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Effect of diurnal changes on dichotic listening in younger adults with normal hearing

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journal of Otology 2022年第4期17卷 191-196页

作者： Praveen Prakash K.P.Vismaya Dhruvan S.Mahesh Prashanth prabhu Department of Audiology All India Institute of Speech and HearingManasagangothriMysuru570006India

Background:Diurnal changes can be defined as the time of the day over an individual's performance level for different activities that involve physical and mental ***:The current study aimed to evaluate the effect of diurnal changes in scores obtained for the Dichotic Consonant-Vowel paradigm by young adults with normal hearing ***:Based on the‘Morningness-Eveningness questionnaire’given by Horne&Ostberg,the subjects were divided into moderately-morning,intermediate and moderately-evening *** Dichotic Consonant-Vowel tests were performed during morning and evening,and the right ear,left ear and double correct scores were compared between morning and evening for each ***:There was significant diurnal changes noted for moderately morning and evening categories,where morning-type individuals performed better during morning and evening-type individuals performed better during the *** scores of intermediate individuals remained unchanged between morning and evening test ***:Diurnal change is a phenomenon associated with an individual's biological clock ***,attention and inhibitory controls aid them in carrying out tasks that require sufficient physical and mental *** current study suggests that clinicians and researchers consider diurnal changes as an extraneous variable that could affect the reliability of the Dichotic Consonant-Vowel test results.

关键词： Diurnal changes Circadian rhythms Dichotic-CV Binaural auditory processing Dichotic listening

Dorsal onlay buccal mucosal graft urethroplasty for female urethral stricture:Techniques and outcomes

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Asian journal of Urology 2024年第4期11卷 611-617页

作者： Vinod Kumar prabhuswamy Harsha Hiriyur Somashekarappa Pradeepa Melinamane Ganeshappa Kumar prabhu Venkatesh Krishnamoorthy NU Hospitals PadmanabhanagarBangaloreKarnatakaIndia

ObjectiveFemale urethral stricture (FUS) accounts for about 4%–13% of cases of female bladder outlet obstruction. FUS was and is still managed by repeated dilatations and/or direct visual internal urethrotomy. There are many alternative options for reconstruction like buccal or vaginal mucosal graft urethroplasty. Our aim was to describe the technique of dorsal onlay buccal mucosal graft (BMG) urethroplasty for FUS and present the *** january 2014 and December 2021, 37 patients who underwent dorsal onlay BMG urethroplasty were included in the study. Their pre-operative diagnosis was confirmed with uroflowmetry, micturating cystourethrogram, urethral calibration, and on table cystoscopy. Bladder catheter was removed after 2 weeks. Patients were followed up at 3 months, 6 months, 1 year, and then annually with urine analysis, uroflowmetry, and post-void residual assessment. We defined success as a maximum flow rate (Q_(max)) above 15 mL/s without the need for an additional *** mean age of patients was 47.8 (standard deviation [SD] 11.3) years. Twenty patients had previously undergone urethral dilatations. The mean pre-operative Q_(max) was 7.79 (SD 3.73) mL/s. However, the mean Q_(max) improved to 23.20 (SD 8.25) mL/s after surgery. The mean post-void residual urine after surgery was 30.50 (SD 10.70) mL. This reduced from a mean value of 139.00 (SD 147.24) mL before surgery. The mean follow-up was 30.2 (SD 18.3, range 18–44) months. There was no post-operative incontinence. There were Clavien–Dindo Grade 1 complications in 6 out of 37 (16.2 %) patients during hospital stay. The only long-term complication was recurrence of stricture in 4 (10.8%) *** onlay BMG urethroplasty in females is a safe, effective technique which can avoid repeated painful dilatations and multiple urethrotomies. One should always consider reconstruction in FUS without any fear of incontinence.

关键词： Female urethral stricture Urethral dilatation Urethrotomy Dorsal onlay Buccal mucosal graft

Studies on the effect of weld defect on the fatigue behavior of welded structures

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China Welding 2018年第1期27卷 53-59页

作者： Ramu Murugan prabhu Raja Venugobal Thyla Pudukkarai Ramaswami Sathiskumar jothi Somu Chinnusamy Department of Mechanical Engineering Amrita School of Engineering Department of Mechanical Engineering PSG College of Technology College of Engineering Swansea University

Structural integrity isstated as the science and technology of margin between safety and disaster. Systematic prediction of structural integrity of critical structures such ascombustion chambers,pressure vessels,nuclear reactor components,boilers etc.,ensures the human safety,environmental protection,and the economical *** present work aims at prediction of fatigue behaviour of symmetric structures like pressure vessels in the presence of common welding defects such as lack of fusion( LOF),lack of penetration( LOP) and porosity.A ring type specimen which replicates the stress pattern in thepressure vessel is considered for the study of severity of weld imperfections. Initial dimensions of weld defects are arrived by performing NDT *** growth analysis is carried out to determine the remaining life of the welded joint with defects.

