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Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats

Asian Pacific journal of Tropical Biomedicine 2023年第12期13卷 507-520,I0002,I0003页

作者： R.B.Daude Rajendra Bhadane j.S.Shah Department of Pharmacy Government PolytechnicJalgaon-425001MaharashtraIndia Structural Bioinformatics Laboratory Faculty of Science and EngineeringBiochemistryAbo Akademi UniversityFI-20520 TurkuFinland Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringPharmacyÅbo Akademi UniversityFI-20520 TurkuFinland Institute of Biomedicine Research Unit for Infection and ImmunityUniversity of TurkuFI-20520 TurkuFinland Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabad-382481GujratIndia

Objective:To investigate the renoprotective effects of luteolin on diabetes in ***:One week after administration of streptozotocin 55 mg/kg intraperitoneally,rats were given 25,50,and 75 mg/kg/day of luteolin orally for another eight *** the end of the experiment,body weight,blood glucose level,biochemical parameters for renal function(serum creatinine,blood urea nitrogen,uric acid,serum albumin,and total protein),kidney histology,matrix metalloproteinase(MMP)-2,MMP-9,and histone deacetylase 2(HDAC-2)expression,and malondialdehyde,myeloperoxidase,and hydroxyproline content in renal tissue were *** glucose-induced damage using NRK-52E cell line was studied to evaluate cell viability and metalloenzyme ***,in silico studies including docking and molecular dynamics simulations were ***:MMP-2,MMP-9,and HDAC-2 expressions were significantly increased in high glucose-induced NRK-52E cells and the renal tissue of diabetic ***,these changes were reversed by luteolin at the administered ***,luteolin significantly reduced oxidative stress,inflammation,and fibrosis,as well as improved biochemical parameters in diabetic ***,luteolin at the examined doses markedly alleviated diabetes-induced histopathological changes in renal ***:Luteolin effectively attenuates streptozotocin-induced diabetic nephropathy in rats by inhibiting MMP-2,MMP-9,and HDAC-2 expression,and reducing oxidative stress and inflammation.

关键词： MMPs HDAC-2 Luteolin NRK-52E Diabetic nephropathy Docking Molecular dynamic simulations

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Changes in soil fertility and microbial communities following cultivation of native grassland in Horqin Sandy Land,China:a 60-year chronosequence

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Ecological Processes 2023年第1期12卷 260-273页

作者： jiao Tang jinzhong Yin Anthony j.Davy Feifei Pan Renhui Miao Xu Han School of Resource and Environmental Sciences Henan Institute of Science and TechnologyXinxiang 453003China Henan Engineering Research Center of Biological Pesticide and Fertilizer Development and Synergistic Application Xinxiang 453003China School of Biological Sciences University of East AngliaNorwich Research ParkNorwich NR47TJUK School of Horticulture and Landscape Architecture Henan Institute of Science and TechnologyXinxiang 453003China School of Life Sciences Henan UniversityKaifeng 475004China Forestry College Beihua UniversityJilin 132013China

Background Grassland conversion to cropland is a prevailing change of land use in traditionally nomadic areas,especially in the Mongolian *** investigated the effects of grassland conversion followed by continuous cultivation on soil properties and microbial community characteristics in Horqin Sandy Land,a typical agro-pastoral transition zone of Northern *** samples were collected from the topsoil(upper 20 cm)across a 60-year cultivation chronosequence(5,15,25,35 and 60 years)and unconverted native *** physico-chemical properties were determined and high-throughput sequencing was used to assess microbial community diversity and *** Grassland cultivation resulted in changes to soil properties in both the short and longer ***,it significantly increased soil bulk density(BD),electrical conductivity(EC),soil total nitrogen(TN),available phosphorus(AP)and available potassium(AK)concentrations,while reducing soil water content(SWC)and soil organic carbon content(SOC).Over the next 35-55 years of continuous cultivation,the trend for most of these characteristics was of reversion towards values nearer to those of native grassland,except for SOC which remained highly *** of grassland substantially altered soil microbial communities at phylum level but there was no significant difference in microbialα-diversity between native grassland and any ***,soil bacterial and fungal community structures at phylum level in the croplands of all cultivation years were different from those in the native *** further revealed that bacterial and fungal structures in cropland tended to become more similar to native grassland after 15 and 25 years of cultivation,*** analysis indicated that SOC,EC and BD were primary determinants of microbial community composition and *** These findings suggest that agricultural cultivation of grassland has considerable effects

关键词： Grassland-cropland conversion Reclamation Soil properties Microbe Horqin Sandy Land

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Effects of resistance training performed to repetition failure or non-failure on muscular strength and hypertrophy:A systematic review and meta-analysis

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journal of Sport and Health Science 2022年第2期11卷 202-211页

