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Fulminant Hepatitis Associated with Chronic Consumption of 3,4-Methylenedioxy-Methamphetamine;Case Report

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Open Journal of Gastroenterology 2024年第5期14卷 161-166页

作者： Ulises Solis Gomez Gustavo Adolfo Hernández Valdez Juan Antonio Contreras Escamilla ivan Alejandro Medina Jimenez Jorge Morales Rojas Jocelyn Nataly Quintero Melendez Marco Antonio González Villar Department of Internal Medicine ISSSTE APP General Hospital of Tepic Tepic Nayarit Mexico

The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA), also called ecstasy, is a neurotoxin widely consumed among young people that has increased in recent years because it is a recreational drug, of which immediate effects are known such as a greater sensation of well-being, extroversion, increased sensory perception. However, its long-term effects have been described very little in the medical literature, including damage to the heart, central nervous system, kidney, etc. One of its little-known effects is hepatotoxicity, of which few cases are known associated with fulminant hepatitis, which is a rapidly deteriorating condition that is generally associated with a syndrome of multiple organ dysfunction and death. Therefore, it is very important to know this type of damage in the short and long term. The following case is of a 39-year-old man who came to our service due to jaundice syndrome and the only history of MDMA consumption, who as the days went by met the criteria for fulminant liver failure, with damage to multiple organs (organ dysfunction syndrome).

关键词： Fulminant Hepatitis Acute Liver Failure Methamphetamine Severe Acute Liver Failure in a User of Drugs of Abuse Hepatology

Topology of Moment-Angle Manifolds Arising from Flag Nestohedra

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1287-1302页

作者： ivan LIMONCHENKO School of Mathematical Sciences Fudan UniversityShanghai 200433China.

The author constructs a family of manifolds, one for each n ≥ 2, having a nontrivial Massey n-product in their cohomology for any given n. These manifolds turn out to be smooth closed 2-connected manifolds with a compact torus Tm-action called momentangle manifolds ZP, whose orbit spaces are simple n-dimensional polytopes P obtained from an n-cube by a sequence of truncations of faces of codimension 2 only(2-truncated cubes). Moreover, the polytopes P are flag nestohedra but not graph-associahedra. The author also describes the numbers β^(-i,2(i+1))(Q) for an associahedron Q in terms of its graph structure and relates it to the structure of the loop homology(Pontryagin algebra)H_*(?ZQ), and then studies higher Massey products in H*(ZQ) for a graph-associahedron Q.

关键词： Moment-angle manifold Flag nestohedra Stanley-Reisner ring Masseyproducts Graph-associahedron

From neurogenesis to neuronal regeneration: the amphibian olfactory system as a model to visualize neuronal development in vivo

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Neural Regeneration Research 2015年第6期10卷 872-874页

作者： ivan Manzini Institute of Neurophysiology and Cellular Biophysics University of Gottingen Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)

How do individual neurons develop and how are they in- tegrated into neuronal circuitry？ To answer this question is essential to understand how the nervous system develops and how it is maintained during the adult life. A neural stem cell must go through several stages of maturation, including proliferation, migration, differentiation, and integration, to become fully embedded to an existing neuronal circuit. The knowledge on this topic so far has come mainly from cell culture studies. Studying the development of individual neurons within intact neuronal networks in vivo is inherently difficult. Most neurons are generated form neural stem cells during embryonic and early postnatal development.

关键词： the amphibian olfactory system as a model to visualize neuronal development in vivo Figure

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海子诗歌俄译的经验与思考

俄罗斯文艺 2024年第4期 124-137页

作者： [俄]易宁吴婵艳北京师范大学文学院首都师范大学外国语学院

2021年由笔者译注的海子诗选(《火焰内部:海子的诗》)在俄出版,本文基于笔者的翻译实践探讨海子诗歌译介相关问题:第一部分介绍译者的选诗策略;第二部分说明翻译的两种取向;第三部分分析译著对当代汉诗俄译的意义。在选诗过程中,译者采... 详细信息

2021年由笔者译注的海子诗选(《火焰内部:海子的诗》)在俄出版,本文基于笔者的翻译实践探讨海子诗歌译介相关问题:第一部分介绍译者的选诗策略;第二部分说明翻译的两种取向;第三部分分析译著对当代汉诗俄译的意义。在选诗过程中,译者采取了侧重诗人研究与侧重作品本身的两种选诗方案。与之相应,译著中的诗歌翻译呈现出“研究性”和“审美性”的两种取向。最后,基于当代汉诗在俄传播与译介现状,笔者认为,译著《火焰内部:海子的诗》属于当代汉诗俄译过程的中间阶段。而译者对翻译过程的反思则为俄汉诗歌翻译提供了参考和借鉴。

关键词：海子文学传播诗歌翻译俄语诗律

Experimental and calculated liquid-liquid interfacial tension in demixing metal alloys

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Rare Metals 2006年第5期25卷 452-456页

作者： Walter Hoyer ivan Kaban Institute of Physics Chemnitz University of Technology D-09107 ChemnitzGermany

Liquid-liquid interracial tension in binary and temary Al-based monotectic systems has been determined experimentally with a tensiometric method in a wide temperature interval. The temperature dependence of the interfacial tension is well described by a power law function of the type σαβ - （1 - T/Tc）δ with the critical exponent δ= 1.3 and a critical temperature Tc. Theoretical models describing the liquid-liquid interface in monotectic alloys and their applicability for calculation of the interfacial tension and its temperature dependence in binary systems are considered.

关键词： immiscible systems Al-based alloys interracial tension

Effects of pre-existing cracks and infillings on strength of natural rocks--Cases of sandstone, argillite and basalt

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1333-1338页

作者： Chen Cui ivan Gratchev School of Engineering Griffith UniversityGold CoastAustralia

This study aims to examine the influence of pre-existing discontinuities on the strengths of four natural rocks of different origins.A series of unconfined compression tests was performed on specimens of two types of sandstones,argillite and basalt that contain open and filled *** was found that the presence of cracks tends to decrease the overall strength for all studied rocks;however,the magnitude of strength reduction is related to the property of *** larger strength decrease was observed for the relatively harder argillite and basalt,compared to the softer *** was also found that the infill material could increase the strength of rock specimens,while the obtained strength depended on the characteristics of the fill material.

关键词： Pre-existing crack Rock strength Infill material Laboratory test

Purinergic Modulation of Activity in the Developing Auditory Pathway

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Neuroscience Bulletin 2020年第11期36卷 1285-1298页

作者： Sasa Jovanovic ivan Milenkovic School of Medicine and Health Sciences Carl von Ossietzky University Oldenburg26129 OldenburgGermany

Purinergic P2 receptors,activated by endogenous ATP,are prominently expressed on neuronal and nonneuronal cells during development of the auditory periphery and central auditory *** the mature cochlea,extracellular ATP contributes to ion homeostasis,and has a protective function against noise ***,we focus on the modulation of activity by extracellular ATP during early postnatal development of the lower auditory *** mammals,spontaneous patterned activity is conveyed along afferent auditory pathways before the onset of acoustically evoked signal *** this critical developmental period,inner hair cells fire bursts of action potentials that are believed to provide a developmental code for synaptic maturation and refinement of auditory circuits,thereby establishing a precise tonotopic *** ATP-release triggers such patterned activity by raising the extracellular K+concentration and contributes to firing by increasing the excitability of auditory nerve fibers,spiral ganglion neurons,and specific neuron types within the auditory brainstem,through the activation of diverse P2 *** review recent studies that provide new models on the contribution of purinergic signaling to early development of the afferent auditory ***,we discuss potential future directions of purinergic research in the auditory system.

关键词： Purinergic signaling Auditory system Development Cochlea Spiral ganglion Auditory brainstem

Dry powder platform for pulmonary drug delivery

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Particuology 2008年第4期6卷 225-238页

作者： Derek ivan Daniher Jesse Zhu Graduate Program in Biomedical Engineering Department of Chemical and Biochemical EngineeringThe University of Western OntarioLondonOntarioCanada

The phenomenon of particle interaction involved in pulmonary drug delivery belongs to a wide variety of disciplines of particle technology, in particular, fluidization. This paper reviews the basic concepts of pulmonary drug delivery with references to fluidization research, in particular, studies on Geldart group C powders. Dry powder inhaler device-formulation combination has been shown to be an effective method for delivering drugs to the lung for treatment of asthma, chronic obstructive pulmonary disease and cystic fibrosis. Even with advanced designs, however, delivery efficiency is still poor mainly due to powder dispersion problems which cause poor lung deposition and high dose variability. Drug particles used in current inhalers must be 1–5 μm in diameter for effective deposition in small-diameter airways and alveoli. These powders are very cohesive, have poor flowability, and are difficult to disperse into aerosol due to cohesion arising from van der Waals attraction. These problems are well known in fluidization research, much of which is highly relevant to pulmonary drug delivery.

关键词： Dry powder inhaler Interparticle forces Aerosol Pulmonary drug delivery Carrier particle Fluidization

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma