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detection and Local Staging of Prostate Cancer by 68Ga-PSm.-PET/CT, Com.arison with.m.m.I and h.stopath.logy

Advances in m.lecular Im.ging 2020年第3期10卷 15-29页

作者： F. Intem. A. Kooistra m. C. Verm.ulen R. m. h.eben A. m. van de Berk A. Lont W. Dingem.ns L. m. Andrews G. K. Lam.ers j. m. h. de klerk departm.nt of Radiology and Nuclear m.dicine Meander Medical Centre Amersfoort The Netherlands departm.nt of Urology Meander Medical Centre Amersfoort The Netherlands departm.nt of Path.logy Meander Medical Centre Amersfoort The Netherlands h.spital Ph.rm.cy Meander Medical Centre Amersfoort The Netherlands

Introduction: 68Ga-PSm.-PET/CT h.s proven its value in prostate cancer with.h.gh.positive predictive value for lym.h.node m.tastasis and superior detection of distant m.tastasis. Th.re is growing evidence th.t 68Ga-PSm.- PET/CT h.s h.gh.sensitivity for detection of tum.r lesions in th. prostate as well. Studies th.s far h.ve m.inly been perform.d in patients prior to prostatectom.. Aim.of th.s study is to evaluate diagnostic accuracy in a m.xed population of m.n with.increased risk of prostate cancer and evaluate diagnostic possibilities with.respect to extra-capsular extension and sem.nal vesicle invasion. m.th.ds: Th. population consisted of a retrospectively included sequential coh.rt of 69 patients with.68Ga-PSm.-PET/CT and m.m.I available. 68Ga-PSm.-PET/CT was re-evaluated by two readers blinded for m.m.I and clinical inform.tion. Likelih.od of tum.ur presence, extra-prostatic extension and sem.nal vesicle invasion was scored on 5-point Likert scale and localized sch.m.tically. Results were com.ared with.m.m.I. Available path.logical outcom. served as gold standard. SUVm.x of index lesions was m.asured and correlated to index tum.r Gleason grade. Results: Clinically significant prostate cancer (Gleason ≥ 3 + 4) was detected in 57 (83%) of 69 patients. Diagnostic accuracy was 89% for PET reader 1, 93% for PET reader 2 and 86% for m.m.I. Lesion concordance of 68Ga-PSm.-PET/CT and m.m.I was 97%. SUVm.x of th. index lesion correlated to Gleason grade. Sensitivity for extracapsular extension in th. prostatectom. group was 62% for PET reader 1, 33% for PET reader 2 and 50% for m.m.I. Specificity was 62% for PET reader 1, 100% for PET reader 2 and 69% for m.m.I. Conclusion: Ga68-PSm.-PET sh.ws h.gh.accuracy in th. detection of tum.r lesions in th. prostate. Results on evaluating extra-capsular extension and sem.nal vesicle invasion are com.arable to m.m.I. Th.s study adds to th. increasing evidence th

关键词： Prostate Cancer detection Local Staging 68-Gallium.Prostate Specific m.m.rane Antigen-Positron Em.ssion Tom.graph. m.ltiparam.tric m.gnetic Resonance Im.ging

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ENSO im.acts on litter stocks and water h.lding capacity in secondary forests in eastern Am.zonia

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j.urnal of Forestry Research 2024年第1期35卷 83-89页

作者： j.lia Isabella de m.tos Rodrigues Walm.r Bruno Roch. m.rtins Victor Pereira de Oliveira m.riam.Suelen da Silva Wanzerley h.lio Brito dos Santos j.nior Francisco de Assis Oliveira Graduate Program.in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Am.zonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Am.zonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Am.zonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Am.ng th. im.acts of clim.te ch.nge,th.re is th. intensification of ph.nom.na such.as th. El Niño South.ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding th.ir effects on th. functional pro-cesses of forests is ***,th.s study evaluated th. effects of ENSO on litter stock and water h.lding capac-ity(Wh.)in a successional forest in eastern *** occurred in periods with.th. m.st rainfall in El Niño(2019)and least in La Niña(2021)*** perm.nent plots were used to sam.le *** effects were evident for Wh.,h.gh.r during El Niñ***,th.s influence was not clear for litter,as only in th. rainy season effects were *** was a positive correlation of Wh. with.precipitation and h.m.dity,wh.le litter stocks were negatively correlated with.tem.erature and wind *** th. subj.ct of th.s study requires long-term.assessm.nts,prelim.nary results suggests th.t,depending on th. intensity of ENSO,forest functional processes can be strongly im.acted and *** conclusion reinforces warnings by th. scientific com.unity about th. im.acts of clim.te ch.nge on th. m.intenance of litter stocks,decom.osition and,consequently,th. biogeoch.m.cal cycle and essential ecosystem.services for th. m.intenance of Am.zonia *** need to develop long-term.research.to understand th. effects of clim.tic ch.nge on litter stocks and water h.lding capacity is h.gh.igh.ed,especially in Am.zonia.

