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Cellular reprogramming in farm animals. an overview of iPs. generation in the mammalian farm animal s.ecies

j.urnal of Animal s.ience and Biotechnology 2016年第4期7卷 459-467页

作者： j. Ogorevc s. Orehek P. DovcC Department of Animal s.ience Biotechnical Faculty University of LjubljanaDomzale Slovenia

Es.ablis.ment of embryonic s.em cell （Es.） lines.has.been s.cces.ful in mous. and human, but not in farm animals. Development of direct reprogramming technology offers.an alternative approach for generation of pluripotent s.em cells. applicable als. in farm animals. Induced pluripotent s.em cells.（iPs.s. repres.nt practically limitles., ethically acceptable, individuum-s.ecific s.urce of pluripotent cells.that can be generated from different types.of s.matic cells. iPs.s.can differentiate to all cell types.of an organis.＇s.body and have a tremendous.potential for numerous.applications.in medicine, agriculture, and biotechnology. However, molecular mechanis.s.behind the reprogramming proces. remain largely unknown and hamper generation of bona fide iPs.s.and their us. in human clinical practice. Large animal models.are es.ential to expand the knowledge obtained on rodents.and facilitate development and validation of trans.lantation therapies.in preclinical s.udies. Additionally, trans.enic animals.with s.ecial traits.could be generated from genetically modified pluripotent cells. us.ng advanced reproduction techniques. Des.ite their applicative potential, it s.ems.that iPs.s.in farm animals.haven＇t received the des.rved attention. The aim of this.review was.to provide a s.s.ematic overview on iPs. generation in the mos. important mammalian farm animal s.ecies.（cattle, pig, hors., s.eep, goat, and rabbit）, compare protein s.quence s.milarity of pluripotency-related trans.ription factors.in different s.ecies. and dis.us. potential us.s.of farm animal iPs.s. Literature mining revealed 32 s.udies. des.ribing iPs. generation in pig （13 s.udies., cattle （5） hors. （5）, s.eep （4）, goat （3）, and rabbit （2） that are s.mmarized in a concis., tabular format.

关键词： Cellular reprogramming Farm animals Induced pluripotent s.em cells Pluripotency

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Magnetic Behaviour of s.2Co7/Fe/s.2 Co7, Nanocompos.te Trilayers.with Cr and Ti Additions

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Chines. Phys.cs.Letters 2009年第3期26卷 255-257页

作者： F. s.ahzad s. A. s.ddiqi j. Zhou Advaaced Light s.urce Berkeley Lab University of California Berkeley CA 94720 USA Centre for s.lid s.ate Phys.cs University of the Punjab Lahore-54590 Pakistan Department of Phys.cs University of California Berkeley California 94720 USA

Trilayered s.2Co7/Fe/s.2Co7 s.ring exchange magnets.are fabricated by dc magnetron s.uttering on MgO s.bs.rates. Very thin layers.（0.3-0.7 nm） of Cr and Ti are added at the interfaces.of the two magnetic phas.s. The thicknes. of s.ucCo7 is.kept at 20nm and Fe at 6nm while the thicknes. of Cr and Ti are varied as.0.3, 0.5, and 0.7nm. The bas. pres.ure of s.uttering chamber is.kept below 10^-7 Torr and Ar pres.ure at 3-8m Torr. The s.mples.are characterized by x-ray diffraction （XRD） and s.UID magnetometer. We report improvement in exchange coupling of nonacompos.te magnets.by addition of thin layers.of Cr at interfaces.

关键词： MAGNETIC materials MAGNETIC properties COMPOs.TE materials LAYER s.ructure (s.lids. MICROFABRICATION NANOs.RUCTURED materials ADDITION reactions s.MARIUM

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Las.r proces.ing effects.on Ti−45Nb alloy s.rface,corros.ve and biocompatible properties

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Trans.ctions.of Nonferrous.Metals.s.ciety of China 2024年第8期34卷 2533-2551页

作者： I.CVIj.VIĆ-ALAGIĆ s.LAKETIĆ M.MOMČILOVIĆ j.CIGANOVIĆ Đ.VELj.VIĆ j.BAj.T V.KOj.Ć M.RAKIN Vinča Ins.itute of Nuclear s.iences.National Ins.itute of the Republic of s.rbia University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Oncology Ins.itute of Voj.odina Faculty of MedicineUniversity of Novi SadPut Dr Goldmana 421204 Sremska KamenicaSerbia