关键词： welding defects fatigue fracture mechanics crack growth fatigue life

Is tinnitus a major concern in individuals with auditory neuropathy spectrum disorder?-Questionnaire based study

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 1-5页

作者： Prashanth prabhu Department of Audiology All India Institute of Speech and HearingManasagangothriNaimisham CampusMysoreKarnataka570006India

Objective:Our study attempted to determine if tinnitus is a major concern in individuals with auditory neuropathy spectrum disorder (ANSD).The study also attempted to determine if pure tone average (PTA),speech identification scores (SIS),or reported duration of hearing loss could predict the tinnitus severity and functional handicap in adults with ***:Tinnitus functional index (TFI) and tinnitus severity index (TSI) were administered on all the 40 participants diagnosed with ***:The mean TFI score was 44.3,which suggested moderate degree of tinnitus related functional *** mean TSI score was found to be 33.3,which suggested moderate degree of severity in individuals with *** study also showed that tinnitus causes functional impairment that leading to sleep disturbances,emotional problems,and affecting the quality of *** was no significant correlation (P > 0.05) between PTA,SIS,reported onset of hearing loss and scores of TFI or ***:Tinnitus in individuals with ANSD should also be given priority during assessment and provide appropriate tinnitus management.

关键词： Tinnitus Functional impairment Severity Questionnaire

应用镇静药物的ICU病人在胸部物理治疗期间视觉诱发电位的变化

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中华麻醉学杂志 1997年第1期17卷 13-16页

作者：王多友 tej Healy CjD Pomfrett 中国医科大学第二临床学院麻醉科英国曼彻斯特大学麻醉科

目的：通过视觉诱发电位（ＶＥＰ）方法，来测定镇静深度的可行性。方法：７例应用镇静药和肌松药的ＩＣＵ病人在进行胸部物理治疗期间视觉诱发电位和血流动力学变化进行了测定。结果：在胸部物理治疗过程中，ＶＥＰ图形中Ｐ６０、Ｎ７... 详细信息

目的：通过视觉诱发电位（ＶＥＰ）方法，来测定镇静深度的可行性。方法：７例应用镇静药和肌松药的ＩＣＵ病人在进行胸部物理治疗期间视觉诱发电位和血流动力学变化进行了测定。结果：在胸部物理治疗过程中，ＶＥＰ图形中Ｐ６０、Ｎ７５、Ｐ１００和Ｎ１２５的时限明显缩短（Ｐ＜０．０５）），如上各点的振幅及平均动脉压虽有上升的趋势，脉搏亦有增快的趋势，但无统计学意义（Ｐ＞０．０５））。结论：ＶＥＰ能够反映镇静病人在行胸部物理治疗期间其中枢神经系统的变化情况，可作为一种监测镇静深度的客观指标。

关键词：催眠麻醉诱发电位麻醉深度全身麻醉

Role of post-translational modification of the Y box binding protein 1 in human cancers

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Genes & Diseases 2015年第3期2卷 240-246页

作者： Lakshmi prabhu Antja-Voy Hartley Matthew Martin Fadumo Warsame Emily Sun Tao Lu Department of Pharmacology and Toxicology Indiana University School of Medicine635 Barnhill DriveIndianapolisIN 46202USA Department of Biochemistry and Molecular Biology Indiana University School of Medicine635 Barnhill DriveIndianapolisIN 46202USA Department of Medical and Molecular Genetics 975 West Walnut StreetMedical Research and Library BuildingIndianapolisIN 46202USA

Y box binding protein-1(YBX1)belongs to a DNA-and RNA-binding family of transcription factors,containing the highly conserved cold shock domain(CSD).YBX1 is involved in a number of cellular functions including transcription,translation,DNA damage repair etc.,and it is upregulated during times of environmental ***1 is localized in both the cytoplasm and the ***,its nuclear translocation is observed in a number of cancers and is associated with poor prognosis and disease ***,YBX1 expression is upregulated in a variety of cancers,pointing towards its role as a potential *** certain circumstances,YBX1 also promotes the expression of multidrug resistance 1(MDR1)gene,which is involved in the development of drug ***,it is critical to understand the mechanism of YBX1 regulation and its downstream effects on promoting cancer development.A number of recent studies have highlighted the mechanisms of YBX1 *** spectrometric analyses have reported several post-translational modifications that possibly play an important role in modulating YBX1 *** is the most widely occurring post-translational modification in *** vivo analyses of sites like S102 and more recently,S165 illustrate the relationship of post-translational regulation of YBX1 in promoting cell proliferation and tumor *** review provides a comprehensive and up-to-date account of post-translational modifications identified in *** knowledge is a key in allowing us to better understand the mechanism of YBX1 regulation,which will aid in development of novel therapeutic strategies to target YBX1 in many types of cancer in the future.

