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Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate

Chinese Chemical Letters 2024年第6期35卷 249-253页

作者： Pei Cao Yilan Wang Lej.an Yu Miao Wang Liming Zhao xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fuj.an Province(IKKEM) Xiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fuj.an Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic ***,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic *** this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical *** have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits.

关键词： Carbon nanotubes fibers Mechanical response Rectification effect Ionic logic gate

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Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians

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j.urnal of Genetics and Genomics 2024年第7期51卷 703-713页

作者： Youwei Pu Siyu Pu Yanyan Chen Qinghong Kong xuyang Liu Qi Zhao Ke xu j.uming Liu Mengyuan Li Xiaoyu xu Xiaoyang Qiao Bing Su j.ng Chen Zhaohui Yang Tianj.an Laboratory of Advanced Biomedical Sciences Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Department of Pediatric Surgery and Laboratory of Pediatric Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi Medical UniversityZunyiGuizhou 563000China Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

The evolution of light-skin pigmentation among Eurasians is considered as an adaptation to the high-latitude *** Asians are ideal populations for studying skin color evolution because of the complex environment of East ***,we report a strong selection signal for the pigmentation gene phenylalanine hydroxylase(PAH)in light-skinned Han Chinese *** intron mutation rs10778203 in PAH is enriched in East Asians and is significantly associated with skin color of the back of the hand in Han Chinese males(Pj.r allele in East Asians)of rs10778203 decreases the binding activity of transcription factors and enhancer ***,the derived T allele of rs10778203 shows a weaker ultraviolet radiation response in A375 cells and zebrafish ***,rs10778203 decreases melanin production in transgenic zebrafish embryos after ultraviolet B(UVB)***,PAH is a potential pigmentation gene that regulates skin tanning *** selection has enriched the adaptive allele,resulting in weakened tanning ability in East Asians,suggesting a unique genetic mechanism for evolutionary skin lightening in East Asians.

关键词： East Asians PAH Skin pigmentation Natural selection Genetic adaptation

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Enhanced High-Temperature Energy Storage Performance of All-Organic Composite Dielectric via Constructing Fiber-Re in forced Structure

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Energy & Environmental Materials 2024年第2期7卷 299-307页

作者： Mengj.a Feng Yu Feng Changhai Zhang Tiandong Zhang xu Tong Qiang Gao Qingguo Chen Qingguo Chi Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080China

Optimizing the high-temperature energy storage characteristics of energy storage dielectrics is of great significance for the development of pulsed power devices and power control *** a polymer with a higher glass transition temperature(T_(g))as the matrix is one of the effective ways to increase the upper limit of the polymer operating ***,current high-T_(g)polymers have limitations,and it is difficult to meet the demand for high-temperature energy storage dielectrics with only one *** example,polyetherimide has high-energy storage efficiency,but low breakdown strength at high *** has high corona resistance,but low high-temperature energy storage *** this work,combining the advantages of two polymer,a novel high-T_(g)polymer fiber-reinforced microstructure is *** is designed as extremely fine fibers distributed in the composite dielectric,which will facilitate the reduction of high-temperature conductivity loss for *** the same time,due to the high-temperature resistance and corona resistance of polyimide,the high-temperature breakdown strength of the composite dielectric is *** the polyimide content with the best high-temperature energy storage characteristics is determined,molecular semiconductors(ITIC)are blended into the polyimide fibers to further improve the high-temperature ***,excellent high-temperature energy storage properties are *** 0.25 vol%ITIC-polyimide/polyetherimide composite exhibits high-energy density and high discharge efficiency at 150℃(2.9 j.cm^(-3),90%)and 180℃(2.16 j.cm^(-3),90%).This work provides a scalable design idea for high-performance all-organic high-temperature energy storage dielectrics.

关键词： all-organic energy storage density high-temperature high-temperature breakdown strength

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Bioinspired nanofluidic iontronics for brain-like computing

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Nano Research 2024年第2期17卷 503-514页

作者： Lej.an Yu Xipeng Li Chunyi Luo Zhenkang Lei Yilan Wang Yaqi Hou Miao Wang xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fuj.an Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Binzhou Institute of Technology Binzhou 256600China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fuj.an Province(IKKEM) Xiamen 361102China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

The human brain performs computations via a highly interconnected network of *** inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired nanofluidic iontronics has been proposed and gradually engineered to overcome the limitations of the conventional electron-based von Neumann architecture,which shows the promising potential to enable efficient brain-like *** and tunable nanofluidic ion transport behaviors and spatial confinement show promising controllability of charge carriers,and a wide range of structural and chemical modification paves new ways for realizing brain-like ***,a comprehensive framework of mechanisms and design strategy is summarized to enable the rational design of nanofluidic systems and facilitate the further development of bioinspired nanofluidic *** review provides recent advances and prospects of the bioinspired nanofluidic iontronics,including ion-based brain computing,comprehension of intrinsic mechanisms,design of artificial nanochannels,and the latest artificial neuromorphic functions ***,the challenges and opportunities of bioinspired nanofluidic iontronics in the pioneering and interdisciplinary research fields are proposed,including brain–computer interfaces and artificial neurons.

