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Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

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World journal of Gastroenterology 2014年第33期20卷 11713-11726页

作者： Bryon W Petschow Anthony T Blikslager Eric M Weaver joy M Campbell javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein j marc rhoads Entera Health Inc. NC 27518 United States College of Veterinary Medicine North Carolina State University Raleigh NC 27607 United States APC Inc. Ankeny IA 50021 United States APC Europe S.A. Barcelona E-08403 Spain University of Texas Health Sciences Center Houston TX 77030 United States

The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy.

关键词： Immunoglobulins Plasma proteins Inflammation Gut barrier Diarrhea Malabsorption Treatment Nutrition

Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets

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World journal of Gastroenterology 2013年第31期19卷 5094-5102页

作者： Sheila K jacobi Adam j Moeser Anthony T Blikslager j marc rhoads Benjamin A Corl Robert j Harrell jack Odle Laboratory of Developmental Nutrition College of Agriculture and Life Sciences North Carolina State University Raleigh NC 27695United States College of Veterinary Medicine North Carolina State University Raleigh NC 27695United States Department of Pediatrics University of Texas Health Science Center at Houston Medical School Houston TX 77030 United States Department of Dairy Science Virginia Poly-technic Institute and State University Blacksburg VA 24061United States

AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet ***: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus *** one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber ***: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P junction protein,occludin,in the cell membrane and increased localization in the ***: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model.

关键词： Rotavirus gastroenteritis Kwashiorkor Occludin Ussing chamber Villus

谷氨酰胺、精氨酸和亮氨酸在肠道中的信号传导(一)

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饲料与畜牧（新饲料） 2011年第9期 13-16页

作者： j.marc rhoads Guoyao Wu 邓会玲中国农业科学院饲料研究所

动植物蛋白中谷氨酰胺和亮氨酸含量丰富且较稳定,而食物和动物体液中精氨酸含量差异较大。除在蛋白质合成中起作用外,这三种氨基酸可独自激活信号传导通路以促进蛋白质的合成,并可能抑制肠上皮细胞自噬介导的蛋白质降解。此外,谷氨酰胺... 详细信息

动植物蛋白中谷氨酰胺和亮氨酸含量丰富且较稳定,而食物和动物体液中精氨酸含量差异较大。除在蛋白质合成中起作用外,这三种氨基酸可独自激活信号传导通路以促进蛋白质的合成,并可能抑制肠上皮细胞自噬介导的蛋白质降解。此外,谷氨酰胺和精氨酸可分别激活有丝分裂原活化蛋白激酶通路和哺乳动物雷帕霉素靶蛋白(mTOR)/p70(s6)激酶通路,从而加强粘膜细胞的迁移和修复。利用一氧化氮依赖型cGMP的信号级联,精氨酸可调节肠道多种生理活动,这有利于细胞的生存和维持动态平衡。动物体内外试验显示,谷氨酰胺和精氨酸可促进细胞增殖,并可针对养分损失、氧化损伤、应激和免疫应激来发挥不同的细胞保护作用。此外,一氧化氮存在时亮氨酸可加强肠道细胞的迁移。因此,通过细胞信号传导机制,精氨酸、谷氨酰胺和亮氨酸在肠道的生长发育和功能完善过程中发挥了关键作用。

关键词：氨基酸细胞信号传导肠道营养

谷氨酰胺、精氨酸和亮氨酸在肠道中的信号传导(二)

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饲料与畜牧（新饲料） 2011年第10期 18-21页

作者： j. marc rhoads Guoyao Wu 邓会玲（译者）刘宁（校者）刘国华（校者）不详中国农业科学院饲料研究所

2.5Gln对紧密接头的稳定是必需的小肠单层细胞研究解释了Gln的丧失和补充影响肠上皮承受损伤能力的机制。Li等（2004）证明在Caco-2细胞单层（暴露在Gln合成酶抑制剂-蛋氨酸磺酸盐）上Gln丧失引起紧密连接（紧密连接包括claudin-1和封... 详细信息

