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乳腺MRI术前评价:利用倾向评分对浸润性小叶癌病人术后预后的评估

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国际医学放射学杂志 2018年第4期 477-478页

作者： S.M.ha E.Y.chae j.h.cha h.h.Kim h.j.Shin W.j.Choi 李彦橙 Department of Radiology Research Institute of RadiologyAsan Medical CenterUniversity of Ulsan College of Medicine

目的利用倾向评分匹配法探讨乳腺浸润性小叶癌(ILC)病人术前乳腺MR成像与手术预后的关系,以确定MRI检查是否对乳腺癌ILC亚型有益。材料与方法 2005年1月—2016年12月期间接受手术的603例ILC病人,其中369例(61.2%)行乳腺MRI检查。本研究... 详细信息

目的利用倾向评分匹配法探讨乳腺浸润性小叶癌(ILC)病人术前乳腺MR成像与手术预后的关系,以确定MRI检查是否对乳腺癌ILC亚型有益。材料与方法 2005年1月—2016年12月期间接受手术的603例ILC病人,其中369例(61.2%)行乳腺MRI检查。本研究对MRI发现但乳腺钼靶和超声检查中未发现的病变进行统计,并分析术中因疾病情况作出的改变。在倾向评分匹配后,将196例病人分成MR组和非MR组,并平衡两组间与病人、肿瘤特征以及各种临床特征有关的17个可能的混杂变量。比较2组手术结果。结果 369例接受MRI检查的病人中,145例(39.3%)发现其他病变,这145例病人中有95例(65.5%)发现恶性病变。在369例病人中有94例(25.5%)因MRI检查结果而改变手术方式。根据病理结果显示,这94例病人中84例(89.4%)手术方式的变更是合理的。在倾向评分匹配分析中,与未进行乳腺MR成像病人相比,乳腺MRI检查与较低重复手术率相关(比值比,0.140;P<0.001)、初始乳腺切除术(比值比,0.876;P=0.528)和最终乳腺切除术(优势比,0.744;P=0.151)相关。结论 ILC病人术前乳腺MRI检查提高了乳腺恶性肿瘤的检出,在不增加乳腺切除率的同时可以显著降低重复手术的可能性。

关键词： MRI 浸润性小叶癌

≤35岁年轻女性乳腺癌病人术前MRI：采用倾向性评分分析对手术结果的益处

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国际医学放射学杂志 2021年第5期 596-596页

作者： A.R.Park E.Y.chae j.h.cha h.j.Shin W.j.Choi h.h.Kim 张俊杰

摘要术前MRI对于≤35岁年轻乳腺癌病人的作用尚存在争议。目的采用倾向评分(PS)分析来研究术前MRI的价值,以探讨≤35岁年轻乳腺癌病人术前MRI与手术结果

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术前乳腺MRI对35岁及以下女性乳腺癌生存结局的影响

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国际医学放射学杂志 2023年第4期 481-481页

作者： A.R.Park E.Y.chae h.j.Kim j.h.cha h.j.Shin W.j.Choi 刘俊彤

摘要术前MRI对35岁及以下乳腺癌病人长期生存结局的影响尚未确定。目的采用倾向评分匹配法评估术前乳腺MRI对35岁及以下乳腺癌病人无复发生存期（RFS）和总

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乳腺癌经保留皮肤乳腺切除术及横行腹直肌皮瓣乳房重建术后局部复发灶的临床和影像特征

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国际医学放射学杂志 2014年第6期 598-598页

作者： h.Yoo B.h.Kim h.h.Kim j.h.cha h.j.Shin T.j.Lee 周朝阳 Department of Radiology and Research Institute of Radiology University of UlsanCollege of MedicineAsan Medical Center86 Asanbyeongwon-gilSongpa-guSeoul 138-736South Korea

摘要目的评价经保留皮肤乳腺切除术(SSM)或保留乳晕皮肤乳腺切除术(NASSM)后行横行腹直肌皮瓣乳房重建术的乳腺癌病人其局部复发灶的临床和影像特征。方法

关键词：乳腺癌乳腺肿瘤腹直肌皮瓣乳房重建术切除术影像特征皮肤解剖部位

Enhanced thermoelectric performance of spark plasma sintered p-type Ca_(3-x)Y_(x)Co_(4)O_(9+δ)systems

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journal of Materials Science & Technology 2020年第20期52卷 212-222页

作者： j.S.cha D.h.Kim h.Y.hong K.Park Faculty of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul05006Republic of Korea

highly textured dense Ca3-xYxCo4 O9+δ(0≤x≤0.3)samples were fabricated by combining sol-gel process with spark plasma sintering(SPS).Y^3+substitution for Ca^2+simultaneously increased the Seebeck coefficient and reduced the thermal *** latter was attributed to the increase in lattice anharmonicity,structural distortion,and grain boundary area,which enhanced the phonon ***2.7Y0.3Co4 O9+δshowed the largest dimensionless figure-of-merit(ZT=0.194)at 1073 K because it had the largest Seebeck coefficient and the lowest thermal *** ZT value was 55%larger than that of undoped Ca3 Co4 O9(0.125 at 1073 K).Therefore,Y^3+substitution,sol-gel powder synthesis,and SPS are highly effective for enhancing the thermoelectric prope rties of Ca_(3)Co_(4)O_(9).

关键词： Electrical conductivity Ca_(3)Co_(4)O_(9) Thermoelectric properties Seebeck coefficient Thermal conductivity Spark plasma sintering

Recent progress on in situ characterizations of electrochemically intercalated transition metal dichalcogenides

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Nano Research 2019年第9期12卷 2126-2139页

作者： Sajad Yazdani Milad Yarali judy j. cha Department of Mechanical Engineering and Materials Science Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale University West CampusWest HavenCT 06516USA

Layered transition metal dichalcogenides(TMDCs)have been extensively studied owing to their unique physical and chemical *** van der Waals(vdW)interact!ons betwee n the stacki ng layers of TMDCs allow intercalati on of various species including mono vale nt alkali,divale nt alkaline earth and multivale nt metal ions,zero-vale nt transiti on metals,as well as orga nic molecules,all of which can drastically alter fun dame ntal properties of the *** urge to understa nd the phe nomena and the desire to exploit them for applicati ons have inspired a great deal of investigations.A large portion of the mystery has been unveiled over the past decade of intense research;however,many questions remain open and require further *** review is concerned with investigations on structural and electronic evolution of TMDCs drive n by electrochemically con trolled in tercalati ***,we aim to survey the rece nt adva nces and experime ntal platforms for mon itoring the in tercalati on processes in situ by utilizi ng nano *** additi on,several in quiries and prospects are outlined in a broader con text for future ave nues of studies.

关键词： transition metal dichalcogenides electrochemical intercalation in situ characterizations transmission electron microscopy(TEM) magnetotransport measurements

Leader-following consensus criteria for multi-agent systems with time-varying delays and switching interconnection topologies

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Chinese Physics B 2012年第11期21卷 144-153页

作者： M.j.Park O.M.Kwon ju h.Park S.M.Lee E.j.cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of MedicineChungbuk National University

We consider multi-agent systems with time-varying delays and switching interconnection topologies. By con- structing a suitable Lyapunov-Krasovskii functional and using the reciprocally convex approach, new delay-dependent consensus criteria for the systems are established in terms of linear matrix inequalities （LMIs）, which can be easily solved by using various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： consensus multi-agent systems time delay Lyapunov method

Synchronization criteria for coupled hopfield neural networks with time-varying delays

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Chinese Physics B 2011年第11期20卷 140-150页

This paper proposes new delay-dependent synchronization criteria for coupled hopfield neural networks with time-varying delays. By construction of a suitable Lyapunov Krasovskii＇s functional and use of Finsler＇s lemma, novel synchronization criteria for the networks are established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： hopfield neural networks coupling delay synchronization Lyapunov method

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus