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Chemotherapy plus percutaneous radiofrequency ablation in patients with inoperable colorectal liver metastases

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World j.urnal of Gastrointestinal Oncology 2011年第4期3卷 60-66页

作者： j.seph Sgouros j.mes Cast Krishna K Garadi Maria Belechri David j.Breen j.hn rt Monson Anthony Maraveyas Academic Department of Oncology Castle Hill HospitalCottinghamHU16 5JQUnited Kingdom "Agii Anargiri" Cancer Hospital Radiology Department Castle Hill Hospital Academic Department of Oncology Castle Hill Hospital Division of Colorectal Surgery Department of Surgery University of Rochester Medical Center

AIM:To access the efficacy of chemotherapy plus radiofrequency ablation(RFA)as one line of treatment in inoperable colorectal liver ***:Eligible patients were included in three PhaseⅡ*** the first study percutaneous RFA was used first followed by 6 cycles of 5-fluorouracil,leucovorin and irinotecan combination(FOLFIRI)(adj.nctive chemotherapy trial).In the other two,chemotherapy(FOLFIRI or 5-fluorouracil,leucovorin and oxaliplatin combination)up to 12 cycles was used first with percutaneous RFA offered to responding patients (primary chemotherapy trials).RESULTS:Thirteen patients were included in the adj.nctive chemotherapy trial and 17 in the other *** inclusion they had 1-4 liver metastases(up to 6.5 cm in size).Two patients died during *** patients in the adj.nctive chemotherapy trial and 44%in the primary chemotherapy studies had their metastases *** PFS and overall survival in the adj.nctive study were 13 and 24 mo respectively while in the primary chemotherapy studies they were 10 and 21 mo *** one percent of the patients had tumour relapse in at least one previously ablated ***:Chemotherapy plus RFA in patients with low volume inoperable colorectal liver metastases seems safe and relatively *** high local recurrence rate is of concern.

关键词： Chemotherapy Colorectal cancer Liver metastases Radiofrequency ablation

Supplementing oat hulls to the diet of suckling piglets altered their intestinal tract and colonic microbiota development

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Animal Nutrition 2023年第1期12卷 284-296页

作者： Hubèrt M.j.van Hees Koen Chiers Leo A.den Hartog Theo A.T.G.van Kempen Dominiek Maes Sam Millet Geert P.j.j.nssens Department of Veterinary and Biosciences Ghent UniversityMerelbekeBelgium Trouw Nutrition Research and Development Amersfoortthe Netherlands Department of Pathology Ghent UniversityMerelbekeBelgium Animal Nutrition Wageningen University and ResearchWageningenthe Netherlands Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Reproduction Obstetrics and Herd HealthGhent UniversityMerelbekeBelgium ILVO(Flanders Research Institute for Agriculture Fisheries and Food)MelleBelgium

Current study evaluated the effect of a fine and coarsely ground insoluble dietary fibre source on the gastrointestinal development of suckling *** hulls(OH)were selected as a model feedstuff,rich in cellulose,lignin,and insoluble dietary *** experimental supplemental diets were formulated:a finely ground,low fibre and nutrient dense diet served as control(CON).For the 2 high fibre diets,15%heat-treated starch in CON was exchanged with OH,either finely(OH-f)or coarsely ground(OH-c).Litters of 10 primi-and multiparous sows(mean litter size 14.6±0.84)were *** a litter,experimental diets were allotted to triplets of 4 *** approximately 12 d of age,piglets’individual feed intakes were recorded 2 times per day when separated from their dam for 70 *** could suckle with their dam for the remainder of the *** d 24 and 25,from the total pool of 120 piglets,seven healthy well-eating piglets per treatment were selected for post-mortem evaluation,resulting in 14 replicates per *** of OH-c and OH-f did not impede clinical health and production performance of *** full stomach weights tended to be greater for OH-c compared to OH-f whereas CON was intermediate(P=0.083).Supplementing OH significantly increased ileal villus height and caecal dry matter concentration(Prt-chain fatty acid concentration and reduced total bacterial count as well asγ-proteobacteria count and proportion(Prted subtle developmental effects on gastrointestinal morphology and colonic microbial *** effects were largely independent from the particle size of the OH.

