检索结果-南通市图书馆

Effects of 12 weeks of power-oriented resistance training plus high-intensity interval training on metabolic syndrome factors in older people with COPD

在线全文

学校读者我要写书评

暂无评论

Translational Exercise Biomedicine

Translational Exercise Biomedicine 2024年第1期1卷 23-31页

作者： Lucia Romero-Valia ivan baltasar-fernandez Carlos Rodriguez-Lopez Jose Losa-Reyna Ana Alfaro-Acha Amelia Guadalupe-Grau Ignacio Ara Luis M.Alegre Francisco J.García-García Julian Alcazar GENUD Toledo Research Group Faculty of Sports SciencesUniversidad de Castilla-La ManchaToledoSpainCarlos III S/N-45071 CIBER on Frailty and Healthy Ageing(CIBERFES) Instituto de Salud Carlos IIIMadridSpain28029 Instituto de Investigación Sanitaria de Castilla-La Mancha(IDISCAM) Junta de Comunidades de Castilla-La Mancha(JCCM)ToledoSpain45071 Geriatric Department Hospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)MadridSpain Valoración del Rendimiento Deportivo Actividad Física y Salud y Lesiones Deportivas(REDAFLED)Universidad de ValladolidSoriaSpain Department of Geriatrics Hospital Virgen del ValleComplejo Hospitalario Universitario de ToledoToledoSpain

Objectives To assess the effects of an exercise training program combining power-oriented resistance training(RT)and high-intensity interval training(HIIT)on metabolic syndrome(MetS)markers in older people with *** Twenty-nine older people(66–90 years old)with COPD were randomly assigned to 12 weeks of exercise training(ET;power-oriented RT+HIIT)or a control group(CON).Waist circumference,diastolic(DBP)and systolic blood pressure(SBP),and serum fasting glucose,triglycerides and HDL cholesterol levels were assessed at baseline and after 12 *** mixed-effects models were used to assess the effects of the intervention,and data were reported as mean and 95%confidence interval *** Waist circumference increased in the CT group,but not in the ET group(2.0[0.2,3.7]vs.1.0[−1.3,3.2]cm,respectively).No changes in fasting glucose(−4.1[−10.3,2.1]vs.−1.0[−8.7,6.7]mg dL−1),triglycerides(3.9[−13.4,21.3]vs.−13.9[−35.6,7.7]mg dL−1)or HDL cholesterol(1.0[−3.4,5.4]vs.2.9[−2.6,8.4]mg dL−1)were found in the CT or ET group,*** ET group exhibited decreased DBP(−5.2[−9.5,−0.8]mmHg)and SBP(−2.7[−22.7,−2.7]mmHg),while no changes were found in the CT group(0.3[−3.2,3.7]and−3.5[−11.4,4.5]mmHg).MetS z-score declined in ET but remained unchanged in CT(−0.88[−1.74,−0.03]vs.0.07[−0.62,0.76],respectively).Conclusions A 12-week exercise training program led to a reduction in blood pressure and MetS z-score in older people with COPD.

关键词： chronic obstructive pulmonary disease lung disease pulmonary rehabilitation concurrent training randomized controlled trial

Neuroprotective therapy for retinal neurodegenerative diseases by stem cell secretome

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第1期16卷 117-118页

作者： Ricardo Usategui-Martín ivan fernandez-Bueno Instituto Universitario de Oftalmobiología Aplicada(IOBA) Retina GroupUniversidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León Red Temática de Investigación Cooperativa en SaludOftaredInstituto de Salud Carlos IIIValladolidSpain

Retinal neurodegenerative diseases like agerelated macular degeneration,glaucoma,diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness *** had been estimated that the prevalence of these diseases varies between 1/750 and 1/5000 depending on the region,the level of consanguinity or ethnicity(Na et al.,2017).The functional and structural complexity of the retina makes it susceptible to multiple types of pathogenic damage.

