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二尖瓣和三尖瓣血流:应用回顾性瓣膜追踪3D速度编码MRI精确测量

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国际医学放射学杂志 2009年第1期32卷 71-71页

作者： j.j. Westenberg S.D. Roes N. Ajmone Marsan N.M. Binnendijk j. Doornbos j.j. bax 周丽娜 Department of Radiology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands

目的验证回顾性瓣膜追踪3D3个方向速度编码MRI对血流量的评估，并在健康志愿者和瓣膜返流病人中与传统2D单向速度编码MRI结果相比较。材料与方法病人和志愿者均知情同意，研究获得当地医学伦理委员会的批准。病人的数据随机选自2006... 详细信息

目的验证回顾性瓣膜追踪3D3个方向速度编码MRI对血流量的评估，并在健康志愿者和瓣膜返流病人中与传统2D单向速度编码MRI结果相比较。材料与方法病人和志愿者均知情同意，研究获得当地医学伦理委员会的批准。病人的数据随机选自2006年7月—2007年7月的MR研究数据库，为回顾性资料。3D3个方向速度编码MRI首先在体外验证，并与2D单向速度编码MRI进行比较。

关键词：速度编码瓣膜返流 MRI 血流量追踪三尖瓣二尖瓣医学伦理委员会

Impact of age on transcatheter aortic valve implantation outcomes：a comparison of patients aged≤ 80 years versus patients ＆gt; 80 years

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journal of Geriatric Cardiology 2016年第1期13卷 31-36页

作者： Frank van der Kley Philippe j van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen jeroen j bax Martin j Schalij Victoria Delgado Heart Lung Center Leiden University Medical Center Leiden the Netherlands

ObjectiveTo investigate the procedural outcomes and the long-term survival of patients undergoing transcatheter aortic valve implantation （TAVI） and compare study results of patients≤ 80 years and patients ＆gt; 80 years *** total of 240 patients treated with TAVI were divided into two groups according to age≤ 80 years （n = 105; 43.8%） and ＆gt; 80 years （n= 135; 56.2%）. The baseline characteristics and the pro-cedural outcomes were compared between these two groups of *** the exception of peripheral artery disease and hypercho-lesterolemia, which were more frequently observed in the older age group, baseline characteristics were comparable between groups. Complica-tion rates did not differ significantly between patients≤ 80 years and patients ＆gt; 80 years. There were no differences in 30-day mortality rates be-tween patients aged≤ 80 years and patients ＆gt; 80 years old （9.5%vs. 7.4%, respectively;P = 0.557）. After a median follow-up of 28 months （in-terquartile range： 16-42 months）, 50 （47.6%） patients aged≤ 80 years died compared to 57 （42%） deaths in the group of patients ＆gt; 80 years old （P= 0.404）.ConclusionThe results of the present single center study showed that age did not significantly impact the outcomes of TAVI.

关键词： Age Survival rate Transcatheter aortic valve implantation

Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： jean-Daniel Malcor Emma j.Hunter Natalia Davidenko Daniel V.bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

多巴酚丁胺应激超声心动描记术后的7年随访:性别对于预后的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 60-61页

作者： Biagini E. Elhendy A. bax j.j. 郝华

The aim of this study was to investigate the effects of gender on long-term prognosis of patients undergoing dobutamine stress echocardiography(DSE). Gender differences in the predictors of outcome among patients with known or suspected coronary artery disease undergoing DSE have not been adequately studied. We studied 2,276 men and 1,105 women with known or suspected coronary artery diseasewho underwent DSE. Followup events were cardiac death and nonfatal myocardial infarction(MI). Dobutamine stress echocardiography was normal in 687 men(30%)and 483 women(44%)(pjusting for stress echocardiographic abnormalities.

关键词：多巴酚丁胺超声心动描记术致命性心肌梗死心脏事件心脏性死亡超声心动图预后信息静息心率运动异常回归分析研究

在急性给予β阻断剂后的恢复阶段观察心室壁运动异常增强了多巴酚丁胺负荷超声心动图的灵敏性

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 32-33页

作者： Karagiannis S.E. bax j.j. Elhendy A. D. Poldermans 姜朝晖 Department of Cardiology Erasmus MC Rotterdam Netherlands Dr.

