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Light(Science & Applications) 2021年第3期10卷 313-319页

作者： M.Gebhardt T.Heuermann R.Klas C.Liu A.Kirsche M.Lenski Z.Wang C.Gaida j.e.antonio-lopez A.Schülzgen R.Amezcua-Correa j.Rothhardt j.Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat JenaAlbert-Einstein-Str.1507745 JenaGermany Helmholtz-Institute jena Frobelstieg 307743 JenaGermany CReOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA Fraunhofer Institute for Applied Optics and Precision engineering Albert-Einstein-Str.707745 JenaGermany Active Fiber Systems GmbH Ernst-Ruska-Ring 1707745 JenaGermany

Bright,coherent soft X-ray radiation is essential to a variety of applications in fundamental research and life *** date,a high photon flux in this spectral region can only be delivered by synchrotrons,free-electron lasers or high-order harmonic generation sources,which are driven by kHz-class repetition rate lasers with very high peak ***,we establish a novel route toward powerful and easy-to-use SXR sources by presenting a compact experimentin which nonlinear pulse self-compression to the few-cycle regime is combined with phase-matched high-orderharmonic generation in a single,helium-illed antiresonant hollow-core *** enables the first 100 kHz-classrepetition rate,table-top soft X-ray source that delivers an application-relevant flux of 2.8×10^6 photon s^-1 eV^-1 around 300 *** fibre integration of temporal pulse self-compression(leading to the formation of the necessarystrong-field waveforms)and pressure-controlled phase matching will allow compact,high-repetition-rate lasertechnology,including commercially available systems,to drive simple and cost-effective,coherent high-flux softX-ray sources.

关键词： pulse repetition fibre

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Building an interoperable space for smart agriculture

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Digital Communications and Networks 2023年第1期9卷 183-193页

作者： Ioanna Roussaki Kevin Doolin antonio Skarmeta George Routis juan antonio lopez-Morales ethel Claffey Manuel Mora juan antonio Martinez Institute of Communications and Computer Systems AthensGreece Walton Institute WaterfordIreland Department of Information and Communications engineering University of MurciaMurciaSpain School of Business Waterford Institute of TechnologyWaterfordIreland R&D Department Odin SolutionsMurciaSpain

The digital transformation in agriculture introduces new challenges in terms of data,knowledge and technology adoption due to critical interoperability issues,and also challenges regarding the identification of the most suitable data sources to be exploited and the information models that must be ***(Building an Interoperable,Data-Driven,Innovative and Sustainable european Agri-Food Sector)addresses these challenges by providing an overarching solution that integrates various heterogeneous hardware and software resources(e.g.,devices,networks,platforms)and enables the seamless sharing of data and knowledge throughout the agri-food *** paper introduces the main concepts of DeMeTeR and its reference architecture to address the data sharing and interoperability needs of farmers,which is validated via two rounds of 20 large-scale pilots along the DeMeTeR *** paper elaborates on the two pilots carried out in region of Murcia in Spain,which target the arable crops sector and demonstrate the benefits of the deployed DeMeTeR reference architecture.

关键词： Smart agriculture Internet of things(IoT) DeMeTeR Reference architecture Interoperability Agricultural information model(AIM) Pilot validation

Sensitivity-based Vulnerability Assessment of State estimation

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journal of Modern Power Systems and Clean energy 2021年第4期9卷 886-896页

作者： Gonzalo e.Constante-Flores antonio j.Conejo jiankang Wang Department of electrical and Computer engineering The Ohio State UniversityColumbusUSA Department of Integrated Systems engineering and the Department of electrical and Computer engineering The Ohio State UniversityColumbusUSA

We propose a technique to assess the vulnerability of the power system state estimation. We aim at identifying the measurements that have a high potential of being the target of false data injection attacks. From the perspective of the adversary, such measurements have the following characteristics: ① being influential on the variable estimates;② corrupting their measured values is likely to be undetected. Additionally, such characteristics should not change significantly with the system operation condition. The proposed technique provides a systematic way of identifying the measurements with such characteristics. We illustrate our methodology on a 4-bus system, the New england 39-bus system, and the Ieee 118-bus test system, respectively.