作者： jozo Grgic Brad j.Schoenfeld john Orazem Filip Sabol Institute for Health and Sport(IHES) Victoria UniversityMelbourneVIC 3011Australia Department of Health Sciences Lehman CollegeBronxNY 10468USA School of Health Sciences Human Services and NursingLehman CollegeBronxNY 10468USA Fitness Academy Zagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia

Purpose:We aimed to perform a systematic review and meta-analysis of the effects of training to muscle failure or non-failure on muscular strength and ***:Meta-analyses of effect sizes(ESs)explored the effects of training to failure ***-failure on strength and *** meta-analyses explored potential moderating effects of variables such as training status(trained ***),training volume(volume equated *** non-equated),body region(upper ***),exercise selection(***-joint exercises(only for strength)),and study design(independent *** groups).Results:Fifteen studies were included in the *** studies included young adults as ***-analysis indicated no significant difference between the training conditions for muscular strength(ES=-0.09,95%confidence interval(95%CI):-0.22 to 0.05)and for hypertrophy(ES=0.22,95%CI:-0.11 to 0.55).Subgroup analyses that stratified the studies according to body region,exercise selection,or study design showed no significant differences between training *** studies that did not equate training volume between the groups,the analysis showed significant favoring of non-failure training on strength gains(ES=-0.32,95%CI:-0.57 to-0.07).In the subgroup analysis for resistance-trained individuals,the analysis showed a significant effect of training to failure for muscle hypertrophy(ES=0.15,95%CI:0.03-0.26).Conclusion:Training to muscle failure does not seem to be required for gains in strength and muscle ***,training in this manner does not seem to have detrimental effects on these adaptations,*** studies should be conducted among older adults and highly trained individuals to improve the generalizability of these findings.

关键词： IRM Cross-sectional area Data synthesis Muscle size

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Mutated trimeric RBD vaccines:a platform against variants of concern

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2038-2040页

作者： Belén Aparicio juan j.Lasarte Pablo Sarobe Programa de Inmunología e Inmunoterapia Centro de Investigación Médica Aplicada(CIMACCUN)Universidad de NavarraPamplona31008Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD) Pamplona31008Spain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplona31008Spain

He et *** reported in Nature Communications1 the development of a protein vaccine against SASR-CoV-2 Omicron variant consisting of a trimer of the spike protein receptor-binding domain(RBD)of the Delta variant fused to heptad-repeat sequences 1 and *** vaccine induced broad-spectrum neutralizing antibodies and fully protected mice and non-human primates against challenge with live Delta and Omicron virus.

关键词： vaccine vaccines

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Lagoonal carbonate deposition preceding rifting-related uplift:evidence from the Bartonian-Priabonian(Eocene)of the northwestern Gulf of Suez(Egypt)

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journal of Palaeogeography 2022年第1期11卷 8-30页

作者： Emad S.Sallam Dmitry A.Ruban A.j.(Tom)Van Loon Department of Geology Faculty of ScienceBen ha UniversityFarid Nad a Street 15Ben ha 13518Egypt K.G.Razumovsky Moscow State University of Technologies and Management(the First Cossack University) Zemlyanoy Val Street 73Moscow 109004Russia c College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

Sedimentary successions in the northwestern Gulf of Suez provide important clues to the understanding of the geological evolution of NE Africa during the middle and late *** study focuses on detailed facies analyses in order to characterize the depositional environments and system tracts of the Bartonian-Priabonian succession cropping out in this ***-Priabonian carbonate deposits in five stratigraphic sections constitute,from base to top,the Gebel Hof,Observatory,Sannur,Qurn,and Wadi Hof *** formations contain four local assemblage zones of larger benthic *** of litho-,bio-,and microfacies in the succession resulted in the recognition of 12 lithofacies *** lithofacies are represented by packages of lime-mudstones,wackestones,packstones,pack-to grainstones,grainstones,rudstones,boundstones and *** lithofacies have been grouped into four geneticallyrelated facies associations that represent,respectively,tidal flats/shallow subtidal,restricted-shelf/lagoonal,shoal bar,and outer-shelf lagoon/reefal depositional environments in a downslope shallow-marine inner-ramp *** vertical transitions of these facies associations,representing facies changes through time,imply fluctuations of the regional sea *** two peaks in the Bartonian correspond to well-known global eustatic sea-level rises;the pronounced Priabonian regression must be ascribed to the known global eustatic sea-level fall in combination with regional tectonic *** facies distribution suggests that the study area was located in the direct vicinity of some islands during the Bartonian-Priabonian.