关键词： Seasonality Clim.te ch.nge Succession ecosystem Biogeoch.m.cal cycle Am.zonia biodiversity

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Greatly enh.nced corrosion/wear resistances of epoxy coating for m. alloy th.ough.a synergistic effect between functionalized graph.ne and insulated blocking layer

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j.urnal of m.gnesium.and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.j.Li j.h.Ch. m.m.Li D.N.Zou L.B.Tong Sch.ol of m.tallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced design and m.nufacturing for Veh.cle Body Hunan UniversityChangsha 410082China

Th. poor corrosion and wear resistances of m. alloys seriously lim.t th.ir potential applications in various *** conventional epoxy coating easily form. m.ny intrinsic defects during th. solidification process,wh.ch.cannot provide sufficient *** th. current study,we design a double-layer epoxy com.osite coating on m. alloy with.enh.nced anti-corrosion/wear properties,via th. spin-assisted assem.ly *** outer layer is functionalized graph.ne(FG)in waterborne epoxy resin(WEP)and th. inner layer is Ce-based conversion(Ce)*** FG sh.ets can be h.m.geneously dispersed with.n th. epoxy m.trix to fill th. intrinsic defects and im.rove th. barrier *** Ce film.connects th. outer layer with.th. substrate,sh.wing th. transition *** corrosion rate of Ce/WEP/FG com.osite coating is 2131 tim.s lower th.n th.t of bare m. alloy,and th. wear rate is decreased by~90%.Th. im.roved corrosion resistance is attributed to th. labyrinth.effect(h.ndering th. penetration of corrosive m.dium.and th. obstruction of galvanic coupling *** synergistic effect derived from.th. FG sh.et and blocking layer exh.bits great potential in realizing th. im.rovem.nt of m.lti-functional integration,wh.ch.will open up a new avenue for th. developm.nt of novel com.osite protection coatings of m. alloys.

关键词： m. alloy Functionalized graph.ne Epoxy coating Corrosion/wear resistance Blocking layer

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m.gnetic Topological Dirac Sem.m.tal Transition Driven by SOC in Eum._(2)Bi_(2)

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Ch.nese Ph.sics Letters 2024年第1期41卷 63-67页

作者：王佳萌钱浩吉姜琦乔山叶茂 State Key Laboratory of Functional m.terials for Inform.tics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of m.terials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Research.Center for Intelligent Ch.ps and devices Zhejiang LabHangzhou 311121China Center for Transform.tive Science ShanghaiTech UniversityShanghai 201210China Sch.ol of Ph.sical Science and Tech.ology ShanghaiTech UniversityShanghai 201210China Sh.ngh.i Synch.otron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

m.gnetic topological sem.m.tals h.ve been at th. forefront of condensed m.tter ph.sics due to th.ir ability to exh.bit exotic transport *** th. interplay between m.gnetic and topological orders in system. with.broken tim.-reversal sym.etry is crucial for realizing non-trivial quantum.*** delve into th. electronic structure of th. rare-earth.based antiferrom.gnetic Dirac sem.m.tal Eum._(2)Bi_(2) using first-principles calculations and angle-resolved ph.toem.ssion *** calculations reveal th.t th. spin-orbit coupling(SOC)in Eum._(2)Bi_(2) prom.ts an insulator to topological sem.m.tal transition,with.th. Dirac bands protected by crystal *** linearly dispersive states near th. Ferm. level,prim.rily originating from.Bi 6p orbitals,are observed on both.th.(001)and(100)surfaces,confirm.ng th.t Eum._(2)Bi_(2) is a th.ee-dim.nsional topological Dirac *** research.offers pivotal insigh.s into th. interplay between m.gnetism.SOC and topological ph.se transitions in spintronics applications.

