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Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates:a randomized clinical trial

World journal of Pediatrics 2022年第6期18卷 398-403页

作者： Silvia Maya-Enero Montserrat Fàbregas-Mitjans Rosa Maria Llufriu-Marquès júlia candel-pau jordi Garcia-Garcia MaríaÁngeles López-Vílchez Department of Neonatology Service of PediatricsHospital del MarParc de Salut MarUniversitat Pompeu FabraPasseig Marítim 25-2908003BarcelonaSpain

Background Neonatal pain may affect long-term neurodevelopment and must be *** is a painful procedure wherein a common strategy to relieve pain(sucking)cannot be used because the technique is performed on the *** essential oil(LEO)has sedative and antispasmodic properties and has been successfully used to treat pain during heel puncture and *** aim was to demonstrate if the use of inhaled LEO is effective in reducing pain during frenotomy in healthy,full-term *** We conducted a randomized clinical trial in neonates who underwent a frenotomy between August 2020 and April *** assessed pain using pre and post-procedure heart rate and oxygen saturation,crying time and Neonatal Infant Pain Scale(NIPS)*** with type 3 tongue tie were randomized into the“experimental group”and“control group”.In both groups,we performed swaddling,administered oral sucrose,and let the newborn suck for two *** the experimental group,we also placed a gauze pad with one drop of LEO under the neonate’s nose for two minutes prior to and during the *** We enrolled 142 patients(71 per group).The experimental group showed significantly lower NIPS scores(1.88 vs 2.92)and cried almost half the amount of time(14.8 vs.24.6 seconds,P=0.006).Comparing with the control group,we observed no side effects in either of the *** We observed a significant decrease in crying time and lower NIPS scores in the neonates who received inhaled LEO and underwent a frenotomy for type 3 ***,we recommend using inhaled LEO during neonatal frenotomies.

关键词： Ankyloglossia Aromatherapy Frenotomy Lavender Neonate Neonatal pain Tongue-tie

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Hankel operators on exponential Bergman spaces

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Science China Mathematics 2022年第2期65卷 421-442页

作者： Zhangjian Hu jordi pau Department of Mathematics Huzhou UniversityHuzhou 313000China Departament de Matematiques i Informatica Universitat de BarcelonaBarcelona 08007Spain

We completely describe the boundedness and compactness of Hankel operators with general symbols acting on Bergman spaces with exponential type weights.

关键词： weighted Bergman space Hankel operator ?-equation

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When Edge Computing Meets IoT Systems: Analysis of Case Studies

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China Communications 2020年第10期17卷 50-63页

作者： Fabio Arena Giovanni pau Faculty of Engineering and Architecture Kore University of EnnaCittadella UniversitariaEnna 94100Italy

On a macroscopic level,an edge computing architecture looks like a distributed and decentralized IT(Information Technology)*** in detail,it could be defined as a mesh network of micro data centers capable of processing and storing critical data locally,and to transmit all data received and/or processed to a central data center or a cloud storage *** network topology,also taking advantage of the availability on the market of cost-effective small form factor(SFF)electronic components and systems decreasing,brings the essential components of processing,storage,and networking closer to the sources that generate the *** typical use case is that of Internet of Things(IoT)devices and implementations,which often face latency problems,lack of bandwidth,reliability,which cannot be addressed through the conventional cloud *** this context,the edge computing architecture can reduce the size of data to be sent to the cloud,processing critical data,sensitive to latency,at the point of origin,via a smart device,or sending it to an intermediate server,located *** aim of this paper is to report some of the main aspects and significant features of edge computing and analyzing several popular case studies.

关键词： edge computing fog computing cloud computing analysis internet of things

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Laplace plane and low inclination geosynchronous radar mission design

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Science China(Information Sciences) 2017年第6期60卷 62-71页

作者： Stephen HOBBS joan pau SANCHEZ School of Aerospace Transport and Manufacturing Cranfield University

This study is inspired by the Laplace orbit plane property of requiring minimal station-keeping and therefore its potential use for long-term geosynchronous synthetic aperture radar(GEOSAR) imaging. A set of GEOSAR user requirements is presented and analysed to identify significant mission requirements. Imaging geometry and power demand are assessed as a function of relative satellite speed(which is determined largely by choice of orbit inclination). Estimates of the cost of station-keeping as a function of orbit inclination and right ascension are presented to compare the benefits of different orbit choices. The conclusion is that the Laplace plane(and more generally, orbits with inclinations up to 15°) are attractive choices for GEOSAR.

关键词： Laplace plane station-keeping geosynchronous inclination GEOSAR

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Circularly and elliptically polarized light under water and the Umov effect

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Light(Science & Applications) 2019年第1期8卷 901-906页

作者： Yitian Ding Stanley pau College of Optical Sciences University of ArizonaTucsonAZ 85721USA

Total internal reflection occurs when light is incident on the interface of high-and low-refractive-index materials at an angle greater than the critical *** with high degree of linear polarization,such as atmospheric scattered skylight,can be converted with a high efficiency up to 53%to circular and elliptical polarizations by total internal reflection under water in the region outside Snell’s *** degree of circular polarization is observed to be inversely dependent on the albedo of underwater objects and is shown to be a direct consequence of the Umov *** results are important for underwater polarimetry,surveillance applications and studies of marine animals’polarized vision near the water-air interface.

关键词： effect. polarized underwater

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species

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journal of Plant Ecology 2018年第1期11卷 26-38页

作者： Cristina Antunes Ana júlia Pereira Patrícia Fernandes Margarida Ramos lia Ascensão Otília Correia Cristina Máguas Centre for Ecology Evolution and Environmental ChangesFaculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisboaPortugal PPG-Ecologia Instituto de BiologiaCP 6109Universidade Estadual de Campinas-UNICAMP13083-970 CampinasSão PauloBrazil SPBotânica-Botanical Society of Portugal Travessa do Jardim 3A-dos-Potes2615-018 Alverca do RibatejoPortugal CESAM-Centre for Environmental and Marine Studies Faculdade de Ciências-CBVUniversidade de Lisboa1749-016 LisboaPortugal

Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich *** the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune *** invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic *** aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive *** addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode *** In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψMD)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought *** Findings The results support our initial hypothesis:although *** clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native *** relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water *** corroborate that woody native species(i)have a conservative water-saving strategy an

关键词： ecophysiology water use strategy leaf morphology Acacia longifolia Corema album Helichrysum italicum

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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