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Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

World Journal of Gastrointestinal Surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak ivan Stresec Branislav Kocman Stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo Bašić Danko Mikulić Department of Surgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Development of Software Nanobit Ltd.Zagreb 10000Croatia

BACKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors Survival analysis Postoperative complications Cox proportional hazard models

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Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients

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World Journal of Diabetes 2024年第4期15卷 664-674页

作者： Drasko M Gostiljac Srdjan S Popovic Vesna Dimitrijevic-Sreckovic Sasa M Ilic Jelena A Jevtovic Dragan M Nikolic ivan A Soldatovic Clinic for Endocrinology Diabetes and Metabolic DiseasesUniversity Clinical Centre of SerbiaBelgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Gastroenterology and Hepatology University Clinical Centre of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets CultureUniversity Clinical Centre of SerbiaBelgrade 11000Serbia

BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(STB)to achieve better effects on postprandial glucose and insulin levels in patients with *** To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2DM *** This trial included 97 patients with T2DM.A parallel group of 16 healthy subjects was also *** participants were given 50 g of rye bread and the same amount of a STB with an herbal mixture on 2 consecutive *** blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of *** Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in T2DM patients who consumed *** relevant differences were found among the healthy *** estimated organoleptic and satiety characteristics are better for STB than for rye *** STB have better effects than rye bread on postprandial glucoregulation in T2DM *** estimated organoleptic and satiety characteristics are better for STB than for rye ***,STB can be recommended for nutrition in T2DM patients.

关键词： Special types of bread Postprandial glucoregulation Insulin Nutrition Type 2 diabetes mellitus

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The Effects of Competence and Auditor Training on Fraud Detection Within Multinational Companies in Sub-Saharan Africa

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Journal of Modern Accounting and Auditing 2024年第1期20卷 1-13页

作者： ivan Djossa Tchokoté Joëlle Tsobze Tiomeguim Catholic University of Central Africa YaoundéCameroon Ernst&Young DoualaCameroun

The aim of this study is to examine the qualities that auditors engaged in detecting potential fraud within multinational corporations in Sub-Saharan Africa should *** achieve this goal,a quantitative approach was used to develop and test a research model based on three theories:agency theory,attribution theory,and cognitive dissonance *** from a panel of two hundred and nine(209)auditors who conducted a legal audit mission in a Sub-Saharan multinational were analyzed using SmartPLS 3.3.3 *** results emphasize the crucial importance of auditors’competence and continuous training in fraud ***,professional skepticism and time pressure were found to be non-significant in this *** conclusion provides essential insights for auditors,highlighting the key qualities needed to effectively address fraud detection within multinational corporations in Sub-Saharan Africa.

关键词： fraud legal audit fraud detection multinationals Sub-Saharan Africa

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Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MARKO SKELIN BRUNA PERKOV-STIPIČIN SANJA VUŠKOVIĆ MARINAŠANDRK PLEHAČEK ANE BAŠIĆ DAVIDŠARČEVIĆ MAJA ILIĆ ivan KREČAK Pharmacy Department General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Department of Oncology University Hospital Center ZagrebZagrebCroatia Pharmacies Joukhadar Sveta NedeljaCroatia Pharmacies Prima Pharme ZagrebCroatia Pharmacy Department General Hospital ZadarZadarCroatia Pharmacy Department General Hospital PulaPulaCroatia Department of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

Background:The European Society for Medical Oncology(ESMO)guidelines are among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOR A(+1%)in the current CPG compared to previous *** proportion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to pharmacotherapy,while the highest proportion of GOR A recommendations was found in the areas of pathology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations are supported by the highest level of *** well-designed randomized clinical trials are needed to increase the proportion of LOEⅠand GOR A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

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3D micro-devices for enhancing the lateral resolution in optical microscopy

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Light(Advanced Manufacturing) 2024年第2期5卷 50-63页

作者： Gordon Zyla Goran Maconi Anton Nolvi Jan Marx Dimitra Ladika Ari Salmi Vasileia Melissinaki ivan Kassamakov Maria Farsari Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklionGreece Electronics Research Laboratory Department of PhysicsUniversity of HelsinkiHelsinkiFinland Applied Laser Technologies Ruhr University BochumBochumGermany

Although optical microscopy is a widely used technique across various multidisciplinary fields for inspecting small-scale objects,surfaces or organisms,it faces a significant limitation:the lateral resolution of optical microscopes is fundamentally constrained by light *** micro-spheres,however,offer a promising solution to this issue as they are capable of significantly enhancing lateral resolution through extraordinary phenomena,such as a photonic *** upon the potential of dielectric micro-spheres,this paper introduces a novel approach for fabricating 3D micro-devices designed to enhance lateral resolution in optical *** proposed 3D micro-device comprises a modified coverslip and a micro-sphere,facilitating easy handling and integration into any existing optical *** manufacture the device,two advanced femtosecond laser techniques are employed:femtosecond laser ablation and multi-photon *** laser ablation was employed to create a micro-hole in the coverslip,which allows light to be focused through this ***-photon lithography was used to fabricate a micro-sphere with a diameter of 20μm,along with a cantilever that positions the above the processed micro-hole and connect it with the *** this context,advanced processing strategies for multi-photon lithography to produce a micro-sphere with superior surface roughness and almost perfect geometry(λ/8)from a Zr-based hybrid photoresist are *** performance of the micro-device was evaluated using Mirau-type coherence scanning interferometry in conjunction with white light illumination at a central wavelength of 600 nm and a calibration grid(Λ=0.28μm,h>50 nm).Here,the 3D micro-device proved to be capable of enhancing lateral resolution beyond the limits achievable with conventional lenses or microscope objectives when used in ***,it maintained the high axial resolution characteristic of Mirau-type coherenc

