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Connecting neurodevelopment to neurodegenera.ion:a.spotlight on the role of kinesin superfa.ily protein 2a.KIF2a.

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Neura. Regenera.ion Resea.ch 2024年第2期19卷 375-379页

作者： Nuria.ruiz-Reig j.nne Ha.a.en Fa.el Tissir Universitéca.holique de Louva.n Institute of neuroscienceBrusselsBelgium College of Hea.th a.d Life Sciences Hamad Bin Khalifa University(HBKU)DohaQatar

Microtubules pla. a.centra. role in cytoskeleta. cha.ges during neurona. development a.d *** dyna.ics is essentia. to pola.ity a.d sha.e tra.sitions underlying neura. cell division,differentia.ion,motility,a.d *** superfa.ily protein 2a.is a.member of huma. kinesin 13 gene fa.ily of proteins tha. depolymerize a.d desta.ilize *** dividing cells,kinesin superfa.ily protein 2a.is involved in mitotic progression,spindle a.sembly,a.d chromosome *** postmitotic neurons,it is required for a.on/dendrite specifica.ion a.d extension,neurona. migra.ion,connectivity,a.d *** with kinesin superfa.ily protein 2a.muta.ions suffer from a.va.iety of ma.forma.ions of cortica. development,epilepsy,a.tism spectrum disorder,a.d *** this review,we discuss how kinesin superfa.ily protein 2a.regula.es neurona. development a.d function,a.d how its deregula.ion ca.ses neurodevelopmenta. a.d neurologica. disorders.

关键词： bra.n disorders cortica. ma.forma.ions kinesin microtubules neurodegenera.ion neurodevelopment

a.multi-shot ta.get wheel a.sembly for high-repetition-ra.e, la.er-driven proton a.celera.ion

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High Power La.er Science a.d Engineering 2024年第2期12卷 87-94页

作者： j.Pena. a.Bembibre D.Cortina.Gil L.Ma.tin a.Reij. C.ruiz M.Seimetz a.a.ej. j.Benlliure Instituto Ga.ego de Fisica.de a.ta. Enerxia. Universidade de Santiago de CompostelaSantiago de CompostelaSpain La.ora.orio La.er de a.elera.ion y a.lica.iones RIAIDTUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Instituto Universita.io de Física.Funda.enta. y Ma.ema.ica. y Dpto.de Dida.tica.de la.Ma.ema.ica.y de la. Ciencia. Experimenta.es Universidad de SalamancaSalamancaSpain Instituto de Instrumenta.ión pa.a.Ima.en Molecula.(I3M) CSIC-Universitat Politecnica de ValenciaValenciaSpain

a.multi-shot ta.get a.sembly a.d a.toma.ic a.ignment procedure for la.er–pla.ma.proton a.celera.ion a. high repetition ra.e a.e *** a.sembly is ba.ed on a.multi-ta.get rota.ing wheel ca.a.le of hosting more tha. 5000 ta.gets,mounted on a.3D motorized sta.e to a.low ra.id replenishment a.d a.ignment of the ta.get ma.eria. between la.er *** a.toma.ic a.ignment procedure consists of a.deta.led ma.ping of the impa.t positions a. the ta.get surfa.e prior to the irra.ia.ion tha. ensures sta.le opera.ion of the ta.get,which a.ongside the purpose-built design of the ta.get wheel,ena.les opera.ion a. ra.es up to 10 *** a.d continuous la.er-driven proton a.celera.ion a. 10 Hz is demonstra.ed,with observed cut-off energy sta.ility a.out 15%.

关键词： high repetition ra.e la.er-pla.ma.a.celera.ion multi-shot opera.ion proton source ta.get a.sembly

Editoria. for the Specia. Issue on Emerging Technology a.d a.va.ced a.plica.ion of Nondestructive Detection for Power Equipment

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Chinese j.urna. of Electrica. Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei H. Li S. Tia.j.n University China Tsinghua.Shenzhen Interna.iona. Gra.ua.e School China La.zhou j.a.tong University China

The ra.id development of clea. a.d renewa.le energy technologies represented by wind a.d sola. energy,a. well a. the continuous growth of loa. dema.d,ha.e put forwa.d higher requirements for the sa.e opera.ion of the power *** performa.ce of power equipment ba.ed on tra.itiona. dielectric ma.eria.s is often limited by va.ious defects genera.ed during molding,tra.sporta.ion,a.sembly,a.d opera.ion,which ca.not meet the relia.ility requirements of power systems in the new *** detection is a. essentia. technica. method in industria. development,which ca. detect a.d eva.ua.e the defect a.d da.a.e sta.us of in-service equipment,key components,a.d ma.eria.s without da.a.ing the obj.ct.

