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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： livia la Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science letters 2025年第1期18卷 52-55页

作者： Ola M.johannessen Tor i.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. in general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic Minimum ice Climate

Creeping fat and gut microbiota in Crohn’s disease

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World journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello imbrizi Ellen CS De Oliveira luiz C Di Stasi ligia Y Sassaki Verum ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

in this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease inflammatory bowel disease

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

PT-symmetry berry phases,topology and PT-symmetry breaking

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Communications in Theoretical Physics 2020年第4期72卷 45-51页

作者： jinghui pi NingNing Sun Rong lü Department of Physics Tsinghua UniversityBeijing 100084China Frontier Science Center for Quantum information BeijingChina State Key laboratory of low-Dimensional Quantum Physics BeijingChina

We study the complex Berry phases in non-Hermitian systems with parity-and time-reversal(PT)*** investigate a kind of two-level system with PT *** find that the real part of the the complex Berry phases have two quantized values and they are equal to either 0 orΠ,which originates from the topology of the Hermitian *** also find that if we change the relative parameters of the Hamiltonian from the unbroken-PT-symmetry phase to the broken-PT-symmetry phase,the imaginary part of the complex Berry phases are divergent at the exceptional *** exhibit two concrete examples in this work,one is a two-level toys model,which has nontrivial Berry phases;the other is the generalized Su-Schrieffer-Heeger(SSH)model that has physical loss and gain in every *** results explicitly demonstrate the relation between complex Berry phases,topology and PT-symmetry breaking and enrich the field of the non-Hermitian physics.

关键词： PT symmetry Berry phases topology PT symmetry breaking

Management of lung cancer in the COViD-19 pandemic:a review

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journal of Cancer Metastasis and Treatment 2021年第1期7卷 145-157页

作者： Fernando Maroto piñeiro Carmen Trinidad lópez javier de la Fuente Aguado Department of internal Medicine Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain Radiology Service Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain.

Since its inception,the COViD-19 pandemic has affected health care as a *** patients in general and those suffering from lung cancer in particular are a vulnerable group because of their many intrinsic characteristics and care *** SARS-CoV-2(COViD-19)infection affects these patients regarding their risk of infection and outcome in this patient cohort is still to be *** this review,we tried to summarize our main concerns regarding COViD-19 in the context of cancer patients from a clinical and multidisciplinary *** types of lung cancer treatments(chemotherapy,radiation therapy and immunotherapy)may also influence the risk of infection and condition the patient´s risk of having a worse *** cancer patients require frequent radiologic study follow-ups,which may be affected by COViD-19 ***-19 related incidental radiologic findings can appear in routinely scheduled radiology tests,which may be difficult to *** cancer treatment induced pneumonitis may have similar radiologic features similar to those in acute SARS-CoV-2 pneumonia and lead to a wrong *** different health care needs,the requirement for continuous health care access and follow-ups,and the clinical traials in which this patient population might be enrrolled are all being affected by the current COViD-19 health *** COViD-19 pandemic has put health care providers and institutions in difficult situations and obliged them to face challenging ethical *** issues,in turn,have also affected the psychological well-being of health care workers.

关键词： COViD-19 cancer ethics CT thorax lung cancer cancer treatment chemotherapy immunotherapy

long-term quality-of-care score for predicting the occurrence of acute myocardial infarction in patients with type 2 diabetes mellitus

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World journal of Diabetes 2023年第7期14卷 1091-1102页

作者： pi-i li How-Ran Guo Department of Family Medicine Chi Mei Medical CenterTainan 710TaiwanChina Department of Pharmacy Chia Nan University of Pharmacy and ScienceTainan 717TaiwanChina Department of Environmental and Occupational Health College of MedicineNational Cheng Kung UniversityTainan 704TaiwanChina Department of Occupational and Environmental Medicine National Cheng Kung University HospitalTainan 704TaiwanChina

BACKGROUND Cardiovascular disease(CVD)is the leading cause of death globally,and diabetes mellitus(DM)is a well-established risk *** the risk factors for CVD,DM is a major modifiable *** the fatal CVD outcomes,acute myocardial infarction(AMi)is the most common cause of *** To develop a long-term quality-of-care score for predicting the occurrence of AMi among patients with type 2 DM on the basis of the hypothesis that good quality of care can reduce the risk of AMi in patients with *** Using Taiwan’s longitudinal Cohort of Diabetes Patients Database and the medical charts of a medical center,we identified incident patients diagnosed with type 2 DM from 1999 to 2003 and followed them until *** constructed a summary quality-of-care score(with values ranging from 0 to 8)with process indicators(frequencies of HbA1c and lipid profile testing and urine,foot and retinal examinations),intermediate outcome indicators(low-density lipoprotein,blood pressure and HbA1c),and co-morbidity of *** associations between the score and the incidence of AMi were evaluated using Cox regression *** A total of 7351 patients who had sufficient information to calculate the score were *** comparison with participants who had scores≤1,those with scores between 2 and 4 had a lower risk of developing AMi[adjusted hazard ratio(AHR)=0.71;95% confidence interval(95%Ci):0.55-0.90],and those with scores≥5 had an even lower risk(AHR=0.37;95%Ci:0.21-0.66).CONClUSiON Good quality of care can reduce the risk of AMi in patients with type 2 *** quality-of-care score developed in this study had a significant association with the risk of AMi and thus can be applied to guiding the care for these patients.

关键词： Acute myocardial infarction Cardiovascular disease Diabetes mellitus Quality-of-care Score

Fractional Moments of Automorphic l-Functions on Gl(m)

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Chinese Annals of Mathematics,Series B 2011年第4期32卷 631-642页

作者： Qinghua pi School of Mathematics Shandong University Jinan 250100 China.

let πr be an irreducible unitary cuspidal representation of Gl,^（AQ）, m ≥ 2. Assume that π is self-contragredient. The author gets upper and lower bounds of the same order for fractional moments of automorphic l-function l（s, π） on the critical line under Generalized Ramanujan Conjecture; the upper bound being conditionally subject to the truth of Generalized Riemann Hypothesis.

关键词： Moments Automorphic l-functions GRC