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International NeuroAIDS: prospects of HIV-1 associated neurological com-plications

Cell Research 2005年第Z1期15卷 962-969页

作者： j roberto trujillo Gilberto jARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA jose E VIDAL joseph BRYANT Robert C GALLO Institute of Human Virology University of Maryland Biotechnology Institute 725 W Lombard Street Baltimore MD 21201 USA Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil Clinical Research Unit in Human Retrovirology University of CampinasSao Paulo 01246 Brazil. Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil

Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain.

关键词： NeuroAIDS HIV-1 neurotropism AIDS dementia complex.

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Ubiquitination and PARylation cross-talk about immunity

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Molecular Plant 2021年第12期14卷 1976-1978页

作者： Marco trujillo Faculty of Biology Cell BiologyⅡUniversity of Freiburg79104 FreiburgGermany

Post-translational modifications(PTMs)allow organisms to quickly respond and acclimate to environmental *** attachment of ubiquitin and its different polymeric forms,act as signals that modulate most aspects of cellular *** is of key importance to maintain protein homeostasis during the immune response by coordinating the major degradation path-ways,namely proteasomal and vacuolar in plants(trujillo,2021).Poly(ADP-ribosyl)ation(PARylation),has also been linked to various stress responses and shows many commonalities to ubiquitination(Rissel and Peiter,2019).Yao et al.(2021)have now uncovered a link between these two PTMs.

关键词： maintain translational polymeric

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EXISTENCE OF SOLUTIONS OF NONLINEAR FRACTIONAL PANTOGRAPH EQUATIONS

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Acta Mathematica Scientia 2013年第3期33卷 712-720页

作者： K. BALACHANDRAN S. KIRUTHIKA j. trujillo Department of Mathematics Bharathiar University Universidad de La Laguna Departamento de Anlisis Matemtico38271 La Laguna Tenerife Spain

This article deals with the existence of solutions of nonlinear fractional pantograph equations. Such model can be considered suitable to be applied when the corresponding process occurs through strongly anomalous media. The results are obtained using fractional calculus and fixed point theorems. An example is provided to illustrate the main result obtained in this article.

关键词： Fractional differential equations pantograph equations fixed point theorems

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Elenoside increases intestinal motility

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World journal of Gastroenterology 2006年第44期12卷 7143-7148页

作者： E Navarro Sj Alonso R Navarro j trujillo E jorge Department of Pharmacology Faculty of Medicine University of La Laguna 38071 La Laguna Apdo. 55 Tenerife Canary Islands Spain Department of Medical and Chirurgical Sciences University of Las Palmas Gran Canaria Canary Islands Spain Centro de Productos Naturales y Agrobiologia CSIC Tenerife Canary Islands Spain

AIM： TO study the effects of elenoside, an arylnaphthalene lignan from justicia hyssopifolia, on gastrointestinal motility in vivo and in vitro in rats. METHODS： Routine in vivo experimental assessments were catharsis index, water percentage of boluses, intestinal transit, and codeine antagonism. The groups included were vehicle control （propylene glycol-ethanolplant oil-tween 80）, elenoside （i.p. 25 and 50 mg/kg）, cisapride （i.p. 10 mg/kg）, and codeine phosphate （intragastric route, 50 mg/kg）. In v/tro approaches used isolated rat intestinal tissues （duodenum, jejunum, and ileum）. The effects of elenoside at concentrations of 3.2 ×10^4, 6.4 ×10^4 and 1.2 ×10^3 mol/L, and cisapride at 10^6 mol/L were investigated. RESULTS： Elenoside in vivo produced an increase in the catharsis index and water percentage of boluses and in the percentage of distance traveled by a suspension of activated charcoal. Codeine phosphate antagonized the effect of 25 mg/kg of elenoside. In vitro, elenoside in duodenum, jejunum and ileum produced an initial decrease in the contraction force followed by an increase. Elenoslde resulted in decreased intestinal frequency in duodenum, jejunum, and ileum. The in vitro and in vivo effects of elenoside were similar to those produced by cisapride. CONCLUSION： Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs. Elenoside, could be an alternative to cisapride in treatment of gastrointestinal diseases as well as a preventive therapy for the undesirable gastrointestinal effects produced by opioids used for mild to moderate pain.

