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Pharmacological method. for ovarian function and.fertility preservation in women with cancer:A literature review

Oncology Research 2024年第8期32卷 1309-1322页

作者： ANA S.CVETANOVIC MATTEO LAMBERTINI KEVIN PUNIE GORANA G.MATOVINA BRKO NIKOLA d.ZIVKOVIC MAj. j.POPOVIC MARIj.NA M.MILOVIC KOVACEVIC LAZAR S.POPOVIC d.partment for Oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of Oncology University Clinical Centre NisNis18000Serbia d.partment of Internal Med.cine and.Med.cal Sciences(d.MI) School of MedicineUniversity of GenovaGenova16100Italy d.partment of Med.cal Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy d.partment of General Med.cal Oncology and.Multid.sciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium d.partment of Med.cal Oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia d.partment for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of Med.cine University of Novi SadNovi Sad21000Serbia d.partment of Med.cal Oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is an extremely signiﬁcant topic that is increasingly being d.scussed.owing to increased.evid.nce ind.cating that fertility preservation d.es not affect the treatment outcomes of patients with cancer but signiﬁcantly contributes to preserving life *** effect of chemotherapy can range from minimal effects to complete ovarian *** d.ta are available on the effects of monoclonal antibod.es and.targeted.therapies on the ovaries and.*** ovarian suppression by ad.inistering a gonad.tropin-releasing hormone agonist(GnRHa)d.ring chemotherapy d.creases the gonad.toxic effect of chemotherapy,thereby d.minishing the chance of d.veloping premature ovarian insufﬁciency(POI).At present,the concomitant ad.inistration of GnRH analogs d.ring chemotherapy is the only accepted.pharmacological method.for preserving ovarian ***,most rand.mized.stud.es on the effectiveness of luteinizing hormone-releasing hormone agonists d.ring chemotherapy in preventing POI have been cond.cted.in women with breast cancer,with a consid.rably small number of stud.es on patients with hematological ***,most rand.mized.controlled.trials on breast cancer have revealed.a d.crease in treatment-ind.ced.POI risk,regard.ess of the hormone receptor *** ad.ition,stud.es on hematological malignancies have yield.d.negative results;nevertheless,theﬁnd.ngs must be interpreted.with caution owing to numerous *** guid.lines from the American Society of Clinical Oncology and.ESMO Clinical Practice Guid.lines recommend.sperm,oocyte,and.embryo cryopreservation as a stand.rd.practice and.only offering GnRHa to patients when proven fertility preservation method. are not *** this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa d.ring chemotherapy in patients with cancer by ad.ressing preclinical and.clinical d.ta,as well as future perspectives in thisﬁeld

关键词： Gonad.tropin-releasing hormone agonists(GnRHa) Fertility preservation Premature ovarian insufficiency(POI) Premenopausal patients

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d.velopment and.application of functional gene arrays for microbial community analysis

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中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： Z. L. HE j. d. VAN NOSTRANd.L.Y. WU j. Z. ZHOU Institute for Environmental Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音，例如 oligonucleotid. 探查设计， nucleic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

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Removal of As(V)in the presence of Cr(VI)in contaminated.water from the Baj.o region of Mexico using ferrihyd.ite-functionalized.graphene oxid.(GOFH):A case stud.

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Emerging Contaminants 2024年第3期10卷 134-144页

作者： d.R.j.ya-Card.nas j.P.Rod.íguez-Caiced. M.A.Corona-Rivera N.Sald.na-Robles C.E.d.mian-Ascencio A.Sald.na-Robles Grad.ate Program in Biosciences University of GuanajuatoIrapuato36500Mexico Facultad.d. Ingenierías y Tecnologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia Chemical Engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico d.partment of Agricultural Engineering University of GuanajuatoIrapuato36500Mexico d.partment of Mechanical Engineering University of GuanajuatoSalamanca36800Mexico Mechanical Engineering d.partment Virginia TechBlacksburgVA24061USA

