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The potential role of fluids during regional granulitefacies dehydration in the lower crust

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Geoscience Frontiers 2012年第6期3卷 813-827页

作者： Daniel e.Harlov GeoForschungsZentrum Telegrafenberg D-14473 PotsdamGermany

High-grade dehydration of amphibolite-facies rocks to granulite-facies is a process that can involve partial melting, fluid-aided solid-state dehydration, or varying degrees of both. On the localized meter scale, solid-state dehydration, due to CO：-rich fluids traveling along some fissure or crack and subsequently outwards along the mineral grain boundaries of the surrounding rock, normally is the means by which the breakdown of biotite and amphibole to orthopyroxene and clinopyroxene occur. Various mineral textures and changes in mineral chemistry seen in these rocks are also seen in more regional orthopyroxene-clinopyroxene-bearing rocks which, along with accompanying amphibolite-facies rocks, form traverses of lower crust. This suggests that solid-state dehydration during high-grade metamorphism could occur on a more regional scale. The more prominent of these fluid-induced textures in the granulite- facies portion of the traverse take the form of micro-veins of K-feldspar along quartz grain boundaries and the formation of monazite inclusions in fluorapatite. The fluids believed responsible take the form of concentrated NaCl- and KCl- brines from a basement ultramafic magma heat source traveling upwards along grain boundaries. Additional experimental work involving CaSO4 dissolution in NaCl-brines, coupled with natural observation of oxide and sulfide mineral associations in granulite-facies rocks, have demonstrated the possibility that NaCl-brines, with a CaSO4 component, could impose the oxygen fugacity on these rocks as opposed to the oxygen fugacity being inherent in their protoliths. These results, taken together, lend credence to the idea that regional chemical modification of the lower crust is an evolutionary process controlled by fluids migrating upwards from the lithospheric mantle along grain boundaries into and through the lower crust where they both modify the rock and are modified by *** presence allows for rapid mass and heat transport and sub

关键词： Charnockite CO2-rich fluids NaCl-KCl brines Granulite-faciesmetamorphism Solid-state dehydrationPetrology

New insights into the role of the endoplasmic reticulum in microglia

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Neural Regeneration Research 2024年第7期19卷 1397-1398页

作者： Veronika e.Neubrand M.Rosario Sepúlveda Department of Cell Biology Faculty of SciencesUniversity of GranadaGranadaSpain

Microglial cells are the only resident immune cells in the central nervous system and constitute its frontline *** are extremely reactive against infections,trauma,or toxins,but are also responsible for mediating inflammation,taking part in the pathogenic course of many neuropathologies(Sierra et al.,2019).Cell-specific staining,ultrastructural analysis by transmission electron microscopy(TeM),or two-photonmicroscopy imaging have been relevant for the characterization of microglia as well as their cell-cell interactions。

关键词： inflammation reticulum

Frequency of Benign and Malignant Tumors in Localized Vitiligo in Comparison to Generalized and Universal Vitiligo

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journal of Cosmetics, Dermatological Sciences and Applications 2016年第4期6卷 133-139页

作者： Khalifa e. Sharquie Adil A. Noaimi Sadiq j. Murtada Department of Dermatology College of Medicine University of Baghdad Baghdad Iraqi Iraqi and Arab Board for Dermatology and Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq Department of Dermatology Baghdad Teaching Hospital Medical City Baghdad Iraq

Background: Autoimmune diseases like pemphigus and systemic lupus erythematosus are protective against skin malignancies like basal cell carcinoma and squamous cell carcinoma. Objective: As vitiligo is an autoimmune diseases, the aim of the present work is to record the frequency of all benign and malignant skin tumors among patients with different severity of vitiligo and to be compared with the skin tumors in healthy control. Patients and Methods: This is a case series, descriptive study done in the Department of Dermatology—Baghdad Teaching Hospital, Baghdad, Iraq, during the period from May 2014-May 2015. History was taken from each patient with vitiligo regarding age, gender, duration, personal and family history of vitiligo and other autoimmune diseases such as diabetes mellitus, thyroid dysfunction, and alopecia areata. Patients were assessed for past and present history of photodermatosis and any skin cancers. Healthy control was considered. Results: Three hundred and fifty patients with vitiligo were included in this study: 50 patients with universal vitiligo, 100 patients with generalized vitiligo, and 200 patients with localized vitiligo as well as 500 subjects as a healthy control. The ages of all studied subjects ranged between 31 and 77 years. Twenty four(48%) patients with universal vitiligo were males and 26 (52%) were females;49(49%) patients with generalized vitiligo were males and 51(51%) were females;101(50.5%) patients with localized vitiligo were males and 99(49.5%) were females and 235(47%) of control were males and 265(53%) were females. All skin tumors were seen to be high in healthy subjects and lower or absent in patients with vitiligo. Also patients with mild vitiligo had a higher frequency of skin tumors including benign and malignant than patients with severe vitiligo especially in patients with universal vitiligo. In addition, no photosensitivity or actinic reticuloid was detected in patients with vitiligo. Conclusions: Vitiligo especi

关键词： Vitiligo Photodamage Photoprotection Benign and Malignant Tumors

Region-specific microRNA signatures in the human epididymis

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Asian journal of Andrology 2018年第6期20卷 539-544页

作者： james A Browne Shih-Hsing Leir Scott e eggener Ann Harris Department of Genetics and Genome Sciences Case Western Reserve UniversityClevelandOH 44106USA Human Molecular Genetics Program Lurie Children＇s Research CenterChicagoIL 60614USA Department of Pediatrics Northwestern University Feinberg School of MedicineChicagoIL 60611USA Section of Urology University of Chicago Medical CenterChicagoIL 60611USA.

The epithelium of the human epididymis maintains an appropriate luminal environment for sperm maturation that is essential for male fertility. Regional expression of small noncoding RNAs such as microRNAs contributes to segment-specific gene expression and differentiated functions. MicroRNA profiles were reported in human epididymal tissues but not specifically in the epithelial cells derived from those regions. Here, we reveal miRNA signatures of primary cultures of caput, corpus, and cauda epididymis epithelial cells and of the tissues from which they were derived. We identify 324 epithelial cell-derived microRNAs and 259 tissue-derived microRNAs in the epididymis, some of which displayed regionalized expression patterns in cells and/or tissues. Caput cell-enriched miRNAs included miR-573 and miR-155. Cauda cell-enriched miRNAs included miR-1204 and miR-770. Next, we determined the gene ontology pathways associated with in silico predicted target genes of the differentially expressed miRNAs. The effect of androgen receptor stimulation on miRNA expression was also investigated. These data show novel epithelial cell-derived miRNAs that may regulate the expression of important gene networks that are responsible for the regionalized gene expression and function of the epididymis.

关键词： caput cauda corpus human epididymis microRNA

Machine learning of superconducting critical temperature from eliashberg theory

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npj Computational Materials 2022年第1期8卷 113-120页

作者： S.R.Xie Y.Quan A.C.Hire B.Deng j.M.DeStefano I.Salinas U.S.Shah L.Fanfarillo j.Lim j.Kim G.R.Stewart j.j.Hamlin P.j.Hirschfeld R.G.Hennig Department of Materials Science and engineering University of FloridaGainesvilleFL32611USA Quantum Theory Project University of FloridaGainesvilleFL32611USA Department of Physics University of FloridaGainesvilleFL32611USA Scuola Internazionale Superiore di Studi Avanzati(SISSA) Via Bonomea 26534136TriesteItaly

The eliashberg theory of superconductivity accounts for the fundamental physics of conventional superconductors,including the retardation of the interaction and the Coulomb pseudopotential,to predict the critical temperature T_(c).McMillan,Allen,and Dynes derived approximate closed-form expressions for the critical temperature within this theory,which depends on the electron–phonon spectral functionα^(2)F(ω).Here we show that modern machine-learning techniques can substantially improve these formulae,accounting for more general shapes of theα^(2)F *** symbolic regression and the SISSO framework,together with a database of artificially generatedα^(2)F functions and numerical solutions of the eliashberg equations,we derive a formula for T_(c)that performs as well as Allen–Dynes for low-T_(c)superconductors and substantially better for higher-T_(c)*** corrects the systematic underestimation of Tc while reproducing the physical constraints originally outlined by Allen and *** equation should replace the Allen–Dynes formula for the prediction of higher-temperature superconductors.

