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Evaluation of Growth and Quality in Latuca Sativa L. under Different Photoperiods

当代农业（中英文版） 2016年第2期5卷 8-12页

作者： K.w.Lam j.c.w.pang K.H.Loo Y.M.Lai S.Y.chau Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Kong SAR China Pong Yuen Holdings Limited Hong Kong SAR China

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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P_(c)(4457)Interpreted as a j^(P)=1/2+State by D^(0)∧_(c)^(+)(2595)-π^(0)P_(c)(4312) Interaction

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chinese Physics Letters 2024年第9期41卷 23-27页

作者： jin-Zi wu jin-Yi pang jia-jun wu School of Physics Sciences University of Chinese Academy of SciencesBeijing 100049China columbian college of Arts&Sciences George Washington University80122nd St.NW Washington DC 20052USA college of Science University of Shanghai for Science and TechnologyShanghai 200093China Southern center for Nuclear-Science Theory Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

P_(c)(4457)has been discovered over five years,but the parity of this particle remains *** propose a new interpretation for P_(c)(4457),which is the state generated from the coupled-channel D^(0)Ac+(2595)andπ^(0)P_(c)(4312)since they can exchange an almost on-shell∑_(c)^(+).In this scenario,the parity of P_(c)(4457)will be positive,which is different from the candidate of the bound state of D*∑_(c).The main decay channel of P_(c)(4457)in this model is Pc(4312)π.we propose three processes∧_(b)^(0)→j/ψKapπ^(-),∧_(b)^(0)→j/ψK-pπ^(0),and∧_(b)^(0)→j/ψpπ^(-)π^(+)k^(-)to verify Pc(4457)→Pc(4312)π.

关键词： parity verify

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. we then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of carcinoma cells

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Engineering 2021年第10期7卷 1424-1433页

作者： w.G.Zhang Z.Y.Liu S.w.pang Department of Electrical Engineering Center for BiosystemsNeuroscienceand NanotechnologyCity University of Hong KongHong Kong 999077China

cancer cell separation is highly desirable for cancer diagnosis and *** biochemical methods,engineered platforms are effective alternatives for sorting carcinoma cells from normal cells based on their unique properties in responding to the physical changes of the surrounding *** this work,three-dimensional(3D)biomimetic scaffold platforms were developed to separate nasopharyngeal carcinoma 43(NPc43)cells from immortalized nasopharyngeal epithelial 460(NP460)cells based on precisely controlled design parameters including stiffness,number of layers,and structural *** migration characteristics of NPc43 and NP460 cells on the scaffold platforms revealed that NPc43 cells could squeeze into 10 lm wide,15 lm deep trenches while NP460 cells could *** different migration behavior was mainly due to cells having different interactions with the surrounding ***43 cells had filopodia-like protrusions,while NP460 cells exhibited a sheet-like *** these 3D biomimetic platforms,89%separation efficiency of NPc43 cells from NP460 cells was achieved on stiffer two-layer scaffold platforms with a 40/10 lm ridge/trench(R/T)grating on the top layer and a 20/10 lm R/T grid on the bottom ***,the separation efficiency was further increased to 93%by adding an active conditioned medium(AcM)that caused the cells to have higher motility and *** results demonstrate the capability to apply biomimetic engineered platforms with appropriate designs to separate cancer cells from normal cells for potential cancer diagnosis and treatment.

关键词： cell separation cell migration Nasopharyngeal carcinoma(NPc) 3D scaffold platform

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Microstructure Evolution of in situ (Ti3Alc+Ti5Si3 )/Ti3Al composite Sheet with a Novel Quasi-continuous chain Reinforcement Distribution Architecture Prepared by Using Roll Bonding and Reaction Annealing

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journal of Materials Science & Technology 2013年第12期29卷 1191-1196页

作者： j.c.pang G.H.Fan X.P.cui A.B.Li L.Geng Z.Z.Zheng Q.w.wang School of Materials Science and Engineering Harbin Institute of Technology

The Ti3Al matrix composite sheet with a novel quasi-continuous chain reinforcement distribution was prepared by using roll bonding and subsequent reaction annealing with pure Ti and Sicp/Al *** (Ti3Alc t Ti5Si3) reinforcements were produced by in situ reaction of the as-rolled Tie(Sic p/Al) laminated composite sheet after a two-stage annealing treatment including first annealing at 660 c and second annealing at 1250 *** microstructure evolution during the reaction annealing was *** the first reaction annealing,TiAl3was formed,and the Sic particles were pushed together due to the Kirkendall effect,and after the second reaction annealing,Ti3Al,Ti3Alc and Ti5Si3were *** addition,the reinforcement distribution presents a quasi-continuous chain microstructure in Ti3Al matrix composite sheet.

