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Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo JoséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da Silva ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos cesar Gonçalves Luciana Rossini Pinto Anete Pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil Department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

On Boolean Lattices of Module Classes

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Algebra Colloquium 2018年第2期25卷 285-294页

作者： Alejandro Alvarado-Garcia cesar Cejudo-Castilla Hugo Alberto Rincon-Mejia ivan Fernando Vilchis-Montalvo Manuel Gerardo Zorrilla-Noriega Facultad de Ciencias Universidad Nacional Autonoma de Mexico Circuito Exterior C.U. C.P. 04510 Ciudad de Mexico Mexico Facultad de Ciencias Fisico Matemdticas Benemerita Universidad Autonoma de Puebla Av. San Claudio y 18 Sur Col. San Manuel Ciudad Universitaria C.P. 72570 Puebla Mexico Facultad de Ciencias Universidad Nacional Autonoma de Mexico Circuito Exterior C.U. C.P. 04510 Ciudad de Mdxico Mdxico Facultad de Ciencias Ffsico Matematicas Benemerita Universidad Autonoma de Puebla Av. San Claudio y 18 Sur Coi. San Manuel Ciudad Universitaria C.P. 72570 Puebla Mexico

一些性质和在几之间的关系(大) 模块班的格子在这份报纸被使用关于模块在上被拿的戒指获得信息。作者到达每个扭转理论在上是世袭的小戒指， semisimple 戒指和某些戒指的描述。

关键词：模块格子戒指信息

Does bilioenteric anastomosis impair results of liver resection in primary intrahepatic lithiasis?

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World Journal of Gastroenterology 2010年第27期16卷 3423-3426页

作者： Paulo Herman Marcos V Perini Vincenzo Pugliese Julio cesar Pereira Marcel Autran C Machado William A Saad Luiz AC D'Albuquerque ivan Cecconello Department of Gastroenterology Hospital Das Clínicas-University of So Paulo Medical SchoolSo Paulo-SP-CEP 05403-000BrazilPaulo HermanPraa Santos Coimbra10So Paulo-SP-CEP 05614-050Brazil

AIM:To evaluate the long-term results of liver resection for the treatment of primary intrahepatic *** factors,especially the impact of bilioenteric anastomosis on recurrence of symptoms were ***:Forty one patients with intrahepatic stones and parenchyma fibrosis/atrophy and/or biliary stenosis were submitted to liver *** was associated with a Roux-en-Y hepaticojejunostomy in all patients with bilateral stones and in those with unilateral disease and dilation of the extrahepatic biliary duct(>2 cm).Late results and risk factors for recurrence of symptoms or stones were ***:There was no operative *** a mean follow-up of 50.3 mo,good late results were observed in 82.9% of patients;all patients submitted to liver resection alone and 58.8% of those submitted to liver resection and hepaticojejunostomy were free of symptoms(P=0.0006).Patients with unilateral and bilateral disease showed good late results in 94.1% and 28.6%,respectively(P<0.001).CONCLUSION:Recurrence of symptoms in patients with hepaticojejunostomy showed that this may not be the ideal *** studies are needed to establish the best treatment for patients with bilateral stones or unilateral disease and a dilated extrahepatic duct.

关键词： Biliary lithiasis Bilioenteric anastomosis Cholangitis Intrahepatic lithiasis Liver resection

Assessment of the Sensitivity of Soil Parameters in Sediment Production in the Ichu River Experimental Basin

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Journal of Environmental Science and Engineering(A) 2023年第1期12卷 1-13页

作者： ivan A.Ayala Bizarro Yunior AHuaman Paitan Marco Lopez Barrantes Jorge Ortega Vargas Omar Caballero sanchez Abdon Olivera Quintanilla cesar Jurado Mancha Jessica Zuniga Mendoza cesar Lifonzo Salcedo Faculty of Civil Engineering National University of HuancavelicaHuancavelica 09001Peru Faculty of Civil Engineering National University of San Cristobal of HuamangaAyacucho 05000Peru

This research aims to determine how much is the sensitivity of soil parameters in the production of sediments through the model distributed at the level of cells in the Ichu River Basin,which is located in the Andes of Peru,with an approximate surface area of 1,380.17 km2,corresponding to the control section and tributary to the Mantaro ***,for the evaluation of sensitivity determine the amount of sediments of the textures:silt,clay and *** achieve the objectives that have been raised in this research has been used the conceptual distributed hydrological model TETIS v9.1,which has been calibrated and validated using the climatic variables that are recorded at the hourly level in six weather stations and a hydrometric station,synthetic precipitation was also used withsatellite stations(CHIRPS)of the Climate Hazards Group that has registered with a grid of 0.05 degrees of resolution,from 1981 to the *** determine the solid component,the TETIS v9.1 model uses the equations developed in the CASCade 2 Dimensional SEDimentation model(CASC2D-SED)that presents conceptual approaches with physical *** sediment processes on slopes this CASC2D-SED model simulates in two dimensions,as well as helps to determine the quantification of sediments at any point in the basin considering all physical *** the other hand,the OpenLandMap data portal has been used for land cover data of the K factor corresponding to the susceptibility of the soil that can suffer losses due to ***,the Moderate Resolution Imaging Spectroradiometer(MODIS)observation system to determine the Normalized Difference Vegetation Indices(NDVI)for the culture factor *** parameter P corresponding to the conservation technique applied,has been developed using remote sensing techniques using the Google Earth Engine(GEE)***,the results obtained from the evaluation of the sensitivity of the parameters are significant,in this way the hypothesis that is raised is approv

关键词： Sediments distributed model CASC2D-SED model

Bowel adhesion and therapy with the stable gastric pentadecapeptide BPC 157,L-NAME and L-arginine in rats

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2020年第5期11卷 93-109页

作者： Lidija Berkopic cesar Slaven Gojkovic ivan Krezic Dominik Malekinusic Helena Zizek Lovorka Batelja Vuletic Andreja Petrovic Katarina Horvat Pavlov Domagoj Drmic Antonio Kokot Josipa Vlainic Sven Seiwerth Predrag Sikiric Department of Pharmacology School of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Pathology School of MedicineUniversity of ZagrebZagreb 10000Croatia Institute Ruder Boskovic Zagreb 10000Croatia

BACKGROUND After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats,there is failed vasculature,and finally,increased adhesion *** hypothesized that unlike nitric oxide(NO)-agents,L-NAME and/or L-arginine,the application of the stable gastric pentadecapeptide BPC 157 with its most recent vascular effects(“vascular recruitment”)means attenuated bowel adhesion formation and NO-and malondialdehyde(MDA)-tissue *** To focused on the bowel adhesion and the therapy with the BPC 157,its most and application of *** Along with defect creation,medication was(1)during surgery,once,at 1 min after defect creation as an abdominal bath(1 mL/rat),BPC 157(10μg/kg,10 ng/kg,1 mL/rat),an equivolume of saline,L-NAME(5 mg/kg),L-arginine(200 mg/kg)alone and/or ***,medication was(2)intraperitoneally once daily,first application at 30 min after surgery,last application 24 h before assessment at d 7 or d *** a postponed therapy to preexisting adhesion(3),BPC 157(10μg/kg,10 ng/kg intraperitoneally,1 mL/rat)was given once daily since d *** recovery effect of the BPC 157 regimens goes with the presence of abundant vascular vessels in and near the defect,which occurs ***,also applied as post-treatment,BPC 157 creates attenuated adhesions,minimal or no ***,NO-agents have diverse initial and final effects:The initial weakening of blood vessel disappearance and finally,severe worsening of adhesions(LNAME)vs the initial weakening of blood vessel disappearance and finally,attenuation of adhesions formation(L-arginine),which counteract each other response given ***,BPC 157 maintains its beneficial effect also when given with NO-agents(L-NAME+BC 157;L-arginine+BPC 157;L-NAME+L-arginine+BPC 157).Finally,with respect to the increased NO-and MDAvalues-adhesion tissue formation relation,unlike diverse effect of the NO-agents,the BPC 157 application effect regularly

关键词： Abdominal wall defect Adhesions BPC 157 Vascular recruitment Nitric oxide-agents Rats

Surgical treatment of fibrolamellar hepatocellular carcinoma:an underestimated malignant tumor?

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 618-621页

作者： Paulo Herman Aline Lopes Chagas Marcos Vinicius Perini Fabricio Ferreira Coelho Gilton Marques Fonseca Venancio Avancini Ferreira Alves Flair José Carrilho ivan Cecconello Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Department of Pathology University of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil

BACKGROUND： Fibrolamellar hepatocellular carcinoma （FLHCC） is a rare disease with an indolent behavior. Its prognosis is better than that of patients with hepatocellular carcinoma. The authors present their experience with resection of FLHCC. METHODS： Twenty-one patients with FLHCC were treated at our institution between 1990 and 2012. Of these patients, 14 were subjected to resection of the tumor. Patient demographics, medical history, results of imaging studies and laboratory tests, surgical data, and pathologic findings were evaluated. RESULTS： The median age of the patients at the diagnosis of the tumor was 20 years and 14 patients were female. None of the patients had tumor-associated chronic liver disease or cirrhosis. The mean tumor size was 12.8 cm （range 6-19） and 18 patients had a single liver nodule. Fourteen patients were subjected to hepatectomy and six of them had lymph node metastases resected. Pathologic evaluation revealed that 5 （35.7%） patients had major vascular invasion. Tumor recurrence was seen in 8 patients （66.7%）, during a follow-up. The median survival time for patients who were subjected to resection was 36 months. The 5-year overall survival rate and disease free survival rate were 28.0% and 8.5%, respectively. Univariate analysis showed that vascular invasion was the only variable associated with the disease free survival ***： Despite an aggressive treatment, patients with FLHCC presented unexpected low survival rates. It seems that an underestimated malignant behavior is attributed to this disease, and that the forms of adjuvant treatment should be urgently evaluated.

关键词： fibrolamellar hepatocellular carcinoma hepatectomy hepatocellular carcinoma lymph node excision survival

Optimization of the Design of Structures in Coverage Using the Genetic Algorithm Method

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Journal of Environmental Science and Engineering(A) 2019年第5期8卷 193-202页

作者： Marco Lopez Barrantes ivan Ayala Bizarro Kevin Escobar Curasma Rocky Ayala Bizarro Pedro Palomino Pastrana cesar Jurado Mancha Department of Civil Engineering National University of HuancavelicaHuancavelica 09001Peru

In this research work,an optimization of the design of steel structures is developed through Genetic Algorithms(Gas)with the objective of reducing the amount of material and with them the cost,for which the programming of the GAs tool in the Fortran programming language with the SAP2000 Application Programming Interface(API)v.19 using Visual Studio Professional 2015-Intel?Visual Fortran with Parallel Studio *** GAs method consists of randomly searching the Objective Function(OF)of the optimal variables with *** OF defined by the weight of the structure,the variables in relation to the cross sections of the structural elements and the constraints are the design of resistance using the method of Load and Resistance Factor Design(LRFD),restriction of displacements and restriction of the ratio of slenderness considered in the National Building Regulations(RNE),whose GAs search parameters are given by probability of crossing 70%by simple crossing strategy,probability of mutation 20%,elitism of 5%and maximum number of generations according to the *** examined metal structure is a cover with five double-body warren arches with 32 m light connected with 24 joists both with welded connections,that is,*** metal structure was evaluated on demand for loads(dead load,live load,snow load,wind load and earthquake loads).The structural design was carried out with the following profiles:circular,tubular,square,angular and Normal Profile with I-shaped section(IPN)of which the most optimal was the tubular *** outer diameters of the cross section are:diagonal with a diameter of 1 in,lower flange with a diameter of 23/8 in,upper flange with a diameter of 11/2 in,inner belt with a diameter of 1 in and *** with a diameter of 11/2 in.

关键词： GA structure optimization resistance design with artificial intelligence design by resistance bending buckling