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Additive Manufacturing of Metal Micro-ring and Tube by Laser-Assisted Electrophoretic Deposition with Laguerre-Gaussian Beam

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Nanomanufacturing and Metrology 2021年第4期4卷 271-277页

作者： Kenta Nakazawa Syunya Ozawa Futoshi iwata Graduate School of Integrated Science and Technology Shizuoka University3-5-1 Johoku.Naka-kuHamamatsu 432-8561.Japan Graduate School of Medical Photonics Shizuoka University3-5-1 JohokuNaka-kuHamamatsu 432-8011Japan Research Institute of Electronics Shizuoka University3-5-1 JohokuNaka-kuHamamatsu 432-8011Japan

We report a method for laser-assisted electrophoretic deposition using a Laguerre-Gaussian beam for maskless patterning of metal rings and *** are structures of utmost importance,particularly in photonic *** nanoparticles,which are gathered in a colloidal solution by a laser trapping technique,are deposited on a substrate via *** deposition pattern is dependent on the focused spot shape during laser *** intensity distribution of the Laguerre-Gaussian beam is *** with different inner diameters can be fabricated by varying the topological charge of the Laguerre-Gaussian *** equivalent inner diameters of the deposited rings with topological charges of 1,3,and 5 were 0.30,0.78,and 1.45μm,*** inner diameter of the deposited ring with a topological charge of 1 was smaller than the wavelength of the laser beam(532 nm).A tube was also fabricated with a topological charge of 3 by vertical displacement of the deposition *** deposition technology developed here using Laguerre-Gaussian beam will contribute to advancements in the fabrication of photonic and nano-fluidic devices.

关键词： Additive manufacturing Laguerre-Gaussian beam Laser trapping Maskless fabrication Electrophoretic deposition

Influence of Fine Sediment on the Fluidity of Debris Flows

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Journal of Mountain Science 2013年第2期10卷 233-238页

作者： Norifumi HOTTA Takahiro KANEKO Tomoyuki iwata Haruo NISHIMOTO Faculty of Life and Environmental Sciences University of Tsukuba3058577 IbarakiJapan Faculty of Agriculture The University of Tokyo1138657 TokyoJapan Graduate School of Agricultural and Life Sciences The University of Tokyo1138657 TokyoJapan

Debris flows include a great diversity of grain sizes with inherent features such as inverse grading, particle size segregation, and liquefaction of fine sediment. The liquefaction of fine sediment affects the fluidity of debris flows, although the behavior and influence of fine sediment in debris flows have not been examined sufficiently. This study used flume tests to detect the effect of fine sediment on the fluidity of laboratory debris flows consisting of particles with various diameters. From the experiments, the greatest sediment concentration and flow depth were observed in the debris flows mixed with fine sediment indicating increased flow resistance. The experimental friction coefficient was then compared with the theoretical friction coefficient derived by substituting the experimental values into the constitutive equations for debris flow. The theoretical friction coefficient was obtained from two models with different fine-sediment treatments： assuming that all of the fine sediments were solid particles or that the particles consisted of a fluid phase involving pore water liquefaction. From the comparison of the friction coefficients, a fully liquefaction state was detected for the fine particle mixture. When the mixing ratio and particle size of the fine sediment were different, some other eases were considered to be in a partially liquefied transition state. These results imply that the liquefaction of fine sediment in debris flows was induced not only by the geometric conditions such as particle sizes, but also by the flow conditions.