关键词： Oat hull Insoluble fibre Gastrointestinal development Suckling piglet

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FBC中含S和Cl煤燃烧下的碳钢退化研究

腐蚀科学与防护技术 2003年第3期15卷 125-129页

作者：彭晓 WP Pan rt Riley 中国科学院金属研究所金属腐蚀与防护国家重点实验室沈阳110016 CombustionLaboratoryMaterialsCharacterizationCenter

在实验室规模的流化床 (FBC)中分别燃烧低S(0 97mass% )与低Cl(0 0 2 6mass% ) ,中S(1 6 8mass% )与高Cl(0 4 2mass % ) ,高S(4 4 8mass% )与高Cl(0 4 1mass% )三种煤各 10 0 0小时后 ,对放置于接近沸腾床位置的A2 10 -C碳钢管的退... 详细信息

在实验室规模的流化床 (FBC)中分别燃烧低S(0 97mass% )与低Cl(0 0 2 6mass% ) ,中S(1 6 8mass% )与高Cl(0 4 2mass % ) ,高S(4 4 8mass% )与高Cl(0 4 1mass% )三种煤各 10 0 0小时后 ,对放置于接近沸腾床位置的A2 10 -C碳钢管的退化情况进行了研究 .结果表明 ,(1)碳钢退化明显受温度影响 ,随表面温度的升高显著加快 ;(2 )碳钢退化明显受飞行粒子带来的冲蚀影响 ;(3)燃烧低S低Cl煤对碳钢的耗损影响最小 ,而燃烧高S高Cl煤对碳钢耗损影响最大 .同时根据对腐蚀产物的观测分析。

关键词：流化床锅炉低碳钢腐蚀冲蚀 FBC 气体腐蚀

Probing Co/Si interface behaviour by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM)

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Nuclear Science and Techniques 2006年第4期17卷 202-211页

作者： PAN j. S. LIU R. S. TOK E. S. Institute of Materials Research and Engineering 3 Research Link Singapore 117602 Department of Physics National University of Singapore Kent Ridge Singapore 119260

In this work, we investigate the Co-Si reaction, the Co growth mode at room temperature, diffusion be- haviour as well as morphology evolution during annealing on both H-terminated and clean Si(001) and Si(111) sur- faces. From in-situ X-ray photoelectron spectroscopy (XPS) investigation, “Co-Si” reaction appears to occur on both H-terminated and clean surfaces at room temperature (rt) and the silicide crystallinity is improved upon annealing. Co growth mode on H-terminated Si surfaces occurs in a pseudo layer-by-layer manner while small close-packed is- land growth mode is observed on the clean Si surface. Upon annealing at different temperatures, Co atom concentra- tion decreases versus annealing time, which in part is attributed to Co atoms inward diffusion. The diffusion behav- iour on both types of surfaces demonstrates a similar trend. Morphology study using ex-situ atomic force microscopy (AFM) shows that the islands formed on Si(001) surface after annealing at 700 °C are elongated with growth direc- tions alternate between the two perpendicular [ 110 ] and [110] directions. Triangular islands are observed on Si (111) surface.

关键词：钴硅金属-半导体界面反应 X射线光电子光谱学原子力显微镜方法表面形态

Outcomes after robot-assisted laparoscopic radical prostatectomy

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Asian j.urnal of Andrology 2009年第1期11卷 94-99页

作者： Declan G. Murphy Benj.min j. Challacombe Anthony j. Costello The Urology Centre Guy＇s ＆ St. Thomas ＇NHS Foundation Trust London SE1 9RT UK Department of Urology Royal Melbourne Hospital Melbourne VIC 3054 Australia

Robot-assisted laparoscopic radical prostatectomy （RALRP） using the da Vinci surgical system is now in widespread use in many countries where economic conditions allow the installation of this expensive technology. Controversy has surrounded the procedure since it was first performed in 2000, with many critics highlighting the lack of evidence to support its use. However, despite the lack of level I evidence, many large studies of patients have confirmed that the procedure is feasible and safe, with low morbidity. Available longer-term oncological data seem to show that outcomes from the robotic approach at least match those of traditional open radical prostatectomy. Functional outcomes also seem satisfactory, although randomized controlled trials are lacking. This paper reviews the current status of RALRP with respect to perioperative data and complications and oncologic and functional outcomes.