关键词： diseases protective degenerative

Ocular findings in Zucker Diabetic Fatty rats emphasize the key role of neuroglia degeneration in diabetic retinopathy pathophysiology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第2期13卷 239-240页

作者： ivan fernandez-bueno yolanda diebold instituto universitario de oftalmobiología aplicada university of valladolidValladolidSpain red temática de investigación cooperativa en salud(retics) oftaredinstituto de salud carlos IIIMadridSpain biomedical research networking center on bioengineering biomaterials and nanomedicineciber-bbnValladolidSpain

Diabetes mellitus is a leading cause of acquired vision loss and one of the world＇s fastest growing chronic diseases. Diabetic retinopathy （DR）, a specific complication of chronic hyperglycemia, is the leading cause of acquired vision loss worldwide in middle-aged and there- fore economically active people that also increases the medical and economic burden on the society （Klein, 2007）.

关键词： Ocular findings in Zucker Diabetic Fatty rats emphasize the key role of neuroglia degeneration in diabetic retinopathy pathophysiology

Phylogenetic Relationships of 3/3 and 2/2 Hemoglobins in Archaeplastida Genomes to Bacterial and Other Eukaryote Hemoglobins

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2011年第1期4卷 42-58页

作者： Serge N. Vinogradov ivan fernandez David Hoogewijs Rail Arredondo-Peter Department of Biochemistry and Molecular Biology Wayne State University School of Medicine Detroit MI 48201 USA Laboratorio de Biofisica y Biologia Molecular Facultad de Ciencias Universidad Autonoma del Estado de Morelos 62210 Cuernavaca Morelos Mexico Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP) University of Zurich Zurich Switzerland

Land plants and algae form a supergroup, the Archaeplastida, believed to be monophyletic. We report the results of an analysis of the phylogeny of putative globins in the currently available genomes to bacterial and other eu- karyote hemoglobins （Hbs）. Archaeplastida genomes have 3/3 and 2/2 Hbs, with the land plant genomes having group 2 2/ 2 Hbs, except for the unexpected occurrence of two group 1 2/2 Hbs in Ricinus communis. Bayesian analysis shows that plant 3/3 Hbs are related to vertebrate neuroglobins and bacterial flavohemoglobins （FHbs）. We sought to define the bacterial groups, whose ancestors shared the precursors of Archaeplastida Hbs, via Bayesian and neighbor-joining anal- yses based on COBALTalignment of representative sets of bacterial 3/3 FHb-like globins and group I and 2 2/2 Hbs with the corresponding Archaeplastida Hbs. The results suggest that the Archaeplastida 3/3 and group 1 2/2 Hbs could have orig- inated from the horizontal gene transfers （HGTs） that accompanied the two generally accepted endosymbioses of a pro- teobacterium and a cyanobacterium with a eukaryote ancestor. In contrast, the origin of the group 2 212 Hbs unexpectedly appears to involve HGT from a bacterium ancestral to Chloroflexi, Deinococcales, Bacilli, and Actinomycetes. Furthermore, although intron positions and phases are mostly conserved among the land plant 3/3 and 2/2 globin genes, introns are absent in the algal 3/3 genes and intron positions and phases are highly variable in their 2/2 genes. Thus, introns are irrelevant to globin evolution in Archaeplastida.

关键词： Algae Archaeplastida evolution hemoglobin land plants truncated Hbs

Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第9期15卷 1631-1638页

作者： Kevin Puertas-Neyra Ricardo Usategui-Martín Rosa MCoco ivan fernandez-Bueno Instituto Universitario de Oftalmobiologia Aplicada Universidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leon ValladolidSpain Red Tematica de Investigacion Cooperativa en Salud OftaredInstituto de Salud CarlosⅢValladolidSpain

Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients' daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.

