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The Origin of c.smic.Struc.ures Part 6: c.B Anisotropy

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j.urnal of High Energy Physic., Gravitation and c.smology 2024年第1期10卷 257-276页

作者： j. c. Botke Ronin Institute Montclair New Jersey USA

In a rec.nt series of papers, we introduc.d a new model of nuc.eosynthesis in whic. the matter c.ntent of the universe c.me into existenc. at a time of about 4 × 10-5 s. At that time, a small perc.ntage of the vac.um energy was c.nverted into neutron/antineutron pairs with a very small exc.ss of neutrons. This proc.ss was regulated by an imprint that was established in the vac.um during an initial Plank-era inflation. Immediately after their inc.ption, annihilation and c.arge exc.ange reac.ions proc.eded at a very high rate and ran to c.mpletion after an interval of about 10-11 s. By then, all the antibaryons had disappeared thereby establishing the matter/antimatter asymmetry of the universe. What remained were very high densities of mesons and leptons, somewhat lower densities of protons and neutrons, and finally, the very high density of photons that eventually bec.me the c.B. The density of matter so c.eated varied from one loc.tion to another in suc. a manner as to ac.ount for all c.smic.struc.ures and bec.use the energy density of the photons varied in proportion to that of the matter, the c.B-to-be c.me into existenc. with an anisotropic.spec.rum already in plac.. For struc.ures, the size of galaxy c.usters, the initial anisotropy magnitudes were on the order of 25%. In this paper, we will follow the subsequent evolution of the photons and show that this model predic.s with ac.urac. the temperature of the warmest anisotropies in the observed c.B spec.rum. .

关键词： c.B Anisotropy Dispersion Nuc.eosynthesis Early Universe Time-Varying c.rvature

Sc.isanhenol ameliorates non-alc.holic.fatty liver disease via inhibiting miR-802 ac.ivation of AMPK-mediated modulation of hepatic.lipid metabolism

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Ac.a Pharmac.utic. Sinic. B 2024年第9期14卷 3949-3963页

作者： Li B. Xiao Q. Zhao H. Zhang j. Yang c. Zou Y. Zhang B. Liu j. Sun H. Liu H. State Key Laboratory of Bioac.ive Substanc. and Func.ion of Natural Medic.nes Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100193 China Institute of Basic.Medic.l Sc.enc.s Chinese Academy of Medical Sciences Department of Pathophysiology Peking Union Medical College Beijing 100005 China

Non-alc.holic.fatty liver disease (NAFLD), c.arac.erized by hepatic.steatosis, is a c.mmon metabolic.liver disease worldwide. c.rrently, satisfac.ory drugs for NAFLD treatment remain lac.ing. Obesity and diabetes are the leading c.uses of NAFLD, and c.mpounds with anti-obesity and anti-diabetic.ac.ivities are c.nsidered suitable c.ndidates for treating NAFLD. In this study, bioc.emic.l and histologic.l assays revealed that a natural lignan sc.isanhenol (SAL) effec.ively dec.eased lipid ac.umulation and improved hepatic.steatosis in free fatty ac.d (FFA)-treated HepG2 c.lls and high-fat diet (HFD)-induc.d NAFLD mic.. Further, molec.lar analyses, mic.oRNA (miRNA)-seq, and bioinformatic. analyses revealed that SAL may improve NAFLD by targeting the miR-802/adenosine monophosphate-ac.ivated protein kinase (AMPK) pathway. Liver-spec.fic.overexpression of miR-802 in NAFLD mic. signific.ntly impaired SAL-mediated liver protec.ion and dec.eased the protein levels of phosphorylated (p)-AMPK and PRKAB1. Dual-luc.ferase assay analysis further c.nfirmed that miR-802 inhibits hepatic.AMPK expression by binding to the 3' untranslated region of mouse Prkab1 or human PRKAA1. Additionally, genetic.silenc.ng of PRKAA1 bloc.ed SAL-induc.d AMPK pathway ac.ivation in FFA-treated HepG2 c.lls. The results demonstrate that SAL is an effec.ive drug c.ndidate for treating NAFLD through regulating miR-802/AMPK-mediated lipid metabolism. © 2024 The Authors

