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Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery

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Neural Regeneration Research 2021年第3期16卷 514-522页

作者： Wang-Xia Wang Paresh Prajapati Hemendra j.Vekaria Malinda Spry Amber L.Cloud Patrick G.Sullivan joe E.Springer Sanders Brown Center on Aging University of KentuckyLexingtonKYUSA Spinal Cord and Brain Injury Research Center University of KentuckyLexingtonKYUSA Department of Pathology&Laboratory Medicine University of KentuckyLexingtonKYUSA Department of Neuroscience University of KentuckyLexingtonKYUSA

MicroRNAs(miRNAs)are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular *** previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation(i.e.,miR-142-3p,miR-142-5p,and miR-146a)are altered in the hippocampus at 3–12 hours following a severe traumatic brain *** the present study,we investigated the temporal expression profile of these inflammatory miRNAs in mitochondria and cytosol fractions at more chronic post-injury times following severe controlled cortical impact injury in *** addition,several inflammatory genes were analyzed in the cytosol *** analysis showed that while elevated levels were observed in cytoplasm,the mitochondria-enriched miRNAs,miR-142-3p and miR-142-5p continued to be significantly reduced in mitochondria from injured hippocampi for at least 3 days and returned to near normal levels at 7 days *** not statistically significant,miR-146a also remained at reduced levels for up to 3 days following controlled cortical impact injury,and recovered by 7 *** contrast,miRNAs that are not enriched in mitochondria,including miR-124a,miR-150,miR-19b,miR-155,and miR-223 were either increased or demonstrated no change in their levels in mitochondrial fractions for 7 *** one exception was that miR-223 levels were reduced in mitochondria at 1 day following *** major alterations were observed in sham operated *** temporal pattern was unique to mitochondria-enriched miRNAs and correlated with injury-induced changes in mitochondrial bioenergetics as well as expression levels of several inflammatory *** observations suggested a potential compartmental re-distribution of the mitochondria-enriched inflammatory miRNAs and may reflect an intracellular mechanism by which specific miRNAs regulate injury-induced inflammatory *** test this,we utilized a novel peptide-based

关键词： cell permeable peptide-delivery controlled cortical impact inflammatory pathway mitochondria-associated microRNA nanoparticle nuclear factor-kappa B traumatic brain injury

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伊伐布雷定和阿替洛尔保护大鼠心肌梗死后冠脉储备的比较研究

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中国药学杂志 2011年第6期46卷 426-429页

作者：张荣林 Robert j.Tomanek 南京大学医学院附属鼓楼医院心血管内科南京210008 美国爱荷华大学医学院心血管病中心艾奥瓦城52242

目的比较伊伐布雷定(Iva)和阿替洛尔(Ate)治疗对大鼠心梗后冠脉储备的保护作用有无差异。方法受试大鼠分为假手术(sham)组、心肌梗死(MI)组、MI+Iva组和MI+Ate组,药物治疗在诱导心肌梗死后开始,疗程28 d。比较大鼠的心梗面积,以及治疗... 详细信息

目的比较伊伐布雷定(Iva)和阿替洛尔(Ate)治疗对大鼠心梗后冠脉储备的保护作用有无差异。方法受试大鼠分为假手术(sham)组、心肌梗死(MI)组、MI+Iva组和MI+Ate组,药物治疗在诱导心肌梗死后开始,疗程28 d。比较大鼠的心梗面积,以及治疗前后的心率、冠脉储备等情况。结果三组心梗大鼠之间基础心率、梗死面积占心室面积的比例均无统计学差异;与MI组相比,术后第28天MI+Iva组和MI+Ate组的心率明显减慢;而MI+Iva组和MI+Ate组相比,术后第28天的心率减慢程度没有统计学差异。与sham组相比,MI组无论游离壁还是室间隔的冠脉储备都显著降低,MI+Ate组室间隔的冠脉储备也显著降低。MI+Iva组无论游离壁还是室间隔的冠脉储备都显著高于MI组和MI+Ate组。结论 Iva治疗对大鼠MI后冠脉储备的保护作用优于Ate。

关键词：心肌梗死伊伐布雷定阿替洛尔冠脉储备

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Negative consequences of reduced protein diets supplemented with synthetic amino acids for performance,intestinal barrier function,and caecal microbiota composition of broiler chickens

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Animal Nutrition 2023年第2期13卷 216-228页

作者： Reza Barekatain Peter V.Chrystal Tanya Nowland Amy F.Moss Gordon S.Howarth Thi Thu Hao Van Robert j.Moore South Australian Research and Development Institute Roseworthy CampusRoseworthySAAustralia School of Animal and Veterinary Sciences Roseworthy CampusUniversity of AdelaideRoseworthySAAustralia School of Science RMIT UniversityBundoora West CampusBundooraVICAustralia School of Environmental and Rural Science University of New EnglandArmidaleNSWAustralia School of Envi1ronmental and Rural Science University of New EnglandArmidaleNSWAustralia

The consequences of feeding broiler chickens with reduced protein(RP)diets for gut health and barrier function are not well *** study was performed to elucidate the effect of reducing dietary protein and source of protein on gut health and performance *** experimental diets included 2 control diets with standard protein levels either containing meat and bone meal(CMBM)or an all-vegetable diet(CVEG),a medium RP diet(17.5%in growers and 16.5%in finisher),and a severe RP diet(15.6%in grower and 14.6%in finisher).Off-sex Ross 308 birds were assigned to each of the 4 diets and performance measurements were taken from d 7 to 42 *** diet was replicated 8 times(10 birds per replicate).A challenge study was conducted on additional 96 broilers(24 birds per diet)from d 13 to *** of the birds in each dietary treatment were challenged by dexamethasone(DEX)to induce a leaky *** birds with RP diets decreased weight gain(Psham and DEX-injected ***-bacteria was the main phylum driving the differences in birds fed 15.6%*** the family level,Bifidobacteriaceae,Unclassified Bifidobacteriales,Enterococcaceae,Enterobacteriaceae,and Lachnospir-aceae were the main taxa in birds fed 15.6%*** supplementation of synthetic amino acids,severe reduction of dietary pro

关键词： Gut health Microbiota Tight junction protein Inflammation Broiler

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Recent Clinical Trials of Acupuncture in the West:Responses from the Practitioners

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Chinese journal of Integrative Medicine 2010年第3期16卷 197-203页

作者： Ted j.Kaptchuk 陈可冀宋军 Harvard Medical School Xiyuan Hospital China Academy of Chinese Medical Sciences Experimental Research Center China Academy of Chinese Medical Sciences

In the West,hundreds of randomized controlled trials（RCTs）have been performed testing *** include two types：those that compare acupuncture to other therapies,usual care or no treatment（pragmatic trials）,and those that have placebo controls（efficacy trials）.Acupuncture has generally performed well against other therapies or no treatment,but until recently,the evidence from placebo controlled trials has been considered equivocal or contradictory.A recent series of large RCTs,mostly performed in Germany and also in the US have included both pragmatic and placebo *** evidence poises a conundrum for the profession of *** essay first describes the two types of RCTs used to examine acupuncture and examine the results of two recent large RCTs for chronic low back pain as representative examples of recent large *** essay then presents the most common Euro-American acupuncture professions＇ interpretation of these *** responses have included：（1）methodological weaknesses; （2）inappropriateness of placebo controls; （3）questions as to whether acupuncture placebo controls are＂inert＂; （4）rejection of evidence-based medicine epistemology; （5）discrepancy between acupuncture performed in RCTs with real world acupuncture; （6）enhanced placebo effects of acupuncture; and（7）needs to re-evaluate acupuncture *** authors do not necessarily agree with all of these responses; they are presented in an attempt to foster critical *** paper also looks at recent neuroimaging experiments on acupuncture that may point to some worthwhile new avenues of ***,the Euro-American health care policy consequences of these recent RCTs are discussed.