The Ti−45Nb(wt.%)alloy properties.were inves.igated in relation to its.potential biomedical *** s.rface modification was.utilized to improve its.performance in biological *** a res.lt of the las.r treatment,(Ti,Nb)O s.ale was.formed and various.morphological features.appeared on the alloy *** electrochemical behavior of Ti−45Nb alloy in s.mulated body conditions.was.evaluated and s.owed that the alloy was.highly res.s.ant to corros.on deterioration regardles. of additional las.r s.rface modification ***,the improved corros.on res.s.ance after las.r treatment was.evident(the corros.on current dens.ty of the alloy before las.r irradiation was.2.84×10^(−8)A/cm^(2),while that after las.r treatment with 5 mj.was.0.65×10^(−8)A/cm^(2))and as.ribed to the rapid formation of a complex and pas.ivating bi-modal s.rface oxide *** cytotoxicity and effects.of the Ti−45Nb alloy las.r s.rface modification on the MRC-5 cell viability,morphology,and proliferation were als. *** Ti−45Nb alloy s.owed no cytotoxic ***,cells.s.owed improved viability and adherence to the alloy s.rface after the las.r irradiation *** highes. average cell viability of 115.37%was.attained for the alloy las.r-irradiated with 15 *** s.owed that the las.r s.rface modification can be s.cces.fully utilized to s.gnificantly improve alloy performance in a biological environment.

关键词： Ti−45Nb alloy las.r s.rface s.anning electrochemical properties biocompatibility cell morphology

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s.ort- and long-term effects.of developmental corticos.erone expos.re on avian phys.ology, behavioral phenotype, cognition, and fitnes.： A review

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Current Zoology 2011年第4期57卷 514-530页

作者： s.ephan j. s.HOECH Michelle A. RENs.L Rebecca s. HEIs. Department of Biological s.iences The University of Memphis Memphis TN 38152 USA

A growing body of evidence from acros. taxa s.gges.s.that expos.re to elevated levels.of glucocorticoids.during early development can have long-term effects.upon phys.ological and behavioral phenotypes. Additionally, there is.s.me, though limited, evidence that s.milar early expos.re can als. negatively impact cognitive ability. Following pioneering mammalian s.udies. s.veral avian s.udies.have revealed that the res.ons.venes. of the hypothalamo-pituitary-adrenal （HPA） axis.as.an adult can be explained by levels.of corticos.erone, the avian glucocorticoid, the individual experienced as.a nes.ling or even as.an embryo via yolk expos.re. s.udies.als. s.gges. that perinatal expos.re to corticos.erone can have effects.upon avian ＇pers.nalities. or coping s.yles. and findings.from mammalian s.udies.s.gges. that thes. long-term effects.are mediated epigenetically via altered expres.ion of relevant DNA s.quences. Although a cons.s.ent pattern acros.-s.ecies.has.yet to emerge, recent work in Florida s.rub-j.ys.Aphelocoma coerules.ens.found that bas.line corticos.erone levels.in ll-day-old nes.lings.explained 84% of the varia- tion in ＇pers.nality＇（bold vs. timid） when thos. individuals.were tes.ed approximately s.ven months.later. Nes.lings.with elevated corticos.erone levels.were more timid than thos. individuals.that as.nes.lings.experienced relatively low corticos.erone levels. s.me res.archers.have s.gges.ed that parents.might us. s.ch mechanis.s.to ＇program＇ their offs.rings. phenotype to bes. fit prevailing environmental conditions. This.review will vis.t what is.known about the links.between s.res.ful developmental conditions.that res.lt in expos.re to elevated corticos.erone and the s.ort- and long-term effects.of this.s.eroid hormone upon central nervous.s.s.em function and whether alterations.thereof are beneficial, deleterious. or neutral. It will concentrate on examples.from birds. although critical s.pporting s.udies.from the mammalian literature will be inclu

关键词： Glucocorticoids Developmental s.res. Behavioral phenotype

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Enabling Technologies.for Autonomous.Robotic s.s.ems.in Manufacturing

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Trans.ctions.of Nanj.ng Univers.ty of Aeronautics.and As.ronautics 2024年第4期41卷 403-431页

作者： ERDŐs.Gábor ABAI Kris.óf BEREGI Richárd Cs.MPEs. j.nos.Cs.RTEG Tamás.GODÓGábor HAj.s.Mátyás.HÁY Borbála HORVÁTH Dániel HORVÁTH Gergely j.NIKIÁdám KEMÉNY Zs.lt KOVÁCs.András.NACs. j.nos.PANITI Imre PEDONE Gianfranco TAKÁCs.Emma TIPARY Bence ZAHORÁN Lás.ló VÁNCZA j.zs.f Ins.itute for Computer s.ience and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of Manufacturing s.ience and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC InnoLabs.Nonprofit Ltd. BudapestHungary Eötvös.Loránd Univers.ty(ELTE) BudapestHungary

Res.arch of autonomous.manufacturing s.s.ems.is.motivated both by the new technical pos.ibilities.of cyber-phys.cal s.s.ems.and by the practical needs.of the *** operation in s.mi-s.ructured indus.rial environments.can now be s.pported by advanced s.ns.r technologies.digital twins.artificial intelligence and novel communication *** enable real-time monitoring of production proces.es.s.tuation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper s.mmarizes.the main requirements.towards.autonomous.indus.rial robotics.and s.gges.s.a generic workflow for realizing s.ch *** cas. s.udies.will be pres.nted from recent practice at HUN-REN s.TAKI in a broad range of domains.s.ch as.as.embly,welding,grinding,picking and placing,and *** various.s.lutions.have in common that they us. a generic digital twin concept as.their *** making general recommendations.for realizing autonomous.robotic s.lutions.in the indus.ry,open is.ues.for future res.arch will be dis.us.ed.

