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Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19

Journal of Geriatric Cardiology 2021年第5期18卷 338-345页

作者： Vincenzo De Marzo Antonio Di Biagio Roberta Della Bona Antonio Vena Eleonora Arboscello Harusha Emirjona Sara Mora Mauro Giacomini Giorgio Da Rin Paolo Pelosi Matteo Bassetti Pietro Ameri italo porto GECOVID study group Cardiovascular Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Internal Medicine University of GenovaGenovaItaly Infectious Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Health Sciences University of GenovaGenovaItaly Emergency Department IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly Laboratory Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Care Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Surgical Sciences and Integrated Diagnostics University of GenovaGenovaItaly

BACKGROUND Increases in cardiac troponin(cTn)in coronavirus disease 2019(COVID19)have been associated with worse ***,data about the significance of cTn in elderly subjects with COVID19 are *** From a registry of consecutive patients with COVID19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,we selected those≥60 yearold and with cTnI measured within three days from the molecular diagnosis of SARSCoV2 *** available,a second cTnI value within 48 h was also *** relationship between increased cTnI and allcause inhospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three *** Of 343 included patients(median age:75.0(68.0−83.0)years,34.7%men),88(25.7%)had cTnI above the upperreference limit(0.046μg/L).Patients with increased cTnI had more comorbidities,greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal ***,they died more(73.9%vs.37.3%,P<0.001)over 15(6−25)days of *** association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model(HR=1.61,95%CI:1.06−2.52,P=0.039)and was linear until 0.3μg/L,with a subsequent *** 191(55.7%)patients with a second cTnI measurement,49(25.7%)had an increasing trend,which was not associated with mortality(univariate HR=1.39,95%CI:0.87−2.22,P=0.265).CONCLUSIONS In elderly COVID19 patients,an initial increase in cTn is common and predicts a higher risk of *** cTn testing may not confer additional prognostic information.

关键词： patients mortality admitted

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A practical approach to the diagnosis of autoimmune pancreatitis

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World Journal of Gastroenterology 2011年第16期17卷 2076-2079页

作者： Luca Frulloni Antonio Amodio Anna Maria Katsotourchi italo Vantini Department of Medicine University of Verona Cattedra di Gastroenterologia Policlinico GB Rossi

Autoimmune pancreatitis is a disease characterized by specific pathological features,different from those of other forms of pancreatitis,that responds dramatically to steroid *** pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging,mimicking pancreatic ***,the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic *** in the presence of a pancreatic mass the probability of tumour is much higher than that of pancreatitis,the physician should be aware that in focal autoimmune pancreatitis the first step before using steroids is to exclude pancreatic *** this review,we briefly analyse the strategies to be followed for a correct diagnosis of autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis Therapy Diagnosis

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The silk road economic belt: balance of interests

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Economic and Political Studies 2018年第3期6卷 293-318页

作者： Yakov Silin Larisa Kapustina italo Trevisan Andrei Drevalev Department of Regional and Municipal Economics and Management Ural State University of EconomicsYekaterinburgRussia Department of Marketing and International Management Ural State University of EconomicsYekaterinburgRussia Department of Economics and Management University of TrentoTrentoItaly

The article makes an analogy between the Great Silk Road and the modern Belt and Road Initiative(BRI,also known as‘One Belt,One Road’[OBOR])of China in the context of their significance for the development of international trade,as well as the Central Asian *** historical role of the Silk Road is considered from the viewpoint of mutual benefit of states along the trade *** authors consider the concept as the co-development of states,suggested by China within the framework of the BRI,which involves international cooperation on the basis of mutual benefits for all participants,promotion of economic growth and welfare,development of modern infrastructure through joint *** attempt is made to assess the interests of Central Asian countries in the Silk Road Economic Belt(SREB)*** interests include construction of modern road infrastructure,exploration and extraction of mineral deposits,transportation of energy resources,establishment of logistics and industrial *** is an increase in the transit role of the Central Asian countries within the framework of the BRI,as well an increase in investments from *** countries along SREB are concerned about potential threats of the inflow of Chinese labour,the use of technologies that can cause environmental problems,the loss of control over strategic assets,and general growth of financial dependence on *** article analyses Russia’s perception of the Chinese *** is concluded that the main mutual interest of the two countries is opposing the US’s attempts to establish a dominating role in the region and thus ensuring the security of the transport system through the institutions of the Eurasian Economic Union(EAEU)and the Shanghai Cooperation Organisation(SCO).The authors reveal a trend of changing the role of Russia as the main transit corridor for Chinese goods exported to Europe and European ones imported to *** key long-term economic interests of China implement

