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Left Ventr.cular.Str.ctur., Geometr. and Systolic Function among Hyper.ensive Black Patients with r.duced Kidney Function

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Wor.d j.ur.al of Car.iovascular.Diseases 2015年第10期5卷 287-295页

作者： B. C. Mpembe F. B. Lepir. F. I. Mbutiwi j. r. makulo E. V. Kintoki M. P. Bayauli j. r. M’Buyamba-Kabangu Division of Car.iology and Hyper.ension Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Division of Nephr.logy Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Division of Endocr.nology and Metabolic Diseases Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo

Obj.ctive: To assess the LV mass, geometr. and systolic function in hyper.ensive patients with r.duced kidney function. Methods: Accor.ing to ASE guidelines, we estimated LV ventr.cular.mass, geometr. and systolic function in 155 consecutive hyper.ensive patients [51% women, mean age 51 ± 12 year., median dur.tion of hyper.ension 7 year.] with r.duced kidney function (eGFr.2 or.dipstick pr.teinur.a ≥ 1+). LVH was defined as LVMI >125 g/m2 in men, >110 g/m2 in non obese women or.>51 g/m2.7 for.obese men or.women. Wher. appr.pr.ate, we used Student t, Mann Whitney, one way ANOVA or.Chi squar. tests. A P value of 0.05 or.less was consider.d significant. r.sults: Seventy four.patients in the ser.es (48%) had r.duced kidney function (eGFr.30 ± 15 ml/min/1.73 m2). Compar.d to patients with r.latively nor.al kidney function, non obese and obese patients with r.duced kidney function had significantly gr.ater.LVM [271 (198 - 348) vs 276 (175 - 284) g/m2, p = 0.008] for.non obese;LVM 72 (47 - 88) vs 54 (44 - 73) g/m2.7, p = 0.007 for.obese] and lower.EF (60 ± 14 vs 68 ± 13%, p r. LVH of mainly concentr.c geometr.c patter. was pr.sent in 68 patients with r.duced kidney function (92%). Conclusion: In the pr.sent case ser.es, r.duced kidney function was associated with incr.ased LVM, concentr.c geometr.c patter. and impair.d systolic function.

关键词： Echocar.iogr.phic-LVH r.duced Kidney Function Hyper.ension Black Afr.cans

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The Ather.genic Dyslipidemia r.tio Log (Tg)/Hdl-C Was Not Associated with Ur.nar. Albumin Excr.tion r.te (Uaer. and Incr.ased Car.iovascular.r.sk in Black Patients with Type 2 Diabetes

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Wor.d j.ur.al of Car.iovascular.Diseases 2016年第1期6卷 14-20页

作者： M. F. Kaj.ngulu B. F. Lepir. I. N. F. Mbutiwi j. r. r. makulo E. Bieleli M. N. Nseka Division of Nephr.logy University of Kinshasa Democratic Republic of Congo Faculty of Medicine University of Kikwit Democratic Republic of Congo Division of Diabetes and Metabolic Diseases University of Kinshasa Hospital University of Kinshasa Democratic Republic of Congo

Obj.ctive: The obj.ctive is to assess the r.lationship of Log (TG)/HDL-c as sur.ogate estimate of ather.genic dyslipidemia with ur.nar. albumin excr.tion r.te and car.iovascular.r.sk among black patients with type 2 diabetes. Patients and methods: A post-hoc analysis of data fr.m 181 type 2 diabetes patients enr.lled in a cr.ss-sectional study of ur.nar. albumin excr.tion r.te seen at a ter.iar. healthcar.. Micr.albuminur.a and macr.albuminur.a wer. defined as ACr.30 - 299.9 mg/g and ACr.≥ 300 mg/g, r.spectively. Quar.iles of Log (TG)/HDL-c wer. used as sur.ogate estimates of ather.genic dyslipidemia. Car.iovascular.r.sk was assessed using WHO char. for.estimation of CV r.sk in low and middle income countr.es. Compar.sons acr.ss Log (TG)/HDL-c quar.iles wer. per.or.ed using one way ANOVA and Chi squar. for.tr.nd as appr.pr.ate. P r.sults: A high pr.valence (69%) of ather.genic dyslipidemia (AD) was obser.ed in the pr.sent case ser.es of Black Afr.cans with type 2 diabetes. Aver.ge total cholester.l levels showed significant (p = 0.010) tr.nds towar.s lower.values acr.ss quar.iles of Log (TG)/ HDL-c. No significant tr.nds wer. obser.ed for.aver.ge UAEr.and car.iovascular.r.sk acr.ss quar.iles of Log (TG)/HDL-c. Conclusion: Log (TG)/HDL-c as a sur.ogate estimate of ather.genic failed to pr.dict car.iovascular.r.sk in the pr.sent case ser.es of black patients with type 2 diabetes.

