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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

On the field method in non-holonomic mechanics

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Acta Mechanica Sinica 2005年第2期21卷 192-196页

作者： ivana Kovacic Department of Mechanics Faculty of Technical SciencesUniversity of Novi Sad.

This paper deals with the generalization of the fieldmethod to non-holonomic systems whose motion is subject toeither non-linear constraints or those of a higher order,whiletheir motion is modeled by the generalized L... 详细信息

关键词： Non-holonomic system Equations of motion Field method

Clinical implications of hepatitis B virus mutations:Recent advances

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World Journal of Gastroenterology 2014年第24期20卷 7653-7664页

作者： ivana Lazarevic Institute of Microbiology and Immunology Faculty of MedicineUniversity of Belgrade11000 BelgradeSerbia

Hepatitis B virus(HBV)infection is a major cause of acute and chronic hepatitis,and of its long-term *** is the most variable among DNA viruses,mostly because of its unique life cycle which includes the activity of error-prone enzyme,reverse transcriptase,and the very high virion production per *** last two decades,numerous research studies have shown that the speed of disease progression,reliability of diagnostic methods and the success of antiviral therapy and immunization are all influenced by genetic variability of this *** was shown that mutations in specific regions of HBV genome could be responsible for unwanted clinical outcomes or evasion of detection by diagnostic tools,thus making the monitoring for these mutations a necessity in proper evaluation of *** success of the vaccination programs has now been challenged by the discovery of mutant viruses showing amino acid substitutions in hepatitis B surface antigen(HBsAg),which may lead to evasion of vaccine-induced ***,the emergence of these mutations has not yet raised concern since it was shown that they develop *** of HBV genetic variability and clinical implications of specific mutations have resulted in significant advances over the past decade,particularly in regard to management of resistance to antiviral *** the era of drugs with high genetic barrier for resistance,on-going monitoring for possible resistance is still essential since prolonged therapy is often *** the frequencies and clinical implications of viral mutations may contribute to improvement of diagnostic procedures,more proper planning of immunization programs and creating the most efficient therapeutic protocols.

关键词： Hepatitis B virus Hepatitis B virus variability Mutation Drug resistance Vaccine escape

Revisiting the theoretical prediction of the explosive performance found by the Trauzl test

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Defence Technology（防务技术） 2024年第6期36卷 163-174页

作者： ivana Dobrilovic Mario Dobrilovic Muhamed Suceska Faculty of Mining Geology and Petroleum EngineeringDepartment of Mining Engineering and GeotechnicsUniversity of ZagrebPierottijeva 6Zagreb10000Croatia

The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive charge in the cavity of a lead *** this paper,we reconsider the possibility of interpreting the Trauzl test results in terms of detonation parameters or *** detonation parameters used in the analysis are calculated using the thermochemical code EXPLO5,while the hydrocode AUTODYN is used to simulate the effect of explosive charge density and reaction rate on the results of the Trauzl *** increase in the volume of the lead block cavity was found to correlate best with the product of the detonation heat and the root of the volume of detonation *** simulation showed that the density of explosive charge and the rate of explosive decomposition affect the dynamics of the interaction of the detonation product and the lead block,and consequently the lead block cavity volume increase.

关键词： Trauzl lead block test Performance of explosives EXPLO5 AUTODYN Detonation heat

CHARACTERIZATIONS OF COMPACT OPERATORS ON SOME EULER SPACES OF DIFFERENCE SEQUENCES OF ORDER m

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Acta Mathematica Scientia 2011年第4期31卷 1465-1474页

作者： ivana Djolovi Eberhard Malkowsky Technical Faculty University of Belgrade Department of Mathematics Faculty of Science Fatih University

In the past, several authors studied spaces of m-th order difference sequences, among them, *** and *** （[17]） defined the Euler spaces of m-th order difference sequences e r 0 （△ （ m ））, e r c （△ （ m ）） and e r ∞ （△ （ m ）） and characterized some classes of matrix transformations on them. In our paper, we add a new supplementary aspect to their research by characterizing classes of compact operators on those spaces. For that purpose, the spaces are treated as the matrix domains of a triangle in the classical sequence spaces c 0 , c and ∞ . The main tool for our characterizations is the Hausdorff measure of noncompactness.

