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Genes & Diseases 2022年第6期9卷 1506-1520页

作者： jon Christiansen Anne-Katrin Guttsches Ulrike Schara-Schmidt Matthias Vorgerd Christoph Heute Corinna Preusse Werner Stenzel Andreas roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e Universitatsmedizin Berlin Freie Universitat Berlin10117 BerlinGermany Humboldt-Universitat zu Berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s Hospital of Eastern Ontario research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MrI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LGMDr12 MMD3 Muscle inflammation Muscle MrI

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单个腺病毒颗粒的原子力显微镜液相成像及样品制备方法

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病毒学报 2015年第6期31卷 601-606页

作者：梁艳李晨 Mariska G M van rosmalen Gijs j L Wuite Wouter H roos 中国水产科学研究院黄海水产研究所青岛266071 阿姆斯特丹自由大学

原子力显微镜(Atomic force microscopy,AFM)作为一种纳米级高分辨率的探针扫描显微镜,在病毒形态学研究等领域有广泛的应用。为更好地利用AFM在接近病毒生理环境(液相)中观测单个病毒颗粒,选择合适的基底吸附病毒样品是重要的前提保障... 详细信息

原子力显微镜(Atomic force microscopy,AFM)作为一种纳米级高分辨率的探针扫描显微镜,在病毒形态学研究等领域有广泛的应用。为更好地利用AFM在接近病毒生理环境(液相)中观测单个病毒颗粒,选择合适的基底吸附病毒样品是重要的前提保障。本文介绍了一种病毒样品制备及AFM液相成像方法。首先制备疏水化处理的玻璃盖玻片作为吸附基底,再将观察样品腺病毒重组载体颗粒(Adenovirus type 5F35,Ad5F35)吸附于基底上,建立在液相下单个病毒颗粒的原子力显微镜成像方法。通过该方法获取了单个腺病毒颗粒在液相下的高分辨率纳米级高度图(height image),且病毒颗粒保持了约90nm的正确测量高度。实验结果表明疏水化处理的玻璃基底具有良好的吸附力,有助于病毒颗粒牢固地吸附在基底上,且不会引起较大的形变。本研究为AFM观测病毒等生物样品提供了一种较为合适的吸附基底和在液相中的AFM成像方法,对后期开展病毒形态结构、物理属性及其与宿主细胞受体相互作用的研究打下基础。

关键词：原子力显微镜液相成像样品制备腺病毒颗粒

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Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the Mr CLEAN registry

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Stroke & Vascular Neurology 2021年第4期6卷 572-580,I0037-I0048页

作者： Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart j Emmer Ivo G H jansen Maxim j H L Mulder robin Lemmens robert-jan B Goldhoorn Marieke j H Wermer jelis Boiten Geert j LycklamaàNijeholt Yvo B W E M roos Adriaan C G M van Es Hester F Lingsma Diederik W j Dippel Wim H van Zwam robert j van Oostenbrugge Ido r van den Wijngaard on behalf of the Mr CLEAN registry investigators Neurology Leiden University Medical CentreLeidenThe Netherlands Neurology Erasmus MCRotterdamThe Netherlands Public Health Erasmus MCRotterdamThe Netherlands Neurology Maastricht University Medical Centre+MaastrichtThe Netherlands radiology and Nuclear Medicine Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Neurology University Hospitals LeuvenLeuvenBelgium Neurosciences Experimental Neurology and Leuven Brain InstituteUniversity of LeuvenLeuvenBelgium VIB Center for Brain&Disease ResearchLaboratory of NeurobiologyLeuvenBelgium Neurology Haaglanden Medical CentreDen HaagThe Netherlands radiology Haaglanden Medical CentreDen HaagThe Netherlands Neurology Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands radiology Leiden University Medical CentreLeidenThe Netherlands radiology Maastricht University Medical Centre+MaastrichtThe Netherlands