关键词： Log (TG)/HDL-C Car.iovascular.r.sk Type 2 Diabetes Black Afr.cans

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Ear.y Syphilis Pr.senting as Thickened Penile Plaques With an Embedded r.cur.ent Ulcer.(Chancr. r.dux): A Case r.por.

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Inter.ational j.ur.al of Der.atology and Vener.ology 2024年第3期7卷 160-162页

作者： Davies S.C. Hannafor. r. Cotter.j. Nor.her. Sydney Sexual Health Ser.ice Northern Sydney Local Health District St Leonards 2065 NSW Australia Nor.her. Beaches Der.atology Mona Vale 2103 NSW Australia

Intr.duction: The manifestations of syphilis ar. var.ed, and ser.logy can establish the diagnosis ear.y, especially in r.r. cases. We r.por. a case of chancr. r.dux (a r.r. r.cur.ence of pr.mar. syphilis), which was embedded within a secondar. syphilitic penile skin plaque. Ther. wer. missed oppor.unities at ear.ier.diagnosis as ser.logy for.syphilis was not or.er.d. Case pr.sentation: A 56-year.old man pr.sented with thickened penile plaques for.five months. He r.por.ed a small penile ulcer.appr.ximately one month pr.or. Ther. was no histor. of other.skin lesions or.r.sh. However. clinically ther. was an asymptomatic, indur.ted ulcer.embedded within a plaque which was swab-positive for.syphilis by PCr. A punch biopsy of a plaque was spir.chaete-positive using an immunoper.xidase stain. The patient's lesions r.solved thr.e weeks after.tr.atment with intr.muscular.benzathine penicillin. Discussion: Uncommonly r.por.ed even in the pr.antibiotic er., chancr. r.dux is now r.r.. The ulcer.usually r.cur. at or.near.the site of the or.ginal chancr., and has similar.mor.hological featur.s. The skin lesions of secondar. syphilis can exhibit r.mar.able mor.hological var.ety. The most common skin manifestation, a gener.lized macular.r.sh, was not pr.sent at any time in this case. r.ther. ther. wer. only a couple of nonspecific penile plaques. If biopsy is per.or.ed, histologic findings ar. var.able, though typically the inflammator. infiltr.te includes plasma cells. A special immunoper.xidase stain can highlight spir.chaetes in biopsy sections. Conclusion: This case highlights the impor.ance of consider.ng syphilis in the differ.ntial diagnosis of per.istent, atypical penile lesions and under.cor.s the need for.appr.pr.ate ser.logical testing in such instances. Copyr.ght © 2023 Hospital for.Skin Diseases (Institute of Der.atology),

关键词： chancr. r.dux genital r.sh immunohistochemistr. immunoper.xidase pr.mar. syphilis secondar. syphilis

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Sickle Cell Tr.it, Hemoglobin Levels and Anemia among Black Patients with Pr.dialysis Chr.nic Kidney Disease: A Post Hoc Analysis

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Wor.d j.ur.al of Car.iovascular.Diseases 2016年第8期6卷 258-264页

