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Doxycycline induces bone repair and changes in Wnt signalling

International journal of Oral Science 2017年第3期9卷 158-166页

作者： kátia do nascimento gomes ana paula negreiros nunes alves paula góes pinheiro dutra glauce socorro de barros viana faculty of dentistry pharmacy and nursingfederal university of cearáFortalezaBrazil faculty of medicine federal university of cearáFortaleza Brazil

Doxycycline （DOX） exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls （CTL） and DOX-treated （10 and 25 mg. kg- 1） molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays. Hematoxylin-eosin staining （7th day） revealed inflammation in the CTL group that was partly reversed after DOX treatment. On the 14th day, the CTL group exhibited bone neoformation, conjunctive tissue, re-epithelization and the absence of inflammatory infiltrate. DOX-treated groups exhibited complete re-epithelization, tissue remodelling and almost no inflammation. Picrosirius red staining in the DOXlO group （7th and 14th days） revealed an increased percentage of type I and III collagen fibres compared with the CTL and DOX25 groups. The DOXlO and DOX25 groups exhibited increases in osteoblasts on the 7th and 14th days. However, there were fewer osteoclasts in the DOXlO and DOX25 groups on the 7th and 14th days. Wnt-lOb- immunopositive cells increased by 130% and 150% on the 7th and 14th days, respectively, in DOX-treated groups compared with the CTL group. On the 7th day, Dickkopf （Dkk）-I immunostaining was decreased by 63% and 46% in the DOXlO and DOX25 groups, respectively. On the 14th day, 69% and 42% decreases in immunopositive cells were observed in the DOXlO and DOX25 groups, respectively, compared with the CTL group. By increasing osteoblasts, decreasing osteoclasts, activating Wnt lOb and neutralising Dkk, DOX is a potential candidate for bone repair in periodontal diseases.

关键词： alveolar bone loss bone diseases bone repair doxycycline Dickkopf-1 immunohistochemistry Wnt-lOb

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Metastasis of Mammary Carcinoma in Bitches: Evaluation of the Sentinel Lymph Node Technique

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Advances in Breast Cancer Research 2016年第2期5卷 58-65页

作者： Hugo Enrique Orsini Beserra Fabrizio Grandi Rozany Mucha Dufloth Luiz Gonzaga Porto pinheiro Hélio Amante Miot Stephane Cássia Oliveira Rosa Vexenat Noeme Sousa Rocha Department of Veterinary Clinics Service of Veterinary Pathology School of Veterinary Medicine and Animal Science Universidade Estadual Paulista (UNESP) Botucatu Brazil Department of Pathology Botucatu Medical School Universidade Estadual Paulista (UNESP) Botucatu Brazil Department of Surgery Medical School Universidade Federal do Ceará (UFC) Fortaleza Brazil Department Dermatology Botucatu Medical School Universidade Estadual Paulista (UNESP) Botucatu Brazil

In recent years the development of extremely accurate techniques for the removal of lymph nodes has been seen, such as the Sentinel Lymph Node Biopsy (SLNB) technique. The technique is based on the staggered progression occurring in the lymphatic drainage of neoplasias, and is currently the main prognostic and diagnostic factor in women suffering from mammary carcinoma. This research aims at assessing the sentinel lymph node biopsy accuracy in female dogs suffering from mammary carcinoma. Forty-one dogs with cytological diagnosis of the tumor were used in the research. After injecting a Patent Blue V dye, mastectomy was conducted jointly with lymphadenectomy (for both sentinel and non-sentinel lymph nodes). The material was then serially sectioned and microscopically evaluated by routine H&E stain and immunohistochemical study with the markers for pancytokeratin AE1/AE3 and myoepithelial cells CK14. The study revealed that 46.3% (19/41) of the animals presented nodal metastasis. The sensitivity and specificity values found for SLNB were respectively 89.5% and 100%, with a kappa coefficient of 0.90 and p < 0.0001. Therefore, the SLNB technique offers high sensitivity in the early detection of metastases, allowing higher precision in the staging of oncological patients and, therefore, offering higher chances of survival.

关键词： Metastasis Sentinel Lymph Node Mammary Neoplasia Patent Blue Female Dog

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Compression strategies for digital holograms in biomedical and multimedia applications

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Light(Advanced Manufacturing) 2022年第3期3卷 234-254页

作者： Peter Schelkens Ayyoub Ahar Antonin Gilles Raees Kizhakkumkara Muhamad Thomas j.Naughton Cristian Perra Antonio pinheiro Piotr Stepien Malgorzata Kujawinska Vrije Universiteit Brussel ETRO Dept.B-1050 BrusselsBelgium imec Digital and User-Centric Solutions(DUCS)B-3001 LeuvenBelgium Institute of Research&Technology b<>com RennesFranc Maynooth University Dept.of Computer ScienceMaynoothCo.KildareIreland University of Cagliari DIEEUdR CNITCagliariItaly Universidade da Beira Interior CovilhaPortugal Instituto de Telecomunicacoes CovilhaPortugal Warsaw University of Technology Institute of Micromechanics and Photonics02-525 WarsawPoland

While 60 years of successful application of holography is celebrated in this special issue,efficient representation and compression of holographic data has received relatively little attention in *** this observation,and particularly due to the digitization that is also penetrating the holographic domain,interest is growing on how to efficiently compress holographic data such that interactive exchange of content,as well as digital storage can be facilitated *** is a particular challenge,not only because of its interferometric nature and the various representation formats,but also the often extremely large data volumes involved in pathological,tomographic,or high-end visualization *** this paper,we provide an overview of the state of the art in compression techniques and corresponding quality metrics for various practical applications in digital *** also consider the future by analyzing the emerging trends for addressing the key challenges in this domain.

