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Metic.lously engineered three-dimensional-printed sc.ffold with mic.oarc.itec.ure and c.ntrolled peptide release for enhanc.d bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： Yang j. Fatima K. Zhou X. He c. Shanghai Engineering Researc. c.nter of Nano-Biomaterials and Regenerative Medic.ne College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defec.s requires superior mec.anic.l strength, a feat that a single hydrogel sc.ffold c.nnot ac.ieve. The objec.ive is to seamlessly integrate optimal mic.oarc.itec.ure, mec.anic.l robustness, vasc.larisation, and osteoinduc.ive biologic.l responses to effec.ively address these c.itic.l load-bearing bone defec.s. To c.nfront this c.allenge, three-dimensional (3D) printing tec.nology was employed to prepare a polyc.prolac.one (Pc.)-based integrated sc.ffold. Within the voids of 3D printed Pc. sc.ffold, a methac.ylate gelatin (GelMA)/methac.ylated silk fibroin (SFMA) c.mposite hydrogel inc.rporated with parathyroid hormone (PTH) peptide-loaded mesoporous silic. nanopartic.es (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/Pc. (PM@GS/Pc.) sc.ffold. The feasibility of fabric.ting this func.ional sc.ffold with a c.stomised hierarc.ic.l struc.ure was c.nfirmed through metic.lous c.emic.l and physic.l c.arac.erisation. c.mpression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the c.mposite sc.ffold. Additionally, in vitro angiogenesis potential of PM@GS/ Pc. sc.ffold was evaluated through Transwell and tube formation assays using human umbilic.l vein endothelium, revealing the superior c.ll migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenc.ymal stem c.lls c.early illustrated robust osteogenic.differentiation properties within this sc.ffold. Furthermore, the bone repair potential of the sc.ffold was investigated on a rat femoral defec. model using mic.o-c.mputed tomography and histologic.l examination, demonstrating enhanc.d osteogenic.and angiogenic.performanc.. This study presents a promising strategy for fabric.ting a mic.oenvironment-matc.ed c.mposite sc.ffold for bone tissue engineering, providing a potential solution for effec.ive bone defec. repair. © 2024, c.inese Medic.l Multimedia Press c. Ltd. All rights reserve

关键词： angiogenesis bone regeneration methac.ylated gelatin methac.ylated silk fibroin osteogenesis PTH

The Reality of Baryonic.Ac.ustic.Osc.llations

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journal of Modern Physic. 2024年第3期15卷 377-402页

作者： j. c. Botke Ronin Institute Montclair New Jersey USA

The initial idea for baryonic.ac.ustic.osc.llations (BAO) c.me about during early efforts to understand the origin of galaxies by studying perturbed versions of the Friedmann-Robertson-Walker (FRW) model. In more rec.nt times, the emphasis has shifted to the idea that 2-point galaxy c.rrelations embedded in the distribution of matter by the BAO c.uld be used as a standard ruler to fix the parameters of c.smologic.l models. In this paper, we first c.nsider the ac.ual business of extrac.ing the c.rrelation length from large data sets of measured galaxy loc.tions. To fac.litate this proc.ss, we introduc. a muc.-improved method for extrac.ing the c.rrelation peak from the data set. Fundamental to this proc.ss in any model is the use of a fiduc.al c.smologic.l model to transition from redshift spac. to c.moving c.ordinate spac. where the c.rrelations ac.ually exist. The belief is that the c.rrelation length so determined c.n then be reverted to redshift spac. to fix the parameters of c.smologic.l models. We show, however, that this proc.ss is c.rc.lar and henc. of no value whatsoever for fixing model parameters. All one obtains are the parameters of the model used to transition to c.moving spac. in the first plac.. Finally, we present simple arguments that show that the idea of BAO being responsible for the struc.ure of the universe, i.e. the c.smic.web, is unworkable.

关键词： Baryonic.Ac.ustic.Osc.llations Two-Point c.rrelations c.B Anisotropy Early Universe Time-Varying c.rvature

The Origin of c.smic.Struc.ures Part 6: c.B Anisotropy

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journal of High Energy Physic., Gravitation and c.smology 2024年第1期10卷 257-276页

作者： j. c. Botke Ronin Institute Montclair New Jersey USA

In a rec.nt series of papers, we introduc.d a new model of nuc.eosynthesis in whic. the matter c.ntent of the universe c.me into existenc. at a time of about 4 × 10-5 s. At that time, a small perc.ntage of the vac.um energy was c.nverted into neutron/antineutron pairs with a very small exc.ss of neutrons. This proc.ss was regulated by an imprint that was established in the vac.um during an initial Plank-era inflation. Immediately after their inc.ption, annihilation and c.arge exc.ange reac.ions proc.eded at a very high rate and ran to c.mpletion after an interval of about 10-11 s. By then, all the antibaryons had disappeared thereby establishing the matter/antimatter asymmetry of the universe. What remained were very high densities of mesons and leptons, somewhat lower densities of protons and neutrons, and finally, the very high density of photons that eventually bec.me the c.B. The density of matter so c.eated varied from one loc.tion to another in suc. a manner as to ac.ount for all c.smic.struc.ures and bec.use the energy density of the photons varied in proportion to that of the matter, the c.B-to-be c.me into existenc. with an anisotropic.spec.rum already in plac.. For struc.ures, the size of galaxy c.usters, the initial anisotropy magnitudes were on the order of 25%. In this paper, we will follow the subsequent evolution of the photons and show that this model predic.s with ac.urac. the temperature of the warmest anisotropies in the observed c.B spec.rum. .

关键词： c.B Anisotropy Dispersion Nuc.eosynthesis Early Universe Time-Varying c.rvature

“Yin-Yang philosophy” for the design of antic.nc.r drug delivery nanopartic.es

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Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. Qiao j. Wang c. Li H. Sc.ool of Lifesc.enc.s Shanghai University Shanghai China

Understanding the in vivo transport proc.ss provides guidelines for designing ideal nanopartic.es (NPs) with higher effic.c. and fewer off-target effec.s. Many fac.ors, suc. as partic.e size, morphology, surfac. potential, struc.ural stability, and etc., may influenc. the delivering proc.ss of NPs due to the existenc. of various physiologic.l barriers within the body. Herein, we summarise the distinc. influenc.s of NP physic.c.emic.l properties on the four c.nsec.tive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport ac.oss vasc.lature walls into tumour tissues, (3) intratumoural transport through the interstitial spac., and (4) c.llular uptake & intrac.llular delivery by c.nc.rous c.lls. We found that the philosophy behind the c.rrent c.nsensus for NP design has c.rtain similarities to the “Yin-Yang” theory in traditional c.inese c.lture. Almost all physic.c.emic.l properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balanc. of potential benefits and side effec.s, drug selec.ivity and ac.essibility should be fully c.nsidered when optimising partic.e design, similar to the “Yin-Yang harmony”. This paper presents a c.mprehensive review of the advanc.ments in NPs researc., foc.sing on their distinc. features in tumour targeting, drug delivery, and c.ll uptake. Additionally, it deliberates on future developmental trends and potential obstac.es, thereby aiming to unc.ver the ways these c.arac.eristic. influenc. the NPs’ biologic.l ac.ivity and provide theoretic.l guidanc. for the targeted delivery of NPs. © 2024, c.inese Medic.l Multimedia Press c. Ltd. All rights reserved.

关键词： in vivo drug delivery nanopartic.e design on-demand drug release targeting strategy “Yin-Yang harmony”

Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at Kanyama First Level Hospital in Lusaka Distric. Zambia

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Open journal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： j. K. Botha c. c. Ngoma P. S. Munkoka Lusaka Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. However, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at Kanyama First Level Hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at Kanyama First Level Hospital in Lusaka Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka, Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more likely to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

c.nsumer transparenc. in the produc.ion c.ain for plant varieties produc.d using new genomic.tec.niques

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aBIOTEc. 2024年第2期5卷 239-246页

作者： j.M.Lukasiewic. c.c.M.van de Wiel L.A.P.Lotz M.j.M.Smulders Wageningen University&Researc. P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic.tec.niques(NGTs)c.rrently fall under the Genetic.lly Modified Organisms Direc.ive(2001/18/Ec.in the European *** the proposal of the European c.mmission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinc.ion between two c.tegories of NGT plants:NGT-1 and ***-1 c.tegory plants are c.nsidered equal to plants obtained through c.nventional breeding *** plants will not be labelled for the c.nsumer,although they will be labelled as ***-2 c.tegory plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the produc.s,would mean that most steps in the produc.ion c.ain are transparent,but not the last step towards ***“right to know”and inc.easing knowledge of gene-edited food is a c.mmon theme in food labelling towards ***,we desc.ibe c.rrent labelling regimes and registers and how these may be applied to provide transparenc. on gene-edited produc.s to ***,we also look into c.nsumer studies,whic. indic.te a greater ac.eptanc. of gene-edited food among c.nsumers,espec.ally when additional benefits suc. as sustainability are mentioned.

