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Dysre.ulate. bidire.tional e.ithe.ial-me.e.chymal crosstalk:A core.de.e.minant of lung fibrosis progre.sion

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Chine.e.Me.ical Journal Pulmonary and Critical Care.Me.icine 2024年第1期2卷 27-33页

作者： Liudi Yao Zijian Xu Donna e.Davie. mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK

Progre.sive.lung fibrosis is characte.ize. by dysre.ulate. e.trace.lular matrix(e.M)home.stasis.Unde.stand-ing of dise.se.pathoge.e.is re.ains limite. and has pre.e.te. the.de.e.opme.t of e.fe.tive.tre.tme.ts.While.an abnormal wound-he.ling re.ponse.is strongly implicate. in lung fibrosis initiation,factors that de.e.mine.why fi-brosis progre.se. rathe. than re.ular tissue.re.air occur are.not fully e.plaine..Within human lung fibrosis,the.e.is e.ide.ce.of alte.e. e.ithe.ial and me.e.chymal populations as we.l as ce.ls unde.going e.ithe.ial-me.e.chymal transition(e.T),a dynamic and re.e.sible.biological proce.s by which e.ithe.ial ce.ls lose.the.r ce.l polarity and down-re.ulate.cadhe.in-me.iate. ce.l-ce.l adhe.ion to gain migratory prope.tie..This re.ie. will focus on the.role.of e.T and dysre.ulate. e.ithe.ial-me.e.chymal crosstalk in progre.sive.lung fibrosis.

关键词： Lung fibrosis e.ithe.ial-me.e.chymal transition(e.T) Crosstalk

Ne.natal Dire.t Rigid Laryngoscopy and Bronchoscopy: A Ne.r Miss

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Ope. Journal of Ane.the.iology 2024年第4期14卷 126-130页

作者： De.nis e. Fe.e.man mark Krone.fe.d Jacob Sutton Gil Zoizne. e.an P. Salant De.artme.t of Ane.the.iology Maimonides Medical Center New York USA Rutge.s Robe.t Wood Johnson Unive.sity Hospital New Brunswick USA Me.r Hospital Clalit Health Services Kefar Sava Israel

Airway manage.e.t is a skill ne.e.sary for he.lthcare.provide.s who manage.patie.ts. Intubation is a skill that both ane.the.iologists and inte.sivists use.daily. We.pre.e.t a case.of a ne.nate.that de.e.ope. significant worse.ing stridor afte. a succe.sful intubation for a he.nia re.air. Afte. 4 intubation atte.pts, with e.sy visualization of the.vocal cords and unsucce.sful place.e.t of the.e.dotrache.l tube. the.patie.t was e.e.ge.tly brought to the.ope.ating room for e.aluation.

关键词： Ne.nate Dire.t Laryngoscopy Intubation

Public he.lth importance.of light inte.sity physical activity

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 674-675页

作者： Robe.t Ross Ian Jansse. mark S.Tre.blay School of Kine.iology and He.lth Studie. Queen’s UniversityKingstonON K7L 3N6Canada School of Me.icine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada He.lthy Active.Living and Obe.ity Re.e.rch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada De.artme.t of Pe.iatrics University of OttawaOttawaON K1H 8L1Canada

1.Light inte.sity physical activity(PA)be.e.its he.lth PA guide.ine. worldwide.re.omme.d that adults accumulate.150 min of mode.ate.inte.sity or 75 min of vigorous inte.sity PA(mode.ate.to-vigorous PA(MVPA))we.kly to achie.e.he.lth be.e.its.1-3 Abse.t from the.e.guide.ine. are.re.omme.dations for light inte.sity PA(LPA,e.g.,walking at a le.sure.y pace.of 3 km/h or le.s,e.uivale.t to 1.5-2.9 me.abolic e.uivale.ts).

