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Rapid on-site evaluation of endoscopic-ultrasound-guided fine-needle aspiration diagnosis of pancreatic masses

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World journal of Gastroenterology 2014年第28期20卷 9451-9457页

作者： julio Iglesias-Garcia jose Lario-Noia Ihab Abdulkader j enrique domínguez-Muoz Department of Gastroenterology and Hepatology Foundation for Research in Digestive DiseasesUniversity Hospital of Santiago de Compostela Department of Pathology University Hospital of Santiago de Compostela

Endoscopic ultrasound (EUS) has become an essential tool for the study of pancreatic diseases. Specifically, EUS plays a pivotal role evaluating patients with a known or suspected pancreatic mass. In this setting, differential diagnosis remains a clinical challenge. EUS-guided fine-needle aspiration (FNA) and fine-needle biopsy (FNB) have been proven to be safe and useful tools in this setting. EUS-guided FNA and FNB, by obtaining cytological and/or histological samples, are able to diagnose pancreatic lesions with high sensitivity and specificity. In this context, several methodological features, trying to increase the diagnostic yield of EUS-guided FNA and FNB, have been evaluated. In this review, we focus on the role of rapid on-site evaluation (ROSE). From data reported in the literature, ROSE may increase diagnostic yield of EUS-FNA specimens by 10%-30%, and thus, diagnostic accuracy. However, we should point out that many recent studies have reported adequacy rates of > 90% without ROSE, indicating that, perhaps, at high-volume centers, ROSE may not be indispensable to achieve excellent results. The use of ROSE can be considered important during the learning curve of EUS-FNA, and also in hospital with diagnostic accuracy rates < 90%.

关键词： Endoscopic-ultrasound-guided fine-needle aspiration Rapid on-site evaluation Solid pancreatic tumors Diagnostic accuracy

Spatiotemporal variation in the adult sex ratio,male aggregation,and movement of two tropical cloud forest dung beetles

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Current Zoology 2022年第6期68卷 635-644页

作者： julliana BARRETTO Martha L.BAENA Israel Huesca domınguez Federico ESCOBAR Red de Ecoetologıa Instituto de EcologıaXalapaC.P.91073Mexico Instituto de Investigaciones Biologicas Universidad Veracruzana.Av.Luis Castelazo Ayala s/n Col.IndustrialAnimasXalapaC.P.91190Mexico

While theory suggests that at conception the sex ratio should be balanced(1:1),this can be variable across space and time in wild ***,studies of the environmental factors that regulate adult sex ratio(ASR)in species with different life history traits are *** capture–recapture over a year,we analyzed the influence of habitat type(forest and nonforest)and season(rainy and dry)on variation in ASR,male aggregation and the trajectory movement of 2 dung beetle species with different life history traits:Deltochilum mexicanum(a hornless roller species)and Dichotomius satanas(a tunneler species with horns on its head and thorax).We found opposite *** *** population tends to be female-biased,but the population of *** tends to be predominantly male,and observed values were not related to habitat type or ***,the 95%confidence intervals estimated were highly variable between seasons depending on *** examining the monthly variation in ASR for both habitats,we found that it depends on the *** addition,male aggregation differed between species depending on habitat type and season,and species movement patterns were closely related to their habitat *** on our results,we argue that comparative population studies of species with different life history traits are necessary to understand the variation in demographic parameters as well as its ecological and evolutionary implications in the face of spatial and climatic environmental variation.

关键词： habitat preference mark-recapture mean crowding seasonality Scarabaeinae sex proportion

Analysis of the hydrological safety of dams combining two numerical tools:Iber and DualSPHysics

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journal of Hydrodynamics 2018年第1期30卷 87-94页

作者： j.González-Cao O.García-Feal j.M.domínguez A.j.C.Crespo M.Gómez-Gesteira Environmental Physics Laboratory (EPHYSLAB) Universidade de Vigo Campus AsLagoas

The upgrade of the hydrological safety of dams is a critical issue to avoid failures that can dramatically affect people and assets. This paper shows a numerical methodology to analyse the safety of the Belesar dam（NW, Spain） based on two different numerical codes. First, a mesh-based code named Iber, suited to deal with large 2-D domains, is used to simulate the impoundment. The initial conditions and the inlet provided to Iber correspond to the maximum water elevation and the maximum expected inflow to the impoundment defined in the technical specifications of the dam, which are associated to the more hazardous operation conditions of the dam. Iber provides information about the time needed for water to attain the crest of the dam when floodgates are closed. In addition, it also provides the velocity of discharge when gates are opened. Then, a mesh-free code named DualSPHysics, which is especially suited to deal with complex and violent 3-D flows, is used to reproduce the behaviour of one of the spillways of the dam starting from the results obtained with Iber, which are used as inlet conditions for DualSPHysics. The combined results of both model show that the left spillway can discharge the surplus of water associated to the maximum inflow to the reservoir if the gates of the spillways are opened before the overtopping of the dam was observed. In addition, water depth measured on the spillway is considerably lower than the lateral walls, preventing overtopping. Finally, velocities at different points of the spillway showed to be in good agreement with theoretical values.

关键词： Hydrological safety dam numerical simulation Iber DualSPHysics

Nanoscale mapping of optically inaccessible bound-states-in-the-continuum

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Light(Science & Applications) 2022年第2期11卷 188-196页

作者： Zhaogang Dong Zackaria Mahfoud Ramón Paniagua-domínguez Hongtao Wang Antonio I.Fernández-domínguez Sergey Gorelik Son Tung Ha Febiana Tjiptoharsono Arseniy I.Kuznetsov Michel Bosman joel K.W.Yang Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-03 Innovis138634 SingaporeSingapore Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Singapore University of Technology and Design 8 Somapah Road487372 SingaporeSingapore Departamento de Física Teórica de la Materia Condensada and Condensed Matter Physics Center Universidad Autónoma de Madrid28049 MadridSpain Singapore Institute of Food and Biotechnology Innovation A*STAR(Agency for ScienceTechnology and Research)31 Biopolis Way#01-02 Nanos138669 SingaporeSingapore

Bound-states-in-the-continuum(BIC)is an emerging concept in nanophotonics with potential impact in applications,such as hyperspectral imaging,mirror-less lasing,and nonlinear harmonic *** true BIC modes are nonradiative,they cannot be excited by using propagating light to investigate their optical *** this paper,for the 1st time,we map out the strong near-field localization of the true BIC resonance on arrays of silicon nanoantennas,via electron energy loss spectroscopy with a sub-1-nm electron *** systematically breaking the designed antenna symmetry,emissive quasi-BIC resonances become *** gives a unique experimental tool to determine the coherent interaction length,which we show to require at least six neighboring antenna *** importantly,we demonstrate that quasi-BIC resonances are able to enhance localized light emission via the Purcell effect by at least 60 times,as compared to unpatterned *** work is expected to enable practical applications of designed,ultra-compact BIC antennas such as for the controlled,localized excitation of quantum emitters.

关键词： antenna states mapping

Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane

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Food Bioscience 2023年第1期51卷 413-419页

作者： Paola Sanchez-Bravo Angel Abellan Pedro jZapata Cristina García-Viguera Raúl domínguez-Perles María jose Gimenez Lab.Fitoquímica y Alimentos saludables(LabFAS) Centro de Edafología y Biología Apliada del Segura(CEBAS)-CSICUniversity Campus-2530100EspinardoMurciaSpain Department of Food Technology EPSOUniveristy Miguel HernandezCtra Beniel km 3.203312OrihuelaAlicanteSpain

Broccoli is a highly consumed vegetable due to its content of bioactive nutrients and non-nutrients,including glucosinolates and ***,the consumption of craft beer has been boosted by the seek for enhanced sensory and functional *** this frame,broccoli have been proven as an ingredient to develop healthy *** objective of the work was to evaluate alternative broccoli materials(sprouts and byproducts powder)to go further from previous results,in a way contributing to the sustainability and circularity of the agro-food chain using underexploited material to supplement beers,which could be a sustainable dietary source of bioactive sulforaphane(SFN).The results showed high concentrations of SFN in beers supplemented with broccoli sprouts and powder(5.00 and 2.54 mg/L,respectively,previous to bottling).These concentrations remained stable until bottling,where they were reduced by>50%.After 150 storage days,the concentrations of SFN were 1.08 and 0.30 mg/L in beers supplemented with sprouts and powder,*** sensory analysis revealed the positive attributes(colour,floral,fruity,and aftertaste as a result of the profile of volatile compounds)of beers developed using sprouts,and significant values of cooked vegetables,alcoholic,and earthy leather,which could be considered negative in *** latter negative tips are the ones offering sensory traits associated to ITC to broccoli-based ***,the addition of broccoli in the format of fresh sprouts is more appropriate according to the SFN content and sensory features,providing a functional alternative that could be appreciated by consumers.

关键词： Healthy foods Beverages Brassica Isothiocyanates UHPLC-ESI-MS/MS Sensory properties

Hepatic rupture secondary to HELLP syndrome: outcomes in three cases

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World journal of Emergency Medicine 2024年第1期15卷 56-58页

作者： Salvador Gomez-Carro Ruben R.Lozano-Salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer Nina Méndez-domínguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico National Institute of Perinatology.Mexico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver *** identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

SARS-CoV-2 spike RBD-specific IgA and IgG antibodies in breast milk after vaccination with the protein subunit vaccine Abdala

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Infectious Medicine 2022年第4期1卷 253-261页

作者： Maylin Pérez-Bernal Carlos Hernández Rafael Ibargollín Midalis Martínez Migdiala Soria Magali Delgado Onel Valdivia DayamíDorta Andy domínguez enrique Pérez Yeosvany Cabreraa Research&Development Department Center for Genetic Engineering and BiotechnologyCircunvalante NorteOlivos IIISancti SpiritusCuba Neonatology Service General Hospital“Camilo Cienfuegos”128 Bartolome MasoSancti SpiritusCuba Production Department Center for Genetic Engineering and BiotechnologyCircunvalante NorteOlivos IIISancti SpiritusCuba

Background:COVID-19 vaccines that trigger a strong secretory antibody response in breast milk may achieve effective passive protection of vulnerable newborns and breastfed infants of immunized *** aim of this work was to investigate the presence of SARS-CoV-2 spike RBD-specific IgA and IgG antibodies in breast milk,5 and 9 weeks after vaccination with 3 doses of the protein subunit vaccine Abdala,compared to those found in breast milk from COVID-19-recovered women,collected at least 40 days after the ***:SARS-CoV-2 spike RBD-specific IgA and IgG antibodies were semi-quantified by indirect ELISA,using a homemade standard generated by pooling twenty breast milk samples with high absorbance values according to preliminary *** validity of the standard curves was proved following the European Medicines Agency *** breast milk samples from 2 unvaccinated women who had not been infected with COVID-19 were included as negative *** neutralizing antibodies was assessed by a SARS-CoV-2 surrogate virus neutralization ***:High levels of anti-RBD IgA antibodies were detected in breast milk samples 9 weeks after vaccination and anti-RBD IgG antibodies rise from the fifth to the ninth *** the post-COVID-19 time that was evaluated,the IgG-type response was notably higher compared to both post-vaccination *** antibody titers were similar in breast milk from vaccinated and COVID-19 recovered ***:This is the first report about the immune response in breast milk after the administration of a COVID-19 protein subunit vaccine,which could provide analogous protection to that conferred by SARS-CoV-2 *** implies a potential passive immunity that breastfed infants receive from their mothers vaccinated with Abdala.

关键词： Abdala vaccine IgA IgG Neutralizing antibody titers SARS-CoV-2

Graphene quantum dots: From efficient preparation to safe renal excretion

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Nano Research 2021年第3期14卷 674-683页

作者： Caroline Hadad joséMiguel González-domínguez Silvia Armelloni Deborah Mattinzoli Masami Ikehata Akcan Istif Adrian Ostric Francesco Cellesi Carlo Maria Alfieri Piergiorgio Messa Belén Ballesteros Tatiana Da Ros Centre of Excellence for Nanostructured Materials(CENMAT) INSTMDepartment of Chemical and Pharmaceutical SciencesUniversity of TriesteVia L.Giorgieri 134127TriesteItaly Laboratoire LG2A-CNRS UMR 7378 Universitéde Picardie Jules Verne33 rue Saint Leu-UFR des Sciences80039AmiensFrance Instituto de Carboquímica(CSIC) C/Miguel Luesma Castán 4E-50018ZaragozaSpain Renal Research Laboratory-Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico via Pace 920122MilanItaly Dipartimento di Chimica Materiali ed Ingegneria Chimica“G.Natta”Politecnico di MilanoVia Mancinelli 720131MilanItaly Unit of Nephrology Dialysis and Renal Transplant Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinicovia della commenda 420122MilanItaly Department of Clinical Sciences and Community Health University of Milan20122MilanItaly Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and the Barcelona Institute of Science and TechnologyCampus UABBellaterra08193BarcelonaSpain

Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots(GQDs)have gained considerable interest thanks to their aqueous solubility and intrinsic fluorescence,which enable their possible use in theranostic approaches,if their biocompatibility and favorable pharmacokinetic are *** prepared ultra-small GQDs using an alternative,reproducible,top-down synthesis starting from graphene oxide with a nearly 100%*** materials were tested to assess their safety,demonstrating good biocompatibility and ability in passing the ultrafiltration barrier using an in vitro *** leads to renal excretion without affecting the ***,we studied the GQDs in vivo biodistribution confirming their efficient renal clearance,and we demonstrated that the internalization mechanism into podocytes is ***,considering the reported characteristics,it appears possible to vehiculate compounds to kidneys by means of GQDs,overcoming problems related to lysosomal degradation.

关键词： graphene quantum dots podocytes biodistribution uptake pathway renal clearance nanocarrier

Macroscopic Quantum Behaviour of Periodic Quantum Systems

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journal of Modern Physics 2014年第1期5卷 44-50页

作者： A. Martín-Ruiz j. Bernal Adrián Carbajal-domínguez Instituto de Ciencias Nucleares Universidad Nacional Autónoma de México México D.F. Mexico Universidad juárez Autónoma de Tabasco División Académica de Ciencias Básicas Cunduacán México

In this paper we introduce a simple procedure for computing the macroscopic quantum behaviour of periodic quantum systems in the high energy regime. The macroscopic quantum coherence is ascribed to a one-particle state, not to a condensate of a many-particle system;and we are referring to a system of high energy but with few degrees of freedom. We show that, in the first order of approximation, the quantum probability distributions converge to its classical counterparts in a clear fashion, and that the interference effects are strongly suppressed. The harmonic oscillator provides a testing ground for these ideas and yields excellent results.

关键词： Matrix Density Quantum Interference Classical Limits