关键词： Lagoonal facies Sea-level fluctuations Middle Eocene Late Eocene Eastern Desert

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作者： j.·布莱克(j. Black)

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Delivery of Micro RNAs by plant virus-based nanoparticles to functionally alter the osteogenic differentiation of human mesenchymal stem cells

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Chinese Chemical Letters 2023年第1期34卷 215-220页

作者： Fei Xue jeroen j.L.M.Cornelissen Quan Yuan Shuqin Cao State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Molecules&Materials MESA+Institute for NanotechnologyUniversity of TwenteEnschede AE 7500the Netherlands

Micro RNA-26a(miR-26a)has been verified to promote osteogenic differentiation of mesenchymal stem cells in recent *** main obstacles to its application in bone regeneration are instability in the physiological environment and low efficiency of cellular membrane *** overcome these problems,we constructed a novel plant virus gene delivery system based on Cowpea chlorotic mottle virus(CCMV).By encapsulating miR-26a with purified capsid protein(CP)dimers derived from CCMV,CPmiR-26a(CP26a)virus-like particles(VLPs)were ***26a retained a structure similar to the native CCMV and protected miR-26a from digestion with its exterior ***,CP26a featured similar cellular uptake efficiency,osteogenesis promotion ability,and better biocompatibility compared with Lipofectamine2000-miR-26a(lipo26a),which indicated a promising prospect for CCMV as a novel gene delivery system.

关键词： VLPs Cowpea chlorotic mottle virus Gene delivery MicroRNAs Osteogenesis

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Rat cardiomyocyte H9c2(2-1)-based sulforhodamine B assay as a promising in vitro method to assess the biological component of effluent toxicity

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journal of Environmental Sciences 2020年第10期32卷 163-170页

作者： Elsa T Rodrigues Susana F Nascimento Maria joao Moreno Paulo j Oliveira Miguel A Pardal University of Coimbra Centre for Functional EcologyDepartment of Life SciencesCalcada Martim de FreitasCoimbra 3000-456Portugal University of Coimbra Coimbra Chemistry CenterDepartment of ChemistryCoimbra 3004-535Portugal Centre for Neuroscience and Cell Biology Uniuersity of CoimbraUC BiotechBiocant ParkCantanhede 3060-197Portugal

The treatment of wastewaters is crucial to maintain the ecological status of receiving waters,and thereby guarantee the protection of aquatic life and human *** quality evaluation is conventionally based on physicochemical parameters,but increasing attention has been paid to integrate physicochemical and biological ***,the regulatory use of fish in biological testing methods has been subject to various ethical and cost concerns,and in vitro cell-based assays have thus become an important topic of ***,the present study intends:(a) to evaluate the efficiency of two different sample pre-concentration techniques (lyophilisation and solid phase extraction) to assess the toxicity of municipal effluents on rat cardiomyoblast H9c2(2-1) cells,and (b) maximizing the use of the effluent sample collected,to estimate the environmental condition of the receiving *** gathered results demonstrate that the H9c2(2-1) sulforhodamine B-based assay is an appropriate in vitro method to assess biological effluent toxicity,and the best results were attained by lyophilising the sample as *** to its response,the H9c2(2-1) cell line might be a possible alternative in vitro model for fish lethal testing to assess the toxicity of municipal *** physicochemical status of the sample suggests a high potential for eutrophication,and iron exceeded the permissible level for wastewater discharge,possibly due to the addition of ferric chloride for wastewater *** general,the levels of carbamazepine and sulfamethoxazole are higher than those reported for other countries,and both surpassed the aquatic protective values for long-term exposure.

关键词： Municipal wastewater treatment plant effluent Lyophilisation Solid phase extraction Cell-based assays H9c2(2-1)cell line SRB assay

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Training β relaxation to rejuvenate metallic glasses

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journal of Materials Science & Technology 2023年第27期158卷 53-62页

作者： L.T.Zhang Yun-jiang Wang Y.Yang j.C.Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Department of Mechanical Engineering College of EngineeringCity University of Hong KongTat Chee AvenueKowloon TongKowloonHong Kong SARChina Department of Materials Science and Engineering College of EngineeringCity University of Hong KongTat Chee AvenueKowloon TongKowloonHong Kong SARChina Innovation Center NPU-ChongqingChongqing 401135China

In the current work,we demonstrated that the rejuvenation of metallic glasses can be achieved through training theβrelaxation *** the increase in the training frequency,a transition from structural relaxation to rejuvenation can be *** rejuvenation treatment is unexpected due to it occurs at a relatively small cyclic strain of 0.2%.Rejuvenation is beneficial to increase the relaxation enthalpy and promotes the decoupling of theβrelaxation process andαrelaxation process.A cluster ofβrelaxation time curves are formulated to describe any energetic state between ultrastable and ultimately rejuvenated metallic *** addition,rejuvenation expands the distribution ofβrelaxation process,anelastic and viscoplastic components during the deformation process.

关键词： Metallic glass βrelaxation Rejuvenation Structural heterogeneity

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作者： j.·奥斯汀(j. Austen)

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