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Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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j.urnal of Traditional Chinese Medicine 2025年

作者： MIN Yu zHENG Meifeng SUN j. PENG zetong CAO zhixian HUANG Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Obj.ctive: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (Il-1β)， interleukin-6 (Il-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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MICROSTRUCTURE AND COMPRESSIVE PROPERTIES OF REACTION-MIllED NiAl-10wt%TiC COMPOSITE

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Acta Metallurgica Sinica(English letters) 1998年第4期11卷 281-285页

作者： l.z zHOU and j.T. GUO(Dept. of Superalloy and Special Casting, Institute of Metal Research, The Chinese Academy of Sciences,Shenyang 110015, China) Inst of Metal Research The Chinese Acad of Sciences Shenyang China

A NiAl- TiC composite with fine grains was prepared by mechanical alloying elemental powders and hot pressing in vacuum. The TiC particles with diameters of about 50-100nm preferentially distribute on grain boundaries and those with a mean size less than 10nm disperse uniformly throughout the grains. Compressive properties of the composite at room temperature show significantly improved ductility and strength over that of cast NiAl, and its high temperature strength is 3 to 4 times as large as that of cast NiAl.

关键词： intermetallics composite microstructure mechanical property

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Development and application of functional gene arrays for microbial community analysis

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中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： z. l. HE j. D. VAN NOSTRAND l.Y. WU j. z. zHOU Institute for Environmental Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音，例如 oligonucleotide 探查设计， nucleic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

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PREPARATION AND CORROSION RESISTANCE OF NiP/TiO_2 COMPOSITE FIlM ON CARBON STEEl IN SUlFURIC ACID SOlUTION

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Acta Metallurgica Sinica(English letters) 2006年第2期19卷 117-123页

作者： l.z. Song S.z. Song j. zhao School of Environment ＆ Chemical Engineering Yanshan University Qinhuangdao 066004 China School of Materials Science and Engineering Tianjin University Tianjin 300072 China

A NiP/TiO2 composite film on carbon steel was prepared by electroless plating and sol-gel composite process. An artificial neural network was applied to optimize the prepared condition of the composite film. Corrosion behavior of the NiP/TiO2 composite film was investigated by polarization resistance measurement, anode polarization, ESEM （environmental scanning electron microscopy） and EIS （electrochemical impedance spectroscopy） measurements. Results showed that the NiP/ TiO2 composite film has a good corrosion resistance in 0.5mol/l H2SO4 solution. The element valence of the composite film was characterized by XPS （X-ray photoelectron spectroscopy） spectrum, and an anticorrosion mechanism of the composite film was discussed.

关键词： electroless plating and sol-gel composite process artificial neural network NiP/TiO2 composite film corrosion resistance

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Computational algorithms for simulating the grain structure formed on steel billets using cellular automaton and chaos theories

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International j.urnal of Minerals,Metallurgy and Materials 2011年第1期18卷 24-34页

作者： A.Ramírez-lópez G.Soto-Cortés j.gonzál.z-Trej. D.Muoz-Negrón Department of Materials Metropolitan Autonomous University Institute Polytechnic National Institute Technologic Autonomous of Mexico

The development of some computational algorithms based on cellular automaton was described to simulate the structures formed during the solidification of steel *** algorithms described take results from the steel thermal behavior and heat removal previously calculated using a simulator developed by present authors in a previous *** time is used for displaying the steel transition from liquid to mushy and *** it is also used to command computational subroutines that reproduce nucleation and grain *** routines are logically programmed using the programming language C＋＋ and are based on a simultaneous solution of numerical methods （stochastic and deterministic） to create a graphical representation of different grain structures *** grain structure obtained is displayed on the computer screen using a graphical user interface （GUI）.The chaos theory and random generation numbers are included in the algorithms to simulate the heterogeneity of grain sizes and morphologies.

关键词： continuous casting solidification grain growth algorithms computer simulation

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Preparation of neodymium-doped yttrium aluminum garnet powders and fibers

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j.urnal of Rare Earths 2008年第5期26卷 670-673页

作者： R. lópez j. zárate E. A. Aguilar j. Muoz-Saldaa Instituto de Investigaciones Metalurgicas UMSNH Morelia Centro de Investigación y de Estudios Avanzados del IPN Unidad Queretaro

Using nitrate precursors, a novel spray-drying assisted citrate gel process for the preparation of neodymium-doped yttrium alumi- num garnet （YAG） phase was developed. Synthesis of single-phase polycrystalline YAG was achieved at temperatures as low as 800 ℃ using the spray-drying methodology whilst conventional approaches currently available require 1000 ℃. Initially, a solution was prepared by mixing aluminum and yttrium nitrates, citric acid, etilenglycol and neodymium oxide. This solution was dried by pulverization （spray dryer） to obtain aggregated precursor powders of the compound. These aggregates were calcined at 800, 850 and 900 ℃ to determine the phase evolution from amorphous to crystalline by X-ray diffraction （XRD）. The morphology of aggregates was characterized by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. Moreover, through XRD it was determined that the crystall.zation of YAG phase started at about 800 ℃ without any intermediate phases. The powders were composed of spherical aggregates with an average diameter of 1 um. From these powders, ceramic fibers with additions of 2at.% and 5at.% Nd, were extracted from the melt with diameters ranging from 30 um to 50 um.

