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Fluorescence imaging of drug target proteins using chemical probes

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Journal of Pharmaceutical Analysis 2020年第5期10卷 426-433页

作者： Hao Zhu itaru Hamachi Department of Synthetic Chemistry and Biological Chemistry Graduate School of EngineeringKyoto UniversityKatsuraNishikyo-kuKyoto615-8510Japan ERATO Innovative Molecular Technology for Neuroscience Project Japan Science and Technology Agency(JST)Kyoto615-8530Japan

Fluorescence imaging can provide valuable information on the expression,distribution,and activity of drug target *** probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and *** this review,we briefly introduce two classes of fluorescent probes for the visualization of drug target *** activatable probes make use of the specific enzymatic transformations that generally produce a fluorogenic response upon reacting with target ***,specific imaging can be conferred with a ligand that drives the probes to target proteins,where the labeling relies on noncovalent binding,covalent inhibition,or traceless labeling by ligand-directed chemistry.

关键词： Fluorescence imaging Drug target Chemical probe Ligand-directed chemistry

Angiogenesis and neuronal remodeling after ischemic stroke

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Neural Regeneration Research 2020年第1期15卷 16-19页

作者： Masahiro Hatakeyama itaru Ninomiya Masato Kanazawa Department of Neurology Brain Research Institute Niigata University

Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal *** raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic *** vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a *** this mini-review,we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral *** occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and ***-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional ***,new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin ***,blood vessels are thought to enhance neurogenesis in three stages:1)Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals,2)microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen,nutrients,and soluble factors as well as serving as a scaffold for migration,and 3)oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature ***,the regions of angiogenesis and surrounding tissue may be coupled,representing novel treatment targets.

关键词： angiogenesis axonal outgrowth cerebral ischemia coupling functional recovery guidance neurogenesis stroke

Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： Masato Kanazawa itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

IgE PRODUCTION IS INVOLVED IN BUTYRATE- ENHANCED NK CELL ACTIVITY IN VIVO

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Chinese Medical Sciences Journal 2001年第2期16卷 76-81页

作者： Ming Zhong Akihiro Tai itaru Yamamoto Department of Immunochemistry Faculty of Pharmaceutical SciencesOkayama UniversityTsushima-naka 1-1-1Okayama 700-8530Japan

It has been demonstrated that patients with asthma have a large number of NK cells and show a stronger NK activity. These results indicate that NK cell activity may be related to total IgE level in serum in healthy subjects. Previously,we have found that sodium butyrate (NaBu) markedly enhanced the IL- 4- induced IgE production in the LPS- stimulated murine splenocytes in vitro, and inductive rat IgE production in vivo, and enhanced the NK cell activity ex vivo .We hypothesized that the IgE production might be involved in butyrate- enhanced NK cell activity in vivo. Mice were intraperitoneally treated/immunized with NaBu or/and Ascaris suum extract (ASC),and the spleen NK cell activity was evaluated. Furthermore, the effect of serum (NAS) on IL- 2- or IFN-γ- induced spleen NK cell activity was determined. The spleen NK cell activity and IL- 2- or IFN-γ- induced spleen NK cell activity of mice treated/immunized with NaBu or/and ASC were stronger than those of untreated/unimmunized mice. Although IL- 4 blocked IL- 2 (100 U/ml)- or IFN-γ (100 U/ml)- induced increase in NK cell activity,these NK cell activities in mice treated/immunized with NaBu/ASC were not inhibited. IgE production showed a tendency to rise in NaBu- treated mice serum, and a synergistic effect was observed with treatment of NaBu and ASC. Moreover, the NAS significantly increased IL- 2(25 U/ml)- or IFN-γ (25 U/ml)- induced NK cell activity, and its effect was inhibited by anti- mouse IgE mAb. These data show that IgE plays an important role in NAS- enhanced IL- 2/IFN-γ- induced NK cell activity, and IL- 4 does not inhibit IgE and IL- 2/IFN-γ- induced NK cell activity in mice.

关键词： immunoglobulin E (IgE) sodium butyrate (NaBu) NK cell activity

Stability improvement mechanism due to less charge accumulation in ternary polymer solar cells

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npj Flexible Electronics 2022年第1期6卷 194-203页

作者： Dong Xue Masahiko Saito itaru Osaka Kazuhiro Marumoto Division of Materials Science University of TsukubaTsukubaIbaraki 305-8573Japan Graduate School of Advanced Science and Engineering Hiroshima UniversityHigashihiroshimaHiroshima 739-8527Japan Tsukuba Research Center for Energy Materials Science(TREMS) University of TsukubaTsukubaIbaraki 305-8571Japan

Ternary polymer solar cells based on a thiazolothiazole-based polymer donor(PTzBT)and a fullerene acceptor(PC61BM)have attracted attention because they show high efficiency and stability by addition of a non-fullerene acceptor(ITIC).However,the performance improvement mechanism is not completely ***,we show the stability improvement mechanism due to less charge accumulation in the PTzBT cells with ITIC using operando electron spin resonance from a microscopic *** observed two correlations between device performance and number of spins(N_(spin))under solar *** correlation is the decrease in short-circuit current and the N_(spin) increase in electrons on PC_(61)BM and holes in PTzBT,where the ITIC addition causes the less these N_(spin).The other correlation is the increase in open-circuit voltage and the N_(spin) decrease in holes in *** findings explain the stability improvement mechanism,showing the correlation between less charge accumulation and higher stability,which is valuable for the development of further efficient and stable polymer solar cells.

关键词： charge stability polymer

Active suspension control of a one-wheel car model using single input rule modules fuzzy reasoning and a disturbance observer

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第4期6卷 251-256页

作者： YOSHIMURA Toshio TERAMURA itaru Department of Mechanical Engineering Faculty of Engineering The University of TokushimaDepartment of Mechanical Engineering Faculty of Engineering The University of Tokushima Tokushima 770-8506 JapanTokushima 770-8506 Japan

This paper presents the construction of an active suspension control of a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model to be treated here can be approximately described as a nonlinear two degrees of freedom system subject to excitation from a road profile. The active control is designed as the fuzzy control inferred by using single input rule modules fuzzy reasoning, and the active control force is released by actuating a pneumatic actuator. The excitation from the road profile is estimated by using a disturbance observer, and the estimate is denoted as one of the variables in the precondition part of the fuzzy control rules. A compensator is inserted to counter the performance degradation due to the delay of the pneumatic actuator. The experimental result indicates that the proposed active suspension system improves much the vibration suppression of the car model. Key words One-wheel car model - Active suspension system - Single input rule modules fuzzy reasoning - Pneumatic actuator - Disturbance observer Document code A CLC number TH16

关键词： One-wheel car model Active suspension system Single input rule modules fuzzy reasoning Pneumatic actuator Disturbance observer

A study on quality evaluation for bituminous mixture using X-ray CT

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Frontiers of Structural and Civil Engineering 2013年第2期7卷 89-101页

作者： Satoshi TANIGUCHI Keiichiro OGAWA Jun OTANI itaru NISHIZAKI Public Works Research Institute Tsukuba 305-8516Japan School of Science and Technology Kumamoto UniversityKumamoto 860-8555Japan

The objective of this paper is to propose a new quality evaluation method for asphalt concrete mixture using X-ray CT *** achieve this aim,asphalt mixtures should be subjected to the X-ray CT scanning and its characteristics should be *** approach employed in this study was as follows:1)Coarse aggregate,fine aggregate,filler and bitumen were prepared;2)dense-graded,coarse-graded and porous asphalt mixtures were made;3)materials and mixtures were subjected to the X-ray CT scanning;4)frequency of CT-value,threshold value,average slice CT-value,average segment CT-value were *** the material examination,CT-value of aggregate becomes smaller in the order of coarse aggregate,fine aggregate and filler and CT image of bitumen was nearly *** the mixture examination,histograms of CT-value and four segmentation images made from CT images expressed the material and mixture characterization such as particle size and the difference in bitumen content and mixture type visibly and the bitumen content varies with the threshold *** addition,the average segment CT-value without threshold value by dividing the fine aggregate from the coarse aggregate and average CT-value of the coarse aggregate,especially is highly correlated with average CT-value of the bitumen.

关键词： asphalt concrete mixture aggregate bitumen bitumen content quality evaluation X-ray CT

Potentiality of immunotherapy against hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第36期21卷 10314-10326页

作者： Nobuhiro Tsuchiya Yu Sawada itaru Endo Yasushi Uemura Tetsuya Nakatsura Division of Cancer Immunotherapy Exploratory Oncology Research and Clinical Trial CenterNational Cancer Center Department of Gastroenterological Surgery Graduate School of MedicineYokohama City University

Hepatocellular carcinoma(HCC),the predominant form of primary liver cancer,is the fifth most common cancer worldwide and the second leading cause of cancer-related death. Despite the high incidence,treatment options remain limited for advanced HCC,and as a result prognosis continues to be poor. Current therapeutic options,surgery,chemotherapy and radiotherapy,have only modest efficacy. New treatment modalities to prolong survival and to minimize the risk of adverse response are desperately needed for patients with advanced HCC. Tumor immunotherapy is a promising,novel treatment strategy that may lead to improvements in both treatment-associated toxicity and outcome. The strategies have developed in part through genomic studies that have yielded candidate target molecules and in part through basic biology studies that have defined the pathways and cell types regulating immune response. Here,we summarize the various types of HCC immunotherapy and argue that the newfound field of HCC immunotherapy might provide critical advantages in the effort to improve prognosis of patients with advanced HCC. Already several immunotherapies,such as tumor-associated antigen therapy,immune checkpoint inhibitors and cell transfer immunotherapy,have demonstrated safety and feasibility in HCC patients. Unfortunately,immunotherapy currently has low efficacy in advanced stage HCC patients; overcoming this chal lenge will place immunotherapy at the forefront of HCC treatment,possibly in the near future.

关键词： Cell transfer immunotherapy Cytokine therapy Hepat

China ASON Network Migration Scenarios and Their Quantitative Analysis

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光学学报 2003年第S1期23卷 667-668页

作者： Soichiro Araki itaru Nishioka Yoshihiko Suemura Networking Research Laboratories NEC CorporationNetworking Research Laboratories NEC CorporationNetworking Research Laboratories NEC Corporation

This paper proposes two migration scenarios from China ring networks to ASON mesh networks. In our quantitative analysis with ASON/GMPLS simulator, a subnetwork protection scheme achieved best balanced performance in ... 详细信息

关键词： ASON it from for be In of China ASON Network Migration Scenarios and Their Quantitative Analysis LSC