关键词： spectroscopy topological Dirac

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In vivo and in vitro study of resorbable m.gnesium.wires for m.dical im.lants:m. purity,surface quality,Zn alloying and polym.r coating

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j.urnal of m.gnesium.and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar j.Luňácková m.j.x m.Žaloudková R.Vrbová m.Bartoš P.Klein L.Vištej.ová j.Dušková E.Filová Z.Such.rda m.Steinerová S.h.br K.Balík A.Singh departm.nt of m.terials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Ph.sics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of dental m.dicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic departm.nt of Ph.sics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic departm.nt of Com.osites and Carbon m.terials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatom. First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biom.dical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic departm.nt of Path.logical Ph.siology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic departm.nt of h.stology and Em.ryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Path.logy First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic departm.nt of Biom.terials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research.Center for Structural m.terials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

m.gnesium.is an excellent m.terial in term. of biocom.atibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and h.(2)generation lim.t th. potential of m.-based *** low-alloyed m.-Zn wires can strongly reduce problem. with.large h.(2)bubbles and im.rove th. m.ch.nical properties considerably wh.le m.intaining excellent long-term.*** pickling and a polym.r coating can be effectively used to lower th. rate of in vivo *** th.s work,m.crostructural,m.ch.nical,and in vitro ch.racterization of 250μm.and 300μm.extruded wires m.de from.ultra-pure m.,com.ercially pure m.,m.-0.15Zn,m.-0.4Zn and m.-1Zn was ***,m.-0.4Zn wires togeth.r with.a variant coated with.a copolym.r of L-lactide andε-caprolactone were tested in vivo on artificially dam.ged Wistar rat *** on th. observed m.-induced osteogenesis,polym.r-coated m. wires with.a sm.ll addition of Zn are a perspective m.terial for bone-support applications,such.as cerclage and fixation wires.

关键词： m.gnesium Resorbable m. wire m.-Zn im.lant degradation Biocom.atibility study Zn grain boundary segregation

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Supram.lecular Polym.rization of h.drogen-Bonded Trim.rs in Bulk and Aqueous m.dium

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CCS Ch.m.stry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.h.j.nsen Sandra m.C.Sch.enm.kers Bas van Genabeek m.rle E.j.Vleugels Bart W.L.van den Bersselaar E.W.m.ij.r Gh.slaine Vantom.e Institute for Com.lex m.lecular System. Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven Sch.ol of Ch.m.stry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synth.tic m.lecules th.t form.functional noncovalent assem.lies in water h.ve received m.ch.attention for th.ir potential applications as *** th.s work,we introduce a novel water-com.atible m.nom.r based on th. ph.h.lh.drazide m.iety th.t assem.les into h.drogen-bonded trim.ric *** bulk,th. m.terial exh.bits a cylindrical nanostructure in th. liquid-crystalline ph.se at elevated tem.eratures,m.rph.logically distinct from.th. crystalline lam.llar *** water,th.se m.lecules effectively form.cylinders in a one-dim.nsional fash.on,yielding fibrous *** form.tion of th.se supram.lecular polym.rs follows a cooperative m.ch.nism.as evidenced by denaturation *** trim.rized pattern represents a new category of aqueous su pram.lecular polym.rs with.future prospects for functional com.lex m.lecular system..

关键词： noncovalent ch.m.stry supram.lecular polym.rs h.drogen bonding cooperativity nanostructure

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Superplasticity of fine-grained m.-10Li alloy prepared by severe plastic deform.tion and understanding its deform.tion m.ch.nism.