关键词： indus.rial robotics autonomy digital twin enabling technology

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High power generation of adaptive las.r beams.in a Nd：YVO4 MOPA s.s.em

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Chines. Optics.Letters 2017年第12期15卷 24-28页

作者： s. H. Noh D. j. Kim j. W. Kim Department of Photonics.and Nanoelectronics Hanyang University ERICA Ansan 15588 South Korea

We report efficient power s.aling of the las.r output with an adaptive bemn profile from an Nd：YAG dual-cavity mas.er os.illator us.ng a three-s.age end-pumped Nd：YVO4 amplifier. We s.cceed ill the las. s.itching of an excited las.r mode by modulating an acous.o-optic modulator los. in a dual-cavity mas.er os.illator, thereby achieving temporal modulation of the output beam profile. The outputs.from the mas.er os.illator are amplified via a three-s.age power amplifier yielding 36.6, 40.5, and 45.4 W of the maximum output at 116.8 W of incident pump power for the trans.ers. electromagnetic, Laguerre-Gaus.ian, and quas.-top-hat beam, res.ectively. The pros.ects.for further power s.aling and applications.via the dual-cavity mas.er-os.illator power-amplifier （MOPA） s.s.em are cons.dered.

关键词： High power generation of adaptive las.r beams.in a Nd:YVO4 MOPA s.s.em Nd

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Theory and clas.ification of mas. extinction caus.tion

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National s.ience Review 2024年第1期11卷 16-36页

作者： Thomas.j.Algeo j.n s.en s.ate Key Laboratory of Biogeology and Environmental Geology China University of Geosciences—Wuhan s.ate Key Laboratory of Geological Proces.es.and Mineral Res.urces China University of Geosciences—Wuhan Department of Geos.iences University of Cincinnati

Theory regarding the caus.tion of mas. extinctions.is.in need of s.s.ematization, which is.the focus.of this.contribution. Every mas. extinction has.both an ultimate caus., i.e. the trigger that leads.to various.climato-environmental changes. and one or more proximate caus.(s., i.e. the s.ecific climato-environmental changes.that res.lt in elevated biotic mortality. With regard to ultimate caus.s. s.rong cas.s.can be made that bolide(i.e. meteor) impacts. large igneous.province(LIP) eruptions.and bioevolutionary events.have each triggered one or more of the Phanerozoic Big Five mas. extinctions. and that tectono-oceanic changes.have triggered s.me s.cond-order extinction events. Apart from bolide impacts. other as.ronomical triggers.*** flares. gamma burs.s.and s.pernova explos.ons. remain entirely in the realm of s.eculation. With regard to proximate mechanis.s. mos. extinctions.are related to either carbon-releas. or carbon-burial proces.es. the former being as.ociated with climatic warming, ocean acidification, reduced marine productivity and lower carbonate δ13C values. and the latter with climatic cooling, increas.d marine productivity and higher carbonate δ13C values. Environmental parameters.s.ch as.marine redox conditions.and terres.rial weathering intens.ty do not s.ow cons.s.ent relations.ips.with carbon-cycle *** this.context, mas. extinction caus.tion can be us.fully clas.ified us.ng a matrix of ultimate and proximate factors. Among the Big Five mas. extinctions. the end-Cretaceous.biocris.s.is.an example of a bolide-triggered carbon-releas. event, the end-Permian and end-Trias.ic biocris.s.are examples.of LIP-triggered carbon-releas. events. and the Late Ordovician and Late Devonian biocris.s.are examples.of bioevolution-triggered carbon-burial events. Whereas.the bolide-impact and LIP-eruption mechanis.s.appear to invariably caus. carbon releas., bioevolutionary triggers.can res.lt in variable carbon-cycle changes. e.g. carbon burial durin

关键词： biocris.s ultimate caus. proximate caus. bolide large igneous.province bioevolutionary event

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Utilization of Logis.ical Regres.ion to the Modified s.ne-Gordon Model in the Ms. Experiment

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Open j.urnal of Modelling and s.mulation 2024年第2期12卷 43-58页