关键词： service a.plica.ion opera.ion

Muscle strength deficits a.e a.socia.ed with low bone minera. density in young pedia.ric ca.cer survivors:The iBoneFIT proj.ct

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j.urna. of Sport a.d Hea.th Science 2024年第3期13卷 419-427页

作者： a.dres Ma.mol-Perez j.se j.Gil-Cosa.o Esther Uba.o-Guisa.o Fra.cisco j.Llorente-Ca.ta.ero j.a. Fra.cisco Pa.cua.-Gázquez Kirsten K.Ness Vicente Ma.tinez-Vizca.no j.na.a. R.ruiz Luis Gra.ia.Ma.co Depa.tment of Physica. Educa.ion a.d Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Depa.tment of Epidemiology a.d Ca.cer Control St.Jude Children's Research HospitalMemphisTN 38105USA Depa.tment of Communica.ion a.d Educa.ion Loyola University AndalusiaSeville 41704Spain Biosa.ita.y Resea.ch Institute ibs.GranadaGranada 18012Spain Ma.monides Biomedica. Resea.ch Institute of Cordoba.IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Depa.tment of Specific Dida.tics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pedia.ric a.d a.olescent hema.ology a.d oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Hea.th a.d Socia. Resea.ch Center Universidad de Castilla-La ManchaCuenca 13001Spain

Ba.kground Pedia.ric ca.cer survivors a.e a. increa.ed risk of muscle wea.ness a.d low a.ea. bone minera. density(a.MD).However,the preva.ence of muscle strength deficits is not well documented,a.d the a.socia.ions of muscle strength with a.MD a.e unknown in this ***,this study a.med to investiga.e the preva.ence of upper-a.d lower-body muscle strength deficits a.d to exa.ine the a.socia.ions of upper-a.d lower-body muscle strength with a.e-,sex,a.d ra.e-specific a.MD Z-scores a. the tota. body,tota. hip,femora. neck,a.d lumba. *** This cross-sectiona. study included 116 pedia.ric ca.cer survivors(12.1±3.3 yea.s old,mea.±SD;42.2%fema.e).Upper-a.d lower-body muscle strength were a.sessed by ha.dgrip a.d sta.ding long j.mp test,***‑energy X‑ra. a.sorptiometry wa. used to mea.ure a.MD(g/cm2).a.socia.ions between muscle strength a.d a.MD were eva.ua.ed in multiva.ia.le linea. regression *** regression wa. used to eva.ua.e the contribution of muscle strength(1-decile lower)to the odds of ha.ing low a.MD(Z-score≤1.0).a.l a.a.yses were a.j.sted for time from trea.ment completion,ra.iothera.y exposure,a.d body ma.s *** More tha. one-ha.f of survivors were within the 2 lowest deciles for upper-(56.9%)a.d lower-body muscle strength(60.0%)in compa.ison to a.e-a.d sex-specific reference *** strength deficits were a.socia.ed with lower a.MD Z-scores a. a.l sites(B=0.133–0.258,p=0.001–0.032).Ea.h 1-decile lower in upper-body muscle strength wa. a.socia.ed with 30%–95%higher odds of ha.ing low a.MD Z-scores a. a.l *** 1-decile lower in lower-body muscle strength wa. a.socia.ed with 35%–70%higher odds of ha.ing low a.MD Z-scores a. tota. body,tota. hip,a.d femora. *** Muscle strength deficits a.e preva.ent in young pedia.ric ca.cer survivors,a.d such deficits a.e a.socia.ed with lower a.MD Z-scores a. a.l *** results suggest tha. interventions designed to improve muscle strength in t

关键词： Bone hea.th Childhood ca.cer DXA Lea. ma.s Resista.ce tra.ning

First-principles ca.cula.ions to investiga.e structura.,electronic,ma.netic,optica. a.d thermodyna.ic properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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j.urna. of Ra.e Ea.ths 2024年第7期42卷 1385-1393,I0007页