关键词： Economy of China BRI(or OBOR) Silk Road Economic Belt(SREB) Silk Road Fund Eurasian integration

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SIR model applied in dynamics of COVID-19 contagion in S˜ao Lu´ıs-MA,Brazil

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第3期12卷 99-111页

作者： Felix Silva Costa italo Jose Lima De Sousa Jose Adson Reis Santos Department of Mathematics and Informatics State University of Maranhao Sao Luıs MA 65054-970Brazil

The dynamics of COVID-19 contagion investigated in S˜ao Lu′ıs-MA,Brazil,is based on the SIR model.S˜ao Lu′ıs was the first city in Brazil to implement the lockdown to control the *** SIR model’s definition and properties are presented in addition to the ways of estimating its *** estimation of their values is due to a database released on the Maranh˜ao State Health Department website during the period March 20 to July 2,*** analysis of the proliferation of the disease shows the evolution of the COVID-19 in the *** graphs illustrate that result.

关键词： COVID-19 population dynamics SIR model

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A remote sensing approach to estimate the load bearing capacity of soil

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Information Processing in Agriculture 2024年第1期11卷 109-116页

作者： italo Rômulo Mendes de Souza Edson Eyji Sano Renato Paiva de Lima Anderson Rodrigo da Silva Statistics and Geoprocessing Laboratory Instituto Federal GoianoGeraldo Silva Nascimento RoadKm 2.575790-000 UrutaíGoiásBrazil Embrapa Cerrados BR-020 RoadKm 18Mailbox 0822373310-970 PlanaltinaDFBrazil Department of Soil Science ‘Luiz de Queiroz’College of AgricultureUniversity of São PauloAv.Pádua Dias235-AgronomiaPiracicabaSP 13418-900Brazil

Preconsolidation pressure(σp)of soil can be considered as an indicator of the Load Bearing Capacity(LBC),which is the tolerated surface pressure before compaction,often caused by the traffic of agricultural *** this pioneering study,a remote sensing approach was introduced to estimate LBC throughσp from soils of the“Rio Preto”Hydrographic Basin,Bahia State,Brazil,in a monthly time lapse from 2016 to ***,σp is measured by a laborious and time demanding laboratory analysis,making it unfeasible to map large *** innovative methodology of this work consists of combining active–passive satellite data on soil moisture and pedotransfer functions of clay content and water matric potential to obtain geo-located estimates ofσ*** were analysed under different classes of soil use,land cover and slope;95%confidence intervals were built for the time series of mean values of LBC for each *** overall seasonal variation in LBC estimates is similar in areas with annual crops,grasslands and natural vegetation,and flat areas are less affected by soil moisture variations over the year(between seasons).LBC decreased,in general,at about 0.5%a year in flat ***,these areas demand attention,since they occupy 86%of the Basin and are mostly subjected to agricultural soil management and surface pressure by heavy machinery.

关键词： Soil compaction SMAP Preconsolidation stress Brazilian Cerrado

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Comparative Evaluation of the Efficacy of the Bimatoprost 0.03%, Brimonidine 0.2%, Brinzolamide 1%, Dorzolamide 2%, and Travoprost 0.004%/Timolol 0.5%-Fixed Combinations in Patients Affected by Open-Angle Glaucoma

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Open Journal of Ophthalmology 2012年第4期2卷 122-126页

作者： italo Giuffre Department of Ophthalmology Medical School Catholic University of Rome Rome Italy

Purpose: This is a retrospective, comparative, head-to-head, not commissioned study about the efficacy of bimato-prost 0.03%, brimonidine 0.2%, brinzolamide 1%, dorzolamide 2%, and travoprost 0.004%/timolol 0.5%-fixed combinations in patients affected by na?ve open-angle glaucoma and IOP > 25 mmHg. Patients and Methods: Files from 70 patients (35 M, 35 F, mean age 69.52 y, S.D. 11.56, range: 37-87y) in our Glaucoma Service were retrospectively analyzed as long as 12 months. Every subgroup, including 14 age- and sex-matched patients, was allocated to 1 of the 5 groups of the fixed combinations monotherapy. Data recorded after 3 months follow-up were statistically analyzed by descriptive and ANOVA statistics as percentage of IOP reduction from baseline. Results: All the fixed combinations were effective in lowering IOP. The mean percentage reduction was: brimonidine/timolol 43.57%, dorzolamide/timolol 37.67%, bimatoprost/timolol 35.60%, travoprost/timolol 33.25% and brinzolamide/timolol 23.0%. The brimonidine/timolol fixed combination showed to be statistically significant more effective only than brinzolamide/timolol fixed combination (p = 0.001). Setting the α error to 5%, the power of the study is 26%, phi: 0.842. Discussion: In all this cohort of patients the target IOP was successfully achieved. All the fixed combinations used in this study had a very good profile of efficacy. Brimonidine, dorzolamide, bimatoprost and travoprost/timolol fixed combinations statistically significantly reduced the percentage of IOP from baseline (p = 0.001) more than brinzolamide/timolol fixed combination.

关键词： Bimatoprost 0.03% Brimonidine 0.2% Brinzolamide 1% Dorzolamide 2% Travoprost 0.004%/Timolol 0.5% Fixed Combinations Efficacy IOP

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Ocular Surface Disease Index in Glaucomatous Patients Treated with Bimatoprost

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Open Journal of Ophthalmology 2014年第2期4卷 36-39页

作者： italo Giuffrè Department of Ophthalmology Medical School Catholic University of Rome Roma Italy

Objectives: To compare ocular surface changes induced via glaucoma treatment in patients using fixed combinations of bimatoprost 0.03%/timolol 0.50%, timolol 0.50% or bimatoprost 0.01% eye drops. Methods: This is a prospective, one center, open-label clinical trial. It was performed on 60 glaucoma patients between 01-01-2012 and 12-31-2012. These patients were randomly divided in three subgroups: bimatoprost 0.03%/timolol 0.50% fixed combination, timolol 0.50% and bimatoprost 0.01%. The Ocular Surface Disease Index (O.S.D.I.) was evaluated in all the glaucomatous patients of the three subgroups at basal time and after 6 and 12 months. All the results were statistically evaluated by Student t-test and one-way ANOVA. The results were considered statistically significant if p < 0.05. Results: All of the patients ended the clinical trial. There was no statistical significant difference between patients treated with the bimatoprost 0.03%/timolol 0.50% fixed combination and timolol 0.50% eye drops alone (p = 0.845). Instead, there was a statistically significant difference between bimatoprost 0.01% and bimatoprost 0.03%/timolol 0.50% patients (p = 0.05) and between bimatoprost 0.01% and timolol 0.50% eye drops alone (p = 0.049). Conclusions: This is a clinical trial based not on the hypotonising effect of these drugs but on their tolerability. The drug which showed the best tolerability is bimatoprost 0.01%.

关键词： Bimatoprost 0.01% Bimatoprost 0.03%/Timolol 0.50% Fixed Combination Glaucoma OSDI Timolol 0.50%

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Virtual Environment for Study and Training:Some 3D Issues

Virtual Environment for Study and Training:Some 3D Issues

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全国计算机辅助教育学会第八届学术年会

作者： italo De Diana Faculty of Educational Science and Technology University of Twente Centre for Telematics and Information Technology University of Twente The Netherlands

In this contribution an overview is given of some Human-Computer Interaction issues as they relate to Interactive Environments for Training and *** is argued that nowadays we are witnessing a shift from rather unnatural looking’flat’two dimensional interfaces to three dimensional *** 3D interfaces can be very realistic and attractive from the point of view of interactive,computer-based training and *** shift is made possible by the application of Virtual Reality technology.A sample prototype of a 3D VR interface for study and training as it has been developed at the University of Twente in The Netherlands will be discussed.

关键词： Virtual Reality Learning Environment 3D Interface

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Model of Wetland Carbon Sequestration in the Venetian Lagoon, Italy

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Journal of Environmental Science and Engineering(B) 2013年第11期2卷 657-671页

作者： Mauro Doimi Angelo Ferrari Daniele DalMolin italo Gardan D&D Consulting s.a.s. Department of lnternational and Environmental Research Venice 30171 Italy Veterinary Medical Research Institute for Piemonte Liguria and the Valle d'Aosta (IZS) Genoa 16129 Italy Bios s.r.l. Department of Environmental Certification BNeutral Marostica 36063 Italy Lecher Research Lab Department Analytical Environmental Services Salzano 30030 Italy

This research deals with an evaluation of the sink of greenhouse gas CO2 in a eutrophic area of the Venetian lagoon where fish is farmed （＂Valle da pesca＂）. Following CDM UNFCCC （Clean Development Mechanism United Nations Framework Convention on Climate Change） criteria, this can be considered relevant to the international standard for the voluntary evaluation of carbon credits on the basis of Annex a of Kyoto Protocol. To identify the ＂Valle da pesca＂ brackish lagoon properties regulating the carbon dioxide （CO2）, a survey has been performed during three seasons in one year and in four different locations. These places are located in the Italian Venetian Lagoon and in the Grado Lagoon in North Italy, Europe. To identify the CO2 sink capacity, a special index is calculated. The CO2 concentrations and sink are regulated by the balance of autotrophic and heterotrophic activities, and the sediment anoxic denitrification and macro algae are crucial tank of CO2 in the valley shallow waters. The ponds potential-CO2 yield of 80-124 kg/m2 per year and the value are related and proportional to the correct human environmental control （water flux control）.

关键词： Carbon sink lagoon fish ponds Valle da pesca Italy.

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Implications of helminth immunomodulation on COVID-19 co-infections

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Life Research 2021年第3期4卷 81-96页

作者： Nathalie Chacon Leonor Chacin-Bonilla italo M.Cesari School of Medicine.Department of Public Health.University of Texas Rio Grande Valley EdinburgUSA Institute of Clinical Research.Zulia State University MaracaiboVenezuela Immunoparasitology Laboratory Center for Microbiology and Cell BiologyVenezuelan Institute of Scientific ResearchAltos de PipeVenezuela

Coronavirus disease 2019(COVID-19)and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized *** coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+T cells,eosinophils,interleukin-4,interleukin-5,and *** the early stages of severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)infection,virus-specific Th1 cytotoxic CD8+T cell,interleukin-6,interferon-γ,and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs,like the ***4+and CD8+T cells are associated with protective immunity against and during ***,viral evasion mechanisms *** of the interferon-γsecretion,like in helminths immunomodulation,can contribute to COVID-19 *** can result in mild,moderate,or severe COVID-19 depending on which helminth is coinfecting by regulating or avoiding host cytokine and pro-inflammatory response,decreasing viral load,and affecting vaccine-induced antibody *** discuss the implications of immunomodulation on COVID-19 caused by helminth co-infection and for public health in the context of COVID-19 vaccine use in helminth endemic zones.

关键词： Co-infection COVID-19 Developing country Helminth Immunomodulation SARS-CoV-2

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