作者： F. B. Lepir. T. K. Mukendi F. I. N. Mbutiwi j. r. makulo E. K. Sumaili P. K. Kayembe N. M. Nseka Division of Nephr.logy University of Kinshasa Hospital Kinshasa Democratic Republic of Congo Kinshasa School of Public Health University of Kinshasa Kinshasa Democratic Republic of Congo

Obj.ctive: To assess the r.lationship between SCT, hemoglobin levels and anemia in CKD black patients. Method: A post-hoc analysis of data fr.m 188 patients, enr.lled in a cr.ss-sectional study of sickle cell tr.it (SCT) and chr.nic kidney disease (CKD), was per.or.ed to assess the r.lationship between SCT, hemoglobin (Hb) levels and anemia defined as Hb r. test wer. used as appr.pr.ate for.differ.nt compar.sons. P r.sults: SCT (HbAS) and nor.al hemoglobin (HbAA) wer. pr.sent in 39 (21%) and 149 (79%) CKD patients, r.spectively. Despite similar.estimated GFr.(eGFr. and age, HbAS patients had significantly lower.Hb levels (8.8 ± 1.8 vs 10 ± 2.2 g/dl;p = 0.001) and a higher.pr.por.ion of anemia (95% vs 72%, p = 0.001). In multiple linear.r.gr.ssion analysis, eGFr. BMI, SBP and SCT emer.ed as independent deter.inants of Hb levels. The pr.sence of SCT was associated with 1.185 g/dl decr.ase in Hb levels. Conclusion: In the pr.sent case ser.es, SCT was associated with lower.Hb levels suggesting its potential contr.bution to the pathogenesis of CKD-associated anemia.

关键词： Anemia Sickle Cell Tr.it Chr.nic Kidney Disease Black Afr.cans

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Pr.valence of Cir.adian Blood Pr.ssur. Patter.s and Factor. Associated with Non-Dipping among Black Patients with Untr.ated and Tr.ated Hyper.ension: A Cr.ss-Sectional Study

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Wor.d j.ur.al of Car.iovascular.Diseases 2017年第11期7卷 399-412页

作者： T. S. Mvunzi Y. Lubenga F. B. Lepir. j. r. makulo A. Nkodila D. K. Kuntonda Y. Samafundu Y. M. Nlandu Y. M. Engole B. P. Kianu F. Kintoki D. Mupepe N. Buila r. M. Kongo E. V. Kintoki Division of Car.iology University of Kinshasa Hospital Kinshasa Congo Division of nephr.logy Department of Internal Medicine University of Kinshasa Hospital Kinshasa Congo Centr. medical cite des aveugles University of Kinshasa Hospital Kinshasa Congo Clinique ngaliema University of Kinshasa Hospital Kinshasa Congo

Obj.ctive: To deter.ine the pr.valence of cir.adian BP patter.s and to assess factor. associated with the non-dipping patter. in untr.ated and tr.ated hyper.ensive patients, studied separ.tely. Methods: Clinical data and ABPM wer. obtained fr.m 52 untr.ated and 168 tr.ated hyper.ensive patients r.fer.ed for.ABPM to Monkole Hospital in Kinshasa. Twenty-four.ABPM was per.or.ed using an oscillometr.c device. Non-dipping patter. encompasses non-dipping (noctur.al systolic BP dip less than 10% of daytime systolic BP) and r.ver.e dipping (mean night SBP higher.than the day SBP). r.sults: the pr.valence of non-dipping patter. was 75% (63.5% non-dipping and 11.5% r.ver.e dipping) and 70% (60.1% non-dipping and 10.1% r.ver.e dipping) in untr.ated and tr.ated hyper.ensive patients, r.spectively. Advanced age (adj.sted Or.1.80;95%CI 1.96 - 3.38;p = 0.015), female sex (adj.sted Or.2.28;95%CI 1.19 - 4.36;p = 0.013), diabetes (adj.sted Or.5.06;95%CI 1.38 - 6.95;p = 0.014), r.duced kidney function (adj.sted Or.3.10;95%CI 1.50 - 6.43;p = 0.018), inflammation (adj.sted Or.2.65;95%CI 1.76 - 6.48;p = 0.031), LVH (adj.sted Or.4.45;95%CI 1.78 - 7.67;p = 0.024) and antihyper.ensive ther.py (adj.sted Or.0.19;95%CI 0.12 - 0.64;p = 0.018) emer.ed as the main independent factor. significantly associated with the non-dipping patter. in the study population. Conclusion: the non-dipping patter. was a common finding in studied patients and associated with tr.ditional and emer.ing r.sk factor. suggesting that this abnor.al patter. could be a mar.er.of high car.iovascular.r.sk.

