Clinical trials on corticosteroids for diabetic macular edema

作     者：Hassan A Al Dhibi J Fernando Arevalo 

作者机构：Vitreoretinal DivisionKing Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Retina DivisionWilmer Eye InstituteJohns Hopkins University School of MedicineBaltimoreMD 21231United States 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2013年第4卷第6期

页      面：295-302页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学] 

主　　题：Corticosteroids Diabetic macular edema Intravitreal triamcinolone acetonide injection Intravitreal steroid sustained-release implants Peribulbar steroid injections Subtenon’ s steroid Injections 

摘      要：Diabetic macular edema(DME)is a common cause of visual impairment in diabetic *** is caused by an increase in the permeability of the perifoveal capillaries and a disruption of the blood *** pathogenesis of DME is *** therapeutic modalities have been proposed for the treatment of *** treatments have emerged as an alternative therapy for persistent DME or refractory to conventional laser photocoagulation and other modalities,due to anti-inflammatory,anti-vascular endothelial growth factor and anti-proliferative *** studies have demonstrated the beneficial therapeutic effect of corticosteroids with improvement to both retinal thickness and visual acuity in short-term on the treatment of *** and intravitreal injections have been used to deliver steroids for DME with frequent injections due to the chronic and recurrent nature of the ***-related side effects include elevated intraocular pressure,cataract,and injection related complications such as endophthalmitis,vitreous hemorrhage,and retinal detachment particularly with intravitreal steroid *** order to reduce the risks,complications and frequent dosing of intravitreal steroids,intravitreal implants have been developed recently to provide sustained release of corticosteroids and reduce repeated intravitreal injections for the management of DME.