关键词： da Vinci laparoscopic outcomes prostate cancer radical prostatectomy robotic

玻璃体平坦部切除术后后囊膜缺损患者1例的白内障手术治疗(英文)

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国际眼科杂志 2010年第9期10卷 1657-1658页

作者： Zsuzsanna Szij.rtó Zsolt Biró 佩奇大学眼科

目的:评价1例54岁女性糖尿病性视网膜病变患者玻璃体平坦部切除术后后囊膜缺损的手术治疗效果。方法:我们使用"内外水轮廓分离"技术进行白内障超声乳化术对此例患者进行手术。结果:使用后房型人工晶状体植入后,手术进展顺利。结论:仔细... 详细信息

目的:评价1例54岁女性糖尿病性视网膜病变患者玻璃体平坦部切除术后后囊膜缺损的手术治疗效果。方法:我们使用"内外水轮廓分离"技术进行白内障超声乳化术对此例患者进行手术。结果:使用后房型人工晶状体植入后,手术进展顺利。结论:仔细散瞳检查后的精确诊断和详细讨论患者的病情,对于晶状体后囊缺损患者的成功治疗是必要的。

关键词：内外水轮廓分离超声乳化术后囊膜缺损

Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells

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j.urnal of Animal Science and Biotechnology 2017年第4期8卷 842-851页

作者： Omar Bulgari Xianwen Dong Alfred L.Roca1 Anna M. Caroli j.an j. Loor Department of Animal Sciences and Division of Nutritional Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA Department of Molecular and Translational Medicine University of BresciaBrescia 25123 Italy Institute of Animal Nutrition Sichuan Agricultural University Chengdu 611130 China Division of Nutritional Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA

Background: Innate immune responses induced by in vitro stimulation of primary mammary epithelial cells(MEC) using Gram-negative lipopolysaccharide(LPS) and Gram-positive lipoteichoic acid(LTA) bacterial cell wall components are well-characterized in bovine species. The obj.ctive of the current study was to characterize the downstream regulation of the inflammatory response induced by Toll-like receptors in primary goat MEC(pgMEC). We performed quantitative real-time rt-PCR(qPCR) to measure mRNA levels of 9 genes involved in transcriptional regulation or antibacterial activity: Toll-like receptor 2(TLR2), Toll-like receptor 4(TLR4), prostaglandin-endoperoxide synthase 2(PTGS2), interferon induced protein with tetratricopeptide repeats 3(IFIT3), interferon regulatory factor 3(IRF3), myeloid differentiation primary response 88(MYD88), nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NFKB1), Toll interacting protein(TOLLIP), and lactoferrin(LTF). Furthermore,we analyzed 7 cytokines involved in Toll-like receptor signaling pathways: C-C motif chemokine ligand 2(CCL2), C-C motif chemokine ligand 5(CCL5), C-X-C motif chemokine ligand 6(CXCL6), interleukin 8(CXCL8), interleukin 1 beta(IL1 B), interleukin 6(IL6), and tumor necrosis factor alpha(TNF).Results: Stimulation of pgMEC with LPS for 3 h led to an increase in expression of CCL2, CXCL6, IL6, CXCL8,PTGS2, IFIT3, MYD88, NFKB1, and TLR4(P < 0.05). Except for IL6, and PTGS2, the same genes had greater expression than controls at 6 h post-LPS(P < 0.05). Expression of CCL5, PTGS2, IFIT3, NFKB1, TLR4, and TOLLIP was greater than controls after 3 h of incubation with LTA(P < 0.05). Compared to controls, stimulation with LTA for 6 h led to greater expression of PTGS2, IFIT3, NFKB1, and TOLLIP(P < 0.05) whereas the expression of CXCL6, CXCL8, and TLR4 was lower(P < 0.05). At 3 h incubation with both toxins compared to controls a greater expression(P < 0.05) of CCL2, CCL5, CXCL6, CXCL8, IL6, PTGS2, IFIT3, IR