关键词： difference sequence spaces of order m matrix transformations compact operators Hausdorff measure of noncompactness

Higher doses of ascorbic acid may have the potential to promote nutrient delivery via intestinal paracellular absorption

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World Journal of Gastroenterology 2021年第40期27卷 6750-6756页

作者： ivana Roosevelt Sequeira Human Nutrition Unit School of Biological ScienceUniversity of AucklandAuckland 1024New Zealand

The significance of plasma ascorbic acid(AA)is underscored by its enzymatic and antioxidant properties as well as involvement in many aspects of health including the synthesis of biomolecules during acute illness,trauma and chronic health *** intake supports maintenance of optimal levels with supplementation at higher doses more likely *** increased intestinal paracellular permeability following high dose AA may be utilised to enhance delivery of other micronutrients across the intestinal *** potential mechanism following dietary intake however needs further study but may provide an avenue to increase small intestinal nutrient co transport and absorption,including in acute and chronic illness.

关键词： Aspirin Ascorbic acid Paracellular permeability Antioxidant Lactulose mannitol test

Conditional Probability on the Kpka's D-posets

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2197-2204页

作者： Karol SAMUELCÍK ivana HOLLÁ Department of Mathematics Faculty of Natural SciencesMatej Bel University

Kopka＇s D-poset is a very important notion in quantum structures. In this paper the conditional probability on the Kopka＇s D-posets is studied. The notion of conditional probability is introduced and the basic prope... 详细信息

关键词： Kopka's D-posers conditional probability on the Kopka's D-posers

Nanostructured Na-ion and Li-ion anodes for battery application： A comparative overview

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Nano Research 2017年第12期10卷 3942-3969页

作者： ivana Hasa Jusef Hassoun Stefano Passerini Helmholtz Institute UIm HelmholtzstraBe 11 UIm 89081 Germany Karlsruhe Institute of Technology (KIT) PO Box 3640 Karlsruhe 76021 Germany Department of Chemical and Pharmaceutical Sciences University of Ferrara via Fossato di Mortara Ferrara 44121 Italy Present address: Energy Storage and Distributed Resources Division Lawrence Berkeley National Laboratory I Cyclotron Road Berkeley CA 94720 USA

This paper offers a comprehensive overview on the role of nanostructures in the development of advanced anode materials for application in both lithium and sodium-ion batteries. In particular, this review highlights the differences between the two chemistries, the critical effect of nanosize on the electrode performance, as well as the routes to exploit the inherent potential of nanostructures to achieve high specific energy at the anode, enhance the rate capability, and obtain a long cycle life. Furthermore, it gives an overview of nanostructured sodium- and lithium-based anode materials, and presents a critical analysis of the advantages and issues associated with the use of nanotechnology.

关键词： nanomaterials sodium-ion batteries lithium-ion batteries anodes nanostructured materials

A need for stratification of metastasis samples according to secondary site in gene expression studies

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BIOCELL 2022年第7期46卷 1747-1750页

作者： ivana SAMARŽIJA Laboratory for Epigenomics Division of Molecular MedicineRuđer BoškovićInstituteZagreb10000Croatia Laboratory for Cell Biology and Signaling Division of Molecular BiologyRuđer BoškovićInstituteZagreb10000Croatia

Comparisons of gene expression profiles between primary tumors and metastasis have revealed genes that are implicated in metastasis ***,gene expression studies conducted on metastasis samples from the same primary site usually do not discriminate between different secondary *** the change in the expression of number of genes is expected to be common to metastasis from the same primary but different secondary sites,herein the data that point to substantial differences are ***,the reciprocal communication between metastatic and host cells that is influencing these differences is outlined to emphasize the need for stratification of metastasis samples in gene expression studies.

关键词： Bone metastasis Brain metastasis Liver metastasis Lung metastases Gene expression