关键词： Non-Dipping Pr.valence r.sk Factor. Hyper.ension Black Afr.cans

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Fir.t-pr.nciples calculations to investigate str.ctur.l,electr.nic,magnetic,optical and ther.odynamic pr.per.ies of r._(2)r._(3)Ge(r.=Pr.Sm)

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j.ur.al of r.r. Ear.hs 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier.r.Masr.ur.M.Hamedoun j.Khar.ach A.r.zzouk A.Hour.atallah N.Benzakour.K.Bouslykhane Labor.tor. of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this paper.we analyzed the physical char.cter.stics of the ter.ar. alloys r._(2)r._(3)Ge(r.=Pr.and Sm)using the fir.t pr.nciples calculation based on functional density theor. integr.ted in the Wien2k *** calculated for.ation ener.ies of Pr.(2)r._(3)Ge and Sm_(2)r._(3)Ge ar.−5.3827 and−5.2782 eV/atom,r.spectively,showing that these alloys may exist *** r.sults of the band str.ctur. and density of states indicate that all of the compounds tested ar. magnetic metals,and their.magnetism is mostly r.lated to the contr.bution of Pr.and Sm *** total magnetic moments of Pr.(2)r._(3)Ge and Sm_(2)r._(3)Ge ar. 4.07245 and 11.16161μB/f.u,*** par.meter. such as heat capacity at constant pr.ssur.,entr.py,Debye temper.tur.,lattice volume,compr.ssibility coefficients,and Gr.neisen par.meter.alloys wer. calculated using the Gibbs algor.thm and studied in depth over.a lar.e temper.tur. r.nge of 0-900 *** Debye temper.tur. incr.ases with incr.asing pr.ssur. and decr.ases with decr.asing ***,the Debye temper.tur.s calculated at p=0 GPa and T=300 K ar. equal to be 342 and 322 K for.Pr.(2)r._(3)Ge and Sm_(2)r._(3)Ge,*** optical char.cter.stics such as the r.al and imaginar. por.ions of the dielectr.c function,the absor.tion coefficient,the ener.y-loss function,and the r.fr.ctive index wer. investigated and discussed in mor. depth.

关键词： Magnetic metals Functional density theor. Density of states Magnetic moment Optical and ther.odynamic pr.per.ies r.r. ear.hs

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Fetal Head Compr.ssion: Its Possible r.le in Neur.logic Inj.r.

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Open j.ur.al of Obstetr.cs and Gynecology 2024年第1期14卷 124-143页

作者： Bar.y S. Schifr.n Br.an j. Koos Wayne r. Cohen Depar.ment of Obstetr.cs and Gynecology The Western University of Health Sciences Pomona USA The David Geffen School of Medicine at UCLA Los Angeles USA The Univer.ity of Ar.zona College of Medicine Tucson USA