关键词： acupuncture sham acupuncture low back pain randomized controlled trials acupuncture neuroimaging

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军事创伤性颅脑损伤的结构MRI表现

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国际医学放射学杂志 2016年第3期 315-315页

作者： G.Riedy j.S.Senseney W.Liu j.Ollinger E.sham P.Krapiva 林竹潇 National Capital Neuroimaging Consortium (NCNC)

摘要目的利用综合MRI参数描述由爆炸引起的主要表现为慢性轻度颅脑损伤(TBI)的军人队列的神经成像表现。材料与方法该研究获得沃尔特里德国军事医疗中心伦理审查委员会的批准,并且符合HIPAA。所有参与者均为2009年8月—2014年8月期间招... 详细信息

摘要目的利用综合MRI参数描述由爆炸引起的主要表现为慢性轻度颅脑损伤(TBI)的军人队列的神经成像表现。材料与方法该研究获得沃尔特里德国军事医疗中心伦理审查委员会的批准,并且符合HIPAA。所有参与者均为2009年8月—2014年8月期间招募的军人或其家属。共834例参与者有TBI病史,42例无TBI的参与者作为对照组

关键词： MRI 军事 TBI

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Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model

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World journal of Gastroenterology 2017年第47期23卷 8321-8333页

作者： Bin-Rui Chen Li-jun Du Hui-Qin He john j Kim Yan Zhao Ya-Wen Zhang Liang Luo Ning Dai Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Division of Gastroenterology Loma Linda University Medical Center

AIM To determine whether fructo-oligosaccharide(FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids(SCFA) in an irritable bowel syndrome(IBS) mouse *** Mice were randomly assigned to daily oral gavage of saline solution with or without FOS(8 g/kg body weight) for 14 d. Mice were further assigned to receive either daily one-hour water avoidance stress(WAS) or sham-WAS for the first 10 d. After 2 wk, visceral sensitivity was measured by abdominal withdrawal reflex in response to colorectal distension and mucosal inflammation was evaluated. Gas chromatography, real-time reverse transcription PCR, and immunohistochemistry assays were used to quantify cecal concentrations of SCFA, intestinal cytokine expression, and number of intestinal mast cells per high-power field(HPF), *** Mice subjected to WAS exhibited visceral hypersensitivity and low-grade inflammation. Among mice subjected to WAS, FOS increased visceral hypersensitivity and led to higher cecal concentrations of acetic acid(2.49 ± 0.63 mmol/L vs 1.49 ± 0.72 mmol/L, P jected to WAS. No difference in visceral sensitivity, intestinal inflammation, or cecal SCFA levels was detected with or without FOS administration in mice subjected to *** FOS administration intensifies visceral hypersensitivity and gut infla

关键词： Fructo-oligosaccharide Stress Irritable bowel syndrome Visceral hypersensitivity Intestinal inflammation Short chain fatty acids FODMAP

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钯与铱、铂、钌、铑和镓的浮选分离研究

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信阳师范学院学报（自然科学版） 2010年第1期23卷 131-133页

作者：李玉玲沈久明汪玲李想马万山信阳师范学院化学化工学院河南信阳464000

在水溶液中, Pd(Ⅱ)与溴化钾和四丁基溴化铵形成不溶于水的三元配合物,此三元配合物浮于盐水相上层形成界面清晰的液-固两相,当溶液中溴化钾和四丁基溴化铵的浓度分别为1.5×10-2mol/L和2.0×10-3mol/L, pH =2.0时, Pd(Ⅱ)被定量浮选.Ir... 详细信息

在水溶液中, Pd(Ⅱ)与溴化钾和四丁基溴化铵形成不溶于水的三元配合物,此三元配合物浮于盐水相上层形成界面清晰的液-固两相,当溶液中溴化钾和四丁基溴化铵的浓度分别为1.5×10-2mol/L和2.0×10-3mol/L, pH =2.0时, Pd(Ⅱ)被定量浮选.Ir(Ⅳ)、Pt(Ⅳ)、Ru(Ⅲ)、Rh(Ⅲ)和Ga(Ⅲ)离子在该体系中不被浮选,实现了Pd(Ⅱ)与这些离子的定量分离,对合成水样中Pd(Ⅱ)的定量浮选分离测定,结果满意.

关键词： Pd(Ⅱ) 溴化钾四丁基溴化铵浮选分离

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Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 622-629页

作者： Krijn P van Lienden Lisette T Hoekstra jessica D van Trigt joris j Roelofs Otto M van Delden Thomas M van Gulik Department of RadiologyAcademic Medical Center University of Amsterdam Department of Surgery (Surgical Laboratory)Academic Medical Center University of Amsterdam Department of PathologyAcademic Medical Center University of Amsterdam

BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor *** latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver *** study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor ***:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 *** weeks after implantation,18 rabbits were used for TAE experiments,5were for sham *** response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating ***:All super-selective arterial tumor embolization procedures were performed *** embolization,the tumor volume increased after an initial steady *** tumor volume after embolization was smaller than that of the sham group,but this difference was not *** necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver *** was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal *** regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained ***:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT *** of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma.

关键词： hypertrophy liver regeneration animal model transarterial embolization hepatic artery

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Effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer

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World journal of Gastroenterology 2004年第4期10卷 560-566页

作者： janeC.-.j.Chao Huei-ChenHung Sheng-HsuanChen Chia-LangFang SchoolofNutritionandHealthSciences TaipeiMedicalUniversity250WuHsingStreetTaipeiTaiwan110China DepartmentofPathology TaipeiMedicalUniversity250WuHsingStreetTaipeiTaiwan110China

AIM:To investigate the effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ***: Sprague-Dawley rats were randomly divided into four groups: sham operation without ginkgo, sham operation with ginkgo, duodenal ulcer without ginkgo, and duodenal ulcer with ginkgo. Rats with duodenal ulcer were induced by 500mL/L acetic acid. Rats with ginkgo were intravenously injected with Ginkgo biloba extract from the tail at a dose of 0.5mg/(kg·d) for 7 and 14 ***:Pathological result showed that duodenal ulcer rats with ginkgo improved mucosal healing and inflammation compared with those without ginkgo after 7d treatment. After 14d treatment, duodenal ulcer rats with ginkgo significantly increased weight gain (34.0±4.5g versus 24.5±9.5g,Psham operation rats with and without ginkgo,Psham operation *** prostaglandin E2 concentration significantly increased by 129% (Psham operation rats without ginkgo. However, duodenal ulcer rats with ginkgo significantly increased erythrocyte superoxide dismutase activity (8.22±1.92 U/mg protein versus 4.87±1.49U/mg protein,Psham operation rats w

关键词：银杏叶提取物细胞保护作用十二指肠溃疡动物模型药理作用

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Symplicity-3 hypertension trial:Basic and clinical insights

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World journal of Hypertension 2015年第2期5卷 74-78页

作者： Benjamin j Scherlag Sunny S Po Heart Rhythm Institute University of Oklahoma Health Sciences CenterOklahoma CityOK 73104United States

Symplicity-3 hypertension(HTN) was a recently completed clinical trial that was assumed to be the basis for the approved use of renal artery denervation for the treatment of resistant hypertension in the United *** reductions in blood pressure had been reported in two clinical trials(Symplicity-1HTN,-2HTN) carried out in Europe,however Symplicity-3HTN did not show a significant reduction of systolic blood pressure in patients with resistant hypertension 6 mo after renal artery denervation as compared with a sham control.(Denervation group,blood pressure reduction:-14 ± 24,sham control:-12 ± 26 mm Hg).In this review we discuss several potential explanations for the failure of efficacy of Symplicity-3HTN taking into account basic and clinical factors which could have played a role in the discrepancy between the European and American experience.

关键词： Hypertension Renal artery denervation Aorticorenal ganglia Atrial fibrillation

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