Background randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen ***,outcomes after EVT in these late window patients without perfusion imaging are largely *** assessed their characteristics and outcomes in routine clinical *** The Multicenter randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and *** perfusion was no standard imaging *** used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified rankin Scale(mrS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous *** included 3-month mrS score,functional independence(defined as mrS 0-2),and *** Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQr 6.9-10.6),of whom 93(87.7%)had unknown time of stroke *** perfusion was not performed in 87/106(80.2%)late window *** window patients were younger(mean 67 vs 70 years,pr ASPECTS(median 8 vs 9,pr collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common Or for 1 point improvement in mrS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/C

关键词： treatment beyond registry

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Immunogenicity and reactogenicity of Vaccine Boosters after ***2.S Priming

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四川生理科学杂志 2021年第11期43卷 1861-1861页

作者： roos S G Sablerolles From the Departments of Internal Medicine (r.S.G.S. M.L.) Hospital Pharmacy (R.S.G.S. W.J.R.R. P.H.M.K.) and Viroscience (D.G. K.S.S. M.P.G.K. C.H.G. R.D.V.) and the Department of Internal Medicine Division of Allergy and Clinical Immunology and Department of Immunology (V.A.S.H.D.) Erasmus University Medical Center Rotterdam the Center of Tropical Medicine and Travel Medicine Department of Infectious Diseases (A.G. H.M.G.G.) and the Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection and Immunity University of Amsterdam (N.A.K.) Amsterdam the Department of Internal Medicine and Infectious Diseases (D.F.P.) and the Department of Medical Microbiology and Infection Prevention University Medical Center Groningen University of Groningen (A.L.W.H. D.B.) Groningen the Department of Infectious Diseases Leiden University Medical Center Leiden (L.G.V.) and the Center for Infectious Disease Control National Institute for Public Health and the Environment Bilthoven (D.B.) — all in the Netherlands.Dr. van der Kuy can be contacted at [email protected] or at the Department of Hospital Pharmacy Erasmus Medical Center Dr. Molewaterplein 40 3015 GD Rotterdam the Netherlands. A full list of the SWITCH Research Group investigators is provided in the Supplementary Appendix available at ***.

Background:The ***2.S vaccine,which was approved as a single-shot immunization regimen,has been shown to be effective against severe coronavirus disease ***,this vaccine induces lower severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)spike protein(S)-specific antibody levels than those induced by messenger rNA(mrNA)-based *** immunogenicity and reactogenicity of a homologous or heterologous booster in persons who have received an ***2.S priming dose are unclear.

关键词： vaccine acute respiratory

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Systolic and Diastolic Strain Measurements Show Left Ventricular Dysfunction in Women with Turner Syndrome

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Congenital Heart Disease 2021年第4期16卷 357-368页

作者： Allard T.van den Hoven Sultan Yilmazer Lidia r.Bons roderick W.jvan Grootel L.W.Geenen An M.van Berendoncks Anthonie L.Duijnhouwer Hans-Marc j.Siebelink jolien W.roos-Hesselink Annemien E.van den Bosch Department of Congenital Cardiology Erasmus MCRotterdamNetherlands Department of Cardiology Radboud University Medical CenterNijmegenNetherlands Department of Cardiology Leiden University Medical CenterRotterdamNetherlands

Aim:This study aimed to describe the systolic left ventricular global longitudinal strain(LvGLS)and left ventricular peak early diastolic strain rate(Sre)in adult women with Turner syndrome(TS)and to determine its relationship with exercise capacity and clinical ***:In this cross-sectional cohort study,consecutively included adult TS women underwent an electrocardiogram,transthoracic echocardiogram(TTE)and cardiopulmonary exercise test(CPET)on the same *** and Sre were measured using 2D speckle tracking analysis(STE)and compared with age-matched healthy female ***:Ninety-four adult women(age 36±13 years)with TS and 32 healthy age-matched female controls were *** with TS had a significantly impaired/reduced systolic LvGLS(–17.82±2.98%vs.–21.80±1.85%,pre(0.98±0.32 s-1 vs.1.27±0.19 s-1,p>0.001),compared to healthy female ***,TS women had reduced diastolic function as measured by conventional echocardiographic parameters:A higher A-wave(pr E/A-ratio(p=0.001),longer deceleration time(p=0.006),and a higher E/E’-ratio(preduced maximal workload(p=0.033),reduced oxygen uptake(preduced maximal heart rate(pring *** linear regression analysis revealed that Age,karyotype and QT-duration were significantly associated with Sre,but not with LvGLS,in the TS ***:Systolic and diastolic strain and exercise capacity were significantly reduced in TS women compared to healthy *** correlation between strain itself and exercise capacity could be demonstrated,but correlations with conventional TTE parameters and baseline characteristics were found.