It is widely assumed that fetal ischemic br.in inj.r. dur.ng labor.der.ves almost exclusively fr.m sever., systemic hypoxemia with mar.ed neonatal depr.ssion and acidemia. Sever. asphyxia, however. is one of sever.l causes of per.natal neur.logical inj.r. and may not be the most common;most neonates diagnosed with hypoxic-ischemic encephalopathy do not have evidence of sever. asphyxia. Sepsis, dir.ct br.in tr.uma, and dr.g or.toxin exposur. account for.some cases, while mechanical for.es of labor.and deliver. that incr.ase fetal intr.cr.nial pr.ssur. sufficiently to impair.br.in per.usion may also contr.bute. Because of bony compliance and mobile sutur. lines, the fetal skull changes shape and r.distr.butes cer.br.spinal fluid dur.ng labor.accor.ing to constr.ints imposed by contr.ctions, and bony and soft tissue elements of the bir.h canal as the head descends. These accommodations, including the incr.ase in intr.cr.nial pr.ssur., ar. adaptive and necessar. for.efficient descent of the head while safeguar.ing cer.br.l blood flow. Autonomic r.flexes mediated thr.ugh centr.l r.ceptor. nor.ally pr.vide ample pr.tection of the br.in fr.m the consider.ble pr.ssur. exer.ed on the skull. On occasion, those for.es, which ar. tr.nsmitted intr.cr.nially, may over.ome the var.ous adaptive anatomical, car.iovascular. metabolic, and neur.logical mechanisms that maintain cer.br.l per.usion and oxygen availability, r.sulting in ischemic br.in inj.r.. Accepting the notion of a potentially adver.e impact of fetal head compr.ssion suggests that avoidance of excessive uter.ne activity and of r.lentless pushing without steady pr.gr.ss in descent may offer.pr.tection for.the fetal br.in dur.ng par.ur.tion. Excessive head compr.ssion should be consider.d in the differ.ntial diagnosis of ischemic encephalopathy.

关键词： Fetal Br.in Inj.r. Fetal Head Compr.ssion Ischemic Encephalopathy Neonatal Encephalopathy

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Heat and Mass Tr.nsfer.for.a Nanofluid Flow in Fluidized Bed Dr.er.in Pr.sence of Induced Magnetic Field

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j.ur.al of Applied Mathematics and Physics 2024年第4期12卷 1401-1425页

作者： Kiptum j. Pur.ty Mathew N. Kinyanj.i Edwar. r. Onyango Pan Afr.can Univer.ity Institute for.Basic Sciences Technology and Innovation Nairobi Kenya Depar.ment of Pur. and Applied Mathematics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

This r.sear.h entails the study of heat and mass tr.nsfer.of nanofluid flow in a fluidized bed dr.er.used in tea dr.ing pr.cesses in pr.sence of induced magnetic field. A mathematical model descr.bing the fluid flow in a Fluidized bed dr.er.was developed using the nonlinear.par.ial differ.ntial equations. Due to their.non-linear.ty, the equations wer. solved numer.cally by use of the finite differ.nce method. The effects of physical flow par.meter. on velocity, temper.tur., concentr.tion and magnetic induction pr.files wer. studied and r.sults wer. pr.sented gr.phically. Fr.m the mathematical analysis, it was deduced that addition of silver.nanopar.icles into the fluid flow enhanced velocity and temper.tur. pr.files. This led to impr.ved heat tr.nsfer.in the fluidized bed dr.er. hence amplifying the tea dr.ing pr.cess. Fur.her.or., it was noted that induced magnetic field tends to decr.ase the fluid velocity, which r.sults in unifor. distr.bution of heat leading to efficient heat tr.nsfer.between the tea par.icles and the fluid, thus impr.ving the dr.ing pr.cess. The r.sear.h findings pr.vide infor.ation to industr.es on ways to optimize ther.al per.or.ance of fluidized bed dr.er..