关键词： spray-drying melt extraction fibers yttrium aluminum garnet rare earths

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Post-acute pancreatitis diabetes:A complication waiting for more recognition and understanding

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World j.urnal of Gastroenterology 2023年第28期29卷 4405-4415页

作者： Diego García-Compeán Alan R j.ménez-Rodríguez j.an M Muñoz-Ayala j.sé A gonzál.z-gonzál.z Héctor j.Maldonado-Garza j.sús z Villarreal-Pérez Department of Gastroenterology Autonomous University of Nuevo LeónMonterrey 64700Nuevo LeónMexico Department of Endocrinology Autonomous University of Nuevo LeónMonterrey 64700Nuevo LeónMexico

Post-acute pancreatitis diabetes(PAPD)is the second most common type of diabetes below type 2 diabetes *** to the boom in research on this entity carried out during the last decade,its recognition has ***,much of the medical community still does not recognize it as a medium and long-term complication of acute pancreatitis(AP).Recent prospective cohort studies show that its incidence is about 23%globally and 34.5%in patients with severe *** the overall increase in the incidence of AP this complication will be certainly seen more *** to its high morbidity,mortality and difficult control,early detection and treatment are ***,its risk factors and pathophysiological mechanisms are not clearly *** diagnosis should be made excluding pre-existing diabetes and applying the criteria of the American Diabetes Association after 90 d of resolution of one or more AP *** review will show the evidence published so far on the incidence and prevalence,risk factors,possible pathophysiological mechanisms,clinical outcomes,clinical characteristics and preventive and corrective management of *** important gaps needing to be clarified in forthcoming studies will also be discussed.

关键词： Acute pancreatitis Diabetes mellitus Chronic pancreatitis Post-pancreatitis diabetes Pancreatogenic diabetes

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Nickel-coated silicon photocathode for water splitting in alkaline electrolytes

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Nano Research 2015年第5期8卷 1577-1583页

作者： j. Feng Ming Gong Michael j. Kenney j.stin z. Wu Bo zhang Yanguang li Hongj.e Dai Department of Chemistry Stanford University Stanford California 94305 USA Institute of Functional Nano & Soft Materials Soochow University Suzhou 215123 China

Photoelectrochemical （PEC） water splitting is a promising approach to harvest and store solar energy [1]. Silicon has been widely investigated for PEC photoelectrodes due to its suitable band gap （1.12 eV） matching the solar spectrum [2]. Here we investigate employing nickel both as a catalyst and protecting layer of a p-type silicon photocathode for photoelectrochemical hydrogen evolution in basic electrolytes for the first time. The silicon photocathode was made by depositing 15 nm Ti on a p-type silicon wafer followed by 5 nm Ni. The photocathode afforded an onset potential of -0.3 V vs. the reversible hydrogen electrode （RHE） in alkaline solution （1 M KOH）. The stability of the Ni/Ti/p-Si photocathode showed a 100 mV decay over 12 h in KOH, but the stability was significantly improved when the photocathode was operated in potassium borate buffer solution （pH ≈ 9.5）. The electrode surface was found to remain intact after 12 h of continuous operation at a constant current density of 10 mA/cm^2 in potassium borate buffer, suggesting that Ni affords good protection of Si based photocathodes in borate buffers.

关键词： photoelectrochemical water splitting silicon photocathode nickel

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large eddy simulation of turbulent diffusion flame combustion using a conserved scalar methodology

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航空动力学报 2007年第7期22卷 1106-1117页

作者： K. Wang z. Yang j. j. McGuirk Department of Aeronautical and Automotive Engineeringloughborough University loughborough Leicestershire LE11 3TU UK

The present paper describes an lES prediction of turbulent diffusion flame combustion in a simplifled axi-symmetric combustor *** calculations are carried out using a well-tested finite volume incompressible lES code which has been modified to handle variable density and reacting *** basic mixture fraction conserved scalar method *** with the chemical state relationships described by fast *** turbulence-chemistry interaction is modelled by a sub-grid PDF method and the PDF is assumed to follow a Beta-function *** lES predictions have been time-averaged over 3.5 flow-through times to generate the mean radial profiles of mixture fraction,product mass fraction,temperature,axial velocity and axial *** agreement of the lES predictions with the experimental data is good for all the above quantities at four different axial positions with largest differences at the first measurement *** lES method also provides information on the unsteady nature of turbulent diffusion *** turbulent reacting flows with large density ratio,it was found necessary to use a relaxation method in order to remove unphysical high-frequency fluctuations and to maintain numerical stability.

关键词：大涡模拟湍流扩散数量方法论弛豫法燃烧理论

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Deformation behaviors of Cu bicrystals with an inclined twin boundary at multiple scales

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j.urnal of Materials Science & Technology 2017年第7期33卷 698-702页

作者： l.l.li z.j.zhang P.zhang j.Tan j.B.Yang z.F.zhang Shenyaag National laboratory for Materials Science lastitute of Metal Research Chinese Academy of Sciences Shenyaag 110016 China

Cu bicrystals of different sizes with a sole twin boundary（TB） inclined at 45？with respect to the loading direction were deformed under unidirectional and cyclic loading, respectively. It is found that the slip bands（SBs） parallel to the TB can be activated near the TB at all scales without obeying the Schmid＇s *** is concerned with the local stress enhancement in the macroscale while it is more closely related to the scarce dislocation sources in the microscale. Moreover, a wedge-shaped zone formed near the TB in the microscale ascribed to the limited specimen size.

关键词： Bicrystal Micropillar Twin boundary Schmid factors Size effect

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