关键词： False data injection attack state estimation sensitivity analysis singular value decomposition

Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease

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World journal of Gastroenterology 2013年第1期19卷 17-25页

作者： elena Garrido elisa Carrera Rebeca Manzano antonio lopez-Sanroman Inflammatory Bowel Disease Clinic Department of GastroenterologyUniversity Hospital Ramón y Cajal28034 MadridSpain Department of Gastroenterology University Hospital of Guadalajara19002 GuadalajaraSpain Department of Gastroenterology Hospital Sureste28500 MadridSpain

Cytomegalovirus(CMV) infection is common in *** virus then enters a "latency phase" and can reactivate to different stimuli such as *** clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of ***,CMV reactivation is frequent in severe or steroid-resistant *** is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe *** methods are used to diagnose CMV *** is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being *** chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic *** endoscopic features have not been described in active UC and CMV *** colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive *** antiviral drugs may be *** controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment.

关键词： Cytomegalovirus Inflammatory bowel disease Crohn’s disease Ulcerative colitis Hematoxylin and eosin Immunohistochemical Polymerase chain reaction Ganciclovir Infectious colitis

Why Marginal Pricing?

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journal of Modern Power Systems and Clean energy 2023年第3期11卷 693-697页

作者： antonio j.Conejo Department of Integrated Systems engineering and the Department of electrical and Computer engineering The Ohio State UniversityColumbusOhio 43210USA

Under perfect competition,marginal pricing results in short-term efficiency and the subsequent right short-term price ***,the main reason for the adoption of marginal pricing is not the above,but investment cost *** is,the fact that the profits obtained by infra-marginal technologies(technologies whose production cost is below the marginal price)allow them just to recover their investment *** the other hand,if the perfect competition assumption is removed,investment over-recovery or under-recovery generally occurs for infra-marginal technologies.

关键词： electricity market marginal pricing investment cost recovery maximum social welfare right spatial and temporal price signals

Unsupervised full-color cellular image reconstruction through disordered optical fiber

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Light(Science & Applications) 2023年第6期12卷 1091-1102页

作者： Xiaowen Hu jian Zhao jose enrique antonio-lopez Rodrigo Amezcua Correa Axel Schülzgen CReOL The College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA The Picower Institute for Learning and Memory Massachusetts Institute of TechnologyCambridgeMA 02139USA

Recent years have witnessed the tremendous development of fusing fiber-optic imaging with supervised deep learning to enable high-quality imaging of hard-to-reach ***,the supervised deep learning method imposes strict constraints on fiber-optic imaging systems,where the input objects and the fiber outputs have to be collected in *** unleash the full potential of fiber-optic imaging,unsupervised image reconstruction is in ***,neither optical fiber bundles nor multimode fibers can achieve a point-to-point transmission of the object with a high sampling density,as is a prerequisite for unsupervised image *** recently proposed disordered fibers offer a new solution based on the transverse Anderson ***,we demonstrate unsupervised full-color imaging with a cellular resolution through a meter-long disordered fiber in both transmission and reflection *** unsupervised image reconstruction consists of two *** the first stage,we perform a pixel-wise standardization on the fiber outputs using the statistics of the *** the second stage,we recover the fine details of the reconstructions through a generative adversarial *** image reconstruction does not need paired images,enabling a much more flexible calibration under various *** new solution achieves full-color high-fidelity cell imaging within a working distance of at least 4 mm by only collecting the fiber outputs after an initial *** imaging robustness is also demonstrated when the disordered fiber is bent with a central angle of 60°.Moreover,the cross-domain generality on unseen objects is shown to be enhanced with a diversified object set.