关键词： Turnersyndrome speckletracking echocardiography strain exercise capacity

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两类新域上的Bergman核函数的显表达式

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中国科学（A辑） 2004年第3期34卷 283-303页

作者：殷慰萍卢克平 G.roos 首都师范大学数学系河南大学数学系 Nevski Prospekt 113/4-53 191024 St Petersburg Russian

在有界对称域上引入两类蛋型域,得到其上Bergman核函数的显表达式。作为辅助工具,利用著名的Selberg积分,计算有界对称域上一般范数(genericnorm)下复幂积分。推广了华罗庚的矩阵积分,得到不可约有界对称域的一个整系数或半整系数特殊... 详细信息

在有界对称域上引入两类蛋型域,得到其上Bergman核函数的显表达式。作为辅助工具,利用著名的Selberg积分,计算有界对称域上一般范数(genericnorm)下复幂积分。推广了华罗庚的矩阵积分,得到不可约有界对称域的一个整系数或半整系数特殊多项式。

关键词： Bergman核函数显表达式 Cartan域全纯自同构群有界对称域华积分 Selberg积分

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Cartan-Hartogs域的Khler-Einstein度量

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中国科学（A辑） 2006年第11期36卷 1201-1233页

作者：王安殷慰萍张利友 roos Guy 首都师范大学数学科学学院 Nevski prospekt 113/4-53 191024 St PetersburgRussian Federation

研究以不可约有界对称域Ω为底空间的一类Hartogs域(?)上的K(?)hler- Einstein度量,这种域称之为Cartan-Hartogs域,是华罗庚域的一种,其中K(?)hler- Einstein度量的生成函数满足一带有边界条件的复Monge-Ampère方程．一般地,域(?)是非... 详细信息

研究以不可约有界对称域Ω为底空间的一类Hartogs域(?)上的K(?)hler- Einstein度量,这种域称之为Cartan-Hartogs域,是华罗庚域的一种,其中K(?)hler- Einstein度量的生成函数满足一带有边界条件的复Monge-Ampère方程．一般地,域(?)是非齐性域,其上有一全纯自同构子群以及群不变轨道X∈[0,1[,因此可以把复Monge-Ampère方程化为常微分方程,并且此方程在临界值μ_0=μ时能够显式解出．临界值μ_0对于研究其他不变度量如Bergman度量也是非常有意义的．文中还给出一个猜想,并且证明了该猜想对于两类两类例外域是成立的．

关键词： Hartogs域 Kfihler—Einstein度量有界对称域例外域 Cartan—Hartogs域

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跨国产业供应链合作关键成功因素的实证研究——以中、德印刷产业为例

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管理工程学报 2013年第2期27卷 209-219页

作者：刁鸿珍李随成 Alexander roos 西安理工大学经济与管理学院陕西西安710048 斯图加特媒介大学德国斯图加特70569

通过国内外文献分析和深度访谈提取出了中、德印刷产业供应链合作的关键成功因素,在此基础上,分别从德方、中方和中德双方视角出发,运用探索性因素分析方法对关键成功因素进行实证研究,根据中、德双方认知的不同,关键成功因素分为一致... 详细信息

通过国内外文献分析和深度访谈提取出了中、德印刷产业供应链合作的关键成功因素,在此基础上,分别从德方、中方和中德双方视角出发,运用探索性因素分析方法对关键成功因素进行实证研究,根据中、德双方认知的不同,关键成功因素分为一致性因素和差异性因素,一致性因素是双方合作成功的基础,而差异性因素则是双方在合作中需要进一步适应和磨合的重点。

关键词：供应链合作跨国合作印刷产业关键成功因素

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