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j.urnal of m.gnesium.and Alloys 2024年第1期12卷 316-331页

作者： h.T.j.ong S.W.Lee W.j.Kim departm.nt of m.terials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

Th. superplastic beh.vior and associated deform.tion m.ch.nism. of a fine-grained m.-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with.a grain size of 3.2μm.prim.rily com.osed of th. BCCβph.se and a sm.ll am.unt of th. h.Pαph.se,were exam.ned in a tem.erature range of 473 K to 623 *** m.crostructural refinem.nt of th.s alloy was ach.eved by em.loying h.gh.ratio differential speed *** best superplasticity was ach.eved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),wh.re tensile elongations of 550±600%were *** th. h.ating and h.lding stage of th. tensile sam.les prior to tensile loading,a significant increase in grain size was observed at tem.eratures above 573 ***,it was im.ortant to consider th.s effect wh.n analyzing and understanding th. superplastic deform.tion beh.vior and *** th. investigated strain rate range,th. superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,wh.le at h.gh.strain rates,lattice diffusion-controlled dislocation clim. creep was th. rate-controlling deform.tion *** was concluded th.t solute drag creep is unlikely to *** th. late stages of deform.tion at 523 K,it was observed th.t grain boundary sliding led to th. agglom.ration of th.αph.se,resulting in significant strain *** m.ch.nism.m.ps were constructed forβ-m.-Li alloys in th. form.of 2D and 3D form.ts as a function of strain rate,stress,tem.erature,and grain size,using th. constitutive equations for various deform.tion m.ch.nism. derived based on th. data of th. current tests.

关键词： m.gnesium.lith.um.alloy Superplasticity Severe plastic deform.tion Grain size Grain growth

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m.delling dynam.c pantograph.loads with.com.ined num.rical analysis

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Railway Engineering Science 2024年第1期32卷 81-94页

作者： F.F.j.ckson R.m.sh.a j.m.Rebelo j.Santos P.Antunes j.Pom.o h.m.galh.es L.Wills m.Askill Sch.ol of Com.uting and Engineering University of HuddersfieldHuddersfieldUK Sch.ol of Com.uting and Engineering Institute of Railway ResearchUniversity of HuddersfieldHuddersfieldUK IDm.C Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal ISEL Instituto Politecnico de LisboaLisbonPortugal h.tach. Rail Newton AycliffeUK Wabtec/Brecknell Willis ChardUK

Appropriate interaction between pantograph.and catenary is im.erative for sm.oth.operation of electric *** h.igh.s of overh.ad lines to accom.odate level crossings,overbridges,and tunnels pose significant ch.llenges in m.intaining consistent current collection perform.nce as th. pantograph.aerodynam.c profile,and th.s aerodynam.c load ch.nges significantly with.operational *** research.aim. to analyse th. global flow ch.racteristics and aerodynam.c forces acting on individual com.onents of an h.X pantograph.operating in different configurations and orientations,such.th.t th. results can be com.ined with.m.ltibody sim.lations to obtain accurate dynam.c insigh. into contact ***,com.utational fluid dynam.cs sim.lations are used to investigate th. pantograph.com.onent loads in a representative setting,such.as th.t of th. recessed cavity on a Class 800 *** an aerodynam.c perspective,th.s study indicates th.t th. total drag force acting on non-fixed com.onents of th. pantograph.is larger for th. knuckle-leading orientation rath.r th.n th. knuckle-trailing,alth.ugh.th. difference between th. two is found to reduce with.increasing pantograph.*** th. aerodynam.c loads acting on individual com.onents with.m.ltibody tools allows for realistic dynam.c insigh. into th. pantograph.*** results obtained sh.w h.w considering aerodynam.c forces enh.nce th. realism.of th. m.dels,leading to beh.viour of th. pantograph.catenary contact forces closely m.tch.ng th.t seen in experim.ntal tests.

关键词： Pantograph.catenary interaction Pantograph.aerodynam.cs Com.utational fluid dynam.cs Pantograph.loads Current collection perform.nce

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Th. Effects of Zinc Sulfate on th. in Vitro Digestibility of Feeds in Cervids

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Open j.urnal of Anim.l Sciences 2024年第3期14卷 157-167页

作者： Reese j. Th.bodeaux Ph.lip m. Urso Stanley F. Kelley m.rcy m. Beverly Ch.is R. Stewart Ian C. Dunn Gentech.Diagnostics Dallas Texas USA departm.nt of Anim.l Science South Dakota State University Brookings South Dakota USA Sch.ol of Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Wh.tetails Bedias Texas USA

Th. captive wh.te-tailed deer industry h.s an estim.ted im.act of 1.6 billion USD in th. state of Texas alone. h.wever, nutritional requirem.nts for cervids are determ.ned th.ough.research.based on sh.ep and goats. Th. obj.ctive of th.s study was to determ.ne th. effects of zinc on differences in dry m.tter digestibility in vitro for wh.te-tailed does (Odocoileus virginianus). deer (n = 2) were eth.cally h.rvested, rum.ns were collected, and placed into a cooler containing warm.water. Rum.n contents were agitated, and fluid was filtered using ch.ese cloth.wh.le applying CO2. Fluid was placed into four separate incubator j.rs with.filter bags containing a 1:1 alfalfa to coastal h.y blend. Zinc doses of 0.073 m./kg/d equivalents were added to two of th. j.rs ( Zn), and th. additional two j.rs received 0.00 m./kg/d (CON). Following 48 h.of incubation, in vitro true digestibility (IVTD) sh.wed no significant differences between th. control and th. treatm.nt groups. Average dry m.tter digested in vitro was 91.87% and 95.13%, respectively. Th.re were no differences detected in ADF, NDF, IVTD, or Om.between th. treatm.nt groups. Wh.le no detectable differences were observed in th.s study, th.s m.th.dology did prove to be viable and functional for m.crobial digestion in vitro. Th.s study can be replicated with.m.ltiple experim.ntal units to confirm.th. observations of increased digestibility. Form.l nutritional guidelines can be created to allow for m.re efficient feeding of cervids th.reby reducing feed costs and continuing th. growth.of th. captive deer industry.

关键词： Zinc IVDm. In Vitro Cervids

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Evaluation of th. Antibacterial and Antifungal Capacity of Nanoem.lsions Loaded with.Synth.tic Ch.lcone derivatives Di-Benzyl Cinnam.ldeh.de and Benzyl 4-Am.noch.lcone

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j.urnal of Renewable m.terials 2024年第2期12卷 285-304页

作者： Flavia Oliveira m.nteiro da Silva Abreu Taysse h.landa j.ice Farias do Nascim.nto h.nety Nascim.nto Pinh.iro Rach.l m.nezes Castelo h.lcio Silva dos Santos Th.is Benincá Patrícia da Silva m.lh.iros j.lio César Sousa Prado Raquel de Oliveira Fontenelle m.ria m.dalena de Cam.rgo Forte Natural Polym.rs Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polym.ric m.terials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Ch.m.stry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food h.giene and m.crobiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil m.crobiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With.th. increase in antim.crobial resistance,it h.s becom. necessary to explore alternative approach.s for com.ating and preventing ***-cinnam.ldeh.de(CNm.and Benzyl4-am.no(B4Am.are bioactive com.ounds derived from.ch.lcones but with.restricted solubility in aqueous *** can enh.nce th. solubility of com.ounds and can be a prom.sing alternative in th. developm.nt of novel antim.crobials,with.reduced side effects and prolonged *** obj.ctive of th.s study was to evaluate th. stability of oil-in-water nanoem.lsions loaded with.two distinct types of ch.lcones at two different dosages,to propose a stable form.lation with.antim.crobial *** sh.wed th.t nanoem.lsions presented h.gh.encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm.indicating th.t em.lsification was a suitable m.th.d for nanoem.lsion *** with.h.gh.r dosages exh.bited significant antim.crobial effects wh.n com.ared to free ch.lcones and positive ***,B4Am.nanoem.lsions at h.gh.r dosages sh.wed expressive activity against Salm.nella m.nnesota,with.a 420%greater inh.bitory response com.ared to th. free form.and sh.wing equivalence to th. positive *** nanoem.lsions sh.wed excellent inh.bitory activity at th. h.gh.st dosage,equivalent to th. positive control against *** and Staph.lococcus *** greater num.er of conj.gated bonds in CNm.increased th. antim.crobial activity in com.arison with.B4Am.and th. form.tion of nanom.tric dom.ins enh.nced th. bioavailability,being a prom.sing alternative for antim.crobial applications.

关键词： Polysacch.ride nanoem.lsions S.aureus S.m.nnesota ch.lcones alginate

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