检索结果-南通市图书馆

Bevacizumab for the management of diabetic macular edema

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Diabetes 2013年第2期4卷 19-26页

作者： Francisco Rosa Stefanini j fernando arevalo Maurício Maia The Retina Division Ophthalmology Department Federal University of So Paulo The Retina Division Wilmer Eye InstituteJohns Hopkins University School of Medicine The King Khaled Eye Specialist Hospital Brazilian Institute of Fighting Against Blindness Assis/Presidente Prudente

Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age population and is relatedto 1%-5% of cases of blindness worldwide. Diabetic macular edema (DME) is the most frequent cause of DR vision loss and is an important public health problem. Recent studies have implicated vascular endothelial growth factor (VEGF) in DR and DME pathogenesis, as well as provided evidence of the benefits of anti-VEGF agents for the management of such conditions. Despite the benefits of intravitreal ranibizumab injection for the management of DME, the cost-effectiveness of intravitreal bevacizumab therapy has gained increasing interest in the scientific community. This review summarizes the studies examining bevacizumab for the management of DME, focusing on the efficacy and duration of the clinical benefits of decreasing DME and the improvement of best-corrected visual acuity (BCVA). There is strong evidence that intravitreal bevacizumab injection therapy has a good cost-effective profile in the management of DME and may be associated with laser photocoagulation; however, its clinical superiority in terms of the duration of DME regression and the improvement of BCVA compared with intravitreal ranibizumab and other intravitreal anti-VEGF therapies remains unclear and deserves further investigation.

关键词： Diabetic macular edema Bevacizumab Antivascular endothelial growth factor Diabetic retinopathy

Diabetic macular edema:Current management 2013

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Diabetes 2013年第6期4卷 231-233页

作者： j fernando arevalo Retina Division Wilmer Eye InstituteJohns Hopkins University School of MedicineBaltimoreMD 21287United States The Vitreoretinal Division The King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia

Diabetic retinopathy(DR)is the leading cause of vision loss of working-age adults,and diabetic macular edema(DME)is the most frequent cause of vision loss related to diabetes.The Wisconsin Epidemiologic Study of Diabetic Retinopathy found the 14-year incidence of DME in type 1 diabetics to be 26%.Similarly the Diabetes Control and Complications Trial reported that 27% of type 1 diabetic patients develop DME within9 years of onset.The most common type of diabetes,type 2,is strongly associated with obesity and a sedentary lifestyle.An even higher incidence of macular edema has been reported in older patients with type 2diabetes.Within the last 5 years,the use of intravitreal corticosteroids and intravitreal anti-vascular endothelial growth factor(VEGF)agents have come into clinical practice for the management of DME and several recent randomized clinical trials have shown improved effectiveness of ranibizumab compared to focal/grid laser.In this theme issue,we discuss the classification of DR and the treatment options currently available for the treatment of DME including corticosteroids,anti-VEGF agents,combined therapy,enzymatic vitrectomy(vitreolysis),and new therapies.

关键词： Diabetic macular edema Diabetic retinopa-thy Enzymatic vitrectomy(vitreolysis) Focal/grid laser Intravitreal anti-vascular endothelial growth factor Intravitreal corticosteroids New therapies

Perfluorocarbon in vitreoretinal surgery and preoperative bevacizumab in diabetic tractional retinal detachment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Diabetes 2014年第5期5卷 724-729页

作者： j fernando arevalo Martin A Serrano juan D Arias From the Retina Division Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore MD 21287 United States the Vitreoretinal Division King Khaled Eye Specialist Hospital Riyadh 11462 Saudi Arabia Division of Ophthalmology Faculty of Medicine and Health Sciences University of Stellenbosch Stellenbosch 7600 South Africa the Retina and Vitreous Service Clinica Oftalmologica Centro Caracas Caracas 1010 Venezuela