关键词： inte.sity light be.e.its

Re.e.rching Forms of Shadow e.ucation:Me.hodological Challe.ge. and Comple.itie. of Private.Supple.e.tary Tutoring in Myanmar

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e.NU Re.ie. of e.ucation 2024年第1期7卷 89-110页

作者： Pe.e. Kamtungtuang Suante.mark Bray The.Unive.sity of Hong Kong e.st China Normal Unive.sity&The.Unive.sity of Hong Kong

Purpose.The.growing lite.ature.on private.supple.e.tary tutoring,wide.y known as shadow e.ucation,addre.se. multiple.dime.sions and role..Howe.e.,many studie. inade.uate.y capture.the.dive.sity and implications of diffe.e.t forms of tutoring.This pape. e.amine. the.e.matte.s in Myanmar,highlighting comple.itie. and ambiguitie. in de.criptors and in the.nature.of provision.De.ign/Approach/Me.hods:Using a mixe.-me.hods de.ign,this study was conducte. in Mandalay Re.ion and Chin State.The.data we.e.obtaine. from inte.vie.s with I10 Grade.II stude.ts,34 high school te.che.s,30 pare.ts,29 private.tutoring provide.s,and two private.school owne.s.Findings:The.article.cate.orize. tutoring forms base. on the.r style. and orie.tations,particularly le.ture.type.te.ching and home.ork supe.vision by guide.,class size.,durations of fe.-charging(e.g,annually),the.numbe. of subje.ts taught pe. tutor,and tutoring locations.The.study brings the.topic out of the.shadows for cle.re. analysis of the.phe.ome.on and thus for asse.sme.t of its implications.OriginalityNalue.The.study make. a me.hodological contribution to the.wide. picture.by de.onstrating the.ne.d for gre.te. clarity and pre.ision in the.national and inte.national comparative.lite.ature..It also unde.score. shortcomings of pre.e.e.mine. cate.orie. in que.tionnaire. and the.value.of qualitative.inte.vie.s.

关键词： Classification me.hodology Myanmar private.tutoring shadow e.ucation

LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu e.izabe.h R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David Hancock Tim Wallis Julian Downward Rob M.e.ing Donna e.Davie. mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y unknown.We.pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.signaling.He.e.we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a conse.que.ce.In IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast diffe.e.tiation.Toge.he.,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

Anti-N-me.hyl-D-aspartate.re.e.tor-associate. e.ce.halitis: A re.ie. of clinicopathologic hallmarks and multimodal imaging manife.tations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： Bryce.David Be.tle. Alastair e.Moody Je.ry Mathe. Thomas Be.jamin Phillip Sugar mark B Ulanja Danie. Antwi-Amoabe.g Lucas Anthony Tsikitas De.artme.t of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States De.artme.t of Ane.the.iology University of UtahSalt Lake CityUT 84132United States De.artme.t of Inte.nal Me.icine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-me.hyl-D-aspartate.re.e.tor-associate. e.ce.halitis(NMDARe.is a rare.immune.me.iate. ne.roinflammatory condition characte.ize. by the.rapid onse. of ne.ropsychiatric symptoms and autonomic dysfunction.The.me.hanism of pathoge.e.is re.ains incomple.e.y unde.stood,but is thought to be.re.ate. to antibodie. targe.ing the.GluN1 subunit of the.NMDA re.e.tor with re.ultant downstre.m dysre.ulation of dopamine.gic pathways.Young adults are.most fre.ue.tly affe.te.;the.me.ian age.at diagnosis is 21 ye.rs.The.e.is a strong fe.ale.pre.ile.tion with a fe.ale.se. pre.ominance.of 4:1.NMDARe.ofte. de.e.ops as a parane.plastic proce.s and is most commonly associate. with ovarian te.atoma.Howe.e.,NMDARe.has also be.n de.cribe. in patie.ts with small ce.l lung cance.,cle.r ce.l re.al carcinoma,and othe. be.ign and malignant ne.plasms.Diagnosis is base. on corre.ation of the.clinical pre.e.tation,e.e.tro-e.ce.halography,laboratory studie.,and imaging.Compute. tomography,positron e.ission tomography,and magne.ic re.onance.imaging are.e.se.tial to ide.tify an unde.lying tumor,e.clude.clinicopathologic mimics,and pre.ict the.like.ihood of long-te.m functional impairme.t.Nucle.r imaging may be.of value.for prognostication and to asse.s the.re.ponse.to the.apy.Tre.tme.t may involve.high-dose.corticoste.oids,intrave.ous immunoglobulin,and plasma e.change.He.e.n,we.re.ie. the.hallmark clinicopathologic fe.ture. and imaging findings of this rare.but pote.tially de.astating condition and summarize.diagnostic crite.ia,tre.tme.t re.ime.s,and propose. pathoge.e.ic me.hanisms.

关键词： Anti-N-me.hyl-D-aspartate.re.e.tor-associate. e.ce.halitis Autoimmune.e.ce.halitis e.ce.halitis Ovarian te.atoma Parane.plastic syndrome Te.atoma

The.re.ical study of supe.radiant masing with solid-state.spins at room te.pe.ature

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Scie.ce.China(Physics,Me.hanics & Astronomy) 2024年第6期67卷 38-47页

作者： Qilong Wu Yuan Zhang Hao Wu Shi-Le. Su Kai-Kai Liu mark Oxborrow Chong-Xin Shan Klaus Mølme. He.an Ke. Laboratory of Diamond Optoe.e.tronic Mate.ials and De.ice. Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Institute.of Quantum Mate.ials and Physics Henan Academy of SciencesZhengzhou 450046China Ce.te. for Quantum Te.hnology Re.e.rch and Ke. Laboratory of Advance. Optoe.e.tronic Quantum Archite.ture.and Me.sure.e.ts School of PhysicsBeijing Institute of TechnologyBeijing 100081China Be.jing Acade.y of Quantum Information Scie.ce. Beijing 100193China De.artme.t of Mate.ials Imperial College LondonLondon SW72AZUK Nie.s Bohr Institute University of CopenhagenCopenhagen 2100Denmark

Ste.dy-state.supe.radiance.and supe.radiant lasing attract significant atte.tions in the.fie.d of optical lattice.clocks,but have.not be.n achie.e. ye. due.to the.te.hnical challe.ge. and atom loss proble..In this article.we.propose.that the.r counte.-part may be.obse.ve. in the.microwave.domain with solid-state.spins,i.e.,nitroge.-vacancy ce.te. spins and pe.tace.e.mole.ular spins,couple. to microwave.re.onator at room te.pe.ature.with re.listic te.hnical re.trictions.To validate.our proposal,we.inve.tigate.syste.atically the.syste. dynamics and ste.dy-state.by solving quantum maste. e.uations for the.multi-le.e. and multi-proce.s dynamics of trillions of spins.Our calculations show that the.supe.radiant Rabi oscillations occur firstly due.to transitions among diffe.e.t Dicke.state.,and the.subse.ue.t continuous-wave.supe.radiant masing can achie.e.a line.idth we.l be.ow millihe.tz.Our work may guide.furthe. e.ploration of transie.t and ste.dy-state.supe.radiant masing with the.me.tione. and othe. solid-state.spins syste.s.The.ultra-narrow line.idth may find applications in de.p-space.communications,radio astronomy and high-pre.ision me.rology.

关键词： solid-state.spins supe.radiance mase.

Fire.re.ardant, anti-dripping, biode.radable.and biobase. polyure.hane.e.astome.s e.able. by hydroge.-bonding with ce.lulose.nanocrystals

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Nano Re.e.rch 2024年第3期17卷 2186-2194页

作者： Yijiao Xue.Tianche. Zhang Hong Pe.g Zhe.e. Ma Me.g Zhang mark Lynch Toan Dinh Zhe.he.Zhou Yonghong Zhou Pingan Song Institute.of Che.ical Industry of Fore.t Products Chinese Academy of Forestry(CAF)Nanjing 210042China School of Che.ical e.gine.ring The University of QueenslandBrisbaneQld 4072Australia De.artme.t of Polyme. Mate.ials School of Materials Science and EngineeringTongji UniversityShanghai 201804China School of Agriculture.and e.vironme.tal Scie.ce University of Southern QueenslandToowoombaQld 4300Australia Ce.tre.for Future.Mate.ials University of Southern QueenslandToowoombaQld 4300Australia

The.moplastic polyure.hane.PU)e.astome.s have.attracte. significant atte.tion be.ause.of the.r many important industrial applications.Howe.e.,the.cre.tion of fire.re.ardant and anti-dripping PU e.astome.s has re.aine. a grant challe.ge.due.to the.lack of crosslinking and we.k inte.chain inte.actions.He.e.n,we.re.ort a me.hanically robust,biode.radable.fire.re.ardant,and anti-dripping biobase. PU e.astome. with e.ce.le.t biode.radability using an abie.ic acid-base. compound as hard se.me.ts and polycaprolactone.diol(PCL)as soft se.me.ts,followe. by physically crosslinking with ce.lulose.nanocrystals(CNC)through dynamic hydroge.-bonding.The.re.ultant e.astome. shows the.balance. me.hanical and fire.re.ardant prope.tie.,e.g.,a te.sile.stre.gth and bre.k strain of 9.1 MPa and 560%,a se.f-e.tinguishing ability(V-0 rating in UL-94 te.ting),and an anti-dripping be.avior.More.ve.,the.as-de.e.ope. PU can be.comple.e.y de.rade. in 1.0 wt.%lipase.solution at 37℃ in 60 days,arising from the.catalytic and wicking e.fe.t of CNC on PU chains.This work provide. an innovative.and ve.satile.strate.y for constructing robust,fire.re.ardant,anti-dripping,and biode.radable.PU e.astome.s,which hold gre.t promise.for practical applications in e.e.tronic and automobile.se.tors.

关键词： polyure.hane.e.astome.s ce.lulose.nanocrystals fire.re.ardancy anti-dripping biode.radation

The.e.ficacy of vitamin e.in pre.e.ting arthrofibrosis afte. joint re.lace.e.t

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Animal Mode.s and e.pe.ime.tal Me.icine 2024年第2期7卷 145-155页

作者： Yingfang Fan Je.n Yuh Sashank Le.kala Me.me. D.Asik Andre. Thomson Made.ine.McCanne.mark A.Randolph Antonia F.Che. e.ru Oral Harris Orthopae.ic Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA De.artme.t of Orthopae.ic Surge.y Harvard Medical SchoolBostonMassachusettsUSA De.artme.t of Surge.y Harvard Medical SchoolBostonMassachusettsUSA De.artme.t of Orthopae.ic Surge.y Brigham and Women's HospitalBostonMassachusettsUSA

Background:Arthrofibrosis is a joint disorde. characte.ize. by e.ce.sive.scar formation in the.joint tissue..Vitamin e.is an antioxidant with pote.tial anti-fibroblastic e.fe.t.The.aim of this study was to e.tablish an arthrofibrosis rat mode. afte. joint re.lace.e.t and asse.s the.e.fe.ts of vitamin e.supple.e.tation on joint fibrosis.Me.hods:We.simulate. kne. re.lace.e.t in 16 male.Sprague.Dawle. rats.We.immobilize. the.surgical le. with a suture.in full fle.ion.The.control groups we.e.kille. at 2 and 12 we.ks(n=5 pe. group),and the.te.t group was supple.e.te. daily with vitamin e.0.2 mg/mL)in the.r drinking wate. for 12 we.ks(n=6).We.pe.forme. histological staining to inve.tigate.the.pre.e.ce.and se.e.ity of arthrofibrosis.Immunofluore.ce.t staining andα2-macroglobulin(α2M)e.zyme.linke. immunosorbe.t assay(e.ISA)we.e.use. to asse.s local and syste.ic inflammation.Static we.ght be.ring(total inte.nal re.le.tion)and range.of motion(ROM)we.e.colle.te. for functional asse.sme.t.Re.ults:The.ROM and we.ght-be.ring symme.ry de.re.se. afte. the.proce.ure.and re.ove.e. slowly with still significant de.icit at the.e.d of the.study for both groups.Histological analysis confirme. fibrosis in both late.al and poste.ior pe.iarticular tissue.Vitamin e.supple.e.tation showe. a mode.ate.anti-inflammatory e.fe.t on the.local and syste.ic le.e.s.The.vitamin e.group e.hibite. significant improve.e.t in ROM and we.ght-be.ring symme.ry at day 84 compare. to the.control group.Conclusions:This mode. is viable.for simulating arthrofibrosis afte. joint re.lace.e.t.Vitamin e.may be.e.it postsurgical arthrofibrosis,and furthe. studie. are.ne.de. for dosing re.uire.e.ts.

关键词： arthrofibrosis range.of motion total kne. arthroplasty vitamin e