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journal of Animal science and Biotechnology 2019年第3期10卷 590-600页

作者： Barbara A.williams Deirdre Mikkelsen Bernadine M.Flanagan Michael j.Gidley The University of Queensland QAAFI Centre for Nutrition and Food SciencesSt. Lucia campus

This review describes dietary fibres originating from a range of foods,particularly in relation to their plant cell *** explores the categorization of dietary fibres into "soluble" or "insoluble".It also emphasizes dietary fibre fermentability,in terms of describing how the gastro-intestinal tract(GIT) microbiota respond to a selection of fibres from these *** is categorized into cereals,legumes,fruits and *** is also made of example whole foods and why differences in physico-chemical characteristics between "purified" and "non-purified"food components are important in terms of ***,recommendations are made as to how dietary fibre could be classified differently,in relation to its functionality in terms of fermentability,rather than only its solubility.

关键词： Cereal grains Dietary fibre Fruits Large intestinal fermentation Legumes Microbial activity Microbiota Plant cell walls short-chain fatty acids Vegetables

A Comprehensive Overview of skeletal Phenotypes Associated with Alterations in Wnt/β-catenin signaling in Humans and Mice

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Bone Research 2013年第1期1卷 27-71页

作者： Kevin A.Maupin Casey j.Droscha Bart O.williams Program for skeletal Pathobiology and Center for Tumor Metastasis Van Andel Research Institute333 Bostwick NEGrand RapidsMI 49503USA

The Wnt signaling pathway plays key roles in differentiation and development and alterations in this signaling pathway are causally associated with numerous human diseases. While several laboratories were examining roles for Wnt signaling in skeletal development during the 1990s, interest in the pathway rose exponentially when three key papers were published in 2001-2002. One report found that loss of the Wnt co-receptor, Low-density lipoprotein related protein-5 （LRPs）, was the underlying genetic cause of the syndrome Osteoporosis pseudoglioma （OPPG）. OPPG is characterized by early-onset osteoporosis causing increased susceptibility to debilitating fractures. shortly thereafter, two groups reported that individuals carrying a specific point mutation in LRP5 （G171V） develop high-bone mass. subsequent to this, the causative mechanisms for these observations heightened the need to understand the mechanisms by which Wnt signaling controlled bone development and homeostasis and encouraged significant investment from biotechnology and pharmaceutical companies to develop methods to activate Wnt signaling to increase bone mass to treat osteoporosis and other bone disease. In this review, we will briefly summarize the cellular mechanisms underlying Wnt signaling and discuss the observations related to OPPG and the high-bone mass disorders that heightened the appreciation of the role of Wnt signaling in normal bone development and homeostasis. We will then present a comprehensive overview of the core components of the pathway with an emphasis on the phenotypes associated with mice carrying genetically engineered mutations in these genes and clinical observations that further link alterations in the pathway to changes in human bone.

关键词： Wnt signaling mouse models Lrp5/Lrp6 -catenin skeletal phenotypes

Mice with a heterozygous Lrp6 deletion have impaired fracture healing

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Bone Research 2016年第2期4卷 101-109页

作者： Travis A Burgers juan F Vivanco juraj zahatnansky Andrew j Vander Moren james j Mason Bart O williams Center for Cancer and Cell Biology Program for Skeletal Disease and Tumor Microenvironment Van Andel Research Institute Grand Rapids MhUSA Faculfad de Ingenieria y Ciencias Adolfo Ib6fiez University Vifia del Mar Chile padnos College of Engineering and Computing Grand Valley State University Grand Rapids MI USA

Bone fracture non-unions, the failure of a fracture to heal, occur in 10%-20% of fractures and are a costly and debilitating clinical problem. The Wnt/fl-catenin pathway is critical in bone development and fracture healing. Polymorphisms of linking low-density lipoprotein receptor-related protein 6 （LRP6）, a Wnt-binding receptor, have been associated with decreased bone mineral density and fragility fractures, although this remains controversial. Mice with a homozygous deletion of Lrp6 have severe skeletal abnormalities and are not viable, whereas mice with a heterozygous deletion have a combinatory effect with Lrp5 to decrease bone mineral density. As fracture healing closely models embryonic skeletal development, we investigated the process of fracture healing in mice heterozygous for Lrp6 （Lrp6~/-） and hypothesized that the heterozygous deletion of Lrp6 would impair fracture healing. Mid-diaphyseal femur fractures were induced in Lrp6~^- mice and wild-type controls （Lrp6~/~）. Fractures were analyzed using micro-computed tomography （~CT） scans, biomechanical testing, and histological analysis. Lrp6~/- mice had significantly decreased stiffness and strength at 28 days post fracture （PF） and significantly decreased BV/TV, total density, immature bone density, and mature area within the callus on day-14 and -21 PF; they had significantly increased empty callus area at days 14 and 21 PF. Our results demonstrate that the heterozygous deletion of Lrp6 impairs fracture healing, which suggests that Lrp6 has a role in fracture healing.

