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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George j.msheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.levi j.mes D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Proj.ct to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International llC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 ml of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular j.nction Schwann cell

Fabrication of Submicron-Diameter and Taper Fibers Using Chemical Etching

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j.urnal of Materials Science & Technology 2012年第4期28卷 308-312页

作者： Hani j. Kbashi Department of Physics College of Science University of Baghdad Baghdad Al-Jadriya-10070 Iraq

The thin, long length and high smoothness silica photonic nanowires and taper optical fiber were fabricated using a simple and low cost chemical etching method. A two-steps wet etch process were used consisting of etching with 30% HF acid to remove cladding and 24% HF acid to decrease fiber core diameter. An approach for on-line monitoring of etching using 1300 nm light power transmitted in the optical fiber was used to determine the diameter of the remaining core and showed a transition between two different operation regimes of nanofiber from the embedded regime, where the mode was isolated from the environment, to the evanescent regime. The data indicated that the diameter of the silica fiber decreased linearly for both 30% and 24% HF acid with 1.2 and 0.1/zm/min grad diameter, respectively at room temperature, and more than 70% of the mode intensity could propagate outside fiber when the core diameter was less than 1μm. The results of fiber taper showed that the fiber was tapered by a factor of 20 while retaining a thin core structure and leaving about more than 85% of core structure.

关键词： Chemical etching Submicron fiber Taper fibers

Soybean aphid intrabiotype variability based on colonization of specific soybean genotypes

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Insect Science 2015年第6期22卷 785-792页

作者： Michelle Pawlowski Curtis B. Hill David j. Voegtlin Glen l. Hartman Department of Crop Sciences National Soybean Research Center University of Illinois Urbana Illinois USA Center for EconomicEntomology Illinois Natural History Survey University of Illinois Champaign Illinois USA USDA Agricultural Research Service National Soybean Research Center University of Illinois Urbana Illinois USA

The soybean aphid, Aphis glycines Matsumura （Hemiptera： Aphididae）, is one of the most destructive insect pests on soybeans in the United States. One method for managing this pest is through host plant resistance. Since its arrival in 2000, 4 aphid biotypes have been identified that are able to overcome soybean aphid resistance （Rag） genes. A soybean aphid isolate collected from Moline, Illinois readily colonized soybean plants with the soybean aphid resistance gene Rag2, unlike biotypes 1 and 2, but similar to soybean aphid biotype 3. Two no-choice experiments compared the virulence of the Moline isolate with biotype 3. In both experiments, differences in aphid population counts were not significant （P 〉 0.05） on soybean genotypes lD08-12957a （Rag2） and lD11-5413a （Rag2）, but the aphid counts for the Moline isolate were significantly （P 〈 0.05） lower than the aphid counts for the biotype 3 isolate on the soybean genotypes Dowling （Rag1）, lD05-16611 （Rag1）, lD11-4576a （Rag1）, and P1567598B （raglb and rag3）. The Moline isolate was a variant of aphid biotype 3, which is the first report showing that soybean aphid isolates classified as the same biotype, based on virulence against specific Rag genes, can differ in aggressiveness or ability to colonize specific host genotypes.

关键词： Aphis glycines biotype biotype variant soybean soybean aphid resistance

On the effects of landscape configuration on summer diurnal temperatures in urban residential areas: application in Phoenix, AZ

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Frontiers of Earth Science 2019年第3期13卷 445-463页

作者： Yiannis KAMARIANAKIS Xiaoxiao lI B. l. TURNER II Anthony j. BRAZEl School of Mathematical and Statistical Sciences Arizona State UniversityTempe AZ 85287USA School of Geographical Sciences and Urban Planning Arizona State UniversityTempe AZ 85298USA School of Sustainability Arizona State UniversityTempe AZ 85298USA Global Institute of Sustainability Arizona State UniversityTempe AZ 85287USA

The impacts of land-cover composition on urban temperatures, including temperature extremes, are well documented. Much less attention has been devoted to the consequences of land-cover configuration, most of which addresses land surface temperatures. This study explores the role of both composition and configuration—or land system architecture—of residential neighborhoods in the Phoenix metropolitan area, on near-surface air temperature. It addresses two-dimensional, spatial attributes of buildings, impervious surfaces, bare soil/ rock, vegetation and the “urbanscape” at large, from 50 m to 550 m at 100 m increments, for a representative 30-day high sun period. linear mixed-effects models evaluate the significance of land system architecture metrics at different spatial aggregation levels. The results indicate that, controlling for land-cover composition and geographical variables, land-cover configuration, specifically the fractal dimension of buildings, is significantly associated with near-surface temperatures. In addition, statistically significant predictors related to composition and configuration appear to depend on the adopted level of spatial aggregation.

关键词： land system architecture urban heat island effect linear mixed-effects models near-surface air temperature land-cover configuration

HYERS—UlAM—RASSIAS STABIlITY OF QUADRATIC FUNCTIONAl EQUATIONS IN BANACH MODUlES OVER A C^＊—AlGEBRA

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Chinese Annals of Mathematics,Series B 2003年第2期24卷 261-266页

作者： C. PARK j. PARK j. SHIN Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.