2.5Gln对紧密接头的稳定是必需的小肠单层细胞研究解释了Gln的丧失和补充影响肠上皮承受损伤能力的机制。Li等（2004）证明在Caco-2细胞单层（暴露在Gln合成酶抑制剂-蛋氨酸磺酸盐）上Gln丧失引起紧密连接（紧密连接包括claudin-1和封闭小带-1）中隔膜成分的溶解。此外,

关键词：谷氨酰胺信号传导 Caco-2细胞亮氨酸精氨酸肠道紧密连接 Gln

Hypoallergenic formula with Lactobacillus rhamnosus GGfor babies with colic:A pilot study of recruitment,retention,and fecal biomarkers

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World journal of Gastrointestinal Pathophysiology 2016年第1期7卷 160-170页

作者： Nicole Y Fatheree Yuying Liu Michael Ferris Melissa Van Arsdall Valarie McMurtry marcela Zozaya Chunyan Cai Mohammad H Rahbar Manouchehr Hessabi Ta Vu Christine Wong juleen Min Dat Q Tran Fernando Navarro Wallace Gleason Sara Gonzalez j marc rhoads Department of Pediatrics the University of Texas Health Science Center at Houston Medical SchoolHoustonTX 77030United States Biostatistics/Epidemiology/Research Design Core Center for Clinical and Translational Sciencesthe University of Texas Health Science Center at HoustonHoustonTX 77030United States Division of Epidemiology Human Genetics and Environmental Sciencesthe University of Texas School of Public Health at HoustonHoustonTX 77030United States Department of Pediatrics Louisiana State University Health Science Center and the Research Institute for ChildrenNew OrleansLA 70112United States Investigational Drug Services Pharmacy Memorial Hermann HospitalHoustonTX 77030United States

AIM: To investigate recruitment, retention, and estimates for effects of formula supplementation with Lactobacillus rhamnosus GG(LGG) on inflammatory biomarkers and fecal microbial community in infants with colic. METHODS: A prospective, double-blind, placebocontrolled trial was conducted in otherwise healthy infants with colic. We screened 74 infants and randomized and analyzed results in 20 infants [9 receiving LGG(LGG+) and 11 not receiving LGG(LGG-)]. LGG was incorporated in the formula(Nutramigen~®)(minimum of 3 × 107 CFU/d) in the LGG+ group. Fecal microbiota and inflammatory biomarkers, including fecal calprotectin(FC), plasma cytokines, circulating regulatory T cells(Tregs), and crying + fussing time were analyzed to determine optimal time points and effect sizes for a larger trial. RESULTS: Recruitment in this population was slow, with about 66% of eligible infants willing to enroll; subject retention was better(75%). These rates were influenced by parents' reluctance to volunteer their infant for a clinical trial and by their tendency to change formulas. The maximal difference of crying + fussing time was observed at day 14, comparing the 2 groups, with a mean difference of-91(95%CI:-76, 259) min(P = NS). FC showed no significant difference, but the optimal time to determine a potential effect was at day 90 [with a mean difference of 121(95%CI:-48, 291) μg/g stool], observing a lower level of FC in the LGG+ group. The fecal microbial communities were chaotic, as determined by Shannon's diversity index and not apparently influenced by the probiotic. No significant change was observed in plasma inflammatory cytokines or Tregs, comparing LGG+ to LGG- groups. CONCLUSION: Designing future colic trials involving a probiotic-supplemented formula for infants in the United States will require consideration for difficult enrollment. Infants with colic have major variations in feal microbiota and calprotectin, both of which improve with time, with optimal time p

关键词： Barr diary Regulatory T cells Cytokines Crying Fussing Probiotic Inflammation Biomarker Newborn Intestine

Full Dynamic Model for Liquid Sloshing Simulation in Cylindrical Tank Shape

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World journal of Mechanics 2024年第4期14卷 55-72页

作者： Omar Noui Mohamed Bouazara marc j. Richard Department of Applied Science University of Quebec at Chicoutimi Chicoutimi Canada Department of Mechanical Engineering Laval University Quebec Canada

This study presents a comprehensive full dynamic model designed for simulating liquid sloshing behavior within cylindrical tank structures. The model employs a discretization approach, representing the liquid as a network of interconnected spring-damper-mass systems. Key aspects include the adaptation of liquid discretization techniques to cylindrical lateral cross-sections and the calculation of stiffness and damping coefficients. External forces, simulating various vehicle maneuvers, are also integrated into the model. The resulting system of equations is solved using Maple Software with the Runge-Kutta-Fehlberg method. This model enables accurate prediction of liquid displacement and pressure forces, offering valuable insights for tank design and fluid dynamics applications. Ongoing refinement aims to broaden its applicability across different liquid types and tank geometries.