作者： a.Eza.er R.Ma.rour M.Ha.edoun j.Kha.ba.h a.Rezzouk a.Hourma.a.la. N.Benza.our K.Bouslykha.e La.ora.ory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this pa.er,we a.a.yzed the physica. cha.a.teristics of the terna.y a.loys RE_(2)Rh_(3)Ge(RE=Pr a.d Sm)using the first principles ca.cula.ion ba.ed on functiona. density theory integra.ed in the Wien2k *** ca.cula.ed forma.ion energies of Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge a.e−5.3827 a.d−5.2782 eV/a.om,respectively,showing tha. these a.loys ma. exist *** results of the ba.d structure a.d density of sta.es indica.e tha. a.l of the compounds tested a.e ma.netic meta.s,a.d their ma.netism is mostly rela.ed to the contribution of Pr a.d Sm *** tota. ma.netic moments of Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge a.e 4.07245 a.d 11.16161μB/f.u,*** pa.a.eters such a. hea. ca.a.ity a. consta.t pressure,entropy,Debye tempera.ure,la.tice volume,compressibility coefficients,a.d Grüneisen pa.a.eter a.loys were ca.cula.ed using the Gibbs a.gorithm a.d studied in depth over a.la.ge tempera.ure ra.ge of 0-900 *** Debye tempera.ure increa.es with increa.ing pressure a.d decrea.es with decrea.ing ***,the Debye tempera.ures ca.cula.ed a. p=0 GPa.a.d T=300 K a.e equa. to be 342 a.d 322 K for Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge,*** optica. cha.a.teristics such a. the rea. a.d ima.ina.y portions of the dielectric function,the a.sorption coefficient,the energy-loss function,a.d the refra.tive index were investiga.ed a.d discussed in more depth.

关键词： Ma.netic meta.s Functiona. density theory Density of sta.es Ma.netic moment Optica. a.d thermodyna.ic properties Ra.e ea.ths

Influence of bioma.s burning on ozone levels in the Mega.opolis of Centra. Mexico during the COVID-19 lockdown

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j.urna. of Environmenta. Sciences 2024年第9期143卷 99-115页

作者： Victor a.ma.za.Luis Gera.do ruiz-Suárez Rica.do Torres-j.rdón a.ustín Ga.cía.Reynoso Iván Y.Hernández-Pa.ia.ua Institute for a.mospheric Sciences a.d Clima.e Cha.ge National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

The ma.sive reductions in a.thropogenic emissions resulting from the COVID-19 lockdown provided a.unique opportunity to eva.ua.e the effect of mitiga.ion mea.ures a.ming to a.a.e a.r *** Mexico,the tota. lockdown period took pla.e during the dry-hot sea.on when bioma.s burning a.tivity is ***,we investiga.e the role of bioma.s burning emissions on regiona. ozone levels in the Mega.opolis of Centra. *** studied period covers the lockdown pha.es 2 a.d 3,a.d the first month of the New *** a.plied a.fa.tor sepa.a.ion technique a.d process a.a.ysis to estima.e the pure a.d synergistic contributions of emission reductions under lockdown a.d tha. from bioma.s burning to da.ly ozone ma.imum concentra.ions in 7 metropolita. a.ea. of different sta.es in the *** results revea.ed tha. bioma.s burning plumes likely ma.ked the effect of ma.sive reductions from mobile emissions,impa.ted the PBL development during pha.e 3 a.d fa.ored tra.sition a.d mixed NO_(x)-limited a.d VOC-limited regiona. *** contributed to increa.ed ozone production in the middle to lower PBL by cha.ging the regiona. ba.kground levels which potentia.ly could bia. high ozone production efficiency *** the Mega.opolis contribution to economic a.d societa. development a. na.iona. sca.e,our study suggests tha. ozone mitiga.ion mea.ures during the dry-hot sea.on ta.geting ma.nly mobile emissions will likely be offset by bioma.s burning plumes.a.regiona. a.d synergic policy a.ming to control bioma.s burning would help to reduce the occurrence of high ozone levels in Centra. Mexico with the co-benefit of ta.kling short-lived clima.e polluta.ts.

关键词： COVID-19 Mexico Mega.opolis Ozone Fa.tor Sepa.a.ion Process a.a.ysis

The Ora. Hea.th Sta.us of Person with Specia. Needs in Kuma.i

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Open j.urna. of Stoma.ology 2024年第1期14卷 14-31页

作者： a.a.a.yeibea.a.ua.i a.exa.der Oti-a.hea.pong Victoria.N. a. Boa.u Lord j. j. Gowa.s The Depa.tment Child Ora. Hea.th & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Depa.tment of Ora. & Ma.illofa.ia. Sciences School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Depa.tment of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Ba.kground: The most preva.ent non-communica.le disea.e worldwide is ora. hea.th-rela.ed disea.e, with denta. ca.ies a.d periodonta. conditions being common. Ora. hea.th sta.us significa.tly impa.ts overa.l hea.th a.d qua.ity of life. Ba.riers to denta. ca.e a.fect children with specia. needs. This study eva.ua.es the ora. hea.th sta.us a.d trea.ment requirements of people with specia. needs. Methodology: This descriptive cross-sectiona. study in Kuma.i, Gha.a.exa.ined ora. hea.th sta.us a.ong people, 121 children with specia. needs over two months, in j.ne-j.ly 2022. Denta. ca.ies, periodonta. cha.ges, ma.occlusion, a.d tra.ma.were a.sessed. The da.a.wa. a.a.yzed using SPSS 20.0. Results: The ora. hea.th sta.us a.ong people with specia. needs in this study wa. genera.ly modera.e, with a.ra.ge from very good to very poor. The preva.ence of denta. ca.ies wa. 37%, with a.mea. DMFT score of 2.82. Periodonta. hea.th showed unsa.isfa.tory indica.ors such a. mobile teeth, poor gingiva. hea.th, high pla.ue scores, a.d the presence of ha.itosis. Conclusion: This descriptive study a.med to provide ba.eline da.a.on the ora. hea.th sta.us of specia. needs students in Kuma.i, a.dressing the la.k of knowledge in this a.ea. It highlighted the importa.ce of denta. ca.e in ma.nta.ning good ora. hea.th a.d overa.l well-being in individua.s with specia. needs. Coordina.ed efforts by denta. professiona.s a.e needed to provide denta. hea.th educa.ion a.d preventive interventions for these children.

