From neurogenesis to neuronal regeneration: the amphibian olfactory system as a model to visualize neuronal development in vivo

作     者：Ivan Manzini 

作者机构：Institute of Neurophysiology and Cellular BiophysicsUniversity of Gottingen Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第6期

页      面：872-874页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 10[医学] 

基　　金：supported by DFG Schwerpunkt program 1392(project MA 4113/2-2) cluster of Excellence and DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain(project B1-9) the German Ministry of Research and Education(BMBF project 1364480) 

主　　题：the amphibian olfactory system as a model to visualize neuronal development in vivo Figure 

摘      要：How do individual neurons develop and how are they in- tegrated into neuronal circuitry？ To answer this question is essential to understand how the nervous system develops and how it is maintained during the adult life. A neural stem cell must go through several stages of maturation, including proliferation, migration, differentiation, and integration, to become fully embedded to an existing neuronal circuit. The knowledge on this topic so far has come mainly from cell culture studies. Studying the development of individual neurons within intact neuronal networks in vivo is inherently difficult. Most neurons are generated form neural stem cells during embryonic and early postnatal development.