AIM: To describe the en bloc perfluorodissection(EBPD) technique and to demonstrate the applicabilityof using preoperative intravitreal bevacizumab duringsmall-gauge vitreoretinal surgery(23-gauge transconjunctival sutureless vitrectomy) in eyes with advancedproliferative diabetic retinopathy(PDR) with tractionalretinal detachment(TRD).METHODS: This is a prospective, interventional caseseries. Participants included 114(eyes) with advancedproliferative diabetic retinopathy and TRD. EBPD wasperformed in 114 eyes(consecutive patients) during23-gauge vitrectomy with the utilization of preoperativebevacizumab(1.25 mg/-0.05 mL). Patients mean age was 45 years(range, 21-85 years). Surgical time had a mean of 55 min(Range, 25-85 min). Mean follow up of this group of patients was 24 mo(range, 12-32 mo). Main outcome measures included best-corrected visual acuity(BCVA), retinal reattachment, and complications.RESULTS: Anatomic success occurred in 100%(114/-114) of eyes. Significant visual improvement [≥ 2 Early Treatment Diabetic Retinopathy Study(ETDRS) lines] was obtained in 69.2%(79/-114), in 26 eyes(22.8%) BCVA remained stable, and in 8 eyes(7%) BCVA decreased(≥ 2 ETDRS lines). Final BCVA was 20/-50 or better in 24% of eyes, between 20/-60 and 20/-400 in 46% of eyes, and worse than 20/-400 in 30% of eyes. Complications included cataract in 32(28%) eyes, iatrogenic retinal breaks in 9(7.8%) eyes, vitreous hemorrhage requiring another procedure in 7(6.1%) eyes, and phthisis bulbi in 1(0.9%) eye.CONCLUSION: This study demonstrates the usefulne-ss of using preoperative intravitreal bevacizumab and EBPD during smallgauge vitreoretinal surgery in eyes with TRD in PDR.

关键词： Avastin Intravitreal bevacizumab Intravitreal injections Proliferative diabetic retinopathy Tractional retinal detachment Perfluorodissection Minimally invasive vitreoretinal surgery Vitrectomy

Enzymatic vitrectomy for diabetic retinopathy and diabetic macular edema

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Diabetes 2013年第6期4卷 319-323页

作者： Manuel Diaz-Llopis Patricia Udaondo jose Maria Millán j fernando arevalo Department of Ophthalmology University and Polytechnic Hospital La Fe of Valencia46009 ValenciaSpain Department of Genetics Hospital Universitario La Fe of Valencia46009 ValenciaSpain Retina Division Wilmer Eye InstituteJohns Hopkins University School of MedicineBaltimoreMD 21231United States King Khaled Eye Specialist Hospital Riyadh 11462Saudi Arabia

The aim of this paper is to determine the role of enzymatic vitrectomy performed by intravitreal injection of autologous plasmin enzyme(APE)in the management of diabetic retinopathy and diabetic macular edema(DME).Diabetic patients with proliferative diabetic retinopathy or DME and evident posterior hyaloid adherence to the retinal surface were included.All cases were treated with an initial intravitreal injection of APE and reevaluated one month later,measuring changes in best-corrected visual acuity(BCVA),macular thickness and the status of the posterior hyaloid.A second APE injection was performed in cases with no evident posterior vitreous detachment(PVD)after the initial treatment.Sixty-three eyes were included in the present review.A complete PVD appeared in 38%of cases(24 eyes)after one injection of plasmin and the total increased to 51%(32 eyes)after the second injection,separated at least by one month.The central macular thickness improved in all cases(100%)and BCVA in89%.Finally,in 50%of eyes with proliferative diabetic retinopathy,a high reduction of new vessels regression was observed.Enzymatic vitrectomy could be considered a good therapeutic alternative in diabetic retinopathy and macular edema.

关键词： Enzymatic vitrectomy Autologous plasmin Diabetic macular edema Diabetic retinopathy

应用地震振幅和动态描述法战略性开发砂岩层气田的实例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

吐哈油气 2006年第3期11卷 289-293页

作者： j.A.arevalo-VILLAGRAN 左新玉

该文的目的在于阐述完善气田开发方案的方法。静、动态描述相结合有助于优化气田的开发。文中列举了墨西哥一气田目前的主要理念、采用的方法和取得的成果。静态描述集中体现在三维地震解释建立起来的一系列地震振幅图上。动态资料包括... 详细信息

该文的目的在于阐述完善气田开发方案的方法。静、动态描述相结合有助于优化气田的开发。文中列举了墨西哥一气田目前的主要理念、采用的方法和取得的成果。静态描述集中体现在三维地震解释建立起来的一系列地震振幅图上。动态资料包括生产数据和划分单储层、确定储层间水力连通性的初始压力梯度。根据动态数据对地震振幅图进行修改,可完善对储层性质的评价及对供气面积、原始天然气地质储量和探明地质储量的预算。综合应用测井、岩心、生产和压力数据对地震振幅图加以校正,便可设计最佳的油田开发策略。

关键词：气田开发方案地震振幅应用砂岩层描述法振幅和实例三维地震解释

维普期刊数据库

Extraction and Characterization of Starch Fractions of Five Phenotypes <i>Pachyrhizus tuberosus</i>(Lam.) Spreng

在线全文

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2014年第19期5卷 1875-1885页

作者： josé Luis Ramírez Ascheri Luz Haydee Bravo Zamudio Carlos Wanderlei Piler Carvalho Arturo Melendez arevalo Lais Martins Fontoura Rheology Laboratory Embrapa Food Technology Avenida das Américas Rio de Janeiro Brazil Agronomy and Veterinary Medicine Faculty Brazilian University Campus Universitário Darcy Ribeiro Brasilia Brazil Graduate Program in Food Science and Technology Federal Rural University of Rio de Janeiro Seropédica Brazil

Pachyrhizus tuberosus is a native plant of short life cycle found in South America riverside, which provides easy starch extraction from its tuberous roots. The aim of this study was to determine the physicochemical, rheological and functionality of the starch granules extracted from the roots of five phenotypes identified as V2, V3, V4, V6 and V7. Protein and ash content of all phenotypes were considerable high when compared to other root sources such as cassava varying from 4.35% to 7.43% and 1.58% to 2.49%, respectively, whereas lipid content was lower, between 0.29 and 0.49%. The starch granules were mostly circular and polygonal with varied sizes. The starch granules structural conformation showed cristallinity A type, normally for cereals. The maximum pasting viscosity at 95℃ ranged from 1644 cP (V7) to 2232 cP (V2). The initial temperature of pasting formation occurred at 69.4℃ for V2, 71.5℃ for V3, 87.9℃ for V4, 69.5℃ for V6 and 71.5℃ for V7. These values showed high variability within the phenotypes and generally high for roots and tubers starches. The maximum viscosity at 95℃ for V2, V3, V4, V6 and V7 were 2232, 2150, 1995, 2214 and 1644 cP, respectively. The viscosity curves showed low tendency to retrogradation. The thermal properties showed that the enthalpy of gelatinization varied from 8.91 j/g (V3) to 11.78 j/g (V2). The initial gelatinization temperature varied from 63.19℃ (V6) to 65.14℃ (V4). The swelling power at 90℃ ranged from 14.7% to 20.1% p/p and solubility from 10.3% (V2) to 27.2% (V7). It is concluded that Pachyrhizus tuberosus starch showed low retrogradation (1320 - 1560 cP) comparable to non-common native waxy starches, a feature which indicates the capability of using this natural and easy extraction starch source as gelling agent in certain manufactured food of undesirable retrogradation.

