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Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentation

Regenerative Biomaterials 2021年第2期8卷 34-42页

作者： Rena Shido Yoshinori Sumita Masahito Hara Mayumi Iwatake Shun Narahara Mayumi Umebayashi Kei-ichiro Miura Yukinobu Kodama izumi asahina Department of Regenerative Oral Surgery Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Basic&Translational Research Center for Hard Tissue Disease Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Laboratory of Craniofacial Tissue Engineering and Stem Cells Faculty of DentistryMcGill University3640 University StreetM43MontrealQuebec H3A 2B2Canada Department of Hospital Pharmacy Nagasaki University Hospital1-7-1 SakamotoNagasaki 852-8501Japan

Gene-activated matrix(GAM)has a potential usefulness in bone engineering as an alternate strategy for the lasting release of osteogenic proteins but efficient methods to generate non-viral GAM remain to be *** this study,we investigated whether an atelocollagen-based GAM containing naked-plasmid(p)DNAs encoding microRNA(miR)20a,which may promote osteogenesis in vivo via multiple pathways associated with the osteogenic differentiation of mesenchymal stem/progenitor cells(MSCs),facilitates rat cranial bone ***,we confirmed the osteoblastic differentiation functions of generated pDNA encoding miR20a(pmiR20a)in vitro,and its transfection regulated the expression of several of target genes,such as Bambi1 and PPARc,in rat bone marrow MSCs and induced the increased expression of ***,when GAMs fabricated by mixing 100 ll of 2%bovine atelocollagen,20mg b-TCP granules and 0.5mg(3.3 lg/ll)AcGFP plasmid-vectors encoding miR20a were transplanted to rat cranial bone surface,the promoted vertical bone augmentation was clearly recognized up to 8 weeks after transplantation,as were upregulation of VEGFs and BMP4 expressions at the early stages of ***,GAM-based miR delivery may provide an alternative non-viral approach by improving transgene efficacy via a small sequence that can regulate the multiple pathways.

关键词： gene-activated matrix in vivo gene transfer bone augmentation atelocollagen mir20a

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Diachronic changes in mouse tumor and fibrous tissue adjacent to mouse tumor subjected to photodynamic therapy

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中国口腔颌面外科杂志 2008年第B5期6卷 155-156页

作者： Masataka Uehara Takayoshi Tobita Seigo Ohba Mihoko Nonaka izumi asahina Department of Regenerative Oral Surgery Unit of TranslationalMedicine Graduate School of Biomedical Sciences NagasakiUniversity. Nagasaki 852-8588 Japan

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Reduction of data amount in data-driven design of linear quadratic regulators

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Control Theory and Technology 2024年第4期22卷 532-542页

作者： Shinsaku izumi Xin Xin School of Systems Engineering Kochi University of TechnologyKamiKochi782-8502Japan School of Automation Southeast Universityand Key Laboratory of Measurement and Control of Complex Systems of EngineeringMinistry of EducationNanjing210096JiangsuChina

This paper discusses the data-driven design of linear quadratic regulators,i.e.,to obtain the regulators directly from experimental data without using the models of *** particular,we aim to improve an existing design method by reducing the amount of the required experimental *** the data amount leads to the cost reduction of experiments and computation for the data-driven *** present a simplified version of the existing method,where parameters yielding the gain of the regulator are estimated from only part of the data required in the existing *** then show that the data amount required in the presented method is less than half of that in the existing method under certain *** addition,assuming the presence of measurement noise,we analyze the relations between the expectations and variances of the estimated parameters and the *** a result,it is shown that using a larger amount of the experimental data might mitigate the effects of the noise on the estimated *** results are verified by numerical examples.

关键词： Data-driven design Linear quadratic regulators Linear systems Riccati equation Stochastic properties

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Perspectives of Science and Technology in Disaster Risk Reduction of Asia

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International Journal of Disaster Risk Science 2016年第4期7卷 329-342页

作者： Rajib Shaw Takako izumi Peijun Shi Integrated Research on Disaster Risks(IRDR) International Research Institute of Disaster Science(IRIDeS) Tohoku University State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University

Science and technology innovation has always been present in Asia,but its application in disaster risk reduction(DRR) has been *** Asia,globally significant hotspots of disasters and economic development have emerged in which the application of science and technology in DRR has become an essential requirement for informed decision *** has supported establishment and implementation of major international initiatives in DRR,including the Hyogo Framework for Action *** more recent Sendai Framework for DRR 2015-2030 recognizes the importance of science and technology in all of its priority action areas,and subsequent global and regional forums and conferences have reconfirmed science and technology's *** perceive and monitor the progress of science and technology in DRR,a qualitative assessment of different countries is made using three major attributes:(1) science-based decision making;(2) investment in science and technology;and(3) the intensity of science's link to the *** assessment exercise points out several strengths and weaknesses in science and technology application;the method can be employed to develop future multistakeholder and multidisciplinary science and technology plans at the country *** implement regional and national activities,a set of 15 recommendations is put forward,which will strengthen the collective regional "science voice" in DRR.

关键词： DRR policy making Science innovation Science investment Sendai Framework Technology application

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Fabrication of a model specimen for understanding micro-galvanic corrosion at the boundary ofα-Mg andβ-Mg17Al12

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Journal of Magnesium and Alloys 2023年第1期11卷 137-153页

作者： Zheng Shao Masashi Nishimoto izumi Muto Yu Sugawara Department of Materials Science Graduate School of EngineeringTohoku University6-6-02 Aza-AobaAramakiAoba-kuSendai 980-0579Japan

A model specimen with a single boundary of theα/βphase simulating Mg-Al alloys was successfully fabricated by spark plasma sintering.A small electrode area ofαphase orβphase was prepared using the model specimen,and the OCPs(open-circuit potentials)of each phase and a small electrode area containing theα/βphase boundary in 0.1 M NaCl at pH 8.0 were compared:theβphase exhibited a higher potential,and theαphase showed a lower *** OCP of the small area containing theα/βphase boundary was the intermediate value of these *** a small area containingα/βphase boundary,discoloration and gas bubbles were observed on theαphase,but no bubble generation was detected on theβ*** gas bubbles were initially generated on theαphase near theβphase,but as the discoloration(corrosion)of theαphase approached theβphase,the bubbles were generated on theβ*** micro-galvanic corrosion of theαandβphases,theβphase did not always function as the preferred ***αphase partially corroded(or discolored)and became the anodes,so that the surrounding areas were most likely to be the *** corroded areas(anodes)in theαphase approached theβphase,theβphase would become *** addition to the micro-galvanic corrosion mechanism,the role of Al in corrosion resistance at theα/βphase boundary was determined by surface analysis.

关键词： Magnesium alloy α/βphase boundary Micro-scale observation technique Micro-galvanic corrosion Spark plasma sintering

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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika Fujii Charles F.Zorumski Yukitoshi izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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WAVE PROPAGATION IN SATURATED GROUND USING THE VOLUME FRACTIONS

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Acta Mechanica Solida Sinica 1999年第2期12卷 144-154页

作者： Kazuya Mitsuji Yoshihiro Sugimura Masanori izumi Department of Architecture Faculty of EngineeringTohoku UniversitySendaiJapan

The purpose of this paper is to study the dynamic behavior of softground including a porous layer by considering porosity change. Inorder to take the porosity change into account, the concept of thevolume fraction, which has been proposed in continuum mechanics, isintroduced. The constitutive equations presented by Bowen are appliedto the analysis of the porous media. According to Bowen's theory, theporosity is considered as a variable called the volume fraction andhas its own consti- Tutive equation.

关键词： volume fraction wave propagation porosity change

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Evaluation of precipitation behavior of zirconium molybdate hydrate

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 65-71页

作者： Liang ZHANG Masayuki TAKEUCHI Tsutomu KOizumi izumi HIRASAWA Graduate School of Applied Chemistry Faculty of Science and Engineering Waseda University Tokyo 169-8555 Japan Japan Atomic Energy Agency Ibaraki 319-1194 Japan

In the dissolution step of spent nuclear fuel, there is a world-concern problem that zirconium molybdate hydrate precipitates as a byproduct, and accumulates in some reprocessing equipments. In order to prevent this accumulation, we have developed a new method based on the controlled reaction crystallization of zirconium molybdate hydrate （ZMH） in the reprocessing solution, followed by solid liquid separation. In order to measure the particle size of ZMH, batch crystallization experiments were conducted by varying nitric acid concentration and operating temperature. In result, almost all particle sizes scatter around 1μm on average, despite the higher concentration of nitric aid and operating temperature, and then small particles grow up as an aggregate sticking to the crystallizer. Moreover, polymorph and color changing were observed by varying the concentration of nitric acid and reaction time. These results suggest that crystal color and adhesiveness are closely related to the particle size of ZMH. And the control of nitric acid concentration and small particle growth would be the useful technique to prevent the ZMH sticking.

关键词： spent nuclear fuel zirconium molybdate hydrate cleaning method accumulation

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Solvent effect for ruthenium porphyrin

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Science China(Physics,Mechanics & Astronomy) 2010年第6期53卷 1005-1012页

作者： IWAKURA izumi YABUSHITA Atshi KOBAYASHI Takayoshi Innovative Use of Light and Materials/life PRESTJST4-1-8 HonchoKawaguchiSaitama 332-0012Japan Department of Electrophysics National Chiao-Tung University University of Electro-Communications ICORP JST4-1-8 HonchoKawaguchiSaitama 332-0012Japan Institute of Laser Engineering Osaka University

Relaxation of electronic excited-state and vibrational dynamics in the electronic excited state in Ru II(TPP)(CO) [TPP=tetraphenylporphyrin] dissolved in N2 bubbled benzene,O2 bubbled benzene,N2 bubbled chloroform and N2 bubbled acetone were clarified using a sub-5fs laser pulse. The result showed that the transition energy from the 1Q x states,consisting of the 1Q x(1,0)(π,π*) state(existing at 18800 cm-1 ) and 1Q x(0,0)(π,π*) state(existing at 17800 cm-1 ),to the 1M state of six-coordinated ruthenium complex is lower than that of the five-coordinated ruthenium complex. The intersystem crossing 1Q x(0,0)(π,π*)→ 3(d,π*) in the five-coordinate Ru II(TPP)(CO) in the solution was found to take place in about 1 ps.

关键词： femtosecond laser ruthenium porphyrin complex real-time spectroscopy

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Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment

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Neural Regeneration Research 2024年第10期19卷 2212-2218页

作者： Yukitoshi izumi Kazuko A.O'Dell Charles F.Zorumski Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there are concerns about toxicity including neurotoxicity that could result in neurological, psychiatric, or cognitive impairment. We recently found that a single injection of glyphosate inhibits long-term potentiation, a cellular model of learning and memory, in rat hippocampal slices dissected 1 day after injection, indicating that glyphosate-based herbicides can alter cognitive function. Glyphosate-based herbicides could adversely affect cognitive function either indirectly and/or directly. Indirectly, glyphosate could affect gut microbiota, and if dysbiosis results in endotoxemia(leaky gut), infiltrated bacterial by-products such as lipopolysaccharides could activate pro-inflammatory cascades. Glyphosate can also directly trigger pro-inflammatory cascades. Indeed, we observed that acute glyphosate exposure inhibits long-term potentiation in rat hippocampal slices. Interestingly, direct inhibition of long-term potentiation by glyphosate appears to be similar to that of lipopolysaccharides. There are several possible measures to control dysbiosis and neuroinflammation caused by glyphosate. Dietary intake of polyphenols, such as quercetin, which overcome the inhibitory effect of glyphosate on long-term potentiation, could be one effective strategy. The aim of this narrative review is to discuss possible mechanisms underlying neurotoxicity following glyphosate exposure as a means to identify potential treatments.

关键词： cognitive impairment glyphosate microglia neuroinflammation roundup toll-like receptor 4 zinc chelation

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