Effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer
Effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer作者机构：SchoolofNutritionandHealthSciencesTaipeiMedicalUniversity250WuHsingStreetTaipeiTaiwan110China DepartmentofPathologyTaipeiMedicalUniversity250WuHsingStreetTaipeiTaiwan110China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2004年第10卷第4期
页 面：560-566页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100602[医学-中西医结合临床] 10[医学]
主 题：银杏叶提取物 细胞保护作用 十二指肠溃疡 动物模型 药理作用
摘 要：AIM:To investigate the effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ***: Sprague-Dawley rats were randomly divided into four groups: sham operation without ginkgo, sham operation with ginkgo, duodenal ulcer without ginkgo, and duodenal ulcer with ginkgo. Rats with duodenal ulcer were induced by 500mL/L acetic acid. Rats with ginkgo were intravenously injected with Ginkgo biloba extract from the tail at a dose of 0.5mg/(kg·d) for 7 and 14 ***:Pathological result showed that duodenal ulcer rats with ginkgo improved mucosal healing and inflammation compared with those without ginkgo after 7d treatment. After 14d treatment, duodenal ulcer rats with ginkgo significantly increased weight gain (34.0±4.5g versus 24.5±9.5g,P0.05) compared with those without ginkgo. Duodenal ulcer rats significantly increased cell proliferation (27.4±4.0 and 27.8±2.3 BrdU-labeled cells in duodenal ulcer rats with and without ginkgo versus 22.4±3.5 and 20.8±0.5 BrdUlabeled cells in sham operation rats with and without ginkgo,P0.05) compared with sham operation *** prostaglandin E2 concentration significantly increased by 129% (P0.05) in duodenal ulcer rats with ginkgo compared with that in those without ginkgo. Duodenal ulcer rats without ginkgo significantly decreased superoxide dismutase activity in the duodenal mucosa and erythrocytes (19.4±6.7U/mg protein versus 38.1±18.9U/mg protein in the duodenal mucosa,and 4.87±1.49 U/rng protein versus 7.78±2.16U/rng protein in erythroo/tes, P0.05) compared with sham operation rats without ginkgo. However, duodenal ulcer rats with ginkgo significantly increased erythrocyte superoxide dismutase activity (8.22±1.92 U/mg protein versus 4.87±1.49U/mg protein,P0.05) compared with those without ginkgo. Duodenal ulcer rats without ginkgo significantly increased plasma lipid peroxides (4.18±1.12 μmol/mL versus 1.60±1.10μmol/mL and 1.80±0.73μmol/mL, P0.05) compared with sham operation rats w
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