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Asian journal of Andrology 2013年第6期15卷 795-798,I0009页

作者： j ullrich schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann Wolfgang Würfel Andrologie Centrum MOnchen MOnchen D-81241 Germany Kinderwunsch Centrum MOnchen MOnchen D-81241 Germany Andrologicum MOnchen MOnchen D-80331 Germany

In 220 consecutive patients with non-obstructive azoospermia, sperm retrieval was attempted by a combination of conventional and microdissection testicular sperm extraction （TESE）. For sperm retrieval, 2-3 conventional biopsies were performed followed by a microdissection TESE in cases of negative conventional biopsies. During the surgery, the vasculature of the testis was assessed using the operative microscope, and the location of positive biopsies was registered in relation to the blood supply. The overall sperm retrieval rate was 58.2%. From the initial conventional biopsies, sperm could be retrieved in 46.8% of the patients. With microdissection TESE, sperm could be retrieved from an additional 11.4% of the patients. The further use of microdissection TESE improved the sperm retrieval rate significantly （P=0.017）. No significant accumulation of positive biopsies was found towards the rete testis or the main testicular vessels.

关键词： intracytoplasmic sperm injection male infertility microdissection testicular sperm extraction non-obstructiveazoospermia sperm retrieval

Bedrock control on the Assu Incised Valley morphology and sedimentation in the Brazilian Equatorial Shelf

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International journal of Sediment Research 2016年第2期31卷 181-193页

作者： Moab Praxedes Gomes Helenice Vital Karl Stattegger Klaus schwarzer Programa de Pós-Graduao em Geodinmica e Geofísica Universidade Federal do Rio Grande do Norte Institute of Geosciences Kiel University

The Assu Incised Valley(AIV) is a new example of an incised-valley system located on the Brazilian Equatorial continental *** valley extends over 40 km from the present-day shoreline to the shelf break,in a passive margin setting,on a shallow(70 m),narrow(43 km) and flat(?1) shelf,with mixed carbonate-siliciclastic sedimentation and a low terrigenous sediment *** investigate the morphology of the incised valley and the surrounding shelf area,we analyzed LandSat images and bathymetric,shallow seismic and sedimentological *** results indicate that the AIV is a coastal-plain incised *** incision was mainly forced by the magnitude of the last fall in sea level,which created the specific geometry of valley,atypically widening landward due to lithological and structural *** AIV is a broad N-S-trending valley with a negative relief of approximately 12 m below the mean shelf topography and low-angle valley walls(3°),surrounded by a highly planar *** valley is asymmetric in cross-section and subdivided into three segments along the shelf:the landward segment is wide(up to 8 km),shallow(< 9 m deep),and 25 km long;the middle segment is narrow(2 km wide),only slightly deeper than the inner segment(< 15 m deep) and 10 km long;the outer segment is very narrow(< 1 km),has incised relief up to 30 m deep and is 8 km *** incised valley changes near the shelf break abruptly to a deeper(300 m) and wider submarine canyon(3 km).The three valleysegments are bounded by transfer faults of W-E *** addition,the accommodation-space response to the last deglacial sea-level rise provided a 30 m thick sedimentary fill above a Pleistocene/Holocene regional unconformity and a morphologically controlled stratigraphic *** antecedent valley topography controls the sedimentation and hydrodynamics of the modern ***,the morphology of the AIV is a key example of the control of the bedrock on valley incision and infill respon

关键词： Incised valley Continental shelf Potiguar basin Sediment dynamics Bedrock control

Multimodal imaging of experimental choroidal neovascularization

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International journal of Ophthalmology(English edition) 2022年第6期15卷 886-893页