关键词： Holography Compression Image quality assessment Standardization

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An application programming interface with increased performance for optimisation problems data

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journal of Management Analytics 2016年第4期3卷 305-332页

作者： Rodrigo Lankaites pinheiro Dario Landa-Silva Rong Qu Ademir Aparecido Constantino Edson Yanaga ASAP Research Group School of Computer ScienceUniversity of NottinghamNottinghamUK Departamento de Informática Universidade Estadual de MaringáMaringáBrazil Unicesumar-Centro Universitário Cesumar MaringáBrazil

An optimisation problem can have many forms and *** may consider different objectives,constraints,and *** that reason,providing a general application programming interface(API)to handle the problem data efficiently in all scenarios is ***,on an R&D environment involving personnel from distinct backgrounds,having such an API can help with the development process because the team can focus on the research instead of implementations of data parsing,objective function calculation,and data ***,some researchers might have a stronger background in programming than others,hence having a standard efficient API to handle the problem data improves reliability and *** paper presents a design methodology to enable the development of efficient APIs to handle optimisation problems data based on a data-centric development *** proposed methodology involves the design of a data parser to handle the problem definition and data files and on a set of efficient data structures to hold the data in ***,we bring three design patterns aimed to improve the performance of the API and techniques to improve the memory access by the user ***,we present the concepts of a Solution Builder that can manage solutions objects in memory better than built-in garbage collectors and provide an integrated objective function so that researchers can easily compare solutions from different solving ***,we describe the positive results of employing a tailored API to a project involving the development of optimisation solutions for workforce scheduling and routing problems.

关键词： optimisation problems data API efficient data structures research and development projects

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From portal to splanchnic venous thrombosis:What surgeons should bear in mind

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World journal of Hepatology 2014年第8期6卷 549-558页

作者： Quirino Lai Gabriele Spoletini Rafael S pinheiro Fabio Melandro Nicola Guglielmo jan Lerut Starzl Unit of Abdominal Transplantation University Hospitals Saint-LucUniversitéCatholique Lou-vainB-1200 BrusselsBelgium Oxford Transplant Centre Churchill HospitalOxford University Hospitals NHS TrustOxford OX3 7LEUnited Kingdom Department of Gastroenterology University of Sao Paulo Medical School05508-070 Sao PauloBrazil Department of General Surgery and Organ Transplantation University SapienzaUmberto I Hospital00186 RomeItaly

The present study aims to review the evolution of surgical management of portal(PVT) and splanch-nic venous thrombosis(SVT) in the context of liver transplantation over the last 5 decades. PVT is more commonly managed by endovenous thrombectomy, while SVT requires more complex technical expedients. Several surgical techniques have been proposed, such as extensive eversion thrombectomy, anastomosis to collateral veins, reno-portal anastomosis, cavo-portal hemi-transposition, portal arterialization and combined liver-intestinal transplantation. In order to achieve satisfactory outcomes, careful planning of the surgical strategy is mandatory. The excellent results that are ob-tained nowadays confirm that, even extended, splanch-nic thrombosis is no longer an absolute contraindication for liver transplantation. Patients with advanced portal thrombosis may preferentially be referred to specialized centres, in which complex vascular approaches and even multivisceral transplantation are performed.

关键词： Liver transplantation Portal vein thrombosis Splanchnic vein thrombosis Thrombectomy Vascular graft Spleno-renal shunt Cavo-portal hemi-transposition Portal vein arterialization Intestinal transplantation Multi-visceral transplant

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Plectranthus amboinicus(Lour.)*** oil as a natural alternative for the conservation of beef patties stored under refrigeration

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Food Bioscience 2022年第5期49卷 397-405页

作者： Bruno Dutra da Silva Patricia Campos Bernardes Patrícia Fontes pinheiro juliana Di Giorgio Giannotti Consuelo Domenici Roberto Department of Food Engineering Center for Agrarian Sciences and EngineeringUniversidade Federal do Espírito SantoAlegreEspírito SantoBrazil Department of Chemistry and Physics Center for ExactNatural and Health SciencesUniversidade Federal do Espírito SantoAlegreEspírito SantoBrazil Department of Rural Engineering Center for ExactNatural and Health SciencesUniversidade Federal do Espírito SantoAlegreEspírito SantoBrazil

