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Molecular regulation of the key specialized metabolism pathways in medicinal plants

Journal of Integrative Plant Biology 2024年第3期66卷 510-531页

作者： Min Shi Siwei Zhang Zizhen Zheng itay maoz Lei Zhang Guoyin Kai Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhou 310053China Department of Postharvest Science Agricultural Research OrganizationVolcani CenterRishonLeZion 7505101Israel Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

The basis of modern pharmacology is the human ability to exploit the production of specialized metabolites from medical plants,for example,terpenoids,alkaloids,and phenolic ***,in most cases,the availability of these valuable compounds is limited by cellular or organelle barriers or spatio-temporal accumulation patterns within different plant *** factors(TFs)regulate biosynthesis of these specialized metabolites by tightly controlling the expression of biosynthetic ***-edge technologies and/or combining multiple strategies and approaches have been applied to elucidate the role of *** this review,we focus on recent progress in the transcription regulation mechanism of representative high-value products and describe the transcriptional regulatory network,and future perspectives are discussed,which will help develop high-yield plant resources.

关键词： biosynthesis medicinal plants omics secondary metabolism transcription factors

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Cytokinin but not gibberellin application had major impact on the phenylpropanoid pathway in grape

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Horticulture Research 2021年第1期8卷 599-613页

作者： Kamal Tyagi itay maoz Bettina Kochanek Noa Sela Larry Lerno Susan EEbeler Amnon Lichter Department of Postharvest Science Agricultural Research OrganizationThe Volcani CenterRishon LeZionIsrael Department of Viticulture and Enology University of CaliforniaDavisCA 95616USA Department of Plant Pathology Agricultural Research OrganizationThe Volcani CenterRishon LeZionIsrael Food Safety and Measurement Facility University of CaliforniaDavisCA 95616USA

Cytokinin and gibberellic acid(GA)are growth regulators used to increase berry size in seedless grapes and it is of interest to understand their effects on the phenylpropanoid pathway and on ripening *** 3 and synthetic cytokinin forchlorfenuron(N-(2-chloro-4-pyridyl)-N′-phenylurea,CPPU)and their combination were applied to 6 mm diameter fruitlets of‘Sable Seedless’,and berries were sampled 51 and 70 days(d)following *** treatments increased berry size and delayed sugar accumulation and acid degradation with a stronger effect of ***,but not GA,reduced berry color and the levels of *** CPPU reduced the levels of anthocyanins by more than 50%,the combined treatment of GA+CPPU reduced the levels by about 25%at 51 *** treatment had minor effects on flavonols content but increased the levels of monomeric flavan-3-ols by more than *** analysis using HPLC showed that proanthocyanidin content was significantly increased by CPPU,whereas mean degree of polymerization was reduced from 26 to *** analysis by GC-MS showed changes in composition with CPPU or GA treatment with potential impact on ***-seq analysis showed that GA had a minor overall effect on the transcriptome whereas CPPU had pronounced effects on gene expression at both 51 and 70 *** the control and CPPU at similar Brix of ca.19.7°,a reduced expression of stilbene synthases(STSs)including their regulators MYB14 and MYB15,and other phenylpropanoid-related genes was observed in CPPU-treated ***,our study shows that CPPU had a major influence on the phenylpropanoid pathway and affected multiple ripening-related processes.

关键词： CPPU impact treatment

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OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila

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Journal of Integrative Plant Biology 2023年第1期65卷 133-149页

作者： Xiaolong Hao Can Wang Wei Zhou Qingyan Ruan Chenhong Xie Yinkai Yang Chengyu Xiao Yan Cai Jingyi Wang Yao Wang Xuebin Zhang itay maoz Guoyin Kai Laboratory of Medicinal Plant Biotechnology School of Pharmaceutical SciencesAcademy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou 310053 China State Key Laboratory of Crop Stress Adaptation and Improvement Henan Joint International Laboratory for Crop Multi-Omics ResearchSchool of Life Sciences Henan UniversityKaifeng 475001 China Department of Postharvest Science ARO The Volcani Center HaMaccabim Rd 68POB 15159Rishon LeZion 7528809 Israel