作者： Ioanna Tsioti Xuan Liu Petra schwarzer Martin S.Zinkernagel Despina Kokona Department of Ophthalmology InselspitalBern University Hospitaland Department of BioMedical ResearchUniversity of BernBern 3010Switzerland Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To compare choroidal neovascularization(CNV)lesion measurements obtained by in vivo imaging modalities,with whole mount histological preparations stained with isolectin GS-IB4,using a murine laser-induced CNV ***:B6 ***-Tg(Csf1 r-EGFP)1 Hume/j heterozygous adult mice were subjected to laser-induced CNV and were monitored by fluorescein angiography(FA),multicolor(MC)fundus imaging and optical coherence tomography angiography(OCTA)at day 14 after CNV *** pigment epithelium(RPE)whole mounts were prepared at the end of the experiment and were stained with isolectin *** areas were measured in all different imaging modalities at day 14 after CNV from three independent raters and were compared to choroidal-RPE whole *** correlation coefficient(ICC)type 2(2-way random model)and its 95%confidence intervals(CI)were calculated to measure the correlation between different raters’***’s rank correlation coefficient(Spearman’s r)was calculated for the comparison between FA,MC and OCTA data and histology ***:FA(early and late)and MC correlates well with the CNV measurements ex vivo with FA having slightly better correlation than MC(FA early Spearman’s r=0.7642,FA late Spearman’s r=0.7097,and MC Spearman’s r=0.7418),while the interobser ver reliability was good for both techniques(FA early ICC=0.976,FA late ICC=0.964,and MC ICC=0.846).In contrast,OCTA showed a poor correlation with ex vivo measurements(Spearman’s r=0.05716)and high variability between different raters(ICC=0.603).CONCLUSION:This study suggests that FA and MC imaging could be used for the evaluation of CNV areas in vivo while caution must be taken and comparison studies should be performed when OCTA is employed as a CNV monitoring tool in small rodents.

关键词： choroidal neovascularization in vivo imaging fluorescein angiography multicolor fundus imaging optical coherence tomography angiography

近阈值下He原子的双电子电离实验中出射电子研究

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物理学报 2007年第11期56卷 6386-6392页

作者：曹士娉马新文 A.Dorn M.Dürr j.ullrich 中国科学院近代物理研究所 Max-Planck-Institute for Nuclear Physics Saupfercheckweg 1Heidelberg 69117Germany

利用适用于低能电子入射的反应显微成像谱仪,对电子入射He原子近阈值下的双电离过程进行了研究,实验测量了反应后3个粒子的全部动量,获得了出射电子间的关联信息.主要介绍近阈值下的双电离实验装置及实验技术,集中分析反应后出射电子的... 详细信息

利用适用于低能电子入射的反应显微成像谱仪,对电子入射He原子近阈值下的双电离过程进行了研究,实验测量了反应后3个粒子的全部动量,获得了出射电子间的关联信息.主要介绍近阈值下的双电离实验装置及实验技术,集中分析反应后出射电子的动量能量关系,对描述近阈值双电离的Wannier理论进行了检验,发现在入射电子能量为106eV时,实验结果具有Wannier理论预言的性质.

关键词：近阈值He原子的双电离反应显微成像谱仪电子入射电离

Electromagnetic Fields and Calcium Signaling by the Voltage Dependent Anion Channel

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Open journal of Veterinary Medicine 2021年第1期11卷 57-86页

作者： Volker ullrich Hans-jürgen Apell Department of Biology University of Konstanz Konstanz Germany

Electromagnetic fields (EMFs) can interact with biological tissues exerting positive as well as negative effects on cell viability, but the underlying sensing and signaling mechanisms are largely unknown. So far in excitable cells EMF exposure was postulated to cause Ca2+ influx through voltage-dependent Ca channels (VDCC) leading to cell activation and an antioxidant response. Upon further activation oxidative stress causing DNA damage or cell death may follow. Here we report collected evidence from literature that voltage dependent anion channels (VDAC) located not only in the outer microsomal membrane but also in the cytoplasmic membrane convert to Ca2+ conducting channels of varying capacities upon subtle changes of the applied EMF even in non-excitable cells like erythrocytes. Thus, VDAC can be targeted by external EMF in both types of membranes to release Ca2+ into the cytosol. The role of frequency, pulse modulation or polarization remains to be investigated in suitable cellular models. VDACs are associated with several other proteins, among which the 18 kDa translocator (TSPO) is of specific interest since it was characterized as the central benzodiazepine receptor in neurons. Exhibiting structural similarities with magnetoreceptors we propose that TSPO could sense the magnetic component of the EMF and thus together with VDAC could trigger physiological as well as pathological cellular responses. Pulsed EMFs in the frequency range of the brain-wave communication network may explain psychic disturbances of electromagnetic hypersensitive persons. An important support is

关键词： Ca Signaling VDAC Benzodiazepine Receptor Mechanistic Concept Pulsed EMFs Electromagnetic Hypersensitivity TSPO Erythrocytes NADH-Oxidase Apoptosis Magnetosensor Membrane Potential Oxidative Stress Brain Signaling Autism

……who has climbed a few Everests himself

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山西中医学院学报 2007年第3期8卷 5-8页

作者： Noel Bruce ullrich Financial & Corporate Services Ltd. P.O.Box 212 ChristchurchNew Zealand

Mr Chancellor, Ladies and gentleman, I would like to extend my warmest congratulations to those graduating today. Today is the culmination of a number of years of hard work, sacrifice and dedication and I know how proud your own family members and colleagues will be. You are also now, life time members of the Massey University ***, as we all well know, is a series of challenges - large and small and with its peaks and troughs, along the way. Way back in 1975 I had been appointed Chairman of an Organizing Committee to send a New Zealand Himalayan Expedition to climb the formidable north face of a mountain called 'jannu'. It was probably the biggest expedition from New Zealand to ever climb in the Himalayas. Sir Edmund Hillary was patron of the expedition and the team contained some of the country's most notable climbers, including Graeme Dingle - but it was also to be a very expensive exercise. Not ever having had any experience of mountaineering, I tried to be innovative in our approach towards the organization of such an event, particularly in the area of fund raising. Along the way, I even declined the offer of a weekend ascent of Mount Cook. I have a fear of *** there was some financial contribution from the team members, we commissioned a medallion for the expedition which was sold through all branches of the Bank of New South Wales (now Westpac), we had a national raffle organised for us, we ran fashion shows as fund raisers (we even got members of the team to appear in dinner suits for the first time ever) and persuaded Television One, for a fee, to send along a crew to cover the expedition for a documentary - it was all a great deal of hard *** to terrible weather and treacherous climbing conditions the team did not reach the summit - a couple of the team had to be flown out with minor frostbite, but we got them back all unscathed, but not at all that keen to return for more. Graeme Dingle also wrote a book'Wall of Shadows'which raised

关键词：目标策略建议毕业演讲高校毕业生

低于再碰撞阈值下强激光场原子非序列双电离(英文)

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物理学进展 2010年第4期30卷 335-345页

作者：刘运全刘杰龚旗煌 Moshammer R ullrich j 物理学院和人工微结构和介观物理国家实验室北京大学北京100871 马克斯普朗克核物理所 D-69117海德堡德国应用物理与技术研究中心北京大学北京100084 北京应用物理与计算数学研究所北京100088

在最近的实验和理论研究中,我们探讨了氩原子和氖原子在红外强激光场中低于再碰撞阈值的非序列双电离问题。在研究中,我们发现在非序列双电离过程中,氖原子的电子关联表现为在激光偏振面内肩并肩出射,而对于氩原子的电子关联行为表现为... 详细信息

在最近的实验和理论研究中,我们探讨了氩原子和氖原子在红外强激光场中低于再碰撞阈值的非序列双电离问题。在研究中,我们发现在非序列双电离过程中,氖原子的电子关联表现为在激光偏振面内肩并肩出射,而对于氩原子的电子关联行为表现为在激光偏振面内的背对背出射,我们采用三维半经典模型(考虑电子隧道电离)很好地解释了实验结果。在阈值附近,我们发现电子在激光场中的多次散射以及电子再碰撞激发后电子隧道电离是氩原子反关联行为的主要原因,而电子在激光场作用下的单次碰撞是电子关联行为的主要原因。通过测量双电离过程中产生电子的横向电子动量分布,观察到了库伦聚焦效应,我们认为这是非经典的关联行为。最后,我们给出了氩原子和氖原子在激光场中阈值的解析模型,并给出了原子的关联和反关联激光强度区域。