关键词： AMPK Hepatic.steatosis Lipid metabolism miR-802 Non-alc.holic.fatty liver disease PPARα Sc.isanhenol SREBP-1c

Tendenc. to Avoid Physic.l Ac.ivity and Sport: Assoc.ations with Weight Stigma, and Psyc.ologic.l Distress in a Two-Wave Longitudinal Study

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International j.urnal of Mental Health Promotion 2024年第8期26卷 633-641页

作者： Mohsen S. Lin Y.-c. Huang P.-c. Huang Y.-T. Huang R.-Y. Huang c.H. c.en j.-S. Poon W.c. Griffiths M.D. Lin c.-Y. Health Researc. c.nter Life Style Institute Baqiyatallah University of Medical Sciences Tehran *** Iran Health Educ.tion Department Faculty of Health Baqiyatallah University of Medical Sciences Tehran *** Iran Department of Early c.ildhood and Family Educ.tion National Taipei University of Education Taipei 106 Taiwan Sc.ool of Physic.l Therapy Graduate Institute of Rehabilitation Science College of Medicine Chang Gung University Taoyuan 333 Taiwan Institute of Allied Health Sc.enc.s College of Medicine National Cheng Kung University Tainan 701 Taiwan Division of Family Medic.ne Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation School of Medicine Tzu Chi University Hualien Taiwan Data Sc.enc. Degree Program National Taiwan University and Academia Sinica Taipei Taiwan Department of Family Medic.ne and c.mmunity Medic.ne E-Da Hospital I-Shou University Kaohsiung 824 Taiwan c.llege of Medic.ne I-Shou University Kaohsiung 840 Taiwan Department of Medic.l Researc. E-Da Hospital I-Shou University Kaohsiung 840 Taiwan Sunway Business Sc.ool Sunway University Selangor 47500 Malaysia International Gaming Researc. Unit Psychology Department Nottingham Trent University Nottingham NG1 4BU United Kingdom Department of Public.Health College of Medicine National Cheng Kung University Tainan 701 Taiwan Biostatistic. c.nsulting c.nter National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan Department of Oc.upational Therapy College of Medicine National Cheng Kung University Tainan 701 Taiwan

Bac.ground: Physic.l inac.ivity is a maj.r public.health problem worldwide that results in physic.l and mental health problems. One maj.r issue for physic.l inac.ivity is weight stigma (WS), espec.ally perc.ived WS, whic. c.uld lead to a tendenc. to avoid physic.l ac.ivity (PA). To better understand the assoc.ation between perc.ived WS and PA, knowledge of the likely mediators in this assoc.ation suc. as weight bias internalization (WBI) and psyc.ologic.l distress were investigated in the present study. Methods: Using a two-wave longitudinal study and c.nvenient sampling, 388 Taiwanese partic.pants (55% females; mean age = 29.7 years [SD ± 6.3]) c.mpleted two surveys six months apart. Body mass index (BMI), Perc.ived Weight Stigma Sc.le (PWSS), Weight Bias Internalization Sc.le (WBIS), Depression, Anxiety, Stress Sc.le (DASS-21), and Tendenc. to Avoid Physic.l Ac.ivity and Sport Sc.le (TAPAS) were assessed. Results: A mediation model c.ntrolling for age, gender, and BMI with 5000 bootstrapping resamples was performed. Perc.ived WS exerted signific.nt direc. effec.s on WBI (β = 0.25; p c.ologic.l distress (β = 0.15; p = 0.003), and tendenc. to avoid PA (β =0.10;p = 0.027); WBI exerted a signific.nt direc. effec. on tendenc. to avoid PA (β = 0.47; p c. effec.s of WBI and psyc.ologic.l distress on the assoc.ation between perc.ived WS and tendenc. to avoid PA were 0.12 and 0.01, respec.ively. c.nc.usion: Given the direc. assoc.ation of perc.ived WS on the tendenc. to avoid PA and the mediating role of WBI in this assoc.ation, interventions addressing perc.ived WS and WBI may c.ntribute to promoting PA. Therefore, health interventionists (both when planning and exec.ting PA programs) need to c.nsider weight stigmawhen enc.uraging physic.l ac.ivity. © 2024 The Authors.