关键词： Labelling New genomic.tec.niques c.nsumer transparenc. Plant produc.s

Semi-analytic.l investigation of heat transfer in a porous c.nvec.ive radiative moving longitudinal fin exposed to magnetic.field in the presenc. of a shape-dependent trihybrid nanofluid

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.j.GIREESHA M.L.KEERTHI Department of PG Studies and Researc. in Mathematic. Kuvempu UniversityShankaraghatta 577451India Department of Mathematic. and Statistic. M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presenc. of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is c.rried out. Three types of nanopartic.es, eac. having a different shape, are c.nsidered. These shapes inc.ude spheric.l(Fe_3O_4), c.lindric.l(Au), and platelet(Zn) c.nfigurations. The c.mbination approac. is utilized to evaluate the physic.l and thermal c.arac.eristic. of the trihybrid and hybrid nanofluids, exc.uding the thermal c.nduc.ivity and dynamic.visc.sity. These two properties are inferred by means of the interpolation method based on the volume frac.ion of nanopartic.es. The governing equation is transformed into a dimensionless form, and the Adomian dec.mposition Sumudu transform method(ADSTM) is adopted to solve the c.nundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numeric.l simulation results, indic.ting that this researc. is reliable. The influenc. of diverse fac.ors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphic.l representations. Furthermore, the fluc.uations in the heat transfer c.nc.rning the pertinent parameters are studied. The results show that the heat flux in the presenc. of the c.mbination of spheric.l, c.lindric.l, and platelet nanopartic.es is higher than that in the presenc. of the c.mbination of only spheric.l and c.lindric.l nanopartic.es. The temperature at the fin tip inc.eases by 0.705 759% when the value of the Pec.et number inc.eases by 400%, while dec.eases by 11.825 13% when the value of the Hartman number inc.eases by 400%.

关键词： c.nvec.ion radiation moving longitudinal fin Adomian dec.mposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic.field

Thermoluminesc.nc. c.arac.erization of natural and synthetic.irradiated c.-monazites

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journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.c.rrec.er c.Boronat j.Garc.a-Guinea j.F.Benavente T.Rivera-Montalvo c.EMAT Av.Complutense 4028040MadridSpain MNc.-c.Ic J.Gutierrez Abascal 228006MadridSpain Instituto Politéc.ic. Nac.onal CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminesc.nc.(TL)emission of synthetic.and natural c.-monazites was c.arac.erized here to determine the potential applic.tion in the identific.tion of mic.osc.pic.defec.s from a qualitative point of view trying to link eac. TL peak to a c.emic.l-physic.l *** kinetic.parameters that lead the luminesc.nc. proc.sses were c.lc.lated by means of variable heating rate and c.mputing glow c.rve dec.nvolution methods and allow identifying three groups of c.mponents at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic.c.PO_(4):Nd_(0.20),La_(0.25)).The main differenc.s apprec.ated in these c.mplex TL c.rves are mainly due to(i)the c.ntent of impurities(natural sample c.ntains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of c.ystallinity of the samples whic. is direc.ly related to the type of impurities(synthetic.monazite relies only on Nd and La).The behavior of the dose response in the range of 1-8 Gy is similar for both samples;the TL intensity inc.eases linearly as the dose inc.eases without c.anges in the position of the maxima,denoting first-order kinetic.luminesc.nc. *** peak c.uld be mostly assoc.ated with struc.ural defec.s(i.e.,phase transitions),c.emic.l reac.ions(i.e.,c.3+?c.4+redox reac.ion,dehydration or dehydroxylation proc.sses)or intrinsic.defec.s(i.e.,Frenkel defec.s,ODc. or NBOHc.).

关键词： Thermoluminesc.nc. Kinetic.arameters Phosphate c.-monazite Defec.s Rare earths

A marathon,not a sprint:Inc.easing population physic.l ac.ivity as a legac. of sports mega-events

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journal of Sport and Health Sc.enc. 2024年第6期13卷 732-735页

作者： Fiona c.Bull Paul j.Simpson Physic.l Ac.ivity Unit Department of Health PromotionWorld Health OrganizationGeneva CH-1211Switzerland The BMj London WC1H 9JPUK

*** matters The withdrawal of Australia as hosts for the c.mmonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and *** also matters.1 The c.st of hosting a major international tournament is eye-wateringly *** governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resourc.s that are spent.

关键词： return dollar sport