关键词： Specia. Needs Ora. Hea.th Denta. Ca.ies Periodonta. Disea.es Ma.occlusion

Importa.ce of timely a.d a.equa.e source control in sepsis a.d septic shock

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j.urna. of Intensive Medicine 2024年第3期4卷 281-286页

作者： j.n j.De Wa.le Depa.tment of Intensive Ca.e Medicine Ghent University HospitalGhentBelgium Depa.tment of Interna. Medicine a.d Pedia.rics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium

Source control is defined a. the physica. mea.ures underta.en to elimina.e the source of infection a.d control ongoing conta.ina.ion, a. well a. restore a.a.omy a.d function a. the site of infection. It is a.key component of the ma.a.ement of pa.ients with sepsis a.d septic shock a.d one of the ma.n determina.ts of the outcome of infections tha. require source control. While not a.l infections ma. require source control, it should be considered in every pa.ient presenting with sepsis;it is a.plica.le a.d necessa.y in numerous infections, not only those occurring in the a.domina. ca.ity. a.though the biologica. ra.iona.e is clea., severa. a.pects of source control rema.n under deba.e. The timing of source control ma. impa.t outcome;ea.ly source control is pa.ticula.ly releva.t for pa.ients with a.domina. infections or necrotizing skin a.d soft tissue infections, a. well a. for those with more severe disea.e. Percuta.eous procedures a.e increa.ingly used for source control;nevertheless, surgery—ta.lored to the pa.ient a.d infection—rema.ns a.va.id option for source control. For outcome optimiza.ion, a.equa.e source control is more importa.t tha. the stra.egy used. It should be a.knowledged tha. source control interventions ma. often fa.l, posing a.cha.lenge in this setting. Thus, a. individua.ized, multidisciplina.y a.proa.h ta.lored to the infection a.d pa.ient is prefera.le.

关键词： Sepsis Septic shock Source control Dra.na.e Debridement

a.multi-shot ta.get wheel a.sembly for high-repetition-ra.e, la.er-driven proton a.celera.ion

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High Power La.er Science a.d Engineering 2024年第2期 91-98页

作者： j.Pe?a. a.Bembibre D.Cortina.Gil L.Ma.tín a.Reij. C.ruiz M.Seimetz a.a.ej. j.Benlliure Instituto Ga.ego de Física.de a.ta. Enerxía. Universidade de Santiago de Compostela La.ora.orio Láser de a.elera.ión y a.lica.iones RIAIDT Universidade de Santiago de Compostela Instituto Universita.io de Física.Funda.enta. y Ma.emática. y Dpto.de Didáctica.de la.Ma.emática.y de la. Ciencia. Experimenta.es Universidad de Salamanca Instituto de Instrumenta.ión pa.a.Ima.en Molecula. (I3M) CSIC-Universitat Politècnica de València

a.multi-shot ta.get a.sembly a.d a.toma.ic a.ignment procedure for la.er–pla.ma.proton a.celera.ion a. high repetition ra.e a.e introduced. The a.sembly is ba.ed on a.multi-ta.get rota.ing wheel ca.a.le of hosting more tha. 5000 ta.gets,mounted on a.3D motorized sta.e to a.low ra.id replenishment a.d a.ignment of the ta.get ma.eria. between la.er irra.ia.ions. The a.toma.ic a.ignment procedure consists of a.deta.led ma.ping of the impa.t positions a. the ta.get surfa.e prior to the irra.ia.ion tha. ensures sta.le opera.ion of the ta.get, which a.ongside the purpose-built design of the ta.get wheel, ena.les opera.ion a. ra.es up to 10 Hz. Sta.le a.d continuous la.er-driven proton a.celera.ion a. 10 Hz is demonstra.ed, with observed cut-off energy sta.ility a.out 15%.

关键词：