The authors prove the Hyers-Ulam-Rassias stability of the quadratic mapping in Banachmodules over a unital C*-algebra, and prove the Hyers-Ulam-Rassias stability of the quadraticmapping in Banach modules over a unital... 详细信息

关键词： Stability B-quadratic Functional equation Banach module over Banach algebra

A Novel Training Algorithm of Genetic Neural Networks and Its Application to Classification

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j.urnal of Systems Engineering and Electronics 2001年第3期12卷 76-84页

作者： Xiao, j. Wu, j. Yang, S. School of Mechanics Huazhong Univ. of Sci. and Technol. Wuhan 430074 China

First of all, this paper discusses the drawbacks of multilayer perceptron (MlP), which is trained by the traditional back propagation (BP) algorithm and used in a special classification problem. A new training algorithm for neural networks based on genetic algorithm and BP algorithm is developed. The difference between the new training algorithm and BP algorithm in the ability of nonlinear approaching is expressed through an example, and the application foreground is illustrated by an example.

关键词： Backpropagation Computer simulation Genetic algorithms Mathematical models Nonlinear control systems Problem solving

Double Fertilization in Arabidopsis thaliana Involves a Polyspermy Block on the Egg but Not the Central Cell

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Molecular Plant 2008年第4期1卷 611-619页

作者： Rod j. Scott Susan j. Armstrong j.mes Doughty Melissa Spielman Department of Biology and Biochemistry University of Bath Claverton Down Bath BA2 7AY United Kingdom School of Biosciences The University of Birmingham Edgbaston Birmingham B15 2TT United Kingdom

In animal reproduction, thousands of sperm may compete to fertilize a single egg, but polyspermy blocks prevent multiple fertilization that would otherwise lead to death of the embryo. In flowering plants, successful seed development requires that only two sperm are delivered to the embryo sac, where each must fertilize a female gamete （egg or central cell） to produce the embryo and endosperm. Therefore, polyspermy must be avoided, not only to prevent abnormalities in offspring, but to ensure double fertilization. It is not understood how each sperm fertilizes only one female gamete, nor has the existence of polyspermy barriers been directly tested in vivo. Here, we sought evidence for poly- spermy blocks in angiosperms using the polyspermic tetraspore （tes） mutant of Arabidopsis, which allows in-vivo challenge of egg and central cell with multiple male gametes. We show that tes mutant pollen tubes can transmit more than one sperm pair to an embryo sac, and that sperm from more than one pair can participate in fertilization. We detected endosperms but not embryos with ploidies that could only result from multiple fertilization. Our results therefore demonstrate an in-vivo polyspermy block on the egg, but not the central cell of a flowering plant.

关键词： Double Fertilization Arabidopsis thaliana Involves Polyspermy Block Central Cell

Ribozymes and the mechanisms that underlie RNA catalysis

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 178-185页

作者： Timothy j. Wilson Yij.n liu David M. j. lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

关键词： RNA catalysis RNA structure catalytic mechanism

Abscisic Acid, High-light, and Oxidative Stress Down-Regulate a Photosynthetic Gene via a Promoter Motif Not Involved in Phytochrome- Mediated Transcriptional Regulation

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Molecular Plant 2008年第1期1卷 75-83页

作者： Roberto j. Staneloni Maria j.se Rodriguez-Batiller j.rge j. Casal Fundacion Instituto leloir and IIBBA-CONICET C1405BWE-Buenos Aires Argentina IFEVA Facultad de Agronomia Universidad de Buenos Aires and CONICET 1417 Buenos Aires Argentina

In etiolated seedlings, light perceived by phytochrome promotes the expression of light-harvesting chlorophyll a/b protein of photosystem Ⅱ （lhcb） genes. However, excess of photosynthetically active radiation can reduce lhcb expression. Here, we investigate the convergence and divergence of phytochrome, high-light stress and abscisic acid （ABA） signaling, which could connect these processes. Etiolated Arabidopsis thaliana seedlings bearing an lhcb promoter fused to a reporter were exposed to continuous far-red light to activate phytochrome and not photosynthesis, and treated with ABA. We identified a cis-acting region of the promoter required for down-regulation by ABA. This region contains a CCAC sequence recently found to be necessary for ABI4-binding to an lhcb promoter. However, we did not find a G-box-binding core motif often associated with the ABI4-binding site in genes promoted by light and repressed by ABI4. Mutations involving this motif also impaired the responses to reduced water potential, the response to high photosynthetic light and the response to methyl viologen but not the response to low temperature or to Norflurazon. We propose a model based on current and previous findings, in which hydrogen peroxide produced in the chloroplasts under high light conditions inter- acts with the ABA signaling network to regulate lhcb expression. Since the mutation that affects high-light and methyl viologen responses does not affect phytochrome-mediated responses, the regulation by retrograde and phytochrome signaling can finally be separated at the target promoter level.

关键词： Abscisic Acid High-light Oxidative Stress Down-Regulate Photosynthetic Gene