关键词： human brain ion transport nanofluidics brain-like computing memristive effect

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LD-pumped acousto-optic 2-switched Pr:YLF pulsed laser at 604 nm

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Chinese Optics Letters 2024年第8期22卷 77-81页

作者： Wei Yuan Canlin j.ang Huiying xu Zhiping Cai School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Center for Modern Educational Technology Guizhou Normal UniversityGuiyang 550001China Fuj.an Key Laboratory of Ultrafast Laser Technology and Applications Xiamen UniversityXiamen 361005China

We demonstrated an actively acousto-optic Q-switched pulsed laser based on Pr:YLF at 604 nm.A 604 nm continuous-wave(CW)laser with a maximum output power of 3.84 W was achieved for the first time,to the best of our *** Q-switched laser with a maximum average output power of 0.384 W,a narrowest pulse duration of 44.5 ns,a maximum single pulse energy of~64.1μj.and a maximum peak power of~1.44 kW was obtained at a repetition rate of 6 *** far as we know,this was the first report of such a narrow pulse duration,high-power,and high-energy Q-switched pulsed laser at604 *** beam quality factors M_x~2and M_y~2were measured to be 2.87 and 2.40,*** results show that acousto-optic Q-switching is a promising method for obtaining pulsed lasers.

关键词： 604 nm acousto-optics Q-switching pulsed laser Pr:YLF crystal

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Microstructure evolution and phase transformation of the mushy zone in a quenchedβ-solidifying TiAl alloy

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j.urnal of Materials Science & Technology 2024年第2期169卷 28-41页

作者： Fuqiang Zhang Xianfei Ding Leming xu Xin Feng Hai Nan j.anping He Yongfeng Liang j.npin Lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Cast Titanium Alloy R&D Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

This study investigates the phase constitutions and transformations that occur in the mushy zone and in the adj.cent phase fields of a directionally solidified Ti-44Al-8Nb-1Cr alloy via quenching *** results indicate that the mushy zone consists of unmeltedβdendrites and interdendritic liquid,whose formation can be attributed to the difference in melting point aroused by local heterogeneity in ***βdendrite is composed of numerous subgrains with various *** quenching,theβdendrite transforms into Widmanstättenαvia a precipitation reaction,owing to the decreasing cooling rate caused by heat transfer from the surrounding ***,after quenching,the interdendritic liquid is transformed intoγ*** the singleβphase field and the lower part of the mushy zone,a massive transformation ofβtoγ***,in theβ+αphase field,bothβandαphases are retained to ambient *** the heating process,the transformation ofα→βgives rise to the formation ofβvariants,which affects the orientation ofβdendrites in the mushy *** growth kinematics of theα→βtransformation was elucidated,revealing the preferential growth directions of111and112forβ***,this study presents an illustration of the formation process of the mushy zone and the microstructural evolution during the heating and quenching process.

关键词： Titanium aluminides Mushy zone Quenching Electron backscattering diffraction Phase transformation

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Large potential of strengthening the land carbon sink in China through anthropogenic interventions

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Science Bulletin 2024年第16期69卷 2622-2631页

作者： xu Yue Hao Zhou Yang Cao Hong Liao Xiaofei Lu Zhen Yu Wenping Yuan Zhu Liu Yadong Lei Stephen Sitch j.rgen Knauer Huij.n Wang j.angsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science&Technology(NUIST)Nanjing 210044China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China j.angsu Nanj.ng Environmental Monitoring Center Nanjing 210013China Key Laboratory of Agrometeorology of j.angsu Province Institute of EcologySchool of Applied MeteorologyNUISTNanjing 210044China Institute of Carbon Neutrality Sino-French Institute for Earth System ScienceCollege of Urban and Environmental SciencesPeking UniversityBeijing 100871China Department of Earth System Science Tsinghua UniversityBeijing 100084China State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing 100081China College of Life and Environmental Sciences University of ExeterExeter EX44RJUK Hawkesbury Institute for the Environment Western Sydney UniversityPenrith 2751Australia Key Laboratory of Meteorological Disaster Ministry of EducationJoint International Research Laboratory of Climate and Environment ChangeCollaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNUISTNanjing 210044China