关键词： Debris flow Fine sediment Friction coefficient Liquefaction Open channel Reynolds stress

Pouchitis and pre-pouch ileitis developed after restorative proctocolectomy for ulcerative colitis:A case report

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World Journal of Gastroenterology 2007年第4期13卷 643-646页

作者： Takashi iwata Takayuki Yamamoto Satoru Umegae Koichi Matsumoto Inflammatory Bowel Disease Center and Department of Surgery Yokkaichi Social Insurance Hospital 10-8 Hazuyamacho Yokkaichi Mie 510-0016 Japan

We report a case of pouchitis and pre-pouch ileitis, and inflammation in the neo-terminal ileum proximal to the pouch, developed after restorative proctocolectomy for ulcerative colitis. A 35-year old female presented with fever and abdominal pain five weeks after ileostomy closure following proctocolectomy. Computed tomography showed collection of feces in the pouch and proximal ileum. A drainage tube was placed in the pouch perianally, and purulent feces were discharged. With antibiotic treatment, her symptoms disappeared, but two weeks later, she repeatedly developed fever and abdominal pain along with anal bleeding. Pouchscopy showed mucosal inflammation in both the pouch and the pre-pouch ileum. The mucosal cytokine production was elevated in the pouch and pre-pouch ileum. With antibiotic and corticosteroid therapy, her symptoms were improved along with improvement of endoscopic inflammation and decrease of mucosal cytokine production. The fecal stasis with bacterial overgrowth is the major pathogenesis of pouchitis and pre-pouch ileitis in our case.

关键词： Mucosal cytokines Pouchitis Pre-pouchileitis Restorative proctocolectomy Ulcerative colitis

Multispectral Phenotyping and Genetic Analyses of Spring Appearance in Greening Plant, Phedimus spp.

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Plant Phenomics 2023年第2期5卷 353-367页

作者： Taeko Koji Hiroyoshi iwata Motoyuki Ishimori Hideki Takanashi Yuji Yamasaki Hisashi Tsujimoto The United Graduate School of Agricultural Sciences Tottori University4-101 Koyamacho minamiTottori-shiTottori 680-8553Japan Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Yayoi-chouBunkyoTokyo 113-8657Japan Arid Land Research Center Tottori University1390 HamasakaTottori-shiTottori 680-0001Japan

The change in appearance during the seasonal transitions in ornamental greening plants is an important *** particular,the early onset of green leaf color is a desirable trait for a *** this study,we established a method for phenotyping leaf color change by multispectral imaging and performed genetic analysis based on the phenotypes to clarify the potential of the approach in breeding greening *** performed multispectral phenotyping and quantitative trait locus(QTL)analysis of an F1 population derived from 2 parental lines of Phedimus takesimensis,known to be a drought and heat-tolerant rooftop plant *** imaging was conducted in April of 2019 and 2020 when dormancy breakage occurs and growth extension *** component analysis of 9 different wavelength values showed a high contribution from the first principal component(PC1),which captured variation in the visible light *** high interannual correlation in PC1 and in the intensity of visible light indicated that the multispectral phenotyping captured genetic variation in the color of *** also performed restriction site-associated DNA sequencing and obtained the first genetic linkage map of Phedimus *** analysis revealed 2 QTLs related to early dormancy *** on the genotypes of the markers underlying these 2 QTLs,the F1 phenotypes with early(late)dormancy break,green(red or brown)leaves,and a high(low)degree of vegetative growth were *** results suggest the potential of multispectral phenotyping in the genetic dissection of seasonal leaf color changes in greening plants.

关键词： breeding cultivar visible

Intraspecific Relationships and Variation of Two <i>Lefua</i>Species (Balitoridae, Cypriniformes) in the Tokai Region, Honshu, Japan

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Journal of Water Resource and Protection 2017年第2期9卷 238-253页

作者： Jun-Ichi Miyazaki Seiya Hida Takurou ozaki Yuichirou Tabata Misaki iwata Masashi Nakazawa Youki Fukasawa Tomonari Asaka Faculty of Education and Human Sciences University of Yamanashi Kofu Japan Department of Education Graduate School of Medical and Engineering University of Yamanashi Kofu Japan Mikawa Freshwater Life Network Toyokawa Japan