关键词： fiber optical image

Tetrapartite entanglement measures of W-class in noninertial frames

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Chinese Physics B 2019年第7期28卷 122-130页

作者： Ariadna j. Torres-Arenas edgar O. lopez-Zuniga j. antonio Saldana-Herrera Qian Dong Guo-Hua Sun Shi-Hai Dong Laboratorio de Información Cuantica CIDETEC Instituto Politecnico Nacional UPALM CDMX 07700 Mexico Facultad de Ciencias Fisico Matematicas Universidad Autónoma de Nuevo Leon San Nicolas de los Garza NL 66450 Mexico Catedratica CONACyT Centro de Investigacion en Computacion Instituto Politecnico Nacional UPALM CDMX 07738 Mexico

We present the entanglement measures of a tetrapartite W-class entangled system in a noninertial frame, where the transformation between Minkowski and Rindler coordinates is *** cases are ***, when one qubit has uniform acceleration whilst the other three remain ***, when two qubits have nonuniform accelerations and the others stay *** 1–1 tangle, 1–3 tangle, and whole entanglement measurements π4 and Π4, are studied and illustrated with graphics through their dependence on the acceleration parameter rd for the first case and rc and rd for the second *** is found that the negativities(1–1 tangle and 1–3 tangle) and π-tangle decrease when the acceleration parameter rd or in the second case rc and rd increase, remaining a nonzero entanglement in the majority of the *** means that the system will be always entangled except for special *** is shown that only the 1–1 tangle for the first case vanishes at infinite accelerations, but for the second case the 1–1 tangle disappears completely when r > *** analytical expression for the von Neumann information entropy of the system is found and we note that it increases with the acceleration parameter.

关键词： W-class tetrapartite entanglement Dirac field noninertial frames nonuniform acceleration

MXene multi-functionalization of polyrotaxane based PCMs and the applications in electronic devices thermal management

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Nano Materials Science 2024年第5期6卷 495-503页

作者： Guangzhong Yin Alba Marta lopez Ignacio Collado antonio Vazquez-lopez Xiang Ao jose Hobson Silvia G.Prolongo Deyi Wang escuela Politecnica Superior Universidad Francisco de VitoriaCtra.Pozuelo-Majadahonda Km 1.80028223 Pozuelo de AlarconMadridSpain IMDeA Materials Institute C/Eric Kandel228906GetafeMadridSpain Materials Science and engineering Area Escuela Superior de Ciencias Experimentales y TecnologíaUniversidad Rey Juan CarlosC/Tulipan s/n28933MadridSpain Universidad Carlos III de Madrid Departamento de Ciencia e Ingeniería de Materiales e Ingeniería QuímicaIAAB.Avda.Universidad3028911LeganesMadridSpain Instituto de Tecnologías para la Sostenibilidad Universidad Rey Juan CarlosC/Tulipan s/n28933MadridSpain

The aim of this work was to improve the thermal conductivity and electromagnetic shielding of the leakage proof phase change materials(PCMs),in which a polyrotaxane(PLR)was used as a support material to encapsulate PeG 1k or PeG 6k and MXene as multi-functional *** PCMs can be processed conveniently by a hot press and the PeG 1k containing samples showed excellent *** conducted a systematic evaluation of the phase transition behavior of the material,thermal conductivity and electromagnetic shielding performance ***,the PCMs achieved a high enthalpy values(123.9–159.6 j/g).The PCMs exhibited an increase of 44.3%,and 137.5%in thermal conductivity values with higher MXene content(5 wt%)for PLR-PeG6k and PLR-PeG1k,respectively,and show high shape stability and no leakage during and after phase *** introduction of MXene can significantly improve the electromagnetic shielding performance of PCM ***,higher conductive samples(samples which contain high MXene contents)offer a higher eMI Se shielding,reaching a maximum of 4.67 dB at 5.6 GHz for *** improvements solve the main problems of organic PeG based PCMs,thus making PLR-PeG-MXene based PCMs good candidates for thermoregulators of both solid-state disks and smart *** is worth pointing out that the sample PLR-1k-MX5 can decrease 4.3C of the reference temperature during cellphone ***,the temperature of the protecting sheet in the simulated solid state disk with PCM was significantly lower(showing a decreasing of 7.9℃)compared with the blank sample.

关键词： Phase change materials Thermal regulation MXene Polyrotaxane Nanocomposites