital of Pittsburgh University of Pittsburgh School of Medicine Pittsburgh PA USA Independent investigator 602 samuel Dr. Madison Wl USA Department of Bioscience Technologies Jefferson School of Health Professions Thomas Jefferson University Philadelphia PA USA

Previously, we established a model in which physiologically adequate function of the autologous β cells was recovered in non-obese diabetic （NOD） mice after the onset of hyperglycemia by rendering them hemopoietic chimera. These mice were termed antea-diabetic. In the current study, we addressed the role of T regulatory （Treg） cells in the mechanisms mediating the restoration of euglycemia in the antea-diabetic NOD model. The data generated in this study demonstrated that the numbers of Treg cells were decreased in unmanipulated NOD mice, with the most profound deficiency detected in the pancreatic lymph nodes （PLNs）. The impaired retention of the Treg cells in the PLNs correlated with the locally compromised profile of the chemokines involved in their trafficking, with the most prominent decrease observed in sDF-1. The amelioration of autoimmunity and restoration of euglycemia observed in the antea-diabetic mice was associated with restoration of the Treg cell population in the PLNs. These data indicate that the function of the sDF-1/CXCR4 axis and the retention of Treg cells in the PLNs have a potential role in diabetogenesis and in the amelioration of autoimmunity and β cell regeneration in the antea-diabetic model. We have demonstrated in the antea-diabetic mouse model that lifelong recovery of the β cells has a strong correlation with normalization of the Treg cell population in the PLNs. This finding offers new opportunities for testing the immunomodulatory regimens that promote accumulation of Treg cells in the PLNs as a therapeutic approach for type 1 diabetes （TID）.

关键词： β cell regeneration T regulatory cell trafficking type 1 diabetes

Does disturbance regime change community assembly of angiosperm plant communities in the boreal forest?

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journal of Plant Ecology 2014年第2期7卷 188-201页

作者： jian Zhang stephen j.Mayor Fangliang He Department of Renewable Resources University of AlbertaEdmontonAlberta T6G 2H1Canada Department of Biological science University of AlbertaEdmontonAlberta T6G 2E9Canada

Aims To examine if and how species and phylogenetic diversity change in relation to disturbance,we conducted a review of ecological literature by testing the consistency of the relationship between phylogenetic diversity and disturbance and compared taxonomic groups,type of disturbance and ecosystem/habitat *** provide a case study of the phylogenetic diversity–disturbance relationship in angiosperm plant communities of a boreal forest region,compared with types of natural and anthropogenic disturbances and plant growth *** Using a large-scale sampling plot network along a complete(0–100%)anthropogenic disturbance gradient in the boreal biome,we compared the changes of angiosperm plant community structure and composition across *** estimated natural disturbance with historical records of major *** then calculated phylogenetic diversity indexes and determined species richness in order to compare linear and polynomial trends along disturbance *** also compared the changes of community structure for different types of anthropogenic disturbances and examined how the relationships between species and phylogenetic diversity and disturbance regimes vary among three different life forms(***,graminoids and woody plants).Important Findings Phylogenetic diversity was inconsistently related to disturbance in previous studies,regardless of taxon,disturbance type or ecosystem *** the understudied boreal ecosystem,angiosperm plant communities varied greatly in species richness and phylogenetic diversity along anthropogenic disturbance gradients and among different disturbance *** general,a quadratic curve described the relationship between species richness and anthropogenic disturbance,with the highest richness at intermediate anthropogenic disturbance ***,phylogenetic diversity was not related to disturbance in any consistent manner and species richness was not correlated with phylogenetic *** rel

关键词： community assembly community phylogenetics community structure biodiversity human disturbance phylogeny taiga

Estimating Pinus palustris tree diameter and stem volume from tree height,crown area and stand-level parameters

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journal of Forestry Research 2014年第1期25卷 43-52页

作者： C.A.Gonzalez-Benecke salvador A.Gezan Lisa j.samuelson Wendell P.Cropper Daniel j.Leduc Timothy A.Martin school of Forest Resources and Conservation P.O.Box 110410University of Florida school of Forestry and Wildlife sciences 3301SFWS BuildingAuburn University UsDA Forest service Southern Research StationAlexandria Forestry Center

Accurate and efficient estimation of forest growth and live biomass is a critical element in assessing potential responses to forest management and environmental change. The objective of this study was to develop models to predict longleaf pine tree diameter at breast height （dbh） and merchantable stem volume （V） using data obtained from field measurements. We used longleaf pine tree data from 3,376 planted trees on 127 permanent plots located in the U.s. Gulf Coastal Plain region to fit equations to predict dbh and V as functions of tree height （H） and crown area （CA）. Prediction of dbh as a function of H improved when CA was added as an additional independent variable. similarly, predic- tions of V based on H improved when CA was included. Incorporation of additional stand variables such as age, site index, dominant height, and stand density were also evaluated but resulted in only small improvements in model performance. For model testing we used data from planted and naturally-regenerated trees located inside and outside the geographic area used for model fitting. Our results suggest that the models are a robust alternative for dbh and V estimations when H and CA are known on planted stands with potential for naturally-regenerated stands, across a wide range of ages. We discuss the importance of these models for use with metrics derived from remote sensing data.

关键词： Longleaf pine diameter-height relationships crown area individual-tree stem volume growth and yield modeling

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Tailoring Microstructures and Mechanical Properties of AlCoCrFeNiTi0.3 High-entropy Alloys by Heat Treatment

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Tailoring Microstructures and Mechanical Properties of AlCoC...

MM5中尺度模式对一次冷锋天气系统模拟结果的评价

中国材料大会2012

作者： j.W.Qiao Y.F.Wang R.Q.Wang j.Y.shi s.B.sang H.j.Yang College of Materials science and Engineering Taiyuan University of Technology Research center of Advanced Materials science and Technology Taiyuan University of Technology MicroNano system Research Center Taiyuan University of Technology Research Institute of surface Engineering Taiyuan University of Technology

ISBN: (纸本)9783037856079

The microstructures and mechanical properties of AlCoCrFeNi0.3 high-entropy alloys （HEAs） are tailored through heat treatment. During heat treatment, the dendrite phase with a body-centered-cubic （bcc） structure transformed into the interdendrite phase with a bcc structure. Due to the element accumulation with higher hardness in the interdendrites and the increase of volume fraction of interdendrites, the average hardness of AlCoCrFeNi0.3 HEAs increased with the heat-treatment temperature, and the highest hardness was 625 HV. After 500 ℃ heat treatment, the optimized mechanical properties under quasi-static compression were achieved, and the yielding strength and fracture plasticity were 2.30 GPa and 9 %, respectively. Upon dynamic loading, the mechanical properties of HEAs were greatly enhanced.

关键词： High-entropy alloy Heat treatment Mechanical properties Dynamic loading

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中山大学学报（自然科学版） 2007年第6期46卷 114-119页

作者：唐灵林嘉仕詹杰民李毓湘中山大学应用力学与工程系广东广州510275 香港理工大学土木及结构工程系

运用MM5模式对2001年3月6-9日华东和华南地区一次冷锋天气系统进行了模拟,模拟的冷锋向南推移进度比观测的锋面大概滞后2～4h。模拟的海平面气压场和观测结果基本吻合。香港3个站点的模拟近地风场在积分的第35～40h时间段的值比观测结... 详细信息

运用MM5模式对2001年3月6-9日华东和华南地区一次冷锋天气系统进行了模拟,模拟的冷锋向南推移进度比观测的锋面大概滞后2～4h。模拟的海平面气压场和观测结果基本吻合。香港3个站点的模拟近地风场在积分的第35～40h时间段的值比观测结果稍偏北、偏大,但总体趋势一致。模拟的相当位温场能较好反映此次冷锋线的位置及南移趋势。500和850hPa位势高度场及风场的模拟结果反映出这段时期华西北-华北高压带的增强、南移及华西南-华中一带低压区的逐渐减弱过程。低压槽在一定程度上对冷锋的南下提供动力上的支持,冷锋的南下加速了低压槽的消散进程。

关键词：中尺度模式数值模拟冷锋低压槽

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Plant responses to simulated warming and drought:a comparative study of functional plasticity between congeneric mid and high elevation species

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journal of Plant Ecology 2018年第3期11卷 364-374页

作者： Elena Hamann Halil Kesselring jürg stöcklin Botanical Institute Department of Environmental SciencesSection Plant EcologyUniversity of BaselSchönbeinstrasse 64056 BaselSwitzerland

