Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation

作     者：Chun Seng Lee Elizabeth J Ryan Glen A Doherty 

作者机构：Centre for Colorectal DiseaseSt. Vincent’s University Hospital School of Medicine and Medical SciencesUniversity College Dublin 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第14期

页      面：3751-3761页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by A Newman Fellowship awarded by the University College Dublin Foundation and sponsored by Helsinn-Birex Pharmaceuticals 

主　　题：Chemotherapy Diarrhea Side-effects Immunogenic cell death Pro-inflammatory cytokines 

摘      要：Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their *** chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further *** is a key factor behind gastrointestinal(GI)toxicity of *** chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic *** we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of *** into the inflammatory response activated during this process gained from various models of GI toxicity are *** inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient *** review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal ***,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed.