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Elderly patients over 80 years undergoing colorectal cancer resection: Development and validation of a predictive nomogram for survival

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 892-905页

作者： Aik Yong Chok Yun Zhao Hui Lionel Raphael Chen ivan en-howe tan Desmond Han Wen Chew Yue Zhao Marianne Kit Har Au Emile John Kwong Wei tan Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Group Finance Analytics Singapore Health ServicesSingapore 168582Singapore Group Finance Singapore Health ServicesSingapore 168582Singapore Singhealth Community Hospitals Singapore 168582Singapore

BACKGROUND Surgery remains the primary treatment for localized colorectal cancer(CRC).Improving surgical decision-making for elderly CRC patients necessitates an accurate predictive *** To build a nomogram to predict the overall survival of elderly patients over 80 years undergoing CRC *** Two hundred and ninety-five elderly CRC patients over 80 years undergoing surgery at Singapore General Hospital between 2018 and 2021 were identified from the American College of Surgeons–National Surgical Quality Improvement Program(ACS-NSQIP)*** variables were selected using univariate Cox regression,and clinical feature selection was performed by the least absolute shrinkage and selection operator regression.A nomogram for 1-and 3-year overall survival was constructed based on 60%of the study cohort and tested on the remaining 40%.The performance of the nomogram was evaluated using the concordance index(C-index),area under the receiver operating characteristic curve(AUC),and calibration *** groups were stratified using the total risk points derived from the nomogram and the optimal cut-off *** curves were compared between the high-and low-risk *** Eight predictors:Age,Charlson comorbidity index,body mass index,serum albumin level,distant metastasis,emergency surgery,postoperative pneumonia,and postoperative myocardial infarction,were included in the *** AUC values for the 1-year survival were 0.843 and 0.826 for the training and validation cohorts,*** AUC values for the 3-year survival were 0.788 and 0.750 for the training and validation cohorts,respectively.C-index values of the training cohort(0.845)and validation cohort(0.793)suggested the excellent discriminative ability of the *** curves demonstrated a good consistency between the predictions and actual observations of overall survival in both training and validation cohorts.A significant difference in overall survival wa

关键词： Colorectal cancer Elderly Nomogram Overall survival Prognostic Risk stratification

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Acute hospital-community hospital care bundle for elderly orthopedic surgery patients:A propensity score-matched economic analysis

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World Journal of Orthopedics 2023年第4期14卷 231-239页

作者： ivan en-howe tan Aik Yong Chok Yun Zhao Yonghui Chen Chee Hoe Koo Junjie Aw Mave Hean Teng Soh Chek Hun Foo Kwok Ann Ang Emile John Kwong Wei tan Andrew Hwee Chye tan Marianne Kit Har Au Group Finance Singapore Health ServicesSingapore 168582Singapore Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Post-Acute and Continuing Care Family MedicineOutram Community HospitalSingapore 168582Singapore Finance Singapore General HospitalSingapore 169608Singapore Department of Orthopedic Surgery Singapore General HospitalSingapore 169856Singapore Singhealth Community Hospital Singapore 168582Singapore

BACKGROUND While Singapore attains good health outcomes,Singapore’s healthcare system is confronted with bed shortages and prolonged stays for elderly people recovering from surgery in acute *** Acute Hospital-Community Hospital(AHCH)care bundle has been developed to assist patients in postoperative *** core concept is to transfer patients out of AHs when clinically recommended and into CHs,where they can receive more beneficial dedicated care to aid in their recovery,while freeing up bed capacities in *** To analyze the AH length of stay(LOS),costs,and savings associated with the AH-CH care bundle intervention initiated and implemented in elderly patients aged 75 years and above undergoing elective orthopedic *** A total of 8621:1 propensity score-matched patients aged 75 years and above who underwent elective orthopedic surgery in Singapore General Hospital(SGH)before(2017-2018)and after(2019-2021)the care bundle intervention period was *** measures were AH LOS,CH LOS,hospitalization metrics,postoperative 30-d mortality,and modified Barthel Index(MBI)*** costs of AH inpatient hospital stay in the matched cohorts were compared using cost data in Singapore *** Of the 862 matched elderly patients undergoing elective orthopedic surgery before and after the care bundle intervention,the age distribution,sex,American Society of Anesthesiologists classification,Charlson Comorbidity Index,and surgical approach were comparable between both *** transferred to CHs after the surgery had a shorter median AH LOS(7 d vs 9 d,Pent cost per patient was 14.9%less for the elderly group transferred to CHs(S$24497.3 vs S$28772.8,Pents within the care bundle were low,with a 0%mortality rate following orthopedic *** elderly patients were discharged from CHs,their MBI scores increased significantly(50.9 vs 71.9,P<0.

关键词： Care bundle Community hospital Orthopedic surgery Cost-effectiveness Care transition Intervention

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Method for passivation of propellant residues in orbital stage tank of launch vehicle

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Chinese Journal of Aeronautics 2024年第1期37卷 64-76页

作者： Valeriy TRUSHLYAKOV ivan LESNYAK Alexey PANICHKIN Department of Aviation and Rocket Building Omsk State Technical UniversityOmsk 644050Russia Sobolev Institute of Mathematics of the Siberian Branch of Russian Academy of Sciences Novosibirsk 630090Russia

The problem of removing unused liquid propellant residues from the tanks of spent spacecraft and orbital stages of Launch Vehicles(LV)leads to their explosion and the formation of space debris in *** provide a solution to this problem,a method for removing liquid propellant residues from the LV tanks after the mission completion is *** method is based on the gasification of liquid propellant residues in the tanks under acoustic-vacuum exposure and the discharge of the gasification products into the surrounding outer *** investigations were carried out on a Ground-based Experimental Installation(GEI)to determine the coefficient of heat transfer from the surface of an acoustic radiator to a *** obtained coefficient was then used to calculate the energy costs for the gasification of *** estimates are given on the example of the tank with kerosene residues from a spent second stage of the LV“Soyuz-2.1 v”.The optimal discharge rate at which kerosene does not freeze is 0.14 m^(3)/***,the acoustic exposure leads to an increase in the mass of evaporated kerosene over a given time by96.1%,and the energy costs are 1756.7 kJ(approximately 50% of the remaining electrical energy).

关键词： Propellant Weightlessness Liquid evaporation Heat and mass transfer Acoustics Vacuum Vapor bubbles

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Oscillatory Dynamics of a Spherical Solid in a Liquid in an Axisymmetric Variable Cross Section Channel

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1219-1232页

作者： ivan Karpunin Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPerm614990Russia

The dynamics of a solid spherical body in an oscillating liquid flow in a vertical axisymmetric channel of variable cross section is experimentally *** is shown that the oscillating liquid leads to the generation of intense averaged flows in each of the channel *** intensity and direction of these flows depend on the dimensionless oscillating *** the region of studied frequencies,the dynamics of the considered body is examined when the primary vortices emerging in the flow occupy the whole region in each *** a fixed frequency,an increase in the oscillation amplitude leads to a phase-inclusion holding effect,i.e.,the body occupies a quasi-stationary position in one of the cells of the vertical channel,while oscillating around its average *** is also shown that the oscillating motion of a liquid column generates an averaged force acting on the body,the magnitude of which depends on the properties of the body and its position in the *** quasi-stationary position is determined by the relative density and size of the body,as well as the dimensionless *** behavior of the body as a function of the amplitude and frequency of fluid oscillation and relative size is discussed in *** findings may be used in the future to control the position of a phase inclusion and/or to strengthen mass transfer effects in a channel of variable cross section by means of fluid oscillations.

关键词： Phase inclusion axisymmetric channel variable cross section oscillations dimensionless frequency averaged force viscous boundary layer

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Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČEK Petr ŠPERKA ivan KŘUPKA Faculty of Mechanical engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

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Applying the Shearlet-Based Complexity Measure for Analyzing Mass Transfer in Continuous-Flow Microchannels

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1743-1758页

作者： Elena Mosheva ivan Krasnyakov Institute of Continuous Media Mechanics UB RAS Perm614013Russia Department of Applied Physics Perm National Research Polytechnic UniversityPerm614990Russia

Continuous-flow microchannels are widely employed for synthesizing various materials,including nanoparticles,polymers,and metal-organic frameworks(MOFs),to name a *** technology allows precise control over reaction parameters,resulting in purer,more uniform,and structurally stable products due to more effective mass transfer ***,continuous-flow synthesis processes may be accompanied by the emergence of spatial convective structures initiating convective *** the one hand,convection can accelerate reactions by intensifying mass *** the other hand,it may lead to non-uniformity in the final product or defects,especially in MOF microcrystal *** ability to distinguish regions of convective and diffusive mass transfer may be the key to performing higher-quality reactions and obtaining purer *** this study,we investigate,for the first time,the possibility of using the information complexity measure as a criterion for assessing the intensity of mass transfer in microchannels,considering both spatial and temporal non-uniformities of liquid’s distributions resulting from convection *** calculate the complexity using shearlet transform based on a local *** contrast to existing methods for calculating complexity,the shearlet transform based approach provides a more detailed representation of local *** analysis involves experimental images illustrating the mixing process of two non-reactive liquids in a Y-type continuous-flow microchannel under conditions of double-diffusive convection *** obtained complexity fields characterize the mixing process and structure formation,revealing variations in mass transfer intensity along the *** compare the results with cases of liquid mixing via a pure diffusive *** analysis,it was revealed that the complexity measure exhibits sensitivity to variations in the type of mass transfer,establishing its feasibility as an ind

关键词： Shearlet analysis complexity measure entropy measure convection microchannels double-diffusive instability

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren tan Mary C.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee ivan C.C.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance Centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and Technological enterprise(CREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity Cognition Heat stress Hyperthermia Motor function

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Three-Dimensional Convection in an Inclined Porous Layer Subjected to a Vertical Temperature Gradient

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Fluid Dynamics & Materials Processing 2024年第9期20卷 1957-1970页

作者： ivan Shubenkov Tatyana Lyubimova Evgeny Sadilov Computational Fluid Dynamics Laboratory Institute of Continuous Media Mechanics UB RASPerm614068Russia Theoretical Physics Department Perm State UniversityPerm614990Russia

In this paper,we study the onset and development of three-dimensional convection in a tilted porous layer saturated with a *** layer is subjected to a gravitational field and a strictly vertical temperature ***,problems of thermal convection in tilted porous media saturated with a liquid are studied by assuming constant different temperatures at the boundaries of the layer,which prevent these systems from supporting conductive(non-convective)*** boundary conditions considered in the present work allow a conductive state and are representative of typical geological *** an earlier work,we carried out a linear stability analysis of the conductive *** was shown that at any layer tilt angles,the most dangerous type of disturbances are longitudinal ***,a non-zero velocity component exists in *** the present work,threedimensional non-linear convection regimes are *** original three-dimensional problem is reduced to two-dimensional one with an analytical expression for the velocity z-component v_(z)=v_(z)(x,y).It is shown that the critical Rayleigh number values obtained through numerical solutions of the obtained 2D problem by a finite difference method for different layer inclination angles,are in a good agreement with those predicted by the linear *** number of convective rolls realized in nonlinear calculations also fits the linear theory predictions for a given cavity *** carried out at low supercriticalities show that a direct bifurcation takes *** increasing supercriticality,no transitions to other convective regimes are *** situation studied in this problem can be observed in oil-bearing rock formations under the influence of a geothermal temperature gradient,where the ensuing fluid convection can affect the distribution of oil throughout the layer.

关键词： Thermal convection inclined layer porous media vertical temperature gradient

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Is Veillonella a unique marker of physical exercise?Commentary on:

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Journal of Sport and Health Science 2024年第5期13卷 682-684页

作者： Viktor Bielik ivan Hric Riadh Hammami Department of Biological and Medical Science Faculty of Physical Education and SportComenius University in BratislavaBratislava 81469Slovakia Department of Molecular Biology Faculty of Natural SciencesComenius University in BratislavaBratislava 84215Slovakia Biomedical Research Center Institute of Clinical and Translational ResearchSlovak Academy of SciencesBratislava 84505Slovakia School of Nutrition Sciences Faculty of Health SciencesUniversity of OttawaOttawaON K1N 6N5Canada Department of Biochemistry Microbiology and ImmunologyFaculty of MedicineUniversity of OttawaOttawaON K1N 6N5Canada

In 2020,Kostic1 published commentary on the bacterial genus Veillonella associated with the interaction between the intestinal microbiota and skeletal *** then,novel perspectives on the bidirectional gut-muscle communication axis have gained a lot of *** purpose of this commentary is to explore some of the challenging issues presented in Scheiman et al.

关键词： skeletal gained

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Products of Commutator Ideals of Some Lie-admissible Algebras

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Acta Mathematica Sinica,english Series 2024年第8期40卷 1875-1892页

作者： ivan KAYGORODOV Farukh MASHUROV Tran Giang NAM Ze Rui ZHANG CMA-UBI Universidade da Beira InteriorCovilhaPortugal Shenzhen International Center for Mathematics(SICM) Southern University of Science and TechnologyShenzhen 518055P.R.China Institute of Mathematics VAST18 Hoang Quoc VietCau GiayHanoiVietnam School of Mathematical Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this article,we mainly study the products of commutator ideals of Lie-admissible algebras such as Novikov algebras,bicommutative algebras,and assosymmetric *** precisely,we first study the properties of the lower central chains for Novikov algebras and bicommutative *** we show that for every Lie nilpotent Novikov algebra or Lie nilpotent bicommutative algebra A,the ideal of A generated by the set{ab−ba|a,b∈A}is ***,we study properties of the lower central chains for assosymmetric algebras,study the products of commutator ideals of assosymmetric algebras and show that the products of commutator ideals have a similar property as that for associative algebras.

关键词： Novikov algebra bicommutative algebra assosymmetric algebra Lie nilpotent algebra

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