关键词： Photonic nanojet Multi-photon lithography Optical microscopy Micro-optics Multi-photon grayscale lithography Extreme manufacturing

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary C.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee ivan C.C.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance Centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and Technological Enterprise(CREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity Cognition Heat stress Hyperthermia Motor function

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A bird's-eye overview of molecular mechanisms regulating feed intake in chickens—with mammalian comparisons

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Animal Nutrition 2024年第2期17卷 61-74页

作者： Anastasiia R.Volyanskaya Ilya R.Akberdin Mikhail A.Kulyashov ivan S.Yevshin Michael N.Romanov Elena I.Shagimardanova Oleg A.Gusev Fedor A.Kolpakov Department of Natural Sciences Novosibirsk State University Biosoft.Ru Ltd. Sirius University of Science and Technology School of Biosciences University of Kent L.K.Ernst Federal Research Centre for Animal Husbandry Regulatory Genomics Research Center Institute of Fundamental Medicine and BiologyKazan Federal University Life Improvement By Future Technologies (LIFT) Center Intractable Disease Research Center Juntendo University

In recent decades, a lot of research has been conducted to explore poultry feeding behavior. However, up to now, the processes behind poultry feeding behavior remain poorly understood. The review generalizes modern expertise about the hormonal regulation of feeding behavior in chickens, focusing on signaling pathways mediated by insulin, leptin, and ghrelin and regulatory pathways with a cross-reference to mammals. This overview also summarizes state-of-the-art research devoted to hypothalamic neuropeptides that control feed intake and are prime candidates for predictors of feeding *** analysis of the signaling pathways that mediate the feed intake regulation allowed us to conclude that there are major differences in the processes by which hormones influence specific neuropeptides and their contrasting roles in feed intake control between two vertebrate clades.

关键词： Chicken Feed intake Hypothalamus Neuropeptide Signaling pathway Hormone

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Optimizing Power Flow in Northern Cameroon’s Interconnected Grid: Challenges and Solutions

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Journal of Power and Energy Engineering 2024年第9期12卷 63-83页

作者： Jean Ndoumbe ivan Basile Kabeina Michael Koumbou Piembe Martin Ndjock Laboratory of Computer Engineering Data Science and Artificial Intelligence National Higher Polytechnic School of Douala University of Douala Douala Cameroon Laboratory of Electronics Electrotechnics Automation and Telecommunications National Higher Polytechnic School of Douala University of Douala Douala Cameroon

This paper presents an analysis of the power flow within the Northern Interconnected Grid of Cameroon. The Newton-Raphson method has been performed, known for its accuracy, under MATLAB software, to model and solve complex power flow equations. This study simulates a series of outage scenarios to evaluate the responsiveness of the grid. The results obtained underline the crucial importance of reactive power management and highlight the urgent need to consolidate the grid infrastructure of North Cameroon. To increase grid resilience and stability, the paper recommends the strategic integration of renewables and the development of interconnections with other power grids. These measures are presented as viable solutions to meet current and future energy distribution challenges, ensuring a reliable and sustainable power supply for Cameroon.

关键词： Power Flow Northern Interconnected Grid Newton-Raphson MATLAB Grid Stability

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基于CT图像三维重建的高温下再生混凝土孔隙特征研究

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材料导报 2024年第5期38卷 214-224页

作者：都思哲张淼张玉 Selyutina Nina Smirnov ivan 马树娟董晓强刘元珍太原理工大学土木工程学院太原030024 Coronation Property Co.Pty Ltd/MN Builders 新南威尔士州2620 圣彼得堡国立大学圣彼得堡190000

高温会导致混凝土微细观结构损伤劣化,进而导致混凝土力学性能下降。本工作利用计算机层析成像(CT)技术对高温后掺加玻化微珠的再生混凝土(Recycled aggregate concrete mixed with glazed hollow beads, GHB-RAC)试件孔隙结构特征进行... 详细信息

高温会导致混凝土微细观结构损伤劣化,进而导致混凝土力学性能下降。本工作利用计算机层析成像(CT)技术对高温后掺加玻化微珠的再生混凝土(Recycled aggregate concrete mixed with glazed hollow beads, GHB-RAC)试件孔隙结构特征进行识别,基于CT扫描与三维重构建模提取并分析了混凝土孔隙结构的特征参数,同时利用灰色关联理论探究孔隙结构特征参数对混凝土残余抗压强度的影响程度。研究结果表明,温度会影响GHB-RAC内部孔隙结构,内部孔隙孔径及表面积随温度升高而增大,温度的升高也会影响混凝土孔隙均匀性,加剧孔隙不均匀性分布;玻化微珠(Glazed hollow beads, GHB)对混凝土温度传导的阻碍作用明显,GHB的掺入改善了混凝土的孔隙结构,减弱了高温导致的孔隙畸化;孔隙尺寸、孔隙球体度及孔隙表面积与残余抗压强度的灰色关联度均在0.55以上,表明孔隙结构参数与残余抗压强度关联性较好。

关键词： CT扫描再生混凝土孔隙结构抗压强度灰色关联度

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Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

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