关键词： Fluid-Structure Interaction Equivalent Mechanical Model Liquid Discretization Spring-Mass Model Spring-Mass Network Liquid Simulation

Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue Luo Yiqi Su Delphine jenny Vandeputte Yuwei jia Guanlei Li Willy Baeyens Marijke Huysmans marc Elskens Yue Gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,Diffusive Gradients in Thin-films(DGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants DGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

＂LOCK＂ing up allergic responses with a Polish probiotic

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Cellular & Molecular Immunology 2016年第2期13卷 263-264页

作者： Yuying Liu marc rhoads Department of Pediatrics Division of Gastroen-terology The University of Texas Health ScienceCenter at Houston Medical School HoustonTexas 77030 USA

Three relatively new lactobacillus species that were developed from fecal samples of a 26-year-old woman （LOCK0900）, a 6-year-old girl （LOCK 0908）, and a 5-year-old boy （LOCK 0919） have been studied by Kozakova ... 详细信息

关键词：内皮缩血管肽类乳杆菌属有益菌种

Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process

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Plant Communications 2024年第8期5卷 69-91页

作者： Sergio Alan Cervantes-Perez Prince Zogli Sahand Amini Sandra Thibivilliers Sutton Tennant Md Sabbir Hossain Hengping Xu Ian Meyer Akash Nooka Pengchong Ma Qiuming Yao Michael j.Naldrett Andrew Farmer Olivier Martin Samik Bhattacharya jasper Klaver marc Libault Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68503USA Division of Plant Science and Technology College of AgricultureFoodand Natural ResourcesUniversity of Missouri-ColumbiaColumbiaMO 65211USA Interdisciplinary Plant Group of Missouri-Columbia ColumbiaMO 65211USA School of Computing University of Nebraska-LincolnLincolnNE 68503USA Proteomics and Metabolomics Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA National Center for Genome Resources Santa FeNM 87505USA INRAE UniversiteParis-SaclayInstitut des Sciences des Plantes de Paris SaclayIPS2Batiment 630 Plateau du MoulonRue Noetzlin91192 Gif sur Yvette CedexFrance Resolve Biosciences Monheim am RheinGermany Present address:The School of Plant Sciences University of ArizonaTucsonAZ 85721USA Present address:GALY Co. 100 Hood Park Dr.BostonMA 02126USA

The soybean root system is *** addition to being composed of various cell types,the soybean root system includes the primary root,the lateral roots,and the nodule,an organ in which mutualistic symbiosis with N-fixing rhizobia occurs.A mature soybean root nodule is characterized by a central infection zone where atmospheric nitrogen is fixed and assimilated by the symbiont,resulting from the close cooperation between the plant cell and the *** date,the transcriptome of individual cells isolated from developing soybean nodules has been established,but the transcriptomic signatures of cells from the mature soybean nodule have not yet been *** single-nucleus RNA-seq and Molecular Cartography technologies,we precisely characterized the transcriptomic signature of soybean root and mature nodule cell types and revealed the co-existence of different sub-populations of ***-infected cells in the mature soybean nodule,including those actively involved in nitrogen fixation and those engaged in *** of the single-cell-resolution nodule transcriptome atlas and the associated gene co-expression network confirmed the role of known nodulation-related genes and identified new genes that control the nodulation *** instance,we functionally characterized the role of GmFWL3,a plasma membrane microdomain-associated protein that controls rhizobial *** study reveals the unique cellular complexity of the mature soybean nodule and helps redefine the concept of cell types when considering the infection zone of the soybean nodule.

关键词： soybean root nodule single-cell RNA-seq nanodomains