Aims Effects of climate change,especially changes in temperatures and precipitation patterns,are particularly pronounced in alpine *** response,plants may exhibit phenotypic plasticity in key functional traits allowing short-term adjustment to novel ***,little is known about the degree of pheno-typic plasticity of high elevation species relative to mid elevation *** We transplanted 14 herbaceous perennial species from high eleva-tion into two common gardens(1050 and 2000 m.a.s.l.)in the swiss Alps,and we examined plastic responses in key functional traits to changes in temperature and soil water *** design was replicated with 14 congeneric species from mid elevation to assess if the degree of phenotypic plasticity differs between mid and high elevation *** was assessed across two growing seasons,while aboveground biomass and specific leaf area(sLA)were measured after the first growing season,and biomass alloca-tion to belowground and reproductive structures after the ***,a phenotypic plasticity index was calculated for the func-tional traits to compare the degree of plasticity between mid and high elevation *** Findings Aboveground biomass was higher in mid elevation species relative to high elevation congeners in all treatments,yet decreased for both with elevation and ***,sLA decreased with elevation and *** mass fraction(RMF)was generally higher in high ele-vation species,and decreased with drought at the lower *** increased the allocation to reproductive structures,especially when plants were grown at their elevation of ***,no differ-ence was found in the degree of phenotypic plasticity averaged across mid and high elevation species for any of the studied functional *** results indicate that phenotypic plasticity in the focal traits did not depend on the elevation of origin of the *** was not related to

关键词： biomass allocation common garden climate change perennial herbaceous species phenotypic plasticity sLA swiss Alps transplant experiment

Deterioration of Early Holocene coral reef due to sea level rise along west coast of India:Benthic foraminiferal testimony

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Geoscience Frontiers 2012年第5期3卷 697-705页

作者： Abhijit Mazumder Rajiv Nigam Pravin j.Henriques Birbal sahni Institute of Palaeobotany 53 University RoadLucknow 226 007India National Institute of Oceanography Dona PaulaGoa 403 004India Department St.Xavier's CollegeMahapalika MargMumbai 400 001India

A total of 103 surface sediment samples collected from the water depth range of 15-3300 m along Vijaydurg-Karwar stretch of central west coast of India were analyzed for foraminiferal content. Relict benthic foraminiferal assemblage was noted within 50--135 m water depth. The relict benthic foraminiferal assemblage that includes Amphistegina, Operculina and Alveolinella in sediment samples within the water depth of 85-- 135 m indicates presence of coral reef at this depth during Early Holocene. The presence of barnacle fouling on Relict foraminifera at 60--90 m confirms the paleo-shoreline. The shallow depth zone is characterized by presence of agglutinated relict foraminifera. The agglutinated forms indicate freshwater influx, which eventually increased the sea level and subsequently deteriorated the paleo-coral reef.

关键词： Relict benthicforaminifera Early Holocene coral reefPaleo-shoreline West coast of India sea level rise

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Uncommon complications of biliary stones

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Open journal of Internal Medicine 2012年第1期2卷 19-26页

作者： s. janssen I. van Mierlo L. P. L. Gilissen s. W. Nienhuijs j. Heemskerk Department of Gastroenterology and Hepatology Catharina Hospital Eindhoven The Netherlands Department of surgery Catharina Hospital Eindhoven The Netherlands Department of surgery Laurentius Hospital Roermond The Netherlands

Gallstone disease has a high incidence, and most common presentations are well known and recognized. Particulalry in the elderly population though, uncommon presentations of gallstone disease are more frequent, and can easily be missed or misinterpreted. In this article we present 5 such patients with an atypical presentation of gallstone disease. We will then discuss atypical gallstone disease in more detail.

关键词： Gallstone Disease Gallstone Complications Elderly

Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation

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World journal of Gastroenterology 2014年第14期20卷 3751-3761页

作者： Chun seng Lee Elizabeth j Ryan Glen A Doherty Centre for Colorectal Disease St. Vincent’s University Hospital school of Medicine and Medical sciences University College Dublin

Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their *** chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further *** is a key factor behind gastrointestinal(GI)toxicity of *** chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic *** we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of *** into the inflammatory response activated during this process gained from various models of GI toxicity are *** inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient *** review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal ***,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed.

关键词： Chemotherapy Diarrhea side-effects Immunogenic cell death Pro-inflammatory cytokines