关键词： Gene expression Inflammation Lactation Mastitis

Evalution of the Accuracy and Performance of Multi-GNSS(MGEX)Positioning for Long Baselines by Using Different Software

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j.urnal of Geodesy and Geoinformation Science 2023年第4期6卷 79-92页

作者： Atinc Pirti Mehmet Ali Yücel Department of Surveying Engineering Davutpasa Yildiz Technical UniversityEsenler 34220Türkiye Department of Geomatics Engineering Canakkale Onsekiz Mart UniversityCanakkale 17100Türkiye

The Global Positioning System(GPS)is a GNSS constellation,but GNSS is not always *** is one of the GNSS constellations used around the *** GNSS constellations include GPS(US),QZSS(j.pan),Beidou/BDS(China),Galileo(EU),and GLONASS(Russia).In 1999,the European Commission(EC)proposed the European Galileo satellite navigation system for the first time.A four-phase development was proposed,including public and private sector *** was intended for both civilian and government use,and is managed and controlled by civil *** is made up of 30 satellites,a number of globally distributed ground stations,and a ground control and monitoring system,all of which are extremely similar to the structure,format,and layout of *** this study,we investigate GPS/GLONASS/Galileo/Beidou/IRNSS/QZSS Navigation Satellite System integration algorithm for long baselines ranging from 1500 km to 3000 km in China,j.pan and *** positioning performance with GPS/GLONASS/Galileo/BDS/IRNSS/QZSS,GPS-only,Galileo-only,GLONASS-only and BDS-only,*** compared in terms of the positioning *** improvement of positioning accuracy over long baselines can be found with GPS/GLONASS/Galileo/BDS/QZSS/IRNSS compared with that of GPS-only and that of *** obtained differences of the two baselines(Topcon Magnet Tools Software(Multi-GNSS)-(CSRS-PPP(GPS/GLONASS),(Trimble-rtX(GPS/GLONASS),(AUSPOS(GPS/GLONASS))Online Processing Software)by using GPS/GLONASS/Galileo/BDS/QZSS/IRNSS signals is between 40 cm and 111.5 cm on three days.

关键词： Multi-GNSS(MGEX) accuracy analysis improvement QZSS Beidou Galileo IRNSS

EXPRESSION OF BCRP GENE IN THE NORMAL LUNG TISSUE AND LUNG CANCER

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Chinese j.urnal of Cancer Research 2001年第1期13卷 22-26页

作者：毛友生 Austin Doyle Weidong Yang Yuetong Wei Mark j. Krasna Douglas D. Ross Greenebaum Cancer Center University of Maryland Medical School

Obj.ctive: To investigate the expression of novel multidrug resistance transporter (BCRP gene) from human MCF-7/AdrVp breast cancer cells in normal lung tissue and non-small lung cancer tissue. Methods: RNA was extracted immediately from fresh normal lung tissue and viable tumor tissue harvested from surgically resected specimens of non-small cell lung cancer patients. cDNA of BCRP gene was prepared by rt-PCR and was then amplified by PCR. cDNA products from those specimens were transferred to blotting membrane through electrophoresis and transferring technique and southern blot hybridization was eventually performed to detect the expression of BCRP gene. Results: RNA were extracted from 8 tumor tissue alone and 12 pairs of tumor tissue and normal lung tissue harvested from the same lung. Four patients’ RNA samples with poor quality due to degrading were discarded. cDNA products of BCRP gene were obtained by rt-PCR and were then amplified by PCR in the remain 16 patients’ RNA samples. Through southern blot hybridization, BCRP gene was found to be slightly expressed in various amounts in all normal lung tissue (10/10) and only in a half of tumor tissue samples (8/16). Conclusion: BCRP gene is slightly expressed in different amount in all normal lung tissue and only in a half of tumor tissue of non-small cell lung cancer patients. It is possible to induce it’s overexpression and to develop multidrug resistance during chemotherapy if using anthracycline anticancer drugs.

关键词： Multidrug resistance BCRP gene Non-small cell lung cancer Chemotherapy