关键词： bone Mice with a heterozygous Lrp6 deletion have impaired fracture healing

Economic efficiency in fish farming: hope for agro-allied industries in Niagara

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Chinese journal of Oceanology and Limnology 2008年第1期26卷 104-115页

作者： R.O.KAREEM A.O.DIPEOLU A.B.AROMOLARAN s.B.williams Obafemi Awolowo University Dept.of Agric Economics Ile-Ife Osun State Nigeria

The challenge to increase the efficiency in food production level in Nigeria appears to be more urgent now than it has ever been in the history of the country. This is in view of the rapidly increasing population, the imminent decline in international economic and food aid and the need to conserve foreign exchange earnings through the production of raw materials to feed the growing industrial sector calls for urgent attention. The study was carded out in Ogun state. The descriptive statistics was used to determine the socio-economic characteristics of the respondents. The stochastic frontiers production analysis was applied to estimate the technical, allocative efficiency and economic efficiency among the fish farmers in the state. The results of economic efficiency revealed that fish farming is economically efficient with a range of between 55% and 84% efficiency level suggesting a favourable hope for the agro-allied industry such as poultry and cottage industries etc in the state. The result of hypothesis of inefficiency sources models showed that years of experience of fish farmers is significant at 1% probability level indicating the factor contributing to the fish farming experience in the state. Thus, the efficiency is due to the fact that farmers are experienced and fairly educated. On the basis of findings, policy is suggested to be directed towards the encouragement of entrepreneurs in fish farming in the state by providing enabling environment like credit facilities, public enlightenment programme and provision of social amenities like feeder roads, pipe-born water etc and given the fact that an increase in the level of formal education variable leads to less inefficiency, government policy should be focused on adopting the best technology （e.g. fast growing species and equipment ） so as to improve the level of efficiency and investment which shall eventually lead to growth in output of fish fanning and a lead to the establishment of agro-allied industries

关键词： Agro-allied industry efficiency stochastic production frontier Niagara

Failed biliary cannulation: Clinical and technical outcomes after tertiary referral endoscopic retrograde cholangiopancreatography

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World journal of Gastroenterology 2011年第45期17卷 4993-4998页

作者： Michael P swan Michael j Bourke stephen j williams sina Alexander Alan Moss Rick Hope David Ruppin Department of Gastroenterology and Hepatology Westmead Hospital

AIM: Prospective evaluation of repeat endoscopic retrograde cholangiopancreatography (ERCP) for failed schutz grade 1 biliary cannulation in a high-volume center. METHODs: Prospective intention-to-treat analysis of patients referred for biliary cannulation following recent unsuccessful ERCP. REsULTs: Fifty-one patients (35 female; mean age: 62.5 years; age range: 40-87 years) with previous failed biliary cannulation were referred for repeat ERCP. The indication for ERCP was primarily choledocholithiasis (45%) or pancreatic malignancy (18%). successful biliary can- nulation was 100%. The precut needle knife sphincterotomy (NKs) rate was 27.4%. Complications occurred in 3.9% (post-ERCP pancreatitis). An identif iable reason for initial unsuccessful biliary cannulation was present in 55% of cases. Compared to a cohort of 940 nave pa-pilla patients (female 61%; mean age: 59.9 years; age range: 18-94 years) who required sphincterotomy over the same time period, there was no statistical difference in the cannulation success rate (100% vs 98%) or postERCP pancreatitis (3.1% vs 3.9%). Precut NKs use was more frequent (27.4% vs 12.7%) (P = 0.017). CONCLUsION: Referral to a high-volume center following unsuccessful ERCP is associated with high technical success, with a favorable complication rate, compared to routine ERCP procedures.

关键词： Failed endoscopic retrograde cholangiopancreatography Failed biliary cannulation Unsuccessful biliary cannulation Tertiary referral endoscopic retrograde cholangiopancreatography Needle knife sphincterotomy Biliary cannulation Precut sphincterotomy Post endoscopic retrograde cholangiopancreatography pancreatitis

Increased Light, Moderate, and severe Clear-Air Turbulence in Response to Climate Change

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Advances in Atmospheric sciences 2017年第5期34卷 576-586页

作者： Paul D. williams Department of Meteorology University of Reading Reading RG6 6BB United Kingdom

Anthropogenic climate change is expected to strengthen the vertical wind shears at aircraft cruising altitudes within the atmospheric jet streams. such a strengthening would increase the prevalence of the shear instabilities that generate clear-air turbulence. Climate modelling studies have indicated that the amount of moderate-or-greater clear-air turbulence on transatlantic flight routes in winter will increase significantly in future as the climate changes. However,the individual responses of light,moderate,and severe clear-air turbulence have not previously been studied,despite their importance for aircraft operations. Here,we use climate model simulations to analyse the transatlantic wintertime clear-air turbulence response to climate change in five aviation-relevant turbulence strength categories. We find that the probability distributions for an ensemble of 21 clear-air turbulence diagnostics generally gain probability in their right-hand tails when the atmospheric carbon dioxide concentration is doubled. By converting the diagnostics into eddy dissipation rates,we find that the ensembleaverage airspace volume containing light clear-air turbulence increases by 59%(with an intra-ensemble range of 43%–68%),light-to-moderate by 75%(39%–96%),moderate by 94%(37%–118%),moderate-to-severe by 127%(30%–170%),and severe by 149%(36%–188%). These results suggest that the prevalence of transatlantic wintertime clear-air turbulence will increase significantly in all aviation-relevant strength categories as the climate changes.

关键词： turbulence climate change aviation jet stream

Disparities in chiropractic utilization by race,ethnicity and socioeconomic status:A scoping review of the literature

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journal of Integrative Medicine 2023年第2期21卷 159-167页

作者： jordan A.Gliedt Antoinette L.spector Michael j.schneider joni williams staci Young Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Department of Rehabilitation sciences and Technology University of Wisconsin-MilwaukeeMilwaukeeWI 53201USA Department of Physical Therapy University of PittsburghPittsburghPA 15219USA Clinical and Translational science Institute University of PittsburghPittsburghPA 15213USA Department of Medicine Division of Internal MedicineMedical College of WisconsinMilwaukeeWI 53226USA Department of Family and Community Medicine Medical College of WisconsinMilwaukeeWI 53226USA

Background Chiropractic is the largest complementary and alternative medicine profession in the United states,with increasing global growth.A preliminary literature review suggests a lack of widespread diversity of chiropractic patient *** There have been no prior studies to comprehensively integrate the literature on chiropractic utilization rates by race,ethnicity,and socioeconomic *** purpose of this scoping review is to identify and describe the current state of knowledge of chiropractic utilization by race,ethnicity,education level,employment status,and income and poverty *** strategy systematic searches were conducted in PubMed,Ovid MEDLINE,Cumulative Index of Nursing and Allied Health Literature(CINAHL),Cochrane Database of systematic Reviews,and Index to Chiropractic Literature from inception to May *** criteria Articles that reported race or ethnicity,education level,employment status,income or poverty level variables and chiropractic utilization rates for adults(≥18 years of age)were eligible for this *** extraction and analysis Data extracted from articles were citation information,patient characteristics,race and ethnicity,education level,employment status,income and poverty level,and chiropractic utilization rate.A descriptive numerical summary of included studies is *** study provides a qualitative thematic narrative of chiropractic utilization with attention to race and ethnicity,education level,income and poverty level,and employment *** A total of 69 articles were eligible for *** articles were published since 2003 and reported data from study populations in the United *** the race,ethnicity and socioeconomic categories that were most commonly reported,chiropractic utilization was the highest for individuals identifying as European American/White/non-Hispanic White/Caucasian(median 20.00%;interquartile range 2.70%-64.60%),those with employment as a main income sourc

关键词： Chiropractic Utilization Health inequities Health disparities Low-back pain Neck pain

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira M.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Theoretical Analysis of the Fluctuation Theorem Applied to Electric Circuits

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Communications in Theoretical Physics 2014年第10期61卷 476-484页

作者： Charlotte F.Petersen Elmars Krausz Denis j.Evans stephen R.williams Research school of Chemistry Australian National UniversityCanberraACT 0200Australia

We carry out a theoretical analysis of the fluctuations in the johnson–Nyquist noise in an RC electric circuit being driven by a non-ideal constant current source. Using the appropriate Langevin equation, we derive the fluctuation theorem for the system. This analysis exhibits some interesting features. Firstly, the average of the dissipation function is not necessarily just an instantaneous entropy production, i.e. the work being done on the circuit by the external power source divided by the ambient temperature. secondly, by appropriate selection of the values for the circuit components,the transient response of the system can be made identical to the nonequilibrium steady state response. In the limit of an ideal current source, the average of the dissipation function reduces to the entropy production. Our analysis accurately reproduces published experimental results.

关键词： circuit analysis fluctuation theorems statistical machanics johnson noise

Extended Evolutionary Fast Learn-to-Walk Approach for Four-Legged Robots

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journal of Bionic Engineering 2007年第4期4卷 255-263页

作者： Muh. Anshar Mary-Anne williams Innovation and Technology Research Laboratory Faculty of Information Technology University of Technology Sydney City Campus 15 Broadway Ultimo NSW 2007 Australia

Robot locomotion is an active research area. In this paper we focus on the locomotion of quadruped robots. An effective walking gait of quadruped robots is mainly concerned with two key aspects, namely speed and stability. The large search space of potential parameter settings for leg joints means that hand tuning is not feasible in general. As a result walking parameters are typically determined using machine learning techniques. A major shortcoming of using machine learning techniques is the significant wear and tear of robots since many parameter combinations need to be evaluated before an optimal solution is found. This paper proposes a direct walking gait learning approach, which is specifically designed to reduce wear and tear of robot motors, joints and other hardware. In essence we provide an effective learning mechanism that leads to a solution in a faster convergence time than previous algorithms. The results demonstrate that the new learning algorithm obtains a faster convergence to the best solutions in a short run. This approach is significant in obtaining faster walking gaits which will be useful for a wide range of applications where speed and stability are important. Future work will extend our methods so that the faster convergence algorithm can be applied to a two legged humanoid and lead to less wear and tear whilst still developing a fast and stable gait.

关键词： legged-robots locomotion learning genetic convergence walking gaits