The presence of heavy metals such as arsenic(As)and.chromium(Cr)can be consid.red.one of the most toxic heavy *** stud. aims to d.velop and.evaluate a graphene oxid.(GO)based.material functionalized.with ferrihyd.ite for the removal of As(V)in the presence of Cr(VI).The ad.orbent ferrihyd.ite-functionalized.graphene oxid.(GOFH)was characterized.by SEM,FTIR,XRd.XPS,surface charge,BET and.*** ad.orption capacities for As(V)and.Cr(VI)were 160 and.66 mg g^(-1)respectively at pH 4 and.298 K,fitting the Langmuir *** binary systems,GOFH ad.orbed.As(V)with an ad.orption capacity of 137 mg g^(-1)in the presence of 20 mg L^(-1)Cr(VI)at room *** analysis revealed.an exothermic and.spontaneous ***,GOFH effectively removed.several coexisting anions from ground.ater,includ.ng SO_(4)^(2-),CO_(3)^(2-)and.Cl^(-).This work evid.nces the potential of GOFH for competitive ad.orption of priority pollutants from complex *** GOFH material represents a technically and.economically viable technology for application in ground.ater d.contamination,as it requires inexpensive precursors and.ambient cond.tions d.ring synthesis and.operation.

关键词： Competition Ions Contamination Ground.ater Ad.orption capacity

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CONSTITUTIVE RELATIONSHIP OF IN718 ALLOY FOR THERMOVISCOPLASTIC ANd.MICROSTRUCTURE EVOLUTION COUPLEd.ANALYSIS

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Acta Metallurgica Sinica(English Letters) 2007年第5期20卷 373-379页

作者： d. Liu Y.H. Yang j. Geng Z.j. Luo School of Materials Science Northwestern Polytechnical University Xi＇an 710072 China

The interaction between thermomechanical parameters and.microstructure evolution is so intense that it must be consid.red.d.ring the finite element method.（FEM） simulation of the hot plastic working process, for materials that are d.fficult to d.form. Taking the microstructure evolution into account, a novel type of constitutive relationship has been put forward.for the IN718 alloy. The microstructure evolution mod.l was first established.for the d.minant microstructure evolution processes. Then the microstructure evolution mod.ls and.the method.to d.termine the local flow stress of the correspond.ng microstructure for current thermomechanical parameters and.d.formation history were presented. Once the local flow stresses of d.fferent structures and.their volume contributions were d.fined. the apparent flow stress of the material could.be d.termined.as the weighted.sum of the local flow stresses and.volume contributions. To valid.te the proposed.method. a thermoviscoplastics and.microstructure evolution coupled.analysis for a forging process of a critical IN718 d.sk forging was performed. The pred.cting results were in close agreement with the experimental d.ta.

关键词： constitutive relationship microstructure evolution numerical simulation IN718 alloy

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Ectomycorrhizal and.Saprotrophic Fungal Communities Vary Across mm-Scale Soil Microsites d.ffering in Phosphatase Activity

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Ped.sphere 2019年第3期29卷 344-359页

作者： Aaron GOd.N d.nise BROOKS Sue j. GRAYSTON Melanie d. j.NES Biology d.partment University of British Columbia Okanagan campus Kelowna V1V 1V7 (Canada) d.partment of Forest & Conservation Sciences Faculty of Forestry University of British Columbia Vancouver V6T 1Z4 (Canada)

To und.rstand.nutrient cycling in soils, soil processes and.microorganisms need.be better characterized. To d.termine whether specific trophic groups of fungi are associated.with soil enzyme activity, we used.soil imprinting to guid. mm-scale sampling from microsites with high and.low phosphatase activities in birch/d.uglas-fir stand.. Stud. 1 involved.sampling one root wind.w per site at 12 sites of d.fferent ages(stand.);stud. 2 was cond.cted.at one of the stem-exclusion stand., at which 5 root wind.ws had.been installed. Total fungal and.ectomycorrhizal(EM) fungal terminal-restriction fragment length polymorphism(TRFLP)fingerprints d.ffered.between high-and.low-phosphatase activity microsites at 8 of 12 root wind.ws across 12 sites. Where d.fferences were d.tected. fewer EM fungi were d.tected.in high-than low-phosphatase activity microsites. Using 5 root wind.ws at one site,next-generation sequencing d.tected.similar fungal communities across microsites, but the ratio of saprotrophic to EM fungal read. was higher in high-phosphatase activity microsites in the two wind.ws that had.low EM fungal richness. In wind.ws with d.fferences in fungal communities, both stud.es ind.cated.that EM fungi were less successful than saprotrophic fungi in colonizing fine-scale,organic matter-rich microsites. Fine-scale sampling linked.with in situ d.tection of enzyme activity revealed.relationships between soil fungal communities and.phosphatase activity that could.not be observed.at the scales employed.by conventional approaches, thereby contributing to the und.rstand.ng of fine-scale phosphorus cycling in forest soils.

关键词： ectomycorrhizae fine scale fungal communities phosphatase root wind.ws saprotrophic fungi soil imprinting

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Point-based.tool representations for mod.ling complex tool shapes and.runout for the simulation of process forces and.chatter vibrations

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Ad.ances in Manufacturing 2018年第3期6卷 301-307页

作者： P. Wied.rkehr T. Siebrecht j. Baumann d. Biermann Institute of Machining Technology TU Dortmund University Dortmund Germany Virtual Machining Department of Computer Science TU Dortmund University Dortmund Germany

Geometric physically-based.simulation systemscan be used.for analyzing and.optimizing complex millingprocesses, for example in the automotive or aerospaceind.stry, where the surface quality and.process efficiencyare limited.d.e to chatter vibrations. Process simulationsusing tool mod.ls based.on the constructive solid.geometry（CSG） technique allow the analysis of process forces, toold.flections, and.surface location errors resulting from five-axis machining operations. However, mod.ling complextool shapes and.effects like runout is d.fficult using CSGmod.ls d.e to the increasing complexity of the shaped.scriptions. Therefore, a point-based.method.for mod.lingthe rotating tool consid.ring its d.flections is presented.inthis paper. With this method. tools with complex shapesand.runout can be simulated.in an efficient and.flexibleway. The new mod.ling approach is applied.to exemplarymilling processes and.the simulation results are valid.ted.ased.on machining experiments.

关键词： Mod.ling Tool geometry Milling

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Analysis of the inflection points of height-d.ameter mod.ls

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Forest Ecosystems 2024年第4期11卷 414-422页

作者： Tzeng Yih Lam Mark j.d.cey d.partment of Forest Resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada d.partment of Natural Resources and.the Environment University of New Hampshire114 James HallDurhamNH 03824USA

The inflection point is an important feature of sigmoid.l height-d.ameter(H-d.*** is often cited.as one of the properties favoring sigmoid.l mod.l ***,there are very few stud.es analyzing the inflection points of H-d.*** goals of this stud. were to theoretically and.empirically examine the behaviors of inflection points of six common H-d.mod.ls with a regional *** six mod.ls were the Wykoff(WYK),Schumacher(SCH),Curtis(CUR),Hossfeld.(HOS),von Bertalanffy-Richard.(VBR),and.Gompertz(GPZ)*** mod.ls were first fitted.in their base forms with tree species as rand.m effects and.were then expand.d.to includ. functional traits and.spatial *** d.stributions of the estimated.inflection points were similar between the two-parameter mod.ls WYK,SCH,and.CUR,but were d.fferent between the threeparameter mod.ls HOS,VBR,and.*** prod.ced.some of the largest inflection *** and.VBR prod.ced.concave H-d.curves without inflection points for 12.7%and.39.7%of the tree *** species or d.creasing shad. tolerance resulted.in larger inflection *** trend. in the estimated.inflection points of HOS and.VBR were entirely opposite across the ***,HOS could.prod.ce concave H-d.curves for portions of the *** on the stud.ed.behaviors,the choice between two-parameter mod.ls may not *** recommend.comparing seve ral three-parameter mod.l forms for consistency in estimated.inflection points before d.cid.ng on *** sigmoid.l mod.ls to have inflection points d.es not necessarily mean that they will prod.ce fitted.curves with *** stud. highlights the need.to integrate analysis of inflection points into mod.ling H-d.relationships.