关键词： clinical trials growth factors intraocular injection intravitreal injection neuroprotection paracrine properties photoreceptors preclinical models retinal diseases stem cells

Experimental control of optical helicity in nanophotonics

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2014年第1期3卷 166-172页

作者： Nora Tischler ivan fernandez-Corbaton Xavier Zambrana-Puyalto Alexander Minovich Xavier Vidal Mathieu L Juan Gabriel Molina-Terriza ARC Centre for Engineered Quantum Systems Department of Physics&AstronomyMacquarie UniversitySydneyNSW 2109Australia Department of Physics&Astronomy Macquarie UniversitySydneyNSW 2109Australia Nonlinear Physics Centre and Centre for Ultrahigh-bandwidth Devices for Optical Systems(CUDOS) Research School of Physics and EngineeringThe Australian National UniversityCanberraACT 0200Australia

An analysis of light–matter interactions based on symmetries can provide valuable insight,particularly because it reveals which quantities are conserved and which ones can be transformed within a physical *** this context,helicity can be a useful addition to more commonly considered observables such as angular *** question arises how to treat helicity,the projection of the total angular momentum onto the linear momentum direction,in practical *** this paper,we put forward a simple but versatile experimental treatment of *** then apply the proposed method to the scattering of light by isolated cylindrical nanoapertures in a gold *** allows us to study the helicity transformation taking place during the interaction of focused light with the *** particular,we observe from the transmitted light that the scaling of the helicity transformed component with the aperture size is very different to the direct helicity component.

关键词： helicity nanoaperture nanophotonics optics symmetry

REGULARITY FOR A GENERALIZED JEFFREY'S INTEGRAL MODEL FOR VISCOELASTIC FLUIDS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2015年第6期35卷 1251-1284页

作者： ivan SOUKUP Department of Numerical Mathematics Faculty of Mathematics and PhysicsCharles University in Prague

We prove a local existence of a strong solution v ：Ω×T→R^3 for a system of nonlinear integrodifferential equations describing motion of an incompressible viscoelastic fluid using standard mathematical tools. The problem is considered in a bounded, smooth domain ΩСR^3 with a Dirichlet boundary condition and a standard initial condition.

关键词： integral model viscoelastic fluid strong solution

Topology of Moment-Angle Manifolds Arising from Flag Nestohedra

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2017年第6期38卷 1287-1302页

作者： ivan LIMONCHENKO School of Mathematical Sciences Fudan UniversityShanghai 200433China.

The author constructs a family of manifolds, one for each n ≥ 2, having a nontrivial Massey n-product in their cohomology for any given n. These manifolds turn out to be smooth closed 2-connected manifolds with a compact torus Tm-action called momentangle manifolds ZP, whose orbit spaces are simple n-dimensional polytopes P obtained from an n-cube by a sequence of truncations of faces of codimension 2 only(2-truncated cubes). Moreover, the polytopes P are flag nestohedra but not graph-associahedra. The author also describes the numbers β^(-i,2(i+1))(Q) for an associahedron Q in terms of its graph structure and relates it to the structure of the loop homology(Pontryagin algebra)H_*(?ZQ), and then studies higher Massey products in H*(ZQ) for a graph-associahedron Q.

关键词： Moment-angle manifold Flag nestohedra Stanley-Reisner ring Masseyproducts Graph-associahedron

From neurogenesis to neuronal regeneration: the amphibian olfactory system as a model to visualize neuronal development in vivo

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第6期10卷 872-874页

作者： ivan Manzini Institute of Neurophysiology and Cellular Biophysics University of Gottingen Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)

How do individual neurons develop and how are they in- tegrated into neuronal circuitry？ To answer this question is essential to understand how the nervous system develops and how it is maintained during the adult life. A neural stem cell must go through several stages of maturation, including proliferation, migration, differentiation, and integration, to become fully embedded to an existing neuronal circuit. The knowledge on this topic so far has come mainly from cell culture studies. Studying the development of individual neurons within intact neuronal networks in vivo is inherently difficult. Most neurons are generated form neural stem cells during embryonic and early postnatal development.

关键词： the amphibian olfactory system as a model to visualize neuronal development in vivo Figure