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Stroke recovery enhancing therapies:lessons from recent clinical trials

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Neural Regeneration Research 2022年第4期17卷 717-720页

作者： Andreas Rogalewski Wolf-Rüdiger schäbitz Department of Neurology Bethel-EVKBUniversity of BielefeldBielefeldGermany

Poststroke recovery processes include restoration or compensation of function,respectively functions initially lost or new functions acquired after an *** interventions can enhance these processes and/or reduce processes impeding *** experimental studies suggest great opportunities for such treatments,but the results from recent large clinical trials using neuromodulators such as dopamine and fluoxetine are *** reasons for this are manifold affecting forward translation of results from animals models into the human ***"translational road block"is defined by differences between animals and humans with regard to the genetic and epigenetic background,size and anatomy of the brain,cerebral vascular anatomy,immune system,as well as clinical function and *** blockade includes the incompatible adaption of targets and outcomes in clinical trials with regard to prior preclinical *** example,the design of clinical recovery trials varies widely and was characterized by the selection of different clinical endpoints,the inclusion a broad spectrum of stroke subtypes and clinical syndromes as well as different time windows for treatment initiation after infarct *** review will discuss these aspects based on the results of the recent stroke recovery trials with the goal to contribute to the currently biggest unmet need in stroke research-the development of a recovery enhancing therapy that improves the functional outcome of a chronic stroke patient.

关键词： amphetamine brain chronic stroke clinical trial dopamine fluoxetine recovery regeneration serotonin reuptake inhibitor translation

Effect of Sacrificial Anode Protection for Steel Pipe Piles at Dandong Port

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China Ocean Engineering 1998年第1期13卷 113-120页

作者： Zhu, XC Ge, Y Ge, rg Nanjing Hydraul Res Inst Dept Mat & Struct Nanjing 210024 Peoples R China

The sacrificial anode protection system for the steel pipe piles of the 3rd berth of Dandong; wharf at Dandong port has operated for eight years. In this paper, the program design and the protection effect of the sacrificial anode protection system are presented. The results of various inspections show that the piles are protected very satisfactorily.

关键词： steel pipe pile corrosion sacrificial anode cathodic protection protection potential protection percentage

Counting and measuring particles sized from soot to pollen

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China Particuology 2007年第5期5卷 359-361页

作者： Martin schmidt Sven schütz Leander Mlter Palas GmbH Greschbachstr. 3b76229 KarlsruheGermany

For number concentration measurements of superfine particles a condensation nucleus counter （CNC） is frequently used. The combination of a new CNC module with a white light aerosol spectrometer and a passive collector makes possible accurate time-resolved determination of particle number within the overall size range of 10 nm to 40 μm and at concentrations up to 10^5 particles/cm^3. With the aerosol spectrometer a high time-resolved particle size determination is also possible in the size range of 0.3-40 μm up to the same high number concentrations of 10^5 particles/cm^3.

关键词： CNC Particles Size

Tree sapling vitality and recovery following the unprecedented 2018 drought in central Europe

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Forest Ecosystems 2023年第5期10卷 597-606页

作者： Mirela Beloiu schwenke Valeska schönlau Carl Beierkuhnlein Institute of Terrestrial Ecosystems ETH ZurichZurichSwitzerland Department of Biogeography University of BayreuthUniversitätsstraße 3095447BayreuthGermany GIB Geographical Institute Bayreuth University of Bayreuth95447BayreuthGermany BayCEER Bayreuth Center of Ecology and Environmental Research University of Bayreuth95448BayreuthGermany