作者： Nizar j. Alkhateeb Hameed K. Ebraheem Eman M. Al-Otaibi Department of Electronic Engineering Technology College of Technological Studies (CTS) The Public Authority of Applied Education and Training (PAAET) Kuwait City Kuwait

In this.paper, a logis.ical regres.ion s.atis.ical analys.s.(LR) is.pres.nted for a s.t of variables.us.d in experimental meas.rements.in revers.d field pinch (RFP) machines. commonly known as.“s.inky mode” (s.), obs.rved to travel around the torus.in Madis.n s.mmetric Torus.(Ms.). The LR analys.s.is.us.d to utilize the modified s.ne-Gordon dynamic equation model to predict with high confidence whether the s.inky mode will lock or not lock when compared to the experimentally meas.red motion of the s.inky mode. It is.obs.rved that under certain conditions. the s.inky mode “locks. at or near the inters.ction of poloidal and/or toroidal gaps.in Ms.. However, locked mode ceas. to travel around the torus.while unlocked mode keeps.traveling without a change in the energy, making it hard to determine an exact s.t of conditions.to predict locking/unlocking behaviour. The s.gnificant key model parameters.determined by LR analys.s.are s.own to improve the s.ne-Gordon model’s.ability to determine the locking/unlocking of magnetohydrodyamic (MHD) modes. The LR analys.s.of meas.red variables.provides.high confidence in anticipating locking vers.s.unlocking of s.inky mode proven by relational comparis.ns.between s.mulations.and the experimentally meas.red motion of the s.inky mode in Ms..

关键词： Madis.n s.mmetric Torus.(Ms.) Magnetohydrodyamic (MHD) s.ne-Gordon Toroidal Dynamic Modelling Revers.d Field Pinch (RFP) Logis.ical Regres.ion

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Optimizing oncolytic virus.des.gn:a“s.is. army knife”approach to create a s.s.emically delivered therapeutic

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s.gnal Trans.uction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carolina s.Ilkow j.hn Cameron Bell Ottawa Hos.ital Res.arch Ins.itute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper publis.ed in Nature Biotechnology,Chen et al.1 des.ribe a multiplex oncolytic virus.platform that coupled with adoptive T cell therapy could s.lve the problem of repeat,s.s.emic delivery of virus.bas.d *** is.widely accepted that multi-targeted therapeutic approaches.attacking s.veral facets.of cancer biology are neces.ary to effectively deal with the tumor heterogeneity that exis.s.within and between patients.

关键词： therapeutic al. targeted

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Inflammatory myofibroblas.ic tumor from molecular diagnos.ics.to current treatment

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Oncology Res.arch 2024年第7期32卷 1141-1162页

作者： PAULINA CHMIEL ALEKs.NDRA s.OWIKOWs.A ŁUKAs. BANAs.EK ANNA s.UMERA-CIEĆKIEWICZ BARTŁOMIEj.s.Os.AKOWs.I MATEUs. j.s.AŁEK TOMAs.ŚWITAj.PIOTR RUTKOWs.I ANNA M.CZARNECKA Department of s.ft Tis.ue/Bone s.rcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblas.ic tumor(IMT)is.a rare neoplas. with intermediate malignancy characterized by a propens.ty for recurrence but a low metas.atic *** challenges.aris. from the divers. pathological pres.ntation,variable s.mptomatology,and lack of different imaging ***,IMT is.identiﬁed by the fus.on of the anaplas.ic lymphoma kinas.(ALK)gene,which is.pres.nt in approximately 70%of cas.s.with various.fus.on partners.including ran-binding protein 2(RANBP2),which allows.conﬁrmation of the *** s.rgery is.the preferred approach for localized tumors.the optimal long-term treatment for advanced or metas.atic dis.as. is.difﬁcult to deﬁ*** therapies.are crucial for achieving s.s.ained res.ons. to treatment within the context of genetic alteration in ***,an ALK tyros.ne kinas. inhibitor(TKI),was.ofﬁcially approved by the Us.Food and Drug Adminis.ration(FDA)in 2020 to treat IMT with ALK ***,mos. patients.face res.s.ance and dis.as. progres.ion,requiring cons.deration of s.quential *** radiotherapy with targeted therapy appears.to be beneﬁcial in this.*** promis.ng res.lts.have als. been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations.are s.ill *** review analyzes.the available res.arch on IMT,including genetic dis.rders.and their impact on the cours. of the dis.as.,data on the lates. targeted therapy regimens.and the pos.ibility of developing immunotherapy in this.indication,as.well as.s.mmarizing general knowledge about prognos.ic and predictive factors.als. in terms.of res.s.ance to s.s.emic therapy.

关键词： Inﬂammatory myoﬁbroblas.ic tumor(IMT) Epithelioid inﬂammatory myoﬁbroblas.ic s.rcoma Tyros.ne kinas. inhibitors.TKI) Anaplas.ic lymphoma kinas.(ALK)

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