关键词：强场非序列双电离再碰撞电离阈值

Fast Trainable Capabilities in Software Engineering-Skill Development in Learning Factories

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计算机教育 2020年第12期 2-10页

作者： Andréullrich Malte Teichmann Norbert Gronau Department of Business Informatics University of PotsdamPotsdam 14482Germany

The increasing demand for software engineers cannot completely be fulfilled by university education and conventional training approaches due to limited ***,an alternative approach is necessary where potential software engineers are being educated in software engineering skills using new *** suggest micro tasks combined with theoretical lessons to overcome existing skill deficits and acquire fast trainable *** paper addresses the gap between demand and supply of software engineers by introducing an actionoriented and scenario-based didactical approach,which enables non-computer scientists to ***,the learning content is provided in small tasks and embedded in learning factory ***,different requirements for software engineers from the market side and from an academic viewpoint are analyzed and synthesized into an integrated,yet condensed skills *** enables the development of training and education units that focus on the most important skills demanded on the *** achieve this objective,individual learning scenarios are *** course,proper basic skills in coding cannot be learned over night but software programming is also no sorcery.

关键词： learning factory programming skills software engineering training

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

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Cellular & Molecular Immunology 2016年第2期13卷 251-262页

作者： Hana Kozakova Martin schwarzer Ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska Laboratory of Gnotobiology Institute of Microbiology Academy of Sciences of the Czech Republic Novy Hradek Czech Republic Department of Pathology the Children's Memorial Health Institute Warsaw Poland Institute of Specific Prophylaxis and Tropical Medicine Medical University of Vienna Vienna Austria Institute of Biochemistry and Biophysics Polish Academy of Sciences Warsaw Poland

Increasing numbers of clinical trials and animal experiments have shown that probiotic bacteria are promising tools for allergy prevention. Here, we analyzed the immunomodulatory properties of three selected lactobacillus strains and the impact of their mixture on allergic sensitization to Bet v I using a gnotobiotic mouse model. We showed that Lactobacillus （L.） rhamnosus LOCK0900, L. rhamnosus LOCK0908 and L. casei LOCK0919 are recognized via Toll-like receptor 2 （TLR2） and nucleotide-binding oligomerization domain-containing protein 2 （NOD2） receptors and stimulate bone marrow-derived dendritic cells to produce cytokines in species- and strain-dependent manners. Colonization of germ-free （GF） mice with a mixture of all three strains （Lmix） improved the intestinal barrier by strengthening the apical junctional complexes of enterocytes and restoring the structures of microfilaments extending into the terminal web. Mice colonized with Lmix and sensitized to the Bet v I allergen showed significantly lower levels of allergen-specific IgE, IgG 1 and IgG2a and an elevated total IgA level in the sera and intestinal lavages as well as an increased transforming growth factor （TGF）-β level compared with the sensitized GF mice. Splenocytes and mesenteric lymph node cells from the Lmix-colonized mice showed the significant upregulation of TGF-β after in vitro stimulation with Bet v 1. Our results show that Lmix colonization improved the gut epithelial barrier and reduced allergic sensitization to Bet v 1. Furthermore, these findings were accompanied by the increased production of circulating and secretory IgA and the regulatory cytokine TGF-β. Thus, this mixture of three lactobacillus strains shows potential for use in the prevention of increased gut permeability and the onset of allergies in humans,

关键词： allergic sensitization germ-free intestinal barrier Lactobacillus probiotics

Emission Characteristics of Three Final Continuum Electrons Produced in Low Energy Double Ionization of Helium

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2007年第1期 131-132页

作者： Cao Shiping Ma Xinwen A. Dorn M. Duerr j. ullrich 不详 Max-Planek-Institute for Nuclear Physics Saupfercheekweg 1 Heidelberg 69117 Germany.