Plectranthus amboinicus essential oil(PAEO)has the potential to be used by the food industry as a natural antimicrobial *** study aimed to evaluate the antibacterial activity of PAEO in vitro against pathogenic bacteria contaminating food and its potential for action when added to intentionally contaminated beef *** composition was determined by GC-MS and GC-FID,and thymol(45.64%)was the main compound present in the *** minimum inhibitory(MIC)and minimum bactericidal(MBC)concentration of the PAEO was evaluated against five pathogenic bacteria(Staphylococcus aureus,Listeria monocytogenes,Escherichia coli,Pseudomonas aeruginosa and Salmonella Typhimurium).The MIC of PAEO was the concentration ranges between 0.25 and 2 mg mL^(-1),and the MBC ranged from 1 to 4 mg mL^(-1).The anti-adhesion and removal of adhered cell assays indicated significant reductions(P<0.05)even at concentrations 8x lower than the MIC of *** patties samples were prepared with PAEO concentrations at MIC(2 mg mL^(-1))and sub-MIC(1 mg mL^(-1)).*** and *** were inoculated individually into the beef *** reductions were observed with a greater reduction in the 12th day of storage for ***(1.52 log CFU.g^(-1))and ***(0.93 log CFU.g^(-1))for beef patties with the MIC of *** has the potential to be applied in meat ***,the application and interactions of the oil in the food matrix need to be better elucidated.

关键词： Thymol Natural antimicrobial Anti-adhesion activity Minimum inhibitory concentration Antimicrobial activity

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Discussion of“Site observations of weathered granitic soils subjected to cementation and partial drainage using SCPTU”[j Rock Mech Geotech Eng 15(2023)984-996]

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journal of Rock Mechanics and Geotechnical Engineering 2024年第10期16卷 4330-4333页

作者： Fernando Artur Brasil Danziger Graziella Maria Faquim jannuzzi Harley Alves da Mata Bacelar Arthur Veiga Silverio pinheiro Federal University of Rio de janeiro Rio de JaneiroBrazil

Comprehensive data from in situ and laboratory tests in residual soil have been presented by Zhang et al.(2023).A number of issues addressed in the paper have been the interest of the discussers,namely the characterisation and behaviour of residual soils,limitation of piezocone testing due to the capacity of the entire system,measurement of shear wave velocity,rate effect of piezocone(CPTU)testing and piezocone testing with dual pore pressure *** and complementation of these issues are required with regard to both the execution and interpretation of the tests.

关键词： Residual soil Seismic piezocone test Laboratory test Soil classification Pore pressure measurement Rate effect

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Biodiverse,Productive,and Socially just Silvopastures:a Solution for the Brazilian Drylands

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journal of Botanical Research 2020年第3期2卷 29-40页

作者： Felipe Machado pinheiro Patrick Hunt University of Florida(UF)School of Natural Resources and Environment and Tropical Conservation&Development Program PhD candidate Intedisciplinary EcologyGainesvilleFL32611US UF Latin American Stuides Tropical Conservation&Development ProgramMA studentGainesvilleFL32611US

Drylands constitute more than 40%of global land and are particularly vulnerable to the impacts of climate *** many of these drylands,livestock activities are a major form of *** Brazil,the two major dryland biomes,Cerrado and Caatinga,play a key role in the country’s livestock *** important economically,these activities also contribute to the emission of high amounts of greenhouse *** suggested strategy for mitigating the impacts of climate change is the adoption of silvopastoral systems(SPS)which combine trees,pasture,and animals simultaneously on the same unit of *** in the drylands of Brazil have a long history of practicing *** practice of silvopasture is relevant to both climate change and the economy,but not necessarily to the issues of biodiversity loss and economic *** lack of interdisciplinarity in rural agricultural development projects in the past,such as those related to the“Green Revolution”,resulted in the aggravation of economic inequalities and biodiversity *** present work,focusing on the Brazilian Drylands,reviews these issues to justify the need for interdisciplinary projects considering multiple variables like soil quality,tree density,biodiversity richness,and farmers’perception.

关键词： Agroecology Livestock Agroforestry Climate Change Mitigation Adaptation Dessertification Arid regions

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Immunohistochemical study of the digestive tract of Oligosarcus hepsetus

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World journal of Gastroenterology 2013年第12期19卷 1919-1929页

作者： Danielle A Vieira-Lopes Nadja L pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema D Gomes Aparecida A Nascimento Departamento de Biologia Animal Instituto de Biologia Universidade Federal Rural do Rio de Janeiro

AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHODS: The digestive tract (DT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was ***: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the ***: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish.

关键词： Fish Esophagus Stomach Intestine Endocrine cells

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Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

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World journal of Gastroenterology 2014年第33期20卷 11780-11787页

作者： Venncio AF Alves Céline pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar Laboratory of Medical Investigation (LIM) 14 Department of Pathology University of S?o Paulo School of Medicine S?oPaulo SP 1246-903 Brazil Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho 4704-553 Braga Portugal ICVS/3B’s-PT Government Associate Laboratory 4710-057 Braga/ Guimar?es Portugal Barretos School of Health Sciences Dr. Paulo Prata-FACISB Barretos S?o Paulo SP 13083-970 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Barretos Sao Paulo 14780-000 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Pio XII Foundation Barretos 14780-000 Brazil

AIM: To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Monocarboxylate transporters Glycolysis Cirrhosis Glucose transporter-1

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