The terrestrial ecosystem in China mitigates 21%-45%of the national contemporary fossil fuel CO_(2) emissions every *** and strengthening the land carbon sink is essential for reaching China’s target of carbon ***,this sink is subj.ct to large uncertainties due to the j.int impacts of climate change,air pollution,and human ***,we explore the potential of strengthening land carbon sink in China through anthropogenic interventions,including forestation,ozone reduction,and litter removal,taking advantage of a well-validated dynamic vegetation model and meteorological forcings from 16 climate *** anthropogenic interventions,considering Shared Socioeconomic Pathways(SSP)scenarios,the land sink is proj.cted to be 0.26-0.56 Pg C a^(-1) at 2060,to which climate change contributes 0.06-0.13 Pg C a^(-1) and CO_(2) fertilization contributes 0.08-0.44 Pg C a^(-1) with the stronger effects for higher emission *** anthropogenic interventions,under a close-to-neutral emission scenario(SSP1-2.6),the land sink becomes 0.47-0.57 Pg C a^(-1) at 2060,including the contributions of 0.12 Pg C a^(-1) by conservative forestation,0.07 Pg C a^(-1) by ozone pollution control,and 0.06-0.16 Pg C a^(-1) by 20%litter removal over planted *** sink can mitigate 90%-110% of the residue anthropogenic carbon emissions in 2060,providing a solid foundation for the carbon neutrality in China.

关键词： Carbon sink Forestation Ozone Litter removal

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Activation of the wnt/β-catenin/CYP1B1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia/reperfusion conditions

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Neural Regeneration Research 2024年第7期19卷 1541-1547页

作者： Xingyong Chen Nannan Yao Yanguang Mao Dongyun Xiao Yiyi Huang xu Zhang Yinzhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Cangzhou Central HospitalCangzhouHebei ProvinceChina Fuj.an Academy of Medical Science FuzhouFujian ProvinceChina Key Testing Laboratory of Fuj.an Province FuzhouFujian ProvinceChina

Accumulating evidence suggests that oxidative stress and the Wnt/β-catenin pathway participate in stroke-induced disruption of the blood-brain ***,the potential links between them following ischemic stroke remain largely *** present study found that cerebral ischemia leads to oxidative stress and repression of the Wnt/β-catenin ***,Wnt/β-catenin pathway activation by the pharmacological inhibito r,TWS119,relieved oxidative stress,increased the levels of cytochrome P4501B1(CYP1B1)and tight j.nction-associated proteins(zonula occludens-1[ZO-1],occludin and claudin-5),as well as brain microvascular density in cerebral ischemia *** r,rat brain microvascular endothelial cells that underwent oxygen glucose deprivation/reoxygenation displayed intense oxidative stress,suppression of the Wnt/β-catenin pathway,aggravated cell apoptosis,downregulated CYP1B1and tight j.nction protein levels,and inhibited cell prolife ration and *** ofβ-catenin or knockdown ofβ-catenin and CYP1B1 genes in rat brain mic rovascular endothelial cells at least partly ameliorated or exacerbated these effects,*** addition,small interfering RNA-mediatedβ-catenin silencing decreased CYP1B1 expression,whereas CYP1B1 knoc kdown did not change the levels of glycogen synthase kinase 3β,Wnt-3a,andβ-catenin proteins in rat brain microvascular endothelial cells after oxygen glucose deprivatio n/***,the data suggest that CYP1B1 can be regulated by Wnt/β-catenin signaling,and activation of the Wnt/β-catenin/CYP1B1 pathway contributes to alleviation of oxidative stress,increased tight j.nction levels,and protection of the blood-brain barrier against ischemia/hypoxia-induced inj.ry.

关键词： blood-brain barrier CYP1B1 oxidative stress oxygen glucose deprivation/reoxygenation tight j.nction vascular endothelial cells Wnt/β-catenin pathway β-catenin

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A Single-Event-Transient Hardened Phase Locked Loop for Clock and Data Recovery

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Chinese j.urnal of Electronics 2024年第2期33卷 353-361页

作者： Hengzhou YUAN Bin LIANG Hao SANG Weixia xu Yang GUO Xi CHEN National University of Defense Technology

A radiation-hardened phase-locked loop is proposed for phase interpolator clock and data recovery purposes. A sensitive node-compressed charge pump and multi-node cross coupling voltage-controlled oscillators are proposed in this phase-locked loop with the goal of achieving good j.tter performance and improving anti-SET（SET,single-event transient） capability. The root mean square（RMS） j.tter of the phase-locked loop is reduced from 3.7 ps to 2.58 ps at 2 GHz, while the laser threshold is improved from 120 p j.to 370 p j.compared to the unhardened phaselocked loop. The hardened phase-locked loop also does not lose its lock state from linear energy transfers（LETs） of 3.3 to 37.3 Me V·cm2/mg.

关键词： Charge pumps Voltage-controlled oscillators Energy exchange Noise Lasers j.tter Phase locked loops

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan j.an Alec C.Bancroft j. Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard j.hoon Lee Sowmya Ramesh Aaron W.j.mes David Hudson Kevin N.Dalby Lin xu Robert j.Tower Benj.min Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal inj.ry remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse inj.ry-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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