Two species Lefua echigonia and Lefua sp. 2 of the eight-barbel loach inhabit the Tokai region of Honshu, Japan. We determined sequences of the mitochondrial D-loop region to elucidate intraspecific phylogenetic relationships and variation in these two species. Lefua sp. 2 represented high intraspecific genetic similarity and complicated haplotype network, but three assemblages were recognized, including specimens mainly from Yahagi, Toyo, and Tenryu River systems, respectively, and named Groups 1 to 3. Divergence of Group 1 from the others was marginally supported, but Group 2 was paraphyletic to Group 3, suggesting the existence of two populations, i.e. Yahagi River population and Toyo-Tenryu River population. Lefua echigonia also represented high intraspecific genetic similarity, and two assemblages with slight genetic differentiation were discernible, including specimens from Shizuoka and southeastern Aichi prefectures and those from northwestern Aichi, Gifu, and Mie prefectures, respectively, and named Groups A and B. Star-like relationships of haplotypes suggested the dispersal origin located in eastern Aichi prefecture. The two species are threatened to extinction and thus we proposed evolutionary significant units for conservation.

关键词： Population Phylogeography Mitochondrial D-Loop Region Conservation River Capturing

Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation

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Bone Research 2020年第1期8卷 39-52页

作者： Akiko Suzuki Kenichi Ogata Hiroki Yoshioka Junbo Shim Christopher AWassif Forbes DPorter Junichi iwata Department of Diagnostic&Biomedical Sciences The University of Texas Health Science Center at HoustonSchool of DentistryHoustonTXUSA Center for Craniofacial Research The University of Texas Health Science Center at HoustonSchool of DentistryHoustonTXUSA Division of Translational Medicine Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentBethesdaMDUSA Pediatric Research Center The University of Texas Health Science Center at HoustonMcGovern Medical SchoolHoustonTXUSA MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences HoustonTXUSA

Human linkage studies suggest that craniofacial deformities result from either genetic mutations related to cholesterol metabolism or high-cholesterol maternal diets. However, little is known about the precise roles of intracellular cholesterol metabolism in the development of craniofacial bones, the majority of which are formed through intramembranous ossification. Here, we show that an altered cholesterol metabolic status results in abnormal osteogenesis through dysregulation of primary cilium formation during bone formation. We found that cholesterol metabolic aberrations, induced through disruption of either Dhcr7(which encodes an enzyme involved in cholesterol synthesis) or Insig1 and Insig2(which provide a negative feedback mechanism for cholesterol biosynthesis), result in osteoblast differentiation abnormalities. Notably, the primary cilia responsible for sensing extracellular cues were altered in number and length through dysregulated ciliary vesicle fusion in Dhcr7 and Insig1/2 mutant osteoblasts. As a consequence, WNT/β-catenin and hedgehog signaling activities were altered through dysregulated primary cilium ***, the normalization of defective cholesterol metabolism by simvastatin, a drug used in the treatment of cholesterol metabolic aberrations, rescued the abnormalities in both ciliogenesis and osteogenesis in vitro and in vivo. Thus, our results indicate that proper intracellular cholesterol status is crucial for primary cilium formation during skull formation and homeostasis.

关键词： metabolism cholesterol homeostasis

Evaluation of crustal deformation and associated strong motions induced by the 2022 Paktika earthquake,Afghanistan

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Earthquake Science 2024年第6期37卷 546-557页

作者： A.Bari Jahed Ömer Aydan Takashi Ito Naoki iwata University of Ryukyus Okinawa 903-0213Japan Chuden Engineering Consultants Hiroshima 734-8510Japan