关键词： Heat Tr.nsfer Induced Magnetic Field Nanofluid Fluidized Bed Dr.er

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Har.essing exosomes for.tar.eted ther.py: str.tegy and application

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Biomater.als Tr.nslational 2024年第1期5卷 46-58页

作者： r.n X. Xu r. Xu C. Su j. Or.anoid r.sear.h Center Institute of Translational Medicine Shanghai University Shanghai China National Center.for.Tr.nslational Medicine (Shanghai) SHU Br.nch Shanghai University Shanghai China Depar.ment of Micr.bial Pathogenesis Yale University School of Medicine New Haven CT United States Depar.ment of Biomedical Engineer.ng City University of Hong Kong Hong Kong Special Administrative Region China Depar.ment of Or.hopedic Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Exosomes, nanoscopic extr.cellular.vesicles pr.duced by cells, ar. pivotal in mediating intr.cellular.communication by tr.nspor.ing nucleic acids, pr.teins, lipids, and other.bioactive molecules, ther.by influencing physiological and pathological states. Their.endogenous or.gin and inher.nt diver.ity confer.distinct advantages over.synthetic vehicles like liposomes and nanopar.icles in diagnostic and ther.peutic applications. Despite their.potential, the clinical utility of exosomes is hamper.d by challenges such as limited stor.ge stability, yield, pur.ty, and tar.eting efficiency. This r.view focuses on exosomes as tar.eted ther.peutic agents, examining their.biogenesis, classification, isolation, and char.cter.sation, while also addr.ssing the cur.ent limitations in yield, pur.ty, and tar.eting. We delve into the liter.tur. to pr.pose optimisation str.tegies that can enhance their.ther.peutic efficacy and acceler.te the tr.nslation of exosome-based ther.pies into clinical pr.ctice. © 2024, Chinese Medical Multimedia Pr.ss Co Ltd. All r.ghts r.ser.ed.

关键词： biomedical engineer.ng exosomes modification nanotechnology tar.eted ther.py

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Bivar.ate Analysis of Pollutants Monthly Maxima in Mexico City Using Extr.me Value Distr.butions and Copula

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j.ur.al of Envir.nmental Pr.tection 2024年第7期15卷 796-826页

作者： j.an A. Vazquez-Mor.les Eliane r. r.dr.gues Hor.ensia j. r.yes-Cer.antes Facultad de Ciencias Fsico-Matemticas Benemrita Universidad Autnoma de Puebla Puebla Mexico Instituto de Matemticas Universidad Nacional Autnoma de Mxico Mexico City Mexico

In the pr.sent wor., we ar. inter.sted in studying the j.int distr.butions of pair. of the monthly maxima of the pollutants used by the envir.nmental author.ties in Mexico City to classify the air.quality in the metr.politan ar.a. In or.er.to obtain the j.int distr.butions a copula will be consider.d. Since we ar. analyzing the monthly maxima, the extr.me value distr.butions of Weibull and Fr.chet ar. taken into account. Using these two distr.butions as mar.inal distr.butions in the copula a Bayesian infer.nce was made in or.er.to estimate the par.meter. of both distr.butions and also the association par.meter. appear.ng in the copula model. The pollutants taken into account ar. ozone, nitr.gen dioxide, sulphur.dioxide, car.on monoxide, and par.iculate matter.with diameter. smaller.than 10 and 2.5 micr.ns obtained fr.m the Mexico City monitor.ng networ.. The estimation was per.or.ed by taking samples of the par.meter. gener.ted thr.ugh a Mar.ov chain Monte Car.o algor.thm implemented using the softwar. OpenBugs. Once the algor.thm is implemented it is applied to the pair. of pollutants wher. one of the coor.inates of the pair.is ozone and the other.var.es on the set of the r.maining pollutants. Depending on the pollutant and the r.gion wher. they wer. collected, differ.nt r.sults wer. obtained. Hence, in some cases we have that the best model is that wher. we have a Fr.chet distr.bution as the mar.inal distr.bution for.the measur.ments of both pollutants and in other. the most suitable model is the one assuming a Fr.chet for.ozone and a Weibull for.the other.pollutant. r.sults show that, in the pr.sent case, the estimated association par.meter.is a good r.pr.sentation to the cor.elation par.meter. between the pair.of pollutants analyzed. Additionally, it is a str.ightfor.ar. task to obtain these cor.elation par.meter. fr.m the cor.esponding association par.meter..

关键词： Copula Extr.me Value Distr.bution Bayesian Infer.nce Air.Pollution Mexico City

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