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0.1%他扎罗汀软膏和赋形剂对光老化皮肤组织学的作用:对面部光老化皮肤患者的6月周期、多中心、双盲、随机、赋形剂对照研究

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 17-18页

作者： Machtinger L.A. Kaidbey K. Lim j. j. sefton 牛新武 Allergan Inc.ClinicalRes earchandDevelopment2525Dupont Drive Irvine CA 92612 United States

Background:Topical tazarotene has been shown to offer efficacy in amelioratin g multiple effects of photodamage. Obj.ctives To evaluate the histological effec ts of tazarotene cream on photodamaged skin. Methods:In this multicentre, doubl e-blind, randomized, vehicle-controlled study, 50 patients with photodamaged f acial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1%crea m or vehicle cream to their face, once daily for 24 weeks. Results:Blinded asse ssments showed that tazarotene was less likely than vehicle to be associated wit h an increase in keratinocytic and melanocytic atypia, and more likely than vehi cle to be associated with a reduction in atypia. Between-group comparisons in d istribution of change from baseline categories of severity were in favour of taz arotene (P=0.055 for keratinocytic atypia, P= 0.034 for melanocytic atypia, and P < 0.001 for the number of granular cell layers). Compared with vehicle, tazaro tene was associatedwithanincreaseinepidermalpolarity(P=0.008)and epidermalthickn ess(P=0.012),and a tendency for stratum corneum compaction,Tazarotene was also a ssociated with widened intercellular spaces (reported as epidermal oede ma) relative to vehicle (P < 0.001). Conclusions:Treatment of photodamaged sk in with tazarotene is associated with an amelioration of keratinocytic and melan ocytic atypia, an improvement in epidermal polarity, and an increase in epiderma l thickness.

关键词：光老化他扎罗汀皮肤组织学角质形成细胞黑素细胞赋形表皮水肿颗粒层异型性色素沉着

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Evaluation of a rehabilitation support service after acute stroke: Feasibility and patient/carer benefit

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Health 2013年第7期5卷 1124-1131页

作者： j.anna j. McAdam Michael j. Leathley Margaret S. Crichton j.lie Dickens Cathy I. A. j.ck Caroline L. Watkins Belfast Health and Social Care Trust Belfast Northern Ireland Crossroads Care (Liverpool Sefton and Warrington) Liverpool UK School of Health University of Central Lancashire Preston UK Therapies Directorate The Royal Liverpool and Broadgreen University Hospitals NHS Trust Liverpool UK

Background: Stroke survivors returning home after discharge from hospital and their carers require support to meet their rehabilitation needs (independence in Activities of Daily Living, exercise, psychosocial support). Voluntary or charitable care providers may be able to address some of these needs. Obj.ctive: To explore the feasibility of delivering and evaluating enhanced support to stroke survivors and their carers, with a Rehabilitation Support Worker (RSW). Methods: 16 consecutive stroke survivors and their carers were included. All participants received usual hospital care. Seven of these patients and their carers were also allocated an RSW from a charitable care provider. The RSW accompanied therapy training sessions with the patient, carer and therapist in hospital. On discharge, the RSW visited the patient and carer at home over the initial 6 week post-discharge period to support them in practising rehabilitation skills. Patient function (Barthel Index) and patient/carer confidence were independently assessed at discharge (Week 0). The above assessments and patient/carer mood (GHQ-12) and Carer Giver Strain were also assessed at Weeks 1, 6 and 12. RSWs were interviewed for their views about the service. Results: Participants’ functional ability at Week 1 post-discharge was significantly higher in the RSW group. At 6 and 12 weeks post-discharge, functional ability was not significantly different between groups. Carers in the intervention group were less confident at all time points, however, this was not significant. There was no significant effect on carer strain or well-being. Interviews with RSWs highlighted areas of their training that could be enhanced and the need for greater clarity as to their role. Conclusions: The results showed that a definitive trial of rehabilitation support is feasible. A number of obstacles however would need to be overcome including: difficulty in identifying suitable patients, clarity of the RSW role, and appropriate training content.

关键词： Stroke Rehabilitation Activities of Daily Living Instrumental Activities of Daily Living

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