Background:Ongoing climate change is anticipated to increase the frequency and intensity of drought events,thereby affecting forest recovery dynamics and elevating tree *** drought of 2018,with its exceptional intensity and duration,had a significant adverse impact on tree species throughout Central ***,our understanding of the resistance to and recovery of young trees from drought stress remains ***,we examined the recovery patterns of native deciduous tree sapling species following the 2018 drought,and explored the impact of soil depth,understory vegetation,and litter cover on this ***:A total of 1,149 saplings of seven deciduous tree species were monitored in the understory of old-growth forests in Northern Bavaria,Central *** vitality of the saplings was recorded from 2018 to 2021 on 170 ***:Fagus sylvatica was the most drought-resistant species,followed by Betula pendula,Acer pseudoplatanus,Quercus spp.,Corylus avellana,Carpinus betulus,and Sorbus *** the drought conditions persisted one year later,all species recovered significantly from the 2018 drought,albeit with a slight decrease in vitality by *** 2018,the drought exhibited a more pronounced adverse effect on saplings in deciduous forests compared to mixed and coniferous ***,sapling recovery in coniferous and mixed forests exceeded that observed in deciduous forests in *** pivotal factors influencing sapling resilience to drought were forest types,soil depth,and understory vegetation,whereas litter and forest canopy cover had a negative ***:Long-term responses of tree species to drought can be best discerned through continuous health *** findings demonstrate the natural regeneration potential of deciduous species in the context of climate *** tree species planting,soil management practices,and promoting understory diversity should be considered when implementing adapt

关键词： Drought stress Temperate forest Deciduous trees Climate change Extreme events Soil depth

Highly efficient passive Tesla valves for microfluidic applications

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Microsystems & Nanoengineering 2022年第5期8卷 125-136页

作者： Sebastian Bohm Hai Binh Phi Ayaka Moriyama Erich Runge Steffen Strehle jörg König Christian Cierpka Lars Dittrich Theoretical Physics I Technische Universität IlmenauWeimarer Straße 2598693 IlmenauGermany Research and Development 5microns GmbHMargarethenstraße 698693 IlmenauGermany Institute of Micro-and Nanotechnologies Gustav-Kirchhoff-Straße 798693 IlmenauGermany Microsystems Engineering Technische Universität IlmenauMax-Planck-Ring 1298693 IlmenauGermany Physics and Astronomy Carleton CollegeOne North CollegeNorthfield 55057 MinnesotaUSA Engineering Thermodynamics Technische Universität IlmenauAm Helmholtzring 198693 IlmenauGermany

A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates,characteristic,e.g.,for almost all microfluidic systems,where passive valves have intrinsic advantages over active *** report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20μl s^(−1) corresponding to a Reynolds number of *** of the design is a topological optimization based on the finite element *** is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic *** numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel *** on the threedimensionally extruded optimized designs,various test structures were fabricated using standard,widely available microsystem manufacturing *** manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic *** the experimentally fabricated chips,the efficiency of the different valve designs,i.e.,the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions,respectively,is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla *** agreement is *** addition to the direct measurement of the diodicities,the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry(μPIV)***,a reasonable good agreement of the measured flow profiles with simulated predictions is observed.

关键词： backward Highly optimization

Proteome-Based Clustering Approaches Reveal Phylogenetic Insights into Amphistegina

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journal of Earth Science 2022年第6期33卷 1469-1479页

作者： Marleen Stuhr Bernhard Blank-Landeshammer Achim Meyer Vera Baumeister jörg Rahnenführer Albert Sickmann Hildegard Westphal Leibniz Centre for Tropical Marine Research(ZMT) BremenGermany Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. DortmundGermany Austrian Competence Center for Feed and Food Quality Safety and InnovationWelsAustria Chrestos Concept GmbH&Co KG EssenGermany Department of Statistics TU Dortmund UniversityDortmundGermany Medizinisches Proteom-Center(MPC) Ruhr-Universität BochumBochumGermany Department of Chemistry University of AberdeenOld AberdeenScotlandUK Department of Geosciences Bremen UniversityBremenGermany King Abdullah University of Science and Technology(KAUST) ThuwalSaudi Arabia