The 2022 Paktika earthquake(moment magnitude:6.2) occurred on June 22,2022,near the border between the Khost and Paktika Provinces of Afghanistan,causing heavy damage and casualties in Paktika *** study evaluated the crustal deformation and associated strong motions induced by the Paktika *** deformations were determined using the Differential Interferometric Synthetic Aperture Radar(DInSAR) technique and three-dimensional finite element method(3DFEM) and the results were *** permanent ground displacements obtained from the DInSAR and 3D-FEM analyses were similar in terms of amplitude and areal *** motions were estimated using the 3D-FEM with and without considering regional *** estimations of maximum ground acceleration,velocity,and permanent ground deformations were compared among each other as well as with those inferred from failures of some simple structures in the Spera and Gayan *** inferred maximum ground acceleration and velocity from the failed adobe structures were more than 300 Gal and 50 cm/s,respectively,nearly consistent with the estimates obtained using empirical *** empirical method yielded a maximum ground acceleration of 347 Gal,whereas the maximum ground velocity was approximately50 cm/*** light of these findings,some surface expressions of crustal deformations and strong ground motions,such as failures of soil and rock slopes and rockfalls,have been *** rock slope failures in the epicentral area were consistent with those observed during various earthquakes in Afghanistan and worldwide.

关键词： Paktika earthquake FEM SAR Afghanistan fault rupture surface deformation slope rockfall

Salvage brachytherapy for locally recurrent prostate cancer after external beam radiotherapy

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Asian Journal of Andrology 2015年第6期17卷 899-903页

作者： Yasuhiro Yamada Koji Okihara Tsuyoshi iwata Koji Masui Kazumi Kamoi Kei Yamada Tsuneharu Miki Department of Urology Kyoto Prefectural Universityof Medicine Kyoto Japan Department of Radiology Kyoto Prefectural University of Medicine KyotoJapan

External beam radiotherapy （EBRT） is a standard treatment for prostate cancer. Despite the development of novel radiotherapy techniques such as intensity-modulated conformal radiotherapy, the risk of local recurrence after EBRT has not been obviated. Various local treatment options （including salvage prostatectomy, brachytherapy, cryotherapy, and high-intensity focused ultrasound [HIFU]） have been employed in cases of local recurrence after primary EBRT. Brachytherapy is the first-line treatment for low-risk and selected intermediate-risk prostate tumors. However, few studies have examined the use of brachytherapy to treat post-EBRT recurrent prostate cancer. The purpose of this paper is to analyze the current state of our knowledge about the effects of salvage brachytherapy in patients who develop locally recurrent prostate cancer after primary EBRT. This article also introduces our novel permanent brachytherapy salvage method.

关键词： Salvage brachytherapy radiotherapy

HER2-positive adenocarcinoma arising from heterotopic pancreas tissue in the duodenum:A case report

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World Journal of Gastroenterology 2021年第28期27卷 4738-4745页

作者： Yoshifumi S Hirokawa Takashi iwata Yoshinaga Okugawa Koji Tanaka Hiroyuki Sakurai Masatoshi Watanabe Department of Oncologic Pathology Mie University Graduate School of MedicineMie 5148507Japan Cancer Center Aichi Medical UniversityAichi 4801195Japan Department of Genomic Medicine Mie University HospitalMie 5148507Japan Department of Surgery IGA City General HospitalMie 5180823Japan Hepato-biliary-pancreatic and Transplant Surgery Mie University HospitalMie 5148507Japan

BACKGROUND Adenocarcinoma originating from heterotopic pancreas tissue is a rare ***,to our knowledge,no HER2-positive cases in the duodenum have been reported in the scientific literature nor has the efficacy of trastuzumab treatment for the disease been *** SUMMARY A 65-year-old woman whose clinical diagnosis was unresectable advanced duodenal cancer with HER2 overexpression responded well to trastuzumab *** main tumor in the duodenum reduced *** patient underwent pancreaticoduodenectomy and lymph node dissection.A small number of cancer cells remained in the submucosal layer of the duodenum and pancreas *** histological and immunohistochemical examination,the patient was diagnosed with duodenal adenocarcinoma originating from heterotopic pancreas *** Trastuzumab treatment is effective in HER2-positive adenocarcinoma originating from heterotopic pancreas tissue in the duodenum.

关键词： Heterotopic pancreas tissue Duodenal cancer Human epidermal growth factor receptor 2 Trastuzumab Conversion surgery Case report