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Clinical efficacy of a combination of Percoll continuous density gradient and swim-up tech.iques for semen processing in h.V-1 serodiscordant couples

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Asian Journal of Andrology 2017年第2期19卷 208-213页

作者： Osamu Inoue Naoaki Kuji h.roe ito Mitsutosh. Yamada Tosh.o h.matani Aimi Oyadomari Sh.ngo Kato h.deji h.nabusa Keiich. Isaka Mamoru Tanaka Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo 1608582 Japan Department of Obstetrics and Gynecology Tokyo Medical College Tokyo 1600023 Japan Department of Microbiology Keio University School of Medicine Tokyo 1608582 Japan Department of h.matology Ogikubo Hospital Tokyo 1670035 Japan

To evaluate th. clinical efficacy of a procedure comprising a combination of Percoll continuous density gradient and modified swim-up tech.iques for th. removal of h.man immunodeficiency virus type 1 （h.V-1） from th. semen of h.V-1 infected males, a total of 129 couples with.an h.V-1 positive male partner and an h.V-1 negative female partner （serodiscordant couples） wh. were treated at Keio University h.spital between January 2002 and April 2012 were examined. A total of 183 ejaculates from 129 h.V-1 infected males were processed. After swim-up, we successfully collected motile sperms at a recovery rate as h.gh.as 100.0% in cases of normozoospermia （126/126 ejaculates）, oligozoospermia （6/6）, and asth.nozoospermia （36/36）. Th. recovery rate of oligoasth.nozoospermia was 86.7% （13/15）. In processed semen only four ejaculates （4/181：2.2%） sh.wed viral nucleotide sequences consistent with.th.se in th. blood of th. infected males. After using th.se sperms, no h.rizontal infections of th. female patients and no vertical infections of th. newborns were observed. Furth.rmore, no obvious adverse effects were observed in th. offspring. Th.s protocol allowed us to collect h.V-1 negative motile sperms at a h.gh.rate, even in male factor cases. We concluded th.t our protocol is clinically effective both.for decreasing h.V-1 infections and for yielding a h.alth. ch.ld.

关键词： assisted reproductive tech.ology h.man immunodeficiency virus type 1 serodiscordant couPle viral nucleotide sequence

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A novel animal model for in vivo study of liver cancer metastasis

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World Journal of Gastroenterology 2012年第29期18卷 3875-3882页

作者： Sh.nsuke Fujiwara h.karu Fujioka Ch.se Tateno Ken Taniguch. Masah.ro ito h.rosh. Oh.sh. Rie Utoh.h.romi Ish.bash. Takash. Kanematsu Katsutosh. Yosh.zato Clinical Research.Center National Hospital Organization Nagasaki Medical Center and Division of HepatologyNagasaki University Graduate School of Biomedical SciencesNagasaki 856-8652Japan Liver Research.Laboratory PhoenixBio Co.LtdHiroshima 739-8511Japan Yosh.zato Project CLUSTERHiroshima Prefectural Institute of Industrial Science and TechnologyHiroshima 739-8511Japan Division of Surgery Ⅱ Nagasaki University Graduate School of Biomedical SciencesNagasaki 856-8652Japan Liver Research.Center Osaka City UniversityGraduate School of MedicineOsaka 532-0025Japan

AIM:To establish.an animal model with.h.man h.patocyte-repopulated liver for th. study of liver cancer ***:Cell transplantation into mouse livers was conducted using alph.-fetoprotein(AFP)-producing h.-man gastric cancer cells(h.GCCs) and h.h.patocytes as donor cells in a transgenic mouse line expressing urokinase-type plasminogen activator(uPA) driven by th. albumin enh.ncer/promoter crossed with.a severe combined immunodeficient(SCID) mouse line(uPA/SCID mice).h.st mice were divided into two groups(A and B).Group A mice were transplanted with.h.GCCs alone,and group B mice were transplanted with.h.GCCs and h.h.patocytes *** replacement index(RI),wh.ch.is th. ratio of transplanted h.GCCs and h.h.patocytes th.t occupy th. examined area of a h.stological section,was estimated by measuring h.AFP and h.albumin concentrations in sera,respectively,as well as by immunoh.stoch.mical analyses of h.AFP and h.man cytokeratin 18 in h.stological ***:Th. h.GCCs successfully engrafted,repopulated,and colonized th. livers of mice in group A(RI = 22.0% ± 2.6%).Th.se mice h.d moderately differentiated adenocarcinomatous lesions with.disrupted glandular structures,wh.ch.is a ch.racteristics feature of gastric *** serum h.AFP level reach.d 211.0 ± 142.2 g/mL(range,7.1-324.2 g/mL).In group B mice,th. h.GCCs and h.h.patocytes independently engrafted,repopulated th. h.st liver,and developed colonies(RI = 12.0% ± 6.8% and 66.0% ± 12.3%,respectively).h.GCC colonies also sh.wed typical adenocarcinomatous glandular structures around th. *** mice survived for th. full 56 day-study and did not exh.bit any metastasis of h.GCCs in th. extrah.patic regions during th. observational *** mice with.an h.h.patocyte-repopulated liver possessed metastasized h.GCCs and th.refore could be a useful h.manized liver animal model for studying liver cancer metastasis in ***:A novel animal model of h.man liver cancer metastas

关键词：动物模型体内试验肝癌尿激酶型纤溶酶原激活剂转基因小鼠 SCID小鼠细胞移植胃癌细胞

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Kidney GATA3^(+) regulatory T cells play roles in th. convalescence stage after antibody-mediated renal injury

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Cellular & Molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ryota Sakai Minako ito Kyoko Komai Mana Iizuka-Koga Kazuh.ko Matsuo Takash. Nakayama Osamu Yosh.e Koich. Amano h.rosh. Nish.masu Osamu Nureki Masato Kubo Akih.ko Yosh.mura Department of Microbiology and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rh.umatology and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan Medical Institute of Bioregulation Kyush. University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Ch.moth.rapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan Th. h.alth.and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological Science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease Models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in periph.ral immune *** addition,Tregs th.t reside or accumulate in nonlymph.id tissues,called tissue Tregs,exh.bit tissue-specific functions and contribute to th. maintenance of tissue h.meostasis and *** an experimental mouse model of crescentic glomeruloneph.itis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in th. kidney on day 10 of disease onset and remained at h.gh.levels(~30–35%of CD4^(+)T cells)during th. late stage(days 21–90),wh.ch.correlated with.stable disease *** depletion on day 21 resulted in th. relapse of renal dysfunction and an increase in Th. cells,suggesting th.t Tregs are essential for disease control during th. convalescence *** Tregs th.t accumulated in th. kidney sh.wed tissue Treg ph.notypes,including h.gh.expression of GATA3,ST2(th. IL33 receptor subunit),amph.regulin(Areg),and PPARγ.Alth.ugh.T-bet^(+) Tregs and RORγt^(+) Tregs were observed in th. kidney,GATA3^(+) Tregs were predominant during th. convalescence stage,and a PPARγagonist enh.nced th. accumulation of GATA3^(+) Tregs in th. *** understand th. function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates th.t ST2,Areg,and CCR4 in Tregs play important roles in th. accumulation of GATA3^(+) Tregs in th. kidney and in th. amelioration of renal *** data suggest th.t GATA3 is important for th. recruitment of Tregs into th. kidney,wh.ch.is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

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Ch.onic Kidney Disease is a New Target of Cardiac Reh.bilitation

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Cardiovascular Innovations and Applications 2017年第B5期2卷 387-393页

作者： Masah.ro Koh.uki Osamu ito Department of Internal Medicine and Reh.bilitation Science Tohoku University Graduate School of MedicineJapan

Ch.onic h.art failure is increasingly prevalent worldwide and is associated with.signifi cant morbidity and *** Coch.ane review demonstrated th.t cardiac reh.bilitation(CR)resulted in improvements in QOL and a reduction in long-term *** kidney disease(CKD)is anoth.r worldwide public h.alth.*** review focuses on th. importance and effi cacy of reh.bilitation for CKD patients as a new target of *** with.CKD on h.modialysis(h.)h.ve a h.gh.mortality rate,with.cardiovascular diseases,such.as ch.onic h.art failure.A new systematic review and meta-analysis of randomized controlled trials reported th.t exercise-based renal reh.bilitation improved aerobic capacity,muscular functioning,cardiovascular function,walking capacity,and QOL in CKD patients with.***,exercise training may h.ve renal protective effects,not only in some animal models of pre-h. CKD,but also in pre-h. CKD *** th.rapy could be an effective clinical strategy in improving renal function,lowering th. need for renal replacement th.rapy,such.as h.,and reducing renal transplant risk in pre-h. CKD *** led th. Ministry of h.alth.Labor and Welfare of Japan to extend renal reh.bilitation partial coverage to stage4pre-h. CKD patients for th. first time in th. world in 2016.

关键词： ch.onic kidney disease reh.bilitation exercise cardio-renal syndrome renal protection

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由柏木制备纳米孔结构炭材料 Ⅱ.电双层电容器中的应用(英文)

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新型炭材料 2007年第4期22卷 321-326页

作者： Eiki ito Sylwia Mozia Masah.ru Okuda Takash. Nakano Masah.ro Toyoda Mich.o Inagaki Faculty of Engineering Aichi Institute of TechnologyYakusaToyota 470-0392JapanIntellectual Property Bank Corp.Toranomon Minato-ku Tokyo 105-0001Japan Faculty ofEngineeringOitaUniversityDannoharu 700Oita 870-1192JapanShimizu Corp.Environ.Solution Div. Shibaura Minato-ku Tokyo105-8007 Japan Sh.mizu Corp.Environ.SolutionDiv.ShibauraMinato-kuTokyo 105-8007Japan Faculty ofEngineeringOitaUniversityDannoharu700Oita 870-1192Japan Faculty of Engineering AichiInstitute of TechnologyYakusaToyota 470-0392Japan

通过过热蒸气活化法制备的柏木炭中含有大量的中孔,可用于制备以1mol/L硫酸为电解液的双电层电容器(EDLCs)。在50mA/g电流密度下,柏木炭的质量比电容(C50)为190F/g;在1000mA/g电流密度下,其质量比电容(C1000)为140F/g。按C1000/C50定义... 详细信息

通过过热蒸气活化法制备的柏木炭中含有大量的中孔,可用于制备以1mol/L硫酸为电解液的双电层电容器(EDLCs)。在50mA/g电流密度下,柏木炭的质量比电容(C50)为190F/g;在1000mA/g电流密度下,其质量比电容(C1000)为140F/g。按C1000/C50定义的性能倍率约为0.72。测得的高电容量可归因于微孔和大孔所造成表面的贡献。以简易浸泡法负载少量NiO粒子后,柏木炭的质量比电容可以提高约13%,体积比电容提高约27%,而其性能倍率保持不变。

关键词：柏木炭过热蒸气电双层电容器 NiO负载

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Antith.ombin Ⅲ injection via th. portal vein suppresses liver damage

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World Journal of Gastroenterology 2012年第16期18卷 1884-1891页

作者： Masayuki Miyazaki Masaki Kato Masatake Tanaka Kosuke Tanaka Sh.nich.ro Takao Motoyuki Koh.ima Tetsuh.de ito Munech.ka Enjoji Makoto Nakamuta Kazuh.ro Kotoh.Ryoich. Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-0065Japan Department of Clinical Ph.rmacology Faculty of Pharmaceutical SciencesFukuoka UniversityFukuoka 814-0180Japan

AIM:To investigate th. effects of antith.ombin Ⅲ(AT Ⅲ) injection via th. portal vein in acute liver ***:Th.rty rats were intraperitoneally ch.llenged with.lipopolysacch.ride(LPS) and D-galactosamine(GalN) and divided into th.ee groups:a control group;a group injected with.AT Ⅲ via th. tail vein;and a group injected with.AT Ⅲ via th. portal *** Ⅲ(50 U/kg body weigh.) was administrated 1 h.after ch.llenge with.LPS and *** levels of inflammatory cytokines and fibrin degradation products,h.patic fibrin deposition,and h.patic mRNA expression of h.poxiarelated genes were ***:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with.tail vein injection,and control *** vein AT Ⅲ injection reduced liver cell destruction and decreased h.patic fibrin *** treatment also significantly reduced h.patic mRNA expression of lactate deh.drogenase and h.me ***:A clinically acceptable dose of AT Ⅲ injection into th. portal vein suppressed liver damage,probably th.ough.its enh.nced anticoagulant and antiinflammatory activities.

关键词：静脉注射抗凝血酶肝损伤 mRNA表达水平 D-半乳糖纤维蛋白血红素加氧酶肝功能衰竭

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高性能85mm短腔光学参变振荡器的Th.电磁波输出特性分析

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光学学报 2006年第4期26卷 616-620页

作者：张显斌碇智文陈颍丽施卫依藤弘昌西安理工大学应用物理系西安710048 日本理化学研究所光动力学研究中心

报道了以MgO：LiNbO2为非线性光学介质，采用85mm长的法布里-珀罗单谐振腔结构形式的光学参变振荡器，产生Th.电磁波的实验结果。使用波长为1064nm的Nd：YAGQ开关脉冲激光器作为抽运光源，通过改变入射角度使参变振荡器的相位匹配条件... 详细信息

报道了以MgO：LiNbO2为非线性光学介质，采用85mm长的法布里-珀罗单谐振腔结构形式的光学参变振荡器，产生Th.电磁波的实验结果。使用波长为1064nm的Nd：YAGQ开关脉冲激光器作为抽运光源，通过改变入射角度使参变振荡器的相位匹配条件发生变化。采用Si真空量热器，并利用Th.波干涉测量仪；或通过测量闲频光的频率对产生的Th.波频率进行了测量。实验表明该参变振荡器输出频率调谐范围为0．9～3．0Th.。在抽运光能量为20mJ／pulse，脉冲宽度16ns，重复频率50h.条件下得到输出峰值位于1．2Th.，能量为102．5PJ／pulse的Th.波输出。通过引入Si棱镜阵列减小了Th.波在晶体中的全反射，从而提高Th.波的能量输出。使用金属缝隙探测器，对辐射的Th.波的波束水平方向空间分布进行了测量，分析了Si棱镜阵列的衍射效应对Th.波束空间分布的影响。

关键词：非线性光学 Th.电磁波光掺变振荡器 LiNbO3

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Genome-Wide Identification and Ch.racterization of th. <i>Dof</i>Transcription Factor Gene Family in <i>Ph.seolus vulgaris</i>L.

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American Journal of Plant Sciences 2017年第12期8卷 3233-3257页

作者： Tania Mayumi ito Claudia Borsari Trevizan Tiago Benedito dos Santos Silvia Graciele h.lse de Souza Programa de Pós-Graduacao em Biotecnologia Aplicada à Agricultura Laboratório de Biologia Molecular Universidade Paranaense (UNIPAR) Umuarama Brazil Programa de Pós-Graduacao em Agronomia Universidade do Oeste Paulista (UNOESTE) Presidente Prudente Brazil

Th. Dof (DNA-binding with.one finger) proteins are a class of plant-specific transcription factors th.t can trigger several processes involved in plant growth.and development, as well as in stress responses. h.re, we performed a systematic bioinformatics analysis to ch.racterize all Dof genes in common bean, wh.ch.included analysis of th. genome sequence, conserved protein domains, ch.omosomal locations, subcellular locations, ph.logenetic relationsh.ps, gene duplications, and gene expression profiles in different tissues. Bioinformatics analysis revealed 36 putative genes related to PvDof th.t were classified into seven subfamilies (A, B1, B2, C1, C2, D1, and, D2) by comparative ph.logenetic analysis. Based on our genome duplication analysis, a total of 36 genes were found to be distributed on all 11 ch.omosomes, and th.y expanded th.ough.gene duplication in tandem, suggesting th. involvement of segmental duplication events in th. evolutionary process. Synteny events and ph.logenetic comparisons of th. Dof proteins of common bean with.th.se of A. th.liana, O. sativa, and G. max L. led to th. identification of several orth.logous and paralogous genes, wh.ch.provided furth.r insigh. into th. diversity of th. evolutionary ch.racteristics of genes of th.s family in oth.r plant species. Expression profiles revealed th.t most of th. PvDof genes were expressed in different tissues, indicating th.t PvDof genes may be involved in various ph.siological functions during plant development. Th. results of th.s study provide additional information and potential biotech.ological resources for furth.r understanding th. molecular basis of th.s gene family and consequently improvement of common bean crops.

关键词： Common Bean DNA-Binding with One Finger (Dof) Domain Proteins Tran-scription Factor

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Mesomorph.c beh.vior of new benzoth.azole liquid crystals h.ving Sch.ff base linker and terminal meth.l group

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Ch.nese Ch.mical Letters 2012年第7期23卷 761-764页

作者： Sie Tiong h. Kok Leei Foo h.ng Ch.u Lin Masato M.ito Kazuma Abe Kenji Kunbo S.Sreeh.ri Sastry Department of Ch.mical Science Faculty of ScienceCentre for Biodiversity ResearchUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Department of Material Science&Engineering National Chiao Tung UniversityHsinchu 300TaiwanChina Faculty of Engineering Soka University1-236 Tangi-choHachiojiTokyo 192-8577Japan Department of Ph.sics Acharya Nagariuna UniversityNagariuna Nagar 522510India

A h.mologous series of h.terocycles,6-meth.l-2-（4-alkoxybenzylidenamino）benzoth.azoles,were synth.sized and ch.racterized using FT-IR,^1h.and ^（13）C NMR and mass spectrometric *** nematic ph.se was observed for sh.rter *** A ph.se only emerged from octyloxy derivative *** terminal meth.l group at th. benzoth.azole fragment and th. Sch.ff base linkage influenced th. mesomorph.c beh.vior of th. present series.

关键词： Sch.ff bases Benzoth.azole Liquid crystal Smectic A Nematic

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h.terocyclic benzoxazole-based liquid crystals:Synth.sis and mesomorph.c properties

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Ch.nese Ch.mical Letters 2011年第10期22卷 1191-1194页

作者： Sie Tiong h. Kok Leei Foo Ramesh.T.Subramaniam Masato M.ito S.Sreeh.ri Sastry Siew Teng Ong Department of Ch.mical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Center for Ionics University Malaya Department of Ph.sics Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia Faculty of Engineering Soka University1-236 Tangi-choHachiojiTokyo 192-8577Japan Department of Ph.sics Acharya Nagarjuna UniversityNagarjuna Nagar 522 510India

New Sch.ff base liquid crystals containing benzoxazole core and alkanoyloxy ch.in at th. end group of th. molecules （C_（n-1）h.（2n-1）COO-,n=14,16,18） was *** present compounds are enantiotropic smectic A liquid *** was also found th.t th. end groups of th. molecules and polar ch.oro substituent at th. benzoxazole fragment h.d effect on th. mesomorph.c properties.

关键词： Sch.ff bases Benzoxazoles Mesomorph.c Smectic A Structure-property relationsh.p

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