关键词： composite Intermetallic Fabrication Reaction synthesis

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Biogenic volatile organic compound analyses by PTR-TOF-MS: calibration, humidity effect and reduced electric field dependency

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journal of Environmental Sciences 2015年第6期27卷 196-206页

作者： Xiaobing pang Key Laboratory for Aerosol-cloud-Precipitation of china Meteorological Administration Nanjing University of Information Science and Technology

Green leaf volatiles（GLVs） emitted by plants after stress or damage induction are a major part of biogenic volatile organic compounds（BVOcs）. Proton transfer reaction time-of-flight mass spectrometry（PTR-TOF-MS） is a high-resolution and sensitive technique for in situ GLV analyses, while its performance is dramatically influenced by humidity, electric field,etc. In this study the influence of gas humidity and the effect of reduced field（E/N） were examined in addition to measuring calibration curves for the GLVs. calibration curves measured for seven of the GLVs in dry air were linear, with sensitivities ranging from 5 to10 ncps/ppbv（normalized counts per second/parts per billion by volume）. The sensitivities for most GLV analyses were found to increase by between 20% and 35% when the humidity of the sample gas was raised from 0% to 70% relative humidity（RH） at 21°c, with the exception of（E）-2-hexenol. Product ion branching ratios were also affected by humidity,with the relative abundance of the protonated molecular ions and higher mass fragment ions increasing with humidity. The effect of reduced field（E/N） on the fragmentation of GLVs was examined in the drift tube of the PTR-TOF-MS. The structurally similar GLVs are acutely susceptible to fragmentation following ionization and the fragmentation patterns are highly dependent on E/N. Overall the measured fragmentation patterns contain sufficient information to permit at least partial separation and identification of the isomeric GLVs by looking at differences in their fragmentation patterns at high and low E/N.

关键词： Biogenic volatile organic compound PTR-TOF-MS Humidity effect Reduced electric field

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A high specific Young's modulus steel reinforced by spheroidal kappa-carbide

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journal of Materials Science & Technology 2021年第28期87卷 54-59页

作者： P.chen j.Fu X.Xu c.Lin j.c.pang X.w.Li R.D.K.Misra G.D.wang H.L.Yi Department of Materials Physics and chemistry School of Materials Science and Engineeringand Key Laboratory for Anisotropy and Texture of MaterialsNortheastern UniversityShenyang 110819China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Angang Steel company Limited Technology centre Anshan 114009China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA

*** High strength steels continue to be developed for automotive applications to increase safety and reduce lightweight by downgauging[1,2].In addition,reducing density is another solution for the lightweight of automotive components[3,4].Aluminum addition could effectively reduce the density of steels,since it has a low atomic mass and invokes a lattice expansion[5].

关键词： carbide steel strength

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Role of grain boundary character on Bi segregation-induced embrittlement in ultrahigh-purity copper

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journal of Materials Science & Technology 2023年第28期159卷 52-61页

作者： Y.X.Hua K.X.Song H.T.Liu j.w.wang c.M.Zhang Y.j.Zhou B.pang j.T.Song j.L.He H.L.Zhao School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Henan Academy of Sciences Zhengzhou 450000China Henan Key Laboratory of Advanced conductor Materials Zhengzhou 450046China Provincial and Ministerial co-construction of collaborative Innovation center of Nonferrous New Materials and Advanced Processing Technology Luoyang 471023China center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China college of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Bismuth(Bi),as an impurity element in copper and copper-based alloys,usually has a strong tendency of grain boundary(GB)segregation,which depends on the GB ***,the influence of such a segregation on the properties of ultrahigh-purity copper has been rarely reported and the exact structural arrangements of Bi atoms at different GBs remain largely *** this study,we investigated the influ-ence of trace amounts of Bi(50-300 wt ppm)on the ductility of an ultrahigh-purity copper(99.99999%)in the range of room temperature to 900°*** tensile results show that the addition of Bi seriously damages the ductility of the ultrahigh-purity copper at temperatures of 450-900°c,which is due to the GB segregation of *** this basis,such a segregation behavior at different types of GBs,including high and low angle GBs(HAGBs/LAGBs),and twin boundaries(TBs),via the scanning electron microscope-electron backscattered diffraction(SEM-EBSD)and aberration-corrected scanning transmission electron microscope(Ac-STEM)investigations,combined with the first-principles calculations were systematically *** atomistic characterizations demonstrate an anisotropic Bi segregation,where severe enrich-ment of Bi atoms typically occurs at the HAGBs,while the absence of Bi adsorption prevails at LAGBs or *** particular,the segregated Bi at random HAGBs exhibited the directional bilayer adsorption,while the special symmetrical7 HAGB presented a unique Bi-rich cluster *** findings pro-vide a comprehensive experimental and computational understanding on the atomic-scale segregation of impurities in metallic materials.

关键词： Grain boundary character Embrittlement Bi segregation Atomic configuration Ultrahigh-purity copper

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