关键词： Pachyrhizus tuberosus Physicochemical Rheological Starch Properties

吲哚青绿引导下光栓疗法联合玻璃体腔注射曲安奈德治疗老年性黄斑变性的中心凹下脉络膜新生血管

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 39-40页

作者： arevalo j. F Garcia R. A Mendoza A. j 王永强(译) Clinica Oftalmologica Centro Caracas Av. Panteon San Bernardino Caracas 1010 Venezuela 不详

Background: There is a need for alternative treatments for the management of exudative age-related macular degeneration (AMD). The purpose of this paper is to determine the feasibility, safety, and clinical effect of indocyanine green (ICG)-mediated photothrombosis (IMP) combined with intravitreal triamcinolone acetonide (TA) in patients with subfoveal choroidal neovascularization (CNV) in AMD. Methods: Thirty-one eyes of 26 patients who were treatedwith IMP immediately followed by an intravitreal injection of 4 mg of TA were investigated in the study. The patients had a mean follow-up of 9 months (range 3 months to 26 months). Patients underwent one to four sessions of IMP combined with intravitreal TA. Results: Visual acuity showed stability in 19 eyes (61.3%), improvement of visual acuity (VA) in seven eyes (22.6%), and worsening of VA in five eyes (16.1%). A significant regression of the CNV, and diminishing of subretinal fluid, was demonstrated with fluorescein angiography and optical coherence tomography. We found no complications associated with the intravitreal injection procedure or IMP. Five (16.1%) eyes developed an increase in intraocular pressure related to the presence of TA in the vitreous cavity. However, it was medically controlled with topical antiglaucoma medications. Nineteen of 31 eyes (61.2%) required at least one re-treatment (mean 1.7; range 1-4) during the study period. Conclusions: Combined IMP and intravitreal TA may provide stability or improvement in visual acuity and fundus findings in choroidal neovascularization. Further evaluation in a multicenter, randomized, placebo-controlled clinical trial with longer follow-up is needed to accurately assess the safety and efficacy of this new treatment modality.

关键词：中心凹下脉络膜新生血管渗出性老年性黄斑变性玻璃体腔注射治疗方法曲安奈德吲哚青绿联合疗法引导玻璃体腔内注射

维普期刊数据库

T1加权动态增强MRI鉴别脊柱非肿瘤性和恶性椎体病变

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2021年第1期44卷 106-106页

作者： Y.Guan K.K.Peck j.Lyo j.Tisnado E.Lis j.arevalo-Perez 田园

摘要动态增强（DCE）灌注MRI可帮助区分脊柱的非肿瘤性病变和恶性病变。目的研究血浆容积分数（vp）(DCE灌注MRI的一个参数)与脊柱病变组织病理学诊断的相关性。

关键词：

玻璃体视网膜手术治疗LASIK矫正近视后黄斑裂孔

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(眼科学分册) 2006年第4期 34-34页

作者： arevalo j.F. Rodriguez F.j. Rosales-Meneses j.L. 宋虎平 Dr.Clinica Oftalmologica Centro Caracas Centro Caracas PH-1 Av Panteon San Bernardino Caracas 1010 Venezuela

Aims: To describe the characteristics and surgical outcomes of full thickness macular hole surgery after laser assisted in situ keratomileusis (LASIK) for the correction of myopia. Methods: 13 patients (14 eyes) who developed a macular hole after bilateral LASIK for the correction of myopia participated in the study. Results: Macular hole formed 1-83 months after LASIK (mean 13 months). 11 out of 13 (84.6%) patients were female. Mean age was 45.5 years old (25-65). All eyes were myopic (range-0.50 to-19.75 dioptres (D); mean-8.4 D). Posterior vitreous detachment (PVD) was not present before and was documented after LASIK on 42.8%of eyes. Most macular hole were unilateral, stage 4 macular hole, had no yellow deposits on the retinal pigment epithelium, had no associated epiretinal membrane, were centric, and had subretinal fluid. The mean diameter of the hole was 385.3 μm (range 200-750 μm). A vitrectomy closed the macular hole on all eyes with an improvement on final best corrected visual acuity (VA) on 13 out of 14 (92.8%) patients. Conclusions: This study shows that vitreoretinal surgery can be successful in restoring vision for most myopic eyes with a macular hole after LASIK.

关键词：黄斑裂孔 LASIK 玻璃体视网膜手术近视屈光不正