关键词： function. critical theory

True grit: ingestion of small stone particles by hummingbirds in West Mexico

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Avian Research 2021年第4期12卷 739-749页

作者： Omar Maya-García Mauricio Ortega-Flores jorge e.Schondube Posgrado en Ciencias Biológicas Unidad de PosgradoCoordinación del Posgrado en Ciencias BiológicasUniversidad Nacional Autónoma de MéxicoEdificio D1er pisoCircuito de PosgradosCiudad UniversitariaDel.CoyoacánC.P.04510 México D.F.Mexico Laboratorio de ecología Funcional Instituto de Investigaciones en Ecosistemas y SustentabilidadUniversidad Nacional Autónoma de MéxicoAntigua Carretera a Pátzcuaro No.8701Col.Ex Hacienda de San Joséde la HuertaC.P.58190 MoreliaMichoacánMexico

Background: Grit is used by birds mainly for grinding hard food items but can also serve a nutritional role as a source of minerals. Ingestion of grit by birds has been documented primarily in species that feed on seeds and *** feeding mainly on nectar and small arthropods, hummingbirds also ingest grit, but why they do so is unclear. We quantified the number of grit particles in the stomachs of six species of hummingbirds during an annual cycle in a seasonal ecosystem of West ***: We compared the number of grit particles in the stomachs of different hummingbird species(Mexican Violetear Colibri thalassinus, Amethyst-throated Mountaingem Lampornis amethystinus, White-eared Hummingbird Basilinna leucotis, Rivoli's Hummingbird eugenes fulgens, Broad-tailed Hummingbird Selasphorus platycercus, and Rufous Hummingbird S. rufus), and between sex and age categories during the different seasons of a year. To deter-mine if grit was used to grind ingested arthropods, we examined the relationships between the number of grit parti-cles, the biomass of arthropods ingested, and their chitin ***: Although species did not differ in the number of grit particles in their stomachs, we found that grit was mostly ingested by female individuals, with only one male of one species(Mexican Violetear) presenting grit in its stomach. We also found that female hummingbirds had grit in their stomachs during the rainy and the cold-dry season(june-February) but not during the warm-dry season(March-May). Our analyses revealed no relationship between the number of grit particles and the amount of ingested arthropods and arthropod chitin content. However,high grit consumption was related to wasp ingestion on Mexican ***: Our results indicate that grit is used mainly by female hummingbirds. The seasonal variation in the ingestion of grit by female individuals suggests that it can be used to meet mineral requirements related to breed-ing;how

关键词： Arthropod chitin content Arthropod digestion Breeding season Mineral nutritional requirements

Unveiling how vitrification affects the porcine blastocyst: clues from a transcriptomic study

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journal of Animal Science and Biotechnology 2022年第3期13卷 735-755页

作者： C.Almiñana F.Dubuisson S.Bauersachs e.Royer P.Mermillod e.Blesbois F.Guignot UMR PRC INRAE 0085CNRS 7247Universitéde ToursIFCEF–37380 NouzillyFrance Functional Genomics Group Institute of Veterinary AnatomyVetSuisse Faculty ZurichUniversity of ZurichZürichSwitzerland UePAO INRAEF–37380 NouzillyFrance

Background:Currently,there is a high demand for efficient pig embryo cryopreservation procedures in the porcine industry as well as for genetic diversity preservation and research *** date,vitrification(VIT)is the most efficient method for pig embryo *** a high number of embryos survives in vitro after vitrification/warming procedures,the in vivo embryo survival rates after embryo transfer are variable among *** far,most studies have focused on cryoprotective agents and devices,while the VIT effects on porcine embryonic gene expression remained *** few studies performed were based on vitrified/warmed embryos that were cultured in vitro(IVC)to allow them to re–***,the specific alterations of VIT,IVC,and the cumulative effect of both remained *** unveil the VIT-specific embryonic alterations,gene expression in VIT versus(vs.)IVC embryos was ***,changes derived from both VIT and IVC *** embryos(CO)were analyzed to confirm the VIT embryonic *** groups of in vivo embryos at the blastocyst stage were analyzed by RNA–sequencing:(1)VIT embryos(vitrified/warmed and cultured in vitro),(2)IVC embryos and(3)CO ***:RNA–sequencing revealed three clearly different mRNA profiles for VIT,IVC and CO *** analysis of mRNA profiles between VIT and IVC identified 321,differentially expressed genes(DeG)(FDReG were found,respectively,with an overlap of 1045 ***-specific functional alterations were associated to response to osmotic stress,response to hormones,and developmental *** alterations in response to hypoxia and mitophagy were related to the sum of VIT and IVC ***:Our findings revealed new insights into the VIT procedure-specific alterations of embryonic gene expression by first comparing differences in VIT *** embryos and second by an integrative transcriptome analysis in

关键词： Blastocyst embryo Gene expression In vitro culture Porcine RNA–sequencing Transcriptomics Vitrification

Methodology for ranking controllable parameters to enhance operation of a steam generator with a combined Artificial Neural Network and Design of experiments approach

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energy and AI 2021年第1期3卷 9-21页

作者： Lara Werncke Vieira Augusto Delavald Marques Paulo Smith Schneider Antônio joseda Silva Neto Felipe antonio Chegury Viana Madhat Abdel-jawad julian David Hunt julio Cezar Mairesse Siluk Federal University of Rio Grande do Sul-UFRGS Porto AlegreBrazil State University of Rio de janeiro-UeRj Nova FriburgoBrazil University of Central Florida OrlandoUCFUnited States Advanced Analysis Australia-AAA PerthAustralia International Institute for Applied Systems Analysis-IIASA ViennaAustria Federal University of Santa Maria-UFSM Santa MariaBrazil

The operation of complex systems can drift away from the initial design conditions,due to environmental condi-tions,equipment wear or specific *** generators are complex equipment and their proper opera-tion relies on the identification of their most relevant *** approach to rank the operational parameters of a subcritical steam generator of an actual 360 MW power plant is *** Artificial Neural Network-ANN delivers a model to estimate the steam generator efficiency,electric power generation and flue gas outlet temperature as a function of seven input *** ANN is trained with a two-year long database,with training errors of 0.2015 and 0.2741(mean absolute and square error)and validation errors of 0.32%and 2.350(mean percent and square error).That ANN model is explored by means of a combination of situations proposed by a Design of experiment-Doe *** seven controlled parameters showed to be relevant to express both steam generator efficiency and electric power generation,while primary air flow rate and speed of the dynamic classifier can be neglected to calculate flue gas temperature as they are not statistically *** also shows the prominence of the primary air pressure in respect to the steam generator efficiency,electric power generation and the coal mass flow rate for the calculation of the flue gas outlet *** ANN and Doe combined methodology shows to be promising to enhance complex system efficiency and helpful whenever a biased behavior must be brought back to stable operation.

关键词： Coal-fired power plant Artificial Neural Network Design of experiments Response surface methodology Steam generator

Accumulation of Natural Radionuclides by Some edible Wild Mushrooms in ekiti State, Southwestern, Nigeria

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World journal of Nuclear Science and Technology 2015年第2期5卷 107-110页

作者： e. B. Faweya M. j. Ayeni j. Kayode Department of Physics Ekiti State University Ado-Ekiti Nigeria Department of Plant Science Ekiti State University Ado-Ekiti Nigeria

Activity concentrations of primordial radionuclides such as 40K, 226Ra and 232Th were determined in edible mushrooms samples in ekiti State Nigeria. The edible mushrooms collected are Termitomyces striatus, Psathyrella atroumbonata, Termitomyces robustus, Pleurotus tuber-regium and Pleurotus squarrosulus. The activity measurements were carried out by gamma spectrometry. The average concentrations of 40K varied from 254.17 ± 46.78 to 416.07 ± 68.43 Bq·kg-1, 226Ra concentrations varied from 2.68 ± 0.82 to 21.64 ± 7.23 Bq·kg-1 and 232Th concentrations varied from 8.57 ± 3.25 to 10.98 ± 4.31 Bq·kg-1. The concentrations were converted to effective dose. effective doses calculated were found to be below maximum permissible levels. Therefore, no health risk is envisaged for those that normally consumed these mushrooms.

关键词： Mushrooms Radioactivity Gamma ekiti Nigeria