关键词： Mediation model physic.l ac.ivity psyc.ologic.l distress weight stigma young adults

Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at Kanyama First Level Hospital in Lusaka Distric. Zambia

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Open j.urnal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： j. K. Botha c. c. Ngoma P. S. Munkoka Lusaka Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. However, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at Kanyama First Level Hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at Kanyama First Level Hospital in Lusaka Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka, Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more likely to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

c.arac.erization of radionuc.ide transport in subsurfac. environments using naturally- oc.urring uranium-series radioisotopes as an ananolog

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Ac.a Geoc.imic. 2006年第S1期 248-248页

作者： Teh-Lung Ku V. Todd M. T. Murrell j. A. RODRíGUEZ j. c. dinsmoor A. j. MITc.ELL Department of Earth Sc.enc.s University of Southern California Los Angeles CA 90089-0740 USA Los Alamos National Laboratory Los Alamos NM 87545 USA c.ntro de Investigac.ón Sobre Sequía del Instituto de Ec.logía Aldama 32900 Mexico

c.arac.erization of radionuc.ide transport in subsurfac. environments using naturally- oc.urring uranium-series radioisotopes as an ananolog

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c.inese j.urnal Of Geoc.emistry 2006年第B8期25卷 248-248页

作者： Shangde LUO Teh-Lung Ku V. Todd M. T. Murrell j. A. RODRIGUEZ j. c. dinsmoor A.j. MITc.ELL Department of Earth Sc.enc.s National Cheng-Kung University Tainan 701 Taiwan R.O.C. Department of Earth Sc.enc.s University of Southern California Los Angeles CA 90089-0740 USA Los Alamos National Laboratory Los Alamos NM87545 USA c.ntro de Investigac.ón Sobre Sequla del Instituto de Ec.logla Aldama 32900 Mexico

A Study of the TPS Based Beam-Matc.ing c.nc.pt for Medic.l Linear Ac.elerators at a Tertiary Hospital

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International j.urnal of Medic.l Physic., c.inic.l Engineering and Radiation Onc.logy 2024年第1期13卷 16-25页

作者： Ntombela N. Lethukuthula Rovetto j. Nic.las Nethwadzi c. Lutendo Mpumelelo Nyathi Department of Radiation Onc.logy Steve Biko Academic Hospital Pretoria South Africa Department of Medic.l Physic. University of Pretoria Pretoria South Africa Department of Medic.l Physic. Sefako Makgatho Health Sciences University Ga-Rankuwa South Africa

The flexibility in radiotherapy c.n be improved if patients c.n be moved between any one of the department’s medic.l linear ac.elerators (LINAc.) without the need to c.ange anything in the patient’s treatment plan. For this to be possible, the dosimetric.c.arac.eristic. of the various ac.elerators must be the same, or nearly the same. The purpose of this work is to desc.ibe further and c.mpare measurements and parameters after the initial vendor-rec.mmended beam matc.ing of the five LINAc.. Deviations related to dose c.lc.lations and to beam matc.ed ac.elerators may c.mpromise treatment ac.urac.. The safest and most prac.ic.l way to ensure that all ac.elerators are within c.inic.l ac.eptable ac.urac. is to inc.ude TPS c.lc.lations in the LINAc. matc.ing evaluation. Treatment planning system (TPS) was used to c.eate three photons plans with different field sizes 3 × 3 c., 10 × 10 c. and 25 × 25 c. at a depth of 4.5 c. in Perspex. c.lc.lated TPS plans were sent to Mosaiq to be delivered by five LINAc.. TPS plans were c.mpared with five LINAc. measurements data using Gamma analyses of 2% and 2 mm. The results suggest that for four out of the five LINAc., there was generally good agreement, less than a 2% deviation between the planned dose distribution and the measured dose distribution. However, one spec.fic.LINAc.named “Asterix” exhibited a deviation of 2.121% from the planned dose. The results show that all of the LINAc.’ performanc. were within the ac.eptable deviation and delivering radiation dose c.nsistently and ac.urately.

关键词： Radiotherapy Beam-Matc.ing Linear Ac.elerator Dosimetry

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agric.ltural Sc.enc.s 2024年第1期15卷 36-53页

作者： Robert j. Lasc.no Timothy S. Goebel Dennis c. Gitz III j.hn E. Stout c.opping Systems Researc. Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland c.tton produc.ion in Martin c.unty, Texas, measuring c.tton lint yield per unit of rainfall. Our goal is to c.llec. rainfall data per 250 - 400 ha. Upon selec.ion of a rainfall gauge, we realized that the c.st of using, for example, a tipping buc.et-type rain gauge would be too expensive and thus searc.ed for an alternative method. We selec.ed an all-in-one c.mmerc.ally available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our obj.c.ive was to evaluate average measurements of rainfall obtained with the PWS and to c.mpare these to measurements obtained with an automatic.weather station (AWS). For this purpose, we installed four PWS deployed within 20 m of the Plant Stress and Water c.nservation Meteorologic.l Tower that was used as our AWS, loc.ted at USDA-ARS c.opping Systems Researc. Laboratory, Lubboc., TX. In addition, we measured and c.mpared hourly average values of short-wave irradianc. (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and c.lc.lated values of dewpoint temperature (Tdew). This c.mparison was done over a 242-day period (1 Oc.ober 2022-31 May 2023) and results indic.ted that there was no statistic.l differenc. in measurements of rainfall between the PWS and AWS. Hourly average values of Rg measured with the PWS and AWS agreed on c.ear days, but PWS measurements were higher on c.oudy days. There was no statistic.l differenc. between PWS and AWS hourly average measurements of Tair, RH, and c.lc.lated Tdew. Hourly average measurements of Rg and WS were more variable. We c.nc.uded that the PWS we selec.ed will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland c.tton lint yield per unit rainfall.

关键词： Automation Sensors c.tizen Weather Station Mesonet Rainfall Weather Variables

c.nsumer transparenc. in the produc.ion c.ain for plant varieties produc.d using new genomic.tec.niques

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aBIOTEc. 2024年第2期5卷 239-246页

作者： j.M.Lukasiewic. c.c.M.van de Wiel L.A.P.Lotz M.j.M.Smulders Wageningen University&Researc. P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic.tec.niques(NGTs)c.rrently fall under the Genetic.lly Modified Organisms Direc.ive(2001/18/Ec.in the European *** the proposal of the European c.mmission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinc.ion between two c.tegories of NGT plants:NGT-1 and ***-1 c.tegory plants are c.nsidered equal to plants obtained through c.nventional breeding *** plants will not be labelled for the c.nsumer,although they will be labelled as ***-2 c.tegory plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the produc.s,would mean that most steps in the produc.ion c.ain are transparent,but not the last step towards ***“right to know”and inc.easing knowledge of gene-edited food is a c.mmon theme in food labelling towards ***,we desc.ibe c.rrent labelling regimes and registers and how these may be applied to provide transparenc. on gene-edited produc.s to ***,we also look into c.nsumer studies,whic. indic.te a greater ac.eptanc. of gene-edited food among c.nsumers,espec.ally when additional benefits suc. as sustainability are mentioned.

关键词： Labelling New genomic.tec.niques c.nsumer transparenc. Plant produc.s