Dobutamine stress echocardiography(DSE) has a modest sensitivity for detecting single- vessel coronary artery disease(CAD). This study assessed the additional diagnostic value of new or worsening wall motion abnormalities during recovery after acute administration of β blockers. The study population consisted of 200 patients(mean 59± 11 years of age, 144 men), who underwent DSE. Images were acquired at rest, low dose, peak dose, and during recovery. Patients received intravenous metoprolol(1 to 5 mg/min). The dose was adjusted to achieve a recovery heart rate within a 10% range of heart rate at rest. Coronary angiography was performed within 2 months. Inducible new wall motion abnormalities were observed in 168 patients(84% ) at peak stress. An additional 14 patients(7% )developed new or worsening wall motion abnormalities during recovery. CAD was detected in 182 patients(86 had single- vessel CAD). Sensitivity, specificity, and accuracy of DSE were 88% , 65% , and 73% at peak stress and 97% , 65% , and 74% during recovery. Sensitivity was particularly higher during recovery than during peak stress in patients with single- vessel CAD(98% vs 81% , p< 0.001). In conclusion, assessment of wall motion abnormalities during the recovery phase after acute β blockade improves sensitivity of DSE, particularly in patients with single- vessel CAD.

关键词：多巴酚丁胺负荷超声心动图室壁运动异常 β阻断剂灵敏性恢复阶段急性单支血管病变 AD患者冠状动脉疾病冠状动脉造影

接受腹主动脉瘤或下肢旁路手术治疗的患者中血浆N末端B型利钠肽前体与术后心脏事件的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 36-37页

作者： Feringa H.H.H. bax j.j. Elhendy A. D. Poldermans 黄浙勇 Department of Anesthesiology Erasmus Medical College University Medical Center Rotterdam Netherlands Dr.

Postoperative cardiac events are related to myocardial ischemia and reduced left ventricular function. The utility of N-terminal pro-B-type natriuretic peptide(NT-pro-BNP) for preoperative cardiac risk evaluation has not been evaluated. The objective of this study was to assess whether plasma NT-pro-BNP predicts postoperative cardiac events in patients who undergo major vascular surgery in addition to clinical and dobutamine stress echocardiographic data. One hundred seventy consecutive patients scheduled for major noncardiac vascular surgery were prospectively evaluated by dobutamine stress echocardiographic andNT-pro-BNP measurements. Multivariable logistic regression analysis was performed to evaluate the predictors of cardiac death and nonfatal myocardial infarction during a follow-up of 30-days. Receiver-operating characteristic analysis was performed to determine the optimal cut-off value of NT-pro-BNP to predict outcome. Patients’mean age was 59±13 years, and 71%were men. The median NT-pro-BNP level was 110 pg/ml(interquartile range 42 to 389). Cardiac events occurred in 2 of 144 patients(1.4%) with NT-pro-BNPjusted odds ratio 52, 95%confidence interval 11 to 256, pjustment for cardiac risk factors and dobutamine stress echocardiographic results, NT-pro-BNP remained significantly associated with cardiac events(adjusted odds ratio 17, 95%confidence interval 3 to 106, p=0.002). In conclusion, in patients scheduled for major vascular surgery, elevated plasma NT-pro-BNP levels are independently associated with an increased risk for postoperative cardiac events. Further studies in a larger number of patients are required to confirm these findings.

关键词： B型利钠肽腹主动脉瘤心脏事件旁路手术负荷超声心动图多巴酚丁胺心脏性死亡非致死性左室功

窦性节律与慢性房颤患者对心脏再同步化治疗反应的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 54-55页

作者： Molhoek S.G. bax j.j. Bleeker G.B. 刘文秀 Dr. Department of Cardiology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden Netherlands

Cardiac resynchronization therapy(CRT) is a new therapeutic option for patients who have drug-refractory end-stage heart failure. Much information has been obtained from patients who have sinus rhythm, but the use of CRT in patients who have chronic atrial fibrillation(AF) has not been studied extensively. Accordingly, we evaluated the clinical response and long-term survival rate of CRT in patients who had heart failure and chronic AF, and the results were compared with those in patients who had sinus rhythm and who underwent CRT. Sixty patients who had end-stage heart failure(30 had sinus rhythm and 30 had chronic AF), New York Heart Association classes III to IV, left ventricular ejection fraction120 ms, and a left bundle branch block received a biventricular pacemaker. New York Heart Association class, Minnesota Quality of Life score, and 6-minutew-alking distance were evaluated at baseline and after 6 months of CRT. Longterm follow-up was ≤2 years. New York Heart Association class, Minnesota Quality of Life score, and 6-minute walking distance improved significantly in the 2 groups after 6 months of CRT. The number of nonresponders was greater among patients who had ***, the long-term survival rate was comparable between patients who had sinus rhythm and those who had AF. Patients who had AF demonstrated comparable benefit from CRT as those who had sinus rhythm.

关键词：慢性房颤心脏再同步化窦性节律左束支传导阻滞心脏协会射血分数窦性心律心功能双心室长期生存率

血管外科患者接受大剂量β受体阻断剂及严格心率控制治疗可减少心肌缺血及肌钙蛋白T释放

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 25-26页

作者： Feringa H.H.H. bax j.j. Boersma E. D. Poldermans 罗亮 Erasmus Medical Center University of Rotterdam Dr. Molewaterplein 40 3015 GD Rotterdam NetherlandsDr.

背景:尽管围术期使用了β受体阻断剂,但不良心脏事件仍时常发生。本研究旨在探讨使用较大剂量的β受体阻断剂以及严格心率控制与减少围术期心肌缺血、肌钙蛋白T释放及改善长期预后之间是否存在相互联系。方法和结果:在此观察性队列研究... 详细信息

背景:尽管围术期使用了β受体阻断剂,但不良心脏事件仍时常发生。本研究旨在探讨使用较大剂量的β受体阻断剂以及严格心率控制与减少围术期心肌缺血、肌钙蛋白T释放及改善长期预后之间是否存在相互联系。方法和结果:在此观察性队列研究中,272例血管外科患者接受心脏危险因素及β受体阻断剂使用情况的术前筛查。β受体阻断剂使用情况采用最大推荐治疗剂量的百分比来表示。

关键词： β受体阻断剂血管外科肌钙蛋白心率控制不良心脏事件队列研究观察性全因死亡导联心电图心

Characterization of a Liquid Crystal Stabilized Pharmaceutical Oil-in-Water Emulsion Optimized for Skin Delivery

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journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 207-217页

作者： Melinda j. Sutton David W. Osborne Kevin Dahl Victoria bax G. Alan Schick Department of Chemistry Missouri State University Springfield MO USA Dow Development Institute Petaluma CA USA KBI Biopharma Boulder CO USA

A moisturizing cream containing 25 wt% of an organic solvent, diethylene glycol monoethyl ether (DEGEE), is observed to be stabilized by an emulsifying wax blend of cetearyl alcohol, dicetyl phosphate, and ceteth-10 phosphate (tradename Crodafos CES). Polarized light microscopy indicates that the Crodafos CES helps to produce a liquid-crystal stabilized oil-in-water emulsion, which is physically stable for months under accelerated aging conditions and chemically stable over the full topical pH range of 3.5 to 9. Emulsion globule size in the cream is observed to be dependent on the degree of emulsifying wax neutralization, with the globule size decreasing with increasing cream pH. The superior solubilizing properties of DEGEE combined with the full pH range and liquid-crystal stabilizing properties of the Crodafos CES give this formulation the potential for a wide range of applications in the topical delivery of active pharmaceutical ingredients.

关键词： Pharmaceutical Emulsion Skin Delivery Liquid Crystal Stabilized Emulsion Polarized Light Microscopy Topical Formulation