关键词： Elenoside Gastrointestinal motility, Smail intestine preparation

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Note on controllability of linear fractional dynamical systems

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journal of Control and Decision 2016年第4期3卷 267-279页

作者： K.Balachandran M.Matar j.j.trujillo Department of Mathematics Bharathiar UniversityCoimbatoreIndia Department of Mathematics Al-Azhar University-GazaGazaPalestine Departamento de Analisis Matemático Universidad de La LaqunaTenerifeSpain

In this article,we obtain the solutions of some fractional differential systems with different orders using the inverse operator method and Mittag–Leffler ***,the controllability of time-invariant linear fractional s... 详细信息

关键词： Controllability fractional systems Mittag-Leffler function

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Dipole and generalized oscillator strength derived electronic properties of an endohedral hydrogen atom embedded in a Debye-Huckel plasma

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Matter and Radiation at Extremes 2018年第5期3卷 227-242页

作者： C.Martínez-Flores R.Cabrera-trujillo Instituto de Ciencias Físicas Universidad Nacional Autonoma de MexicoAp.Postal 43-8CuernavacaMorelos62251Mexico

We report electronic properties of a hydrogen atom encaged by an endohedral cavity under the influence of a weak plasma interaction. Weimplement a finite-difference approach to solve the Schrodinger equation for a hydrogen atom embedded in an endohedral cavity modeled by theWoods-Saxon potential with well depth V0, inner radius R0, thickness D, and smooth parameter g. The plasma interaction is described by aDebye-Hu¨ckel screening potential that characterizes the plasma in terms of a Debye screening length lD. The electronic properties of theendohedral hydrogen atom are reported for selected endohedral cavity well depths, V0, and screening lengths, lD, that emulate differentconfinement and plasma conditions. We find that for low screening lengths, the endohedral cavity potential dominates over the plasma interaction by confining the electron within the cavity. For large screening lengths, a competition between both interactions is observed. We assessand report the photo-ionization cross section, dipole polarizability, mean excitation energy, and electronic stopping cross section as function of lD and V0. We find a decrease of the Generalized Oscillator Strength (GOS) when the final excitation is to an s state as the plasma screeninglength decreases. For a final excitation into a p state, we find an increase in the GOS as the endohedral cavity well-depth increases. For the caseof the electronic stopping cross section, we find that the plasma screening and endohedral cavity effects are larger in the low-to-intermediateprojectile energies for all potential well depths considered. Our results agree well to available theoretical and experimental data and are afirst step towards the understanding of dipole and generalized oscillator strength dependent properties of an atom in extreme conditions encagedby an endohedral cavity immersed in a plasma medium.

关键词： Oscillator strengths Debye-Huckel plasma Cavities Endohedral Energy loss Stopping power

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Improvement of transfection with reprogramming factors in urine-derived cells

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BIOCELL 2020年第3期44卷 401-409页

作者： OLIVIA A.ROBLES-RODRÍGUEZ MARÍA j.LOERA-ARIAS jOSÉj.PÉREZ-trujillo ARNULFO VILLANUEVA-OLIVO ERNESTO PICÓN-GALINDO LAURA VILLARREAL-MARTÍNEZ ADOLFO SOTO-DOMÍNGUEZ HUMBERTO RODRÍGUEZROCHA ARACELY GARCÍA-GARCÍA ODILA SAUCEDO-CÁRDENAS roberto MONTES DE OCA-LUNA Facultad de Medicina Departamento de HistologíaUniversidad Autónoma de Nuevo LeónMonterreyC.P.64460México Hospital Universitario“Dr.joséEleuterio González González” Servicio de HematologíaUniversidad Autónoma de Nuevo LeónMonterreyC.P.64460México Centro de Investigación Biomédica del Noreste Departamento de Genética MolecularInstituto Mexicano del Seguro SocialMonterreyC.P.64720México

Human-induced pluripotent stem cells(iPSCs)are an accessible source of adult-derived,patient-specific pluripotent stem cells for use in basic research,drug discovery,disease modeling,and stem cell *** the accessibility of methods to obtain iPSCs regardless of the cell source can enhance their clinical ***,our purpose is to report a simple protocol to obtain iPS-like cells from urine-derived renal epithelial cells(RECs)using different extracellular matrices and transfection *** this study,we began by culturing urine-derived cells from healthy donors to establish a primary culture of renal epithelial cells,followed by their ***,we generated iPS-like cells by transfecting renal epithelial cells(RECs)with vectors expressing Oct4,Sox2,L-Myc,Lin-28,and Klf4,and we compared the efficacy of different extracellular matrices and transfection *** resultant iPS-like cells showed a human embryonic stem cell-like morphology and expressed the specific pluripotency markers Oct3/4,Nanog,Lin28,and *** concluded that Lipofectamine Stem Cell transfection reagent is more effective than FuGENE in obtaining iPS-like cells under the conditions ***,the three matrices are similar in their efficiency of obtaining iPS-like *** report provides an experimental protocol for obtaining and generating iPS-like cells from urine samples for further cell therapy research on different human diseases.

关键词： Reprogramming factors iPSCs Renal epithelial cells Extracellular matrix Transfection reagent

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Lighting,colour and geometry:Which has the greatest influence on students’cognitive processes?

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Frontiers of Architectural Research 2023年第4期12卷 575-586页

作者： Marıa Luisa Nole Fajardo juan Luis Higuera-trujillo Carmen Llinares Instituto Universitario de Investigacio´n en Tecnologı´a Centrada en el Ser Humano(HUMAN-tech) Universitat Polite`cnica de Vale`nciaValencia 46022Spain School of Architecture Art and DesignTecnologico de MonterreyMonterrey 64849Mexico

Many studies have analysed the effects that design elements,such as lighting and colour,have on students’cognitive *** analyses,while providing useful information,do not allow researchers to compare the effects of multiple design *** objective of the present study is to analyse the relative influence of lighting,colour and geometry on attention and memory,the main cognitive functions that underlie learning,and on *** a controlled,virtual reality(VR)-based experiment,200 university students(100 male/100 female)performed attention,memory and preference tests in classrooms with different configurations of lighting(colour temperature and illuminance),colour(saturation and hue)and geometry(height and width).The results identified significant gender-based differences,which demonstrates the need to segment,by gender,samples in this type of *** had the greatest influence,significantly affecting males’memories,females’attention and the preferences of both *** was also an influential element,significantly affecting females’attention,while geometry was the least ***,it should be highlighted that attention was the metric most sensitive to design *** results may be of interest to architects,interior designers and engineers who wish to create classrooms that satisfy students’psychological needs.

关键词： Classroom design Memory Attention Preference Virtual classroom

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Pyrenetetraone-based covalent organic framework as an effective electrocatalyst for oxygen reduction reaction

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Nano Research 2022年第5期15卷 3907-3912页

作者： Paloma Garcia-Arroyo Emiliano Martinez-Perinan jorge j.Cabrera-trujillo Elena Salagre Enrique G.Michel jose I.Martinez Encarnacion Lorenzo jose L.Segura Departamento de Quimica Organica I Facultad de CC.QuimicasUniversidad Complutense de Madrid28040 MadridSpain Departamento de Quimica Analitica y Analisis Instrumental Facultad de CienciasUniversidad Autónoma de Madrid28049 MadridSpain Departamento de Fisica de la Materia Condensada Universidad Autónoma de Madrid28049 MadridSpain Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de Madrid28049 MadridSpain Departamento de Nanoestructuras SuperficiesRecubrimientos y Astrofisica MolecularInstituto de Ciencia de Materiales de Madrid(ICMMCSIC)28049 MadridSpain Instituto Madrileno de Estudios Avanzados en Nanociencia(IMDEA-Nanociencia) 28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autonoma de Madrid28049 MadridSpain

A novel porous and crystalline two-dimensional(2D)electrochemically active covalent organic framework(COF)based on ortho-quinone units has been prepared as an innovative approach towards the development of organic cathode materials with multiple redox sites as an efficient electrocatalyst for the oxygen reduction reaction(ORR).In contrast with most of the previously reported COFs as electrocatalysts for the ORR,the electrocatalytic application of this material towards ORR has been investigated without adding any metal or conductive supporting material and avoiding any additional carbonization ***,the electrochemical properties of the COF material have been compared with two analogue amorphous frameworks with similar chemical composition,which points out the important role of the enhanced crystallinity and porosity of the COF network in its superior performance as an electrocatalyst towards ORR.

关键词： electrocatalysis oxygen reduction reaction metal free pyrenetetraone covalent organic framework

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The impact of the design of learning spaces on attention and memory from a neuroarchitectural approach:A systematic review

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Frontiers of Architectural Research 2022年第3期11卷 542-560页

作者： Mar Llorens-Gamez juan Luis Higuera-trujillo Carla Sentieri Omarrementeria Carmen Llinares Department of Architectural Projects Universitat Politecnica de ValenciaValencia 46022Spain Institute for Research and Innovation in Bioengineering(i3B) Universitat Politecnica de ValenciaValencia 46022Spain

Enriched environments in animal models have demonstrated that exposure to an optimal stimulus improves behavior,cognition,and ***,the evidence base for the neurophysiological influence of human environment enrichment has not been extensively *** systematic review compiles indicators about the effect of built,indoor environments on the cognitive processes of memory and attention in *** work pursues two main objectives:(1)to define current knowledge and the methods that are useful and identify whether previously published studies indicate consistencies and(2)to report the approaches and strategies that can be used in evaluating cognitive processes affected by environment *** of this systematic review show that(1)form and geometry,(2)space distribution and context,(3)color and texture,(4)height,width,and enclosure,(5)transition and circulation,and(6)light,sound,and temperature have an impact on memory and/or attention,and they can be assessed *** all the advances in this field,methodological limitations and a lack of cross-validated standard protocols are ***,future research is necessary to provide a deep insight into how human cognition can be heightened by the environment to which it is exposed.

关键词： Built environment Neuroarchitecture Cognition Attention Memory Learning spaces

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