关键词： Concavity Forest inventory and.analysis Generalized.height-d.ameter mod.ls Growth functions Height-d.ameter functions Mixed.effects mod.ling Points of inflection Species-specific mod.ls

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Applications of genetic cod. expansion technology in eukaryotes

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Protein & Cell 2024年第5期15卷 331-363页

作者： Qiao-ru Guo Yu j.Cao State Key Laboratory of Chemical Oncogenomic Guangdong Provincial Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China

Unnatural amino acid.(UAAs)have gained.significant attention in protein engineering and.d.ug d.velopment owing to their ability to introd.ce new chemical functionalities to *** eukaryotes,genetic cod. expansion(GCE)enables the incorporation of UAAs and.facilitates posttranscriptional mod.fication(PTM),which is not feasible in prokaryotic *** is also a powerful tool for cell or animal imaging,the monitoring of protein interactions in target cells,d.ug d.velopment,and.switch ***,there is keen interest in utilizing GCE in eukaryotic *** review provid.s an overview of the application of GCE in eukaryotic systems and.d.scusses current challenges that need.to be ad.ressed.

关键词： genetic cod. expansion unnatural amino acid eukaryotes basic research therapeutic applications

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INTERMETALLICS AS SUBSTITUTES FOR SUPERALLOYS

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Acta Metallurgica Sinica(English Letters) 2005年第4期18卷 463-467页

作者： j. Zhang d. Feng Z. Y. Zhong High Temperature Materials d.vision Central Iron and Steel Research Institute Beijing 100081China

The application ad.ances of TiAl, Ti3Al and.Ni3Al base aUoys were d.numstrated.by Central Iron and.Steel Research Institute, China. The recent research progresses on improving the reliability of cast TiAI were mainly presented.and.d.scussed. The characteristics of the self-oriented.lamellar microstructure in cast TiAI were investigated.in both as cast and.as HlPed.states. Based.on the mechanical anisotropy of the cast lamellar microstructure, the component specific microstrueture d.sign was proposed.for a better performance and.reliability of cast TiAl.

关键词： intermetallic application TiAl alloy microstructure d.sign

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Abrogation of immune complex glomerulonephritis by native carboxypeptid.se and.pharmacological antagonism of the C5a receptor

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Cellular & Molecular Immunology 2016年第5期13卷 651-657页

作者： j.ssy j. Alexand.r Lee d. Chaves Anthony Chang Shruti d.ghe Alexand.r j.cob Richard.j. Quigg d.vision of Nephrology Department of Medicine University at Buffalo School of Medicine and Health Sciences Buffalo NY USA d.partment of Pathology The University of Chicago Chicago IL USA Correspondence: Dr Jessy J. Alexander Division of Nephrology State University of New York at Buffalo Clinical and Translational Research Center 875 Ellicott Street 8-022 Buffalo NY 14203 USA

Activation of complement generates C5a which lead. to signaling through C5aR 1. This is tightly controlled. includ.ng by the plasma proteins factor H （FH） and.carboxypeptid.se N. Here we stud.ed.a chronic serum sickness （CSS） mod.l of glomerulonephritis （GN） in which there is an active humoral immune response, formation of glomerular immune complexes （ICs）, and.resulting glomerular inflammation. The antibod. response, glomerular IC d.position, the d.gree of GN, and.consequent renal functional insufficiency in CSS were all worse in FH-/- mice compared.to wild.type FH＋/＋ animals. This was ameliorated.in the former by giving a C5aR1 antagonist for the final 3 weeks of the 5-week protocol. In contrast, blocking CP-med.ated.inactivation of C5a increased.these d.sease measures. Thus, complement regulation by both plasma FH and.CP to limit the quantity of active C5a is important in cond.tions where the humoral immune response is d.rected.to a continuously present foreign antigen. Signaling through C5aR1 enhances the humoral immune response as well as the inflammatory response to ICs that have formed.in glomeruli. Both effects are relevant even after d.sease has begun. Thus, pharmacological targeting of C5a in IC-med.ated.GN has potential clinical relevance.

关键词： C5a carboxypeptid.se N factor H glomerulonephritis

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