关键词： Cancer Cold shock domain Phosphorylation Post-translational modification Y box binding protein 1

A complex signature network that controls the upregulation of PRMT5 in colorectal cancer

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Genes & Diseases 2022年第2期9卷 285-287页

作者： Han Wei Antja-Voy Hartley Aishat Motolani Guanglong jiang Ahmad Safa Lakshmi prabhu Yunlong Liu Tao Lu Department of Pharmacology and Toxicology Indiana University School of Medicine635 Barnhill DriveIndianapolisIN 46202USA Department of Medical&Molecular Genetics Indiana University School of Medicine975 W.Walnut StreetIndianapolisIN 46202USA Department of Biochemistry and Molecular Biology Indiana University School of Medicine635 Barnhill DriveIndianapolisIN 46202USA Current address:Beckman Coulter Life Sciences 5350 Lake-view Pkwy S DrIndianapolisIN 46268USA Current address:Dana-Farber Cancer Institute Harvard Med-ical School450 Brookline Ave.BostonMA 02215USA Current address:Gilead Sciences Inc.333 Lakeside Drive Foster CityCA 94404USA

Protein arginine methyltransferase 5(PRMT5)deregulation has emerged as an important prognostic indicator in human *** aberrant methylation-mediated epige-netic modification of signaling molecules,PRMT5 over-expression contributes to dysregulation of a variety of cellular processes related to cancer progression.1 However,the mechanisms governing PRMT5 expression levels in cancer remain largely *** this study,we examined factors that regulate PRMT5 expression at multiple levels.

关键词： cancer PRMT5 colorectal

Emergence of staphylococcal cassette chromosome mec type Ⅰ with high-level mupirocin resistance among methicillin-resistant Staphylococcus aureus

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Asian Pacific journal of Tropical Biomedicine 2017年第3期7卷 193-197页

作者： prabhu Raj joshi Mahesh Acharya Rajan Aryal Kamal Thapa Trishna Kakshapati Rathanin Seng Anjana Singh Sutthirat Sitthisak Central Department of Microbiology Tribhuvan UniversityKirtipurKathmanduNepal Department of Microbiology Kantipur College of Medical ScienceTribhuvan UniversitySitapailaKathmanduNepal Department of Microbiology Kathmandu College of Science and TechnologyTribhuvan UniversityKalimatiKathmanduNepal Department of Pathology Annapurna Neurological Institute and Allied SciencesMaitigharKathmanduNepal Department of Microbiology and Parasitology Faculty of Medical SciencesNaresuan UniversityPhitsanulokThailand Centre of Excellence in Medical Biotechnology Faculty of Medical ScienceNaresuan UniversityPhitsanulokThailand

Objective: To investigate the molecular epidemiology and antimicrobial resistance patterns of methicillin-resistant Staphylococcus aureus(MRSA) among healthcare workers and ***: MRSA isolates were recovered from nasal swabs collected at a tertiary care hospital of Nepal and confirmed on the basis of Gram staining, conventional biochemical tests, and PCR amplification of mec A gene. PCRs were also used for detection of the different resistance genes and staphylococcal cassette chromosome(SCC) mec *** susceptibility patterns of isolates were assessed by disc diffusion method and minimum inhibitory concentrations were determined by ***: A total of 29 MRSA were isolated from 536 nasal swabs(5.4%) of health care workers and patients at a tertiary care hospital in Nepal. All isolates were susceptible to amikacin, gentamicin, vancomycin(minimal inhibitory concentrations 1 024 mg/m L).Fourteen isolates were found harboring the mup A gene and one isolate was found carrying the novel mup B gene. High prevalence(68%) of SCCmec I type was found, followed by SCCmec V(13%) and SCCmec III(3%) among all the MRSA ***: We found the emergence of SCCmec type I with high-level mupirocin resistance among MRSA in Nepal. Data also suggest that MRSA SCCmec type V strain has spread from the community to the hospital.

关键词： Methicillin-resistant Staphylococcus aureus Staphylococcal cassette chromosome mec types Mupirocin resistance Nasal carriage

Diurnal changes in differential sensitivity and temporal resolution in morning-type and evening-type individuals with normal hearing

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第4期4卷 229-233页

作者： j.Nikhil K.N.Megha Prashanth prabhu Department of Audiology All India Institute of Speech and HearingMysoreKarnatakaIndia

The present study attempts to determine diurnal changes by testing the differential sensitivity and temporal resolution in morning-type,evening-type,and intermediate-type individuals with normal *** participants with normal hearing were divided into morningtype,evening-type,and intermediate-type using“MorningnesseEveningness Questionnaire”.The tests of differential sensitivity and temporal resolution were administered to all the participants in the morning and evening,*** differences in the test results between different timing across all the three groups were *** results of the study showed that there was a significant diurnal effect on psychoacoustic tests as morning-type individuals performed better when tested in morning and evening-type performed better when they were tested in ***,there was no diurnal effect found in intermediate *** lack of inhibitory control and poor cognitive load in off peak time could have lead to poor ***,the variable of diurnal effects should be considered in further studies on psychoacoustic tests,especially in young ***,studies could be performed to explore diurnal effects on objective audiological tests in a larger group of population in the future.

关键词： Differential sensitivity Temporal processing Morningness Eveningness Diurnal changes