Camptothecin(CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. Ophiorrhiza pumila, the herbaceous plant from the Rubiaceae family, has emerged as a model plant for studying camptothecin biosynthesis and regulation. In this study, a high-quality reference genome of O. pumila with estimated size of ~456.90Mb was reported, and the accumulation level of camptothecin in roots was higher than that in stems and leaves. Based on its spatial distribution in the plant, we examined gene functions and expression by combining genomics with transcriptomic *** loganic acid O-methyltransferase(OpLAMTs)were identified in strictosidine-producing plant ***, and enzyme catalysis assays showed that OpLAMT1 and not OpLAMT2 could convert loganic acid into loganin. Further knock-out of OpL AMT1expression led to the elimination of loganin and camptothecin accumulation in O. pumila hairy *** key residues were identified in OpLAMT1 protein crucial for the catalytic activity of loganic acid to loganin. By co-expression network, we identified a NAC transcription factor, OpNAC1, as a candidate gene for regulating camptothecin *** hairy roots and biochemical assays demonstrated that OpNAC1 suppressed OpLAMT1 expression. Here, we reported on two camptothecin metabolic engineering strategies paving the road for industrial-scale production of camptothecin in CPT-producing plants.

关键词： camptothecin biosynthesis metabolic engineering strategies Ophiorrhiza pumila plant secondary metabolism transcriptional regulation

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A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids

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Plant Communications 2024年第1期5卷 231-244页

作者： Wei Zhou Can Wang Xiaolong Hao Fei Chen Qikai Huang Tingyao Liu Jiang Xu Shuai Guo Baosheng Liao Zhixiang Liu Yue Feng Yao Wang Pan Liao Jiayu Xue Min Shi itay maoz Guoyin Kai Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Sanya Nanfan Research Institute from Hainan University Hainan Yazhou Bay Seed LaboratorySanya 572025China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Department of Postharvest Science Agricultural Research OrganizationVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel

Tropane alkaloids(TAs),which are anticholinergic agents,are an essential class of natural compounds,and there is a growing demand for TAs with anesthetic,analgesic,and spasmolytic *** acutan-gulus(Solanaceae)is a TA-producing plant that was used as an anesthetic in ancient *** this study,we assembled a high-quality,chromosome-scale genome of *** with a contig N50 of 7.4 Mb.A recent whole-genome duplication occurred in *** after its divergence from other Solanaceae species,which resulted in the duplication of ADC1 and UGT genes involved in TA *** catalytic activities of H6H enzymes were determined for three Solanaceae *** the basis of evolution and co-expressed genes,AaWRKY11 was selected for further analyses,which revealed that its encoded tran-scription factor promotes TA biosynthesis by activating AaH6H1 *** provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.

关键词： Anisodus acutangulus tropane alkaloid biosynthesis hyoscyamine 6 b-hydroxylase AaWRKY11

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Tea plant (Camellia sinensis) lipid metabolism pathway modulated by tea field microbe (Colletotrichum camelliae) to promote disease

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Horticulture Research 2023年第3期10卷 110-123页

作者： Shouan Liu Shuhan Zhang Shengnan He Xiaoyan Qiao A.Runa Laboratory of Tea and Medicinal Plant Biology College of Plant SciencesJilin UniversityChangchun 130062China Laboratory of Molecular Plant Pathology College of Plant SciencesJilin UniversityChangchun 130062China Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization Guangdong Academy of Agricultural Sciences Tea Research InstituteGuangzhou 510640China

Tea is one of the most popular healthy and non-alcoholic beverages *** anthracnose is a disease in tea mature leaves and ultimately affects yield and *** camelliae is a dominant fungal pathogen in the tea field that infects tea plants in *** pathogenic factors of fungus and the susceptible factors in the tea plant are not *** this work,we performed molecular and genetic studies to observe a cerato-platanin protein CcCp1 from ***,which played a key role in fungal pathogenicity.CcCp1 mutants lost fungal virulence and reduced the ability to produce *** and metabolome were then performed and analysed in tea-susceptible and tea-resistant cultivars,Longjing 43 and Zhongcha 108,upon *** wild-type CCA andCcCp1 infection,*** differentially expressed genes and the differentially accumulated metabolites in tea plants were clearly overrepresented such as linolenic acid and linoleic acid metabolism,glycerophospholipid metabolism,phenylalanine biosynthesis and metabolism,biosynthesis of f lavonoid,f lavone and f lavonol *** particular,the accumulation of jasmonic acid was significantly increased in the susceptible cultivar Longjing 43 upon CCA infection,in the fungal CcCp1 protein dependent manner,suggesting the compound involved in regulating fungal *** addition,other metabolites in the glycerophospholipid and phenylalanine pathway were observed in the resistant cultivar Zhongcha 108 upon fungal treatment,suggesting their potential role in defense *** together,this work indicated *** CcCp1 affected the tea plant lipid metabolism pathway to promote disease while the lost function of CcCp1 mutants altered the fungal virulence and plant response.

关键词： field metabolism Tea

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