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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-Lin ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Physics-informed machine learning for metamodeling thermal comfort in non-air-conditioned buildings

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Building Simulation 2023年第2期16卷 299-316页

作者： issa Jaffal Laboratoire du froid et des systèmesénergétiques et thermiques(Lafset) CnamHESAM UniversitéParisFrance

There is a growing need for accurate and interpretable machine learning models of thermal comfort in ***-informed machine learning could address this need by adding physical consistency to such *** paper presents metamodeling of thermal comfort in non-air-conditioned buildings using physics-informed machine *** studied metamodel incorporated knowledge of both quasi-steady-state heat transfer and dynamic simulation *** thermal comfort in an office located in cold and hot European climates was studied with the number of overheating hours as index.A one-at-a-time method was used to gain knowledge from dynamic simulation with TRNSYS *** knowledge was used to filter the training data and to choose probability distributions for metamodel forms alternative to *** response of the dynamic model was positively skewed;and thus,the symmetric logistic and hyperbolic secant distributions were inappropriate and outperformed by positively skewed *** physical knowledge into the metamodel was much more effective than doubling the size of the training *** highly flexible Kumaraswamy distribution provided the best performance with R2 equal to 0.9994 for the cold climate and 0.9975 for the hot ***-informed machine learning could combine the strength of both physics and machine learning models,and could therefore support building design with flexible,accurate and interpretable metamodels.

关键词： adaptive thermal comfort overheating physics-informed machine learning metamodel surrogate model probability distributions

光照不均匀条件下无人机航拍低照度图像增强方法

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现代电子技术 2025年第1期48卷 55-59页

作者：黄静欧余韬桂林电子科技大学计算机工程学院广西北海536000

增强图像时高低频参数未增强,没有更好地保留图像的细节和平衡图像的亮度,因此,提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像,实现无人机航拍图像中的噪声抑制,将预处理后的图像通过... 详细信息

增强图像时高低频参数未增强,没有更好地保留图像的细节和平衡图像的亮度,因此,提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像,实现无人机航拍图像中的噪声抑制,将预处理后的图像通过小波分解得到图像的高频参数和低频参数,分别通过双边滤波算法、软阈值方法和直方图对图像的低频参数和高频参数进行增强,采用小波重构对增强后的图像高频参数和低频参数进行重构,得到增强后的无人机航拍图像。通过实验验证,该方法能够实现一种效果较好的图像增强,在原始图像基础上,通过文中方法增强原始亮度8.14%、对比度提高了37.90%以及清晰度增加了31.01%,使得图像的整体质量得到了显著提升,为后续的图像分析、处理提供了更加准确、丰富的信息。

关键词：无人机航拍低照度图像增强高斯滤波小波分解与重构双边滤波算法软阈值方法

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Analysis of Chinese Anti-Suit Injunctions in SEP Litigation

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科技与法律（中英文） 2025年第1期 138-148页

作者： ou Fuyong Zhang Xiaoxiao Law School Hunan Normal UniversityChangsha 410081China

In this article,two cases of Standard Essential Patents,ruled by the Supreme People's Court of the People's Republic of China,are presented and *** first Chinese anti-suit injunction in SEP litigation appeared in the first case through the method of behavior preservation,and the second case illustrates a clear intent by the Chinese courts to compete for global royalty rate *** international concerns raised about these cases,it is proved that the anti-suit injunction cases in China do not show any abusive or illegal *** worldwide anti-suit injunctions in China are granted legitimately with legal jurisdiction over the cases,sufficient legal grounds for behavior preservation with the nature of anti-suit injunctions,the necessity of granting worldwide injunctions,and suitable granting *** pieces of advice are proposed for the future application of anti-suit injunctions,including improvements in the predictability of validity scope,consistency of implementation,and clarification of penalties.

关键词： anti-suit injunction anti-anti-suit injunction FRAND royalty rate jurisdiction SEP

A Review on Thermophysical Properties and Nusselt Number Behavior of Al2O3 Nanofluids in Heat Exchangers

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Journal of Thermal Science 2021年第2期30卷 418-431页

作者： issa Roy Jean College of Engineering West Texas A&M UniversityCanyonTexas 79016USA

During the last several years,the increase in cooling power requirements for heat exchangers have led to an escalation in heat transfer studies being performed on the use of nanofluids as heat transfer ***,limited effort has been attempted to relate and interpret these findings or the anomalies associated with *** paper compiles test data from several studies conducted on different types of heat *** this review,a concentrated effort is spent to clarify the ambiguities regarding the effect of nanoparticle size on the nanofluid thermal conductivity and Nusselt *** show that the nanofluid thermal conductivity is not influenced by the nanoparticle size,but by the clustering of the particles *** less compact the structure of the nanoparticle clustering is,the greater the enhancement in the nanofluid thermal conductivity *** were also compiled to interpret the relation between the nanofluid flow pattern,nanoparticles volume fraction in the base fluid,and the convective heat *** results from the majority of the heat exchanger studies show an increase in the heat transfer coefficient with the increase in nanoparticle volume ***,studies conducted on plate heat exchanges display some *** the majority of the heat exchanger studies with the exception of few,the decrease in the nanoparticle size is shown to result in an enhancement of the bulk fluid Nusselt *** test data also reveal that the effectiveness of the alumina nanoparticles is dependent on the flow *** increase in the nanoparticles concentration is shown to result in an increase in the nanofluid heat transfer enhancement as the fluid is transitioning from laminar to turbulent *** general,the smaller the nanoparticle size is,the greater the enhancement in the fluid Nusselt number is.

关键词： heat exchanger Nusselt number alumina nanofluid

Heat Transfer Optimization for Air-Mist Cooling between a Stack of Parallel Plates

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Journal of Thermal Science 2010年第3期19卷 253-260页

作者： Roy J.issa Mechanical Engineering Division Department of Engineering and Computer Science West Texas A&M University CanyonTexas 79016USA

A theoretical model is developed to predict the upper limit heat transfer between a stack of parallel plates subject to multiphase cooling by air-mist *** model predicts the optimal separation distance between the plates based on the development of the boundary layers for small and large separation distances,and for dilute mist *** results show the optimal separation distance to be strongly dependent on the liquid-to-air mass flow rate loading ratio,and reach a limit for a critical *** these dilute spray conditions,complete evaporation of the droplets takes *** results also show the optimal separation distance decreases with the increase in the mist flow *** proposed theoretical model shall lead to a better understanding of the design of fins spacing in heat exchangers where multiphase spray cooling is used.

关键词： Air-mist Multiphase Heat transfer Liquid-to-air loading

A macro-level global seismic damage model considering higher modes

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Earthquake Engineering and Engineering Vibration 2014年第3期13卷 425-436页

作者： He Zheng ou Xiaoying ou Jinping Department of Civil Engineering Dalian University of Technology School of Civil Engineering Harbin Institute of Technology

For modal pushover analysis procedures, the model proposed by Ghobarah et al. （called the G model hereafter, 1999） has been extended to account for the contributions of transient higher modes to global seismic damage of structures excited by strong ground motions. The proposed model has physically and perfectly bridged the G model and the final softening model proposed by DiPasquale and Cakmak （1988）. Modal damage indexes corresponding to all considered vibration modes are combined by the CQC rule or the SRSS rule. Incremental dynamic analysis （IDA） is performed on three example RC frames to validate the proposed model, and a comprehensive comparison is carried out. The demonstration indicates that the proposed model is easy to implement and reflects the influence of the transition in transient vibration periods and modes on structural damage evolution. Some limitations associated with the proposed model are also addressed. Further experimental validations are needed to improve the model in the future.

关键词： seismic damage modal pushover analysis incremental dynamic analysis

Physical modeling of behaviors of cast-in-place concrete piled raft compared to free-standing pile group in sand

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第4期10卷 703-716页

作者： Mehdi Sharafkhah issa Shooshpasha Faculty of Civil Engineering Babol Noshiravani University of Technology

Similar to free-standing pile groups, piled raft foundations are conventionally designed in which the piles carry the total load of structure and the raft bearing capacity is not taken into account. Numerous studies indicated that this method is too conservative. Only when the pile cap is elevated from the ground level,the raft bearing contribution can be neglected. In a piled raft foundation, pileesoileraft interaction is complicated. Although several numerical studies have been carried out to analyze the behaviors of piled raft foundations, very few experimental studies are reported in the literature. The available laboratory studies mainly focused on steel piles. The present study aims to compare the behaviors of piled raft foundations with free-standing pile groups in sand, using laboratory physical models. Cast-in-place concrete piles and concrete raft are used for the tests. The tests are conducted on single pile, single pile in pile group, unpiled raft, free-standing pile group and piled raft foundation. We examine the effects of the number of piles, the pile installation method and the interaction between different components of foundation. The results indicate that the ultimate bearing capacity of the piled raft foundation is considerably higher than that of the free-standing pile group with the same number of piles. With installation of the single pile in the group, the pile bearing capacity and stiffness increase. Installation of the piles beneath the raft decreases the bearing capacity of the raft. When the raft bearing capacity is not included in the design process, the allowable bearing capacity of the piled raft is underestimated by more than 200%. This deviation intensifies with increasing spacing of the piles.

关键词： Free-standing pile group Piled raft Pileesoileraft interaction Physical modeling Cast-in-place concrete piles