Foraminifera are highly diverse and have a long evolutionary *** key bioindicators,their phylogenetic schemes are of great importance for paleogeographic applications,but may be hard to recognize *** phylogenetic relationships within the prominent genus Amphistegina are still *** studies on Amphistegina have so far only focused on genetic diversity within single species and suggested a cryptic diversity that demands for further *** molecular sequencing-based approaches,different mass spectrometry-based proteomics approaches are increasingly used to give insights into the relationship between samples and organisms,especially as these do not require reference *** better understand the relationship of amphisteginids and test different proteomics-based approaches we applied de novo peptide sequencing and similarity clustering to several populations of Amphistegina lobifera,*** and *** also analyzed the dominant photosymbiont community to study their influence on holobiont *** analyses indicate that especially de novo peptide sequencing allows to reconstruct the relationship among foraminiferal holobionts,although the detected separation of *** from *** and *** may be partly influenced by their different photosymbiont *** resulting dendrograms reflect the separation in two lineages previously suggested and provide a basis for future studies.

关键词： large benthic foraminifera de novo peptide sequencing tandem mass spectra clustering LC-MS/MS runs proteomics symbiont diversity phylogeography Fragilariales

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Enhanced π-π Interactions Between a C_(60) Fullerene and a Buckle Bend on a Double-Walled Carbon Nanotube

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Nano Research 2010年第2期3卷 92-97页

作者： Sandeep Gorantla Stanislav Avdoshenko Felix Börrnert Alicja Bachmatiuk Maria Dimitrakopoulou Franziska schäffel Ronny schönfelder jürgen Thomas Thomas Gemming jamie HWarner Gianaurelio Cuniberti jürgen Eckert Bernd Büchner Mark H.Rümmeli IFW Dresden P.O.Box 270116D-01171 DresdenGermany Institute for Materials Science and Max Bergmann Center of Biomaterials Dresden University of TechnologyDresden 01062Germany Department of Materials University of OxfordParks Rd.Oxford OX13PHUnited Kingdom

In situ low-voltage aberration corrected transmission electron microscopy(TEM)observations of the dynamic entrapment of a C_(60) molecule in the saddle of a bent double-walled carbon nanotube is *** fullerene interaction is non-covalent,suggesting that enhancedπ-πinteractions(van der Waals forces)are *** molecular dynamics calculations confirm that the increased interaction area associated with a buckle is sufficient to trap a ***,they show hopping behavior in agreement with our experimental *** findings further our understanding of carbon nanostructure interactions,which are important in the rapidly developing field of low-voltage aberration corrected TEM and nano-carbon device fabrication.

关键词： Carbon nanotubes fullerenes low-voltage transmission electron microscopy molecule trap

Temperature-dependent phonon spectra of magnetic random solid solutions

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npj Computational Materials 2018年第1期4卷 606-612页

作者： Yuji Ikeda Fritz Körmann Biswanath Dutta Abel Carreras Atsuto Seko jörg Neugebauer Isao Tanaka Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Center for Elements Strategy Initiative for Structural Materials(ESISM) Kyoto UniversityKyoto 606-8501Japan Max-Planck-Institut für Eisenforschung GmbH D-40237 DüsseldorfGermany Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628 CD DelftNetherlands Precursory Research for Embryonic Science and Technology(PRESTO) Japan Science and Technology Agency(JST)Kawaguchi 332-0012Japan Center for Materials Research by Information Integration National Institute for Materials Science(NIMS)Tsukuba 305-0047Japan Nanostructures Research Laboratory Japan Fine Ceramics CenterNagoya 456-8587Japan

A first-principles-based computational tool for simulating phonons of magnetic random solid solutions including thermal magnetic fluctuations is *** method takes fluctuations of force constants due to magnetic excitations as well as due to chemical disorder into *** developed approach correctly predicts the experimentally observed unusual phonon hardening of a transverse acoustic mode in Fe–Pd an Fe–Pt Invar alloys with increasing *** peculiar behavior,which cannot be explained within a conventional harmonic picture,turns out to be a consequence of thermal magnetic *** proposed methodology can be straightforwardly applied to a wide range of materials to reveal new insights into physical behaviors and to